CN100493576C - Chinese medicine preparation for treating diabetic eye complication - Google Patents
Chinese medicine preparation for treating diabetic eye complication Download PDFInfo
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- CN100493576C CN100493576C CNB2006100509695A CN200610050969A CN100493576C CN 100493576 C CN100493576 C CN 100493576C CN B2006100509695 A CNB2006100509695 A CN B2006100509695A CN 200610050969 A CN200610050969 A CN 200610050969A CN 100493576 C CN100493576 C CN 100493576C
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Abstract
The Chinese medicine preparation for treating diabetes and chronic diabetic retinopathy includes one recipe I and one recipe II capable of being used alone. The recipe I consists of astragalus root, gastrodia tuber, glossy ganoderma and other four kinds of Chinese medicinal materials in certain weight proportion; and the recipe II consists of astragalus root, gastrodia tuber and glossy ganoderma in certain weight proportion. The recipe I and the recipe II are prepared through conventional preparation process into medicine powder or capsule. During treatment, the recipe I medicine is first taken until basically recovering, and the recipe II medicine is then taken for curing radically. Compared with available technology, the present invention has the advantages of determined curative effect and no side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, relate in particular to a kind of Chinese medicine preparation for the treatment of diabetes and ocular complications, oral formulations.
Background technology
Diabetes are commonly encountered diseases, frequently-occurring diseases of harm people's health.Diabetes are one of big killers of four in the modern disease, and its harm to human body is only second to cancer.In fact, diabetes itself are not fearful, fearful is the complication of diabetes, the harm that diabetes are brought, nearly all from its complication, the complication of diabetes is the metabolic syndromes that caused by Different types of etiopathogenises, it is general, can cause the morbidity of all histoorgans of human body, be the multiple chronic complicating diseases that produces on arteriosclerosis and microangiopathies basis, causes losing one's sight as diabetic cardiopathy, diabetic retina capillary vessel pathological changes etc.If blood glucose can not get effective control for a long time, will each organ of harmful to human, cause each organ injury such as the heart, brain, kidney, nerve, eyes.Data according to World Health Organization's issue shows, at present, distribution of diabetes is only second to ND cardiovascular and cerebrovascular vessel, cerebrovascular disease and tumor, has every year the millions of people to lose one's sight because of diabetes in the world or dies from complication, and diabetes are serious threat human life and health.Data showed in 1996, and the diabetes prevalence of China reaches 3.21%, and annual rate of growth is about 0.1%.According to estimates, present national diabetics sum has reached about 4,000 ten thousand.In China, diabetes have become the main cause that causes liver, the depleted disease of kidney merit, though diabetes are difficult to radical cure, can control fully, can adopt drug treatment, blood sugar lowering, because some complication also can be done some treatments with agents alleviate, what have then needs the treatment that undergos surgery, then need be in hospital's treatment that undergos surgery as ophthalmology diabetic retina capillary vessel pathological changes, because technological progress, hypertrophy retina capillary vessel disease surgery success rate improves greatly.In addition, in motherland's traditional Chinese medical science treasure-house, many prescriptions and proved recipe are arranged for all kinds diabetes, as application number CN200410064515.4, name is called " Chinese medicine preparation and the preparation method of treatment diabetic chronic retinopathy " and introduces a kind of Chinese medicine preparation and preparation method for the treatment of diabetic chronic retinopathy, is used to solve the problem that adopts Chinese medicine preparation treatment diabetic chronic retinopathy.Its scheme is, described medicament is by Radix Trichosanthis 15～30, winged euonymus 15～30, and Flos Carthami 5～15, Flos Buddlejae 5～15, Folium Mori 10～20, Flos Chrysanthemi 10～20 is formed, through batching, pulverize and make powder.This invention preparation is with clearing away heat and promoting production of body fluid, blood circulation promoting and blood stasis dispelling and execute, and is used for diabetes deficiency of both qi and yin with blood stasis disease and sees blurring of vission.Its prescription Chinese medicine active component can suppress aldose reductase, effectively delays, stops the generation of diabetic renal papillary necrosis.Nephropathy, neuropathy to diabetic complication also have good therapeutical effect.It is CN91108966.7 that application number is arranged in addition, name is called " a kind of compound for reducing blood suger and manufacture method thereof of making eye bright ", application number is CN98121682.X, name is called＜Typhlosis-resistant liquid for ophthalmopathy as complication of diabetes〉and application number be CN00110652.X, name is called patent applications such as " ' Yanming ' capsules for clearing eyes " and has also introduced the application that some treat the diabetes Chinese medicine preparation.
The Chinese medicine preparation of some treatment diabetes has the advantage of improving clinical symptoms in the Chinese medicine.Sometimes, though the patient takes a large amount of Western medicine antidiabetic drugs, even multiple antidiabetic drug uses simultaneously, clinical symptoms still can not be alleviated, sometimes even blood glucose may occur having reduced, and the situation that diabetic symptom increases the weight of on the contrary, at this moment, use some treatments by Chinese herbs if add, then can improve symptoms such as patient's bitter taste in the mouth and dry throat, tired, dizziness and blurred vision, insomnia rapidly.
The present invention seeks to develop one and be used for the treatment of the Chinese medicine preparation that diabetes have good curative effect, through years of researches relevant treat diabetes experience of tcm and materia medica theory, by self practice, constantly sum up and innovation, invented this finally and be used for the treatment of the extract oral medicament of diabetes.Wherein one side, Er side all can set up and use Er side that some serious symptoms or particularly retinopathy complication of diabetes are used separately, after using one side, the state of an illness turns for the better by and large, patient still has under the situation of some corresponding symptoms, answer the treatment of Huan Yong Er side this moment, ocular disease can better be recovered.Event one side, Er side is all a treatment prescription, lists in the present patent application to propose.
Summary of the invention
A kind of Chinese medicine preparation for the treatment of diabetic eye complication, it is characterized in that preparation is for being Cordyceps 10～20: the Radix Astragali 10～20: Rhizoma Gastrodiae 100～150: Bulbus Lilii 10～20: the Radix Paeoniae Alba 10～20: Radix Puerariae 7～15: Caulis Bambusae In Taeniam 12～20 by prescription one side of mass ratio: Ganoderma 10～20 is formed Er side by Cordyceps 5～10: the Radix Astragali 10～20: Rhizoma Gastrodiae 100～750: Ganoderma 60～100 is formed, the Chinese medicine preparation manufacture method is to mix according to the load weighted Chinese medicine of prescription, and the conventional manufacture method of the powder of employing Chinese medicine promptly can be produced the Chinese medicine preparation of this medicine.
The Chinese medicine preparation of this treatment diabetic eye complication, it is characterized in that its optimum formula, one side's oral formulations is Cordyceps 10: the Radix Astragali 20: Rhizoma Gastrodiae 150: Bulbus Lilii 10: the Radix Paeoniae Alba 10: Radix Puerariae 15: Caulis Bambusae In Taeniam 20 by mass ratio: Ganoderma 20 is formed ， Er side by Cordyceps 5: the Radix Astragali 10: Rhizoma Gastrodiae 720: Ganoderma 65 is formed.
The production method of the Chinese medicine preparation of this treatment diabetic eye complication, it is characterized in that wherein production method is to make according to the method for conventional Chinese medicine patent medicine, with each Chinese medicine of above-mentioned prescription at normal temperatures with them, behind the pulverize separately, powder is crossed 50～80 mesh sieves, uniform mixing then, and packing is gone in the medicated bag, or divide in the capsule of packing into, promptly get oral powder, capsule.
Below introduce Chinese medicine character effect used among the above-mentioned we:
Cordyceps: Cordyceps sinensis again, Cordyceps.Be the Stroma of Clavicipitaceae plant Cordyceps fungus and the larva cadaveric complex of parasitic Hepialidae insecticide Cordyceps Hepialus armorieanus Oberthur thereof.Nature and flavor: sweet, warm.Function cures mainly: tonify deficiency profit and loss vital essence, relieving cough and resolving phlegm.Control cough due to fluid-retention, dyspnea due to deficiency, consumptive disease are coughed, spitting of blood, and spontaneous sweating, impotence and seminal emission, soreness of waist gonalgia, prolonged deficiency is not multiple after being ill.
The Radix Astragali: have another name called Radix Astragali, be the dry root of the leguminous plant Radix Astragali.Nature and flavor: Gan Xin, temperature.Function cures mainly: the energy invigorating the spleen and replenishing QI, benefit is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening.Control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and do not hold back for a long time.Moxibustion is used: invigorating the spleen and replenishing QI.Control the internal injury overstrain, and the disease of all weakness of QI blood deficiency.
Rhizoma Gastrodiae, another name, RHIZONA GASTRODIAE, water ocean an ancient wind instrument, the winter Peng, solely shake sesame etc.Be orchid Rhizoma Gastrodiae rhizome.Perennial parasitic draft, root is sturdy, and stem is high about 60～100 centimetres.Nature and flavor: sweet, flat.Function cures mainly: endogenous wind stopping, arresting convulsion.Control dizzy pupil, wind syndrome of head headache, numb limbs and tense tendons, hemiplegia, aphasia, Xiao Jing Epilepsy wind symptom.
Bulbus Lilii is a liliaceous plant, and its bulb contains elements such as multiple alkaloid, starch, protein, fat, polysaccharide and calcium, phosphorus, ferrum; The traditional Chinese medical science is used as medicine with bulb and flower, and cold nature, sweet in the mouth have the function of invigorating the spleen and replenishing QI, nourishing YIN and moistening the lung cough-relieving, clearing away heart-fire for tranquillization, cure mainly diseases such as chronic cough hemoptysis, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.
Radix Paeoniae Alba: have another name called the Radix Paeoniae Alba, golden Radix Paeoniae, be the root of ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor: picric acid, cold.Function cures mainly: the energy nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing are received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia etc.
Radix Puerariae, i.e. the tuber of Pueraria lobota, leguminous plant contains multiple flavones ingredient, and main active is big legumin, daidzin, puerarin-7-xyloside.Its property is flat, sweet in the mouth is hot, having induces sweat bring down a fever, promote the production of body fluid rash, yang invigorating antidiarrheal, the diseases such as can controlling fever caused by exogenous pathogens headache, hypertension, neck pain, angina pectoris, measles without adequate eruption, hematodiarrhoea dysentery of being used as medicine.
Caulis Bambusae In Taeniam has another name called monk Zhu's Tan, belongs to Basidiomycetes, Phallaceae.Its thalline is a lip pencil, and bell cap is arranged at the top, and lid takes on a red color, and there is mucus on the surface.Lid has the white reticular part that lets droop down.Volva is rufous.Volva excision, cap head are cut, after drying fragrant is arranged.Caulis Bambusae In Taeniam often is born in the bamboo grove, is distributed in China south, and is maximum with Guizhou Province especially.Caulis Bambusae In Taeniam is rich in amino acid, vitamine and the trace element that multiple human body needs, and to improving body immunity very big benefit is arranged.
Ganoderma: different name three shows, sesame, mattress.Be the Herb of Polyporaceae plant Ganoderma or Ganoderma lucidum (Leyss. Ex Fr.) Karst., nature and flavor: sweet, flat.Function cures mainly: alive, blood Shujin, it is suitable to control gas, insomnia, dyspepsia.
Above data is mainly taken from Shanghai science tech publishing house " Chinese medicine voluminous dictionary " 1985.10.These kinds Chinese medicine is shown the conventional use of treatment to disease, belongs to Chinese medicine commonly used, uses as abideing by doctor's advice.There are not toxicity and ill effect, so do not list animal experiment and toxicity test data.By their synergism, diabetes and ocular complication there is curative effect preferably.
The Chinese medicine preparation of this treatment diabetes of the present invention, can be applicable to various treatment of diabetes, prove through clinical practice, compare with the Chinese and western drugs of the treatment diabetes of other types, this medicine has no side effect to the medication person, and has curative effect certainly, and the time of medicine for treatment is shorter, instant effect, the characteristics that the price of medicine is not high.Simultaneously, the inventor carried out comprehensively research and practice according to the property of medicine, the pharmacology of various Chinese medicines, and the taboo of taking of having found out this medicine when this Chinese medicine preparation is taken, requires: 1, contraindication in pregnancy or adhere rigidly to doctor's advice, and use amount can not surpass recipe quantity; 2, avoid edible sweet food, life, cold, serious irritable food after patient takes medicine, prohibit and drink, smoke, to avoid producing disadvantageous physiological metabolism reaction.
The specific embodiment
The manufacture method of 1: one side's powder of embodiment, oral capsule, take by weighing various Chinese medicines, mass ratio is respectively Cordyceps 10: the Radix Astragali 20: Rhizoma Gastrodiae 150: Bulbus Lilii 10: the Radix Paeoniae Alba 10: Radix Puerariae 15: Caulis Bambusae In Taeniam 20: Ganoderma 20, cross 80 orders behind the pulverize separately, uniform mixing promptly gets the powder product then, the treatment diabetes, must abide by the doctor's advice prescription and take medicine, be grown up general 20～40g/3 time day.
The manufacture method of 2: one side's powder of embodiment, oral capsule, take by weighing various Chinese medicines, mass ratio is respectively Cordyceps 20: the Radix Astragali 10: Rhizoma Gastrodiae 100: Bulbus Lilii 20: the Radix Paeoniae Alba 20: Radix Puerariae 7: Caulis Bambusae In Taeniam 12: Ganoderma 10, pulverize the back and cross 80 orders, uniform mixing promptly gets the powder product then, incapsulates to obtain capsule, during the treatment diabetes, must abide by the doctor's advice prescription and take medicine, be grown up general 20～40g/3 time day.
The manufacture method of 3: one side's powder of embodiment, oral capsule, take by weighing various Chinese medicines, mass ratio is respectively Cordyceps 20: the Radix Astragali 10: Rhizoma Gastrodiae 150: Bulbus Lilii 20: the Radix Paeoniae Alba 20: Radix Puerariae 7: Caulis Bambusae In Taeniam 20: Ganoderma 20,, pulverize the back and cross 50 orders, uniform mixing promptly gets the powder product, incapsulates to obtain capsule, during the treatment diabetes, must abide by the doctor's advice prescription and take medicine, be grown up general 20～40g/3 time day.
The manufacture method of embodiment 4: Er side powders, oral capsule, get above-mentioned various Chinese medicine, quality is respectively Cordyceps 5: the Radix Astragali 10: Rhizoma Gastrodiae 150: Ganoderma 100 with them at normal temperatures, powder is crossed 75 mesh sieves behind the pulverize separately, uniform mixing, divide in 9 medicated bags of packing into, or divide in 27 capsules of packing into, promptly get oral powder or capsule product, when the treatment diabetes, must abide by the doctor's advice prescription and take medicine, increase and decrease, be grown up general 20～40g/3 time day according to the state of an illness.
The manufacture method of embodiment 5: Er side powders, oral capsule, get above-mentioned various Chinese medicine, quality is respectively Cordyceps 5: the Radix Astragali 10: Rhizoma Gastrodiae 550: Ganoderma 70 with them at normal temperatures, powder is crossed 75 mesh sieves behind the pulverize separately, uniform mixing, packing is gone in the medicated bag, or divides in the capsule of packing into, promptly gets oral powder or capsule product, when the treatment diabetes, must take medicine by adhere rigidly to doctor's advice prescription, increase and decrease, be grown up general 20～40g/3 time day according to the state of an illness.
The manufacture method of embodiment 5: Er side powders, oral capsule, get above-mentioned various Chinese medicine, quality is respectively Cordyceps 5: the Radix Astragali 10: Rhizoma Gastrodiae 720: Ganoderma 60 with them at normal temperatures, powder is crossed 65 mesh sieves behind the pulverize separately, uniform mixing, packing is gone in the medicated bag, or divides in the capsule of packing into, promptly gets oral powder or capsule product, when the treatment diabetes, must take medicine by adhere rigidly to doctor's advice prescription, increase and decrease, be grown up general 20～40g/3 time day according to the state of an illness.
Clinical case is to the explanation of curative effect of the present invention.Now curing the case healing process with regard to some is set forth in down:
Case 1: the week * *, the woman, 61 years old, live the Guiyang * * district, in 2003, be diagnosed as type ii diabetes through hospital, carry out diagnosis and treatment through adopting this side, after three courses of treatment that take this medicine, the process further consultation.Diabetic symptom is eliminated, and does not see that so far recurrence is with uncomfortable.1 month is a course of treatment.
Case 2: the king * *, 56 years old, live the Qingzhen City, Guiyang, in 2003, thirsty, drink water in a large number, nocturia is frequent, and vision sharply descends, and vision drops to correct vision+4.0DS=0.6 (near vision test type) by 1.5, through examination in hospital, blood glucose is 12.3, comprehensively other check results, be diagnosed as type ii diabetes through the city large hospital, the generation DR of diabetic renal papillary necrosis, blurred vision, vitreous opacity, adopt one side to carry out diagnosis and treatment, then, the treatment of Huan Yong Er side, adopt the high limit of dosage, take this medicine after three courses of treatment, through hospital's further consultation, blood glucose is reduced to normal level, be generally 5.2～6.8, no nocturia, correcting defects of vision is that 2.5DS, correct vision are 1.5 (near vision test types), the vitreous opacity complete obiteration, vision is recovered.Diabetes are fully recovered, and do not see that so far recurrence is with uncomfortable.
Case 3: the king * *, man, 56 years old, living Xiangcheng, Henan county Zheng Guo people from town, in 2004, is I, type ii diabetes through hospital diagnosis, the insulin dependency person repeatedly is in hospital and rescues blurred vision, test eyesight at the moment that index is 20cm, just be diagnosed as PDRV, its vision is near blind, there are 3 years approximately to course of disease evolution in 2005, carry out diagnosis and treatment through adopting this side, after two courses of treatment that take this medicine, still normally use insulin therebetween, every day 3 times, detect through large hospital.Diabetes get the controlled and alleviation of symptom, and puffiness of face disappears, and naked vision returns to 0.06 now, and vision continues to take a turn for the better, now still in treatment.
In sum, this treatment Recipe of diabetes has significant curative effect, and cure rate is higher.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of diabetic eye complication, it is characterized in that preparation by the prescription of mass ratio by: Cordyceps 5～10: the Radix Astragali 10～20: Rhizoma Gastrodiae 100～750: 60～100 of Ganodermas are formed, the Chinese medicine preparation manufacture method is to mix according to the load weighted Chinese medicine of prescription, promptly can produce the Chinese medicine preparation of this medicine by the conventional manufacture method of Chinese powder medicine.
2, the Chinese medicine preparation of treatment diabetic eye complication according to claim 1, it is characterized in that Chinese powder medicine by the prescription of mass ratio by: Cordyceps 5: the Radix Astragali 10: Rhizoma Gastrodiae 720: Ganoderma 65 is formed.
3, the production method of the Chinese medicine preparation of treatment diabetic eye complication according to claim 1, it is characterized in that production method carries out according to the manufacture method of conventional Chinese powder medicine, with each Chinese medicine of above-mentioned prescription, at normal temperatures, behind the pulverize separately, powder is crossed 50～80 mesh sieves, and uniform mixing promptly gets Chinese powder medicine.
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| CNB2006100509695A CN100493576C (en) | 2006-03-08 | 2006-03-08 | Chinese medicine preparation for treating diabetic eye complication |
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| CNB2006100509695A CN100493576C (en) | 2006-03-08 | 2006-03-08 | Chinese medicine preparation for treating diabetic eye complication |
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| CN100493576C true CN100493576C (en) | 2009-06-03 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105596704A (en) * | 2016-01-19 | 2016-05-25 | 济南思拓新源医药科技有限公司 | Medicine for treating diabetic angiopathy |
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Non-Patent Citations (2)
| Title |
|---|
| 中医药治疗糖尿病的主要进展述评和定位思考. 施麟等.中国中医急症，第14卷第11期. 2005 |
| 中医药治疗糖尿病的主要进展述评和定位思考. 施麟等.中国中医急症，第14卷第11期. 2005 * |
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