CN100490643C - Farm chemical microemulsifying assistant composition - Google Patents
Farm chemical microemulsifying assistant composition Download PDFInfo
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- CN100490643C CN100490643C CNB2004100906239A CN200410090623A CN100490643C CN 100490643 C CN100490643 C CN 100490643C CN B2004100906239 A CNB2004100906239 A CN B2004100906239A CN 200410090623 A CN200410090623 A CN 200410090623A CN 100490643 C CN100490643 C CN 100490643C
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Abstract
The present invention relates to efficient general farm chemical microemulsifying assistant composition, which has non-ionic surfactant, anionic surfactant, co-surfactant and proper amount of organic solvent as main components, is prepared through mixing and is used for most of pyrethroid pesticide and microlide pesticide. The pyrethroid pesticide or microlide pesticide may be mixed with the farm chemical microemulsifying assistant composition to form new stable microemulsified pesticide preparation with raised environment compatibility.
Description
Technical field
The present invention relates to non-ionic surface active agent, anion surfactant, cosurfactant and an amount of organic solvent is key component, the efficient general type farm chemical microemulsifying assistant composition that is used for most pyrethroid pesticides, macrolides agricultural chemical compound preparation microemulsified through being mixed and processed.Say so in more detail pyrethroid pesticide, macrolides agricultural chemical compound mixes with certain proportion with this farm chemical microemulsifying assistant composition, can spontaneous formation meets the microemulsion pesticides new formulation of stablizing, having better Environmental compatibility of China's relevant criterion specification requirement.
Background technology
The formulations of pesticide are the important means that realize the transmission of pesticide active ingredient effective dose, improve chemistry security, determined to a great extent agricultural chemical compound to the biologically active of control target, to the mankind's safety and with the compatibility of environment.Enhancing along with human environment protection consciousness; the traditional missible oil formulation that with the organic solvent is dispersible carrier is subjected to unprecedented challenge; the mankind forbid or to limit pesticidal preparations processing cry with an organic solvent gradually high, become the important trend of world's formulations of pesticide development as the water base property formulations of pesticide such as microemulsion of dispersible carrier with water to replace organic solvent.
Yet, because microemulsion belongs to newer research field, start from the seventies in 20th century abroad, China starts from the nineties in last century, it forms and stable basic theory and the experimental technique that relates generally to subjects such as colloid and surface chemistry, the most agricultural chemicals preparation research personnel of enterprise of China understand and grasp inadequately basic theories such as the formation of agricultural chemicals microemulsion, phasor drafting, stabilities, can not characterize the performance of agricultural chemicals microemulsion effectively and instruct the exploitation of efficient special surfactant, and mainly rely on experience with this; In addition, China's agricultural surfactant kind is primarily aimed at conventional dosage forms preparations such as missible oil, each manufacturer uses different factory formulas, properties of product exist than big-difference, in the processing of conventional formulation such as missible oil, still can not cause qualitative significant difference, but just very obvious for very rigorous its influence of microemulsion of prescription.Thereby cause at present mostly product to have that dosage of surfactant is big, the preparation effective content is low, poor product quality, shelf life are short, occur problems such as phase inversion, layering, pesticide active ingredient decomposition in the storing, are the key technologies that the pesticidal preparations microemulsified faces.
At present, the efficient general type farm chemical microemulsifying assistant composition patent of invention at a plurality of pesticide species yet there are no report at home and abroad.
At this present situation, we utilize the big quantity research microemulsion of colloid and surface chemistry scientific and technological achievement and up-to-date research technique form with the formulation and characterizing method process of stablizing each components selection principle and synergetical principle in micromechanism, the pharmaceutical formulation, preparation basic mechanical design feature index in, synthetic or the surfactant structure modification by target, dissimilar surfactant are collaborative, have filtered out the functional agricultural surfactant composition that meets China's farm chemical microemulsifying formulation development need.This farm chemical microemulsifying assistant composition can satisfy the needs of most pyrethroid pesticides, macrolides agricultural chemical compound preparation microemulsified substantially; In addition, these kinds are taken formulation as the leading factor with missible oil at present, occupation rate of market is big, development prospect is wide, the problem that exists in solving its microemulsifying formulations production and using, not only can save a large amount of organic solvents, reduce environmental pollution, can also improve the soup deposition, reduce fluid loss, reduce the agricultural chemicals injected volume.This has very important Science ﹠ Society meaning undoubtedly.
Summary of the invention
The objective of the invention is to release a kind of efficient general type farm chemical microemulsifying assistant composition that can be applicable to most pyrethroid pesticides, macrolides agricultural chemical compound preparation microemulsified, thereby optimize the microemulsion pharmaceutical formulation, simplify production technology, improve the quality of the pharmaceutical preparations, reduce environmental pollution and person poultry poisoning, realize the sustainable development of the formulations of pesticide.
To achieve these objectives, 1. the present invention selects to take formulation as the leading factor with missible oil at present, and the pyrethroid pesticide that occupation rate of market is big, development prospect is wide, macrolides agricultural chemicals are the microemulsified object.Through optimization of C, simplification technology, improve the quality of the pharmaceutical preparations, can produce the economy and society benefit rapidly.At present, the research report that does not also have this respect.2. the synthetic or surfactant structure modification by target, adopt dissimilar surfactant synergistic combination, can give full play to the surface-active of surfactant, improve the ability that the anti-hard water of surface activator composition, heatproof degree change.Thereby make microemulsifying formulations have better anti-bin stability.3. according to present China microemulsion current situation, an amount of organic solvent and cosurfactant have been added in the farm chemical microemulsifying assistant composition, the agricultural chemical compound composition is dissolved in earlier and forms homogeneous phase transparent solution in an amount of farm chemical microemulsifying assistant composition, under agitation add the moisture of needs then according to prescription, can spontaneous formation microemulsion.Can utilize the missible oil production equipment to produce microemulsion fully, not need the investment that increases manufacturing facilities in addition.
The technical solution used in the present invention is: a kind ofly be applicable to most pyrethroid pesticides, the efficient general type farm chemical microemulsifying assistant composition of macrolides agricultural chemical compound preparation microemulsified, wherein contain non-ionic surface active agent, anion surfactant, cosurfactant and an amount of organic solvent, it is characterized in that: 1. non-ionic surface active agent is a castor oil polyoxyethylene ether, alkylphenol polyoxyethylene, the phenethyl phenol polyethenoxy ether, phenethyl phenol formaldehyde resin APEO, alkyl phenol formaldehyde resin polyoxyethylene ether, some or mixture that certain is several in the triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer, weight percentage is 10～90%; 2. anion surfactant is some or a mixture that certain is several in calcium dodecyl benzene sulfonate, lauryl sodium sulfate, the nekal, and weight percentage is 1～50%; 3. cosurfactant is some or a mixture that certain is several in isopropyl alcohol, ethylene glycol, butanols, the octanol, and weight percentage is 1～50%; 4. organic solvent is some or a mixture that certain is several in dimethylbenzene, methyl alcohol, cyclohexanone, the dimethyl formamide, and weight percentage is 1～50%.
Wherein, farm chemical microemulsifying assistant composition of the present invention, used non-ionic surface active agent are in the mixture of mixture, alkylphenol polyoxyethylene and the triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer of castor oil polyoxyethylene ether and alkyl phenol formaldehyde resin polyoxyethylene ether and triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer weight percentage 4:1:1.5 and phenethyl phenol formaldehyde resin APEO weight percentage 1:4:0.5 any one group; Used anion surfactant is the mixture of calcium dodecyl benzene sulfonate and lauryl sodium sulfate weight percentage 15:1; Used cosurfactant is the mixture of isopropyl alcohol and octanol weight percentage 1:5; Used organic solvent is the mixture of dimethylbenzene and methyl alcohol and cyclohexanone weight percentage 1:1:1.5; The preferable range of used non-ionic surfactant composition weight percentage is 10～90%; The preferable range of used anionic surfactant compositions weight percentage is 1～50%; The preferable range of used cosurfactant composition weight percentage composition is 1～50%; The preferable range of used organic solvent composition weight percentage composition is 1～50%;
The preparation method of farm chemical microemulsifying assistant composition of the present invention, it is characterized in that at first non-ionic surface active agent, anion surfactant, cosurfactant, organic solvent accurately being taken by weighing by formula rate, fully mix to the regulation technical indicator in the adding blender;
The purposes of farm chemical microemulsifying assistant composition of the present invention is characterized in that being used for the preparation microemulsified of most pyrethroid pesticides, macrolides agricultural chemical compound.
Embodiment
Further specified the present invention in order to illustrate better below by embodiment.But what it should be appreciated by those skilled in the art is that the application not merely is limited to the scope of following embodiment.
Embodiment 1:
Require accurately to take by weighing castor oil polyoxyethylene ether 30.77 grams, alkyl phenol formaldehyde resin polyoxyethylene ether 7.69 grams, triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer 11.54 grams, calcium dodecyl benzene sulfonate 18.75 grams, lauryl sodium sulfate 1.25 grams, isopropyl alcohol 0.83 gram, octanol 4.27 grams, dimethylbenzene 5.6 grams, methyl alcohol 5.6 grams, cyclohexanone 8.3 grams according to prescription, add in 2000 milliliters of blenders, fully mixed 20 minutes, it is qualified to detect every technical indicator, promptly gets farm chemical microemulsifying assistant composition.
Embodiment 2:
Require accurately to take by weighing alkylphenol polyoxyethylene 10.91 grams, triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer 43.64 grams, phenethyl phenol formaldehyde resin APEO 5.45 grams, calcium dodecyl benzene sulfonate 9.38 grams, lauryl sodium sulfate 0.63 gram, isopropyl alcohol 0.83 gram, octanol 4.27 grams, dimethylbenzene 5.6 grams, methyl alcohol 5.6 grams, cyclohexanone 8.3 grams according to prescription, add in 2000 milliliters of blenders, fully mixed 20 minutes, it is qualified to detect every technical indicator, promptly gets farm chemical microemulsifying assistant composition.
Embodiment 3:
Require accurately to take by weighing castor oil polyoxyethylene ether 27.69 grams, alkyl phenol formaldehyde resin polyoxyethylene ether 6.92 grams, triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer 10.39 grams, calcium dodecyl benzene sulfonate 18.75 grams, lauryl sodium sulfate 1.25 grams, isopropyl alcohol 0.83 gram, octanol 4.27 grams, dimethylbenzene 7.02 grams, methyl alcohol 7.02 grams, cyclohexanone 10.44 grams according to prescription, add in 2000 milliliters of blenders, fully mixed 20 minutes, it is qualified to detect every technical indicator, promptly gets farm chemical microemulsifying assistant composition.
Realize that best mode of the present invention is embodiment 1 and embodiment 2.
It is as follows to adopt farm chemical microemulsifying assistant composition of the present invention to be used for the preparation microemulsified instantiation of pyrethroid pesticide, macrolides agricultural chemical compound:
Example 1:4.5% beta-cypermethrin microemulsion
Accurately take by weighing in farm chemical microemulsifying assistant composition 250 grams and blender of embodiment 1, add the former medicine of 46.4 gram 97% beta-cypermethrins, fully mix and be dissolved to homogeneous phase transparent solution.The water that under stirring condition, slowly adds surplus.Continue to stir, until the mixed solution homogeneous phase transparent.It is qualified to detect every technical indicator, promptly gets 4.5% beta-cypermethrin microemulsion.
By the 4.5% beta-cypermethrin microemulsion formulation that this prescription is produced, transparent warm area is-2～60 ℃, and the other technologies index all reaches the requirement of China's relevant criterion.
Example 2:2.0% avermectin micro-emulsion
Accurately take by weighing in farm chemical microemulsifying assistant composition 250 grams and blender of embodiment 2, add the former medicine of 21.7 gram 92% Avermectin, fully mix and be dissolved to homogeneous phase transparent solution.The water that under stirring condition, slowly adds surplus.Continue to stir, until the mixed solution homogeneous phase transparent.It is qualified to detect every technical indicator, promptly gets 2.0% avermectin micro-emulsion.
By the 2.0% avermectin micro-emulsion preparation that this prescription is produced, transparent warm area is-2～60 ℃, and the other technologies index all reaches the requirement of China's relevant criterion.
Example 3:4.5% beta-cypermethrin microemulsion
Accurately take by weighing in farm chemical microemulsifying assistant composition 300 grams and blender of embodiment 3, add the former medicine of 46.4 gram 97% beta-cypermethrins, fully mix and be dissolved to homogeneous phase transparent solution.The water that under stirring condition, slowly adds surplus.Continue to stir, until the mixed solution homogeneous phase transparent.It is qualified to detect every technical indicator, promptly gets 4.5% beta-cypermethrin microemulsion.
By the 4.5% beta-cypermethrin microemulsion formulation that this prescription is produced, transparent warm area is-2～56 ℃, and the other technologies index all reaches the requirement of China's relevant criterion.
Prove by Multitest, farm chemical microemulsifying assistant composition of the present invention has been compared following advantage with the farm chemical emulgent of existing similar market circulation: 1. the present invention's synthetic or surfactant structure modification by target, adopt non-ionic surface active agent, the anion surfactant synergy, rationally add cosurfactant, compositions such as organic solvent, the surface-active height, formulation stability is good, can satisfy most pyrethroid pesticides substantially, the needs of macrolides agricultural chemical compound preparation microemulsified are the functional agricultural surfactant compositions that meets China's farm chemical microemulsifying formulation development need.2. the present invention's farm chemical microemulsifying assistant composition is applicable to the needs of most pyrethroid pesticides, macrolides agricultural chemical compound preparation microemulsified.These kinds are taken formulation as the leading factor with missible oil at present, occupation rate of market is big, development prospect is wide, the problem that exists in solving its microemulsifying formulations production and using, not only can save a large amount of organic solvents, reduce environmental pollution, can also improve the soup deposition, reduce fluid loss, reduce the agricultural chemicals injected volume.Greatly reduce preparation toxicity, improved safety in utilization, meet " high poison substitutes " policy that China takes at present.3. the present invention's farm chemical microemulsifying assistant composition can directly dissolve former medicine in the use, can add water then and realize the preparation microemulsified.Operating procedure is simple, energy consumption is low.
Claims (3)
1. the farm chemical microemulsifying assistant composition of a pyrethroid pesticide beta-cypermethrin, macrolides agricultural chemical compound Avermectin preparation, wherein contain non-ionic surface active agent, anion surfactant, cosurfactant and an amount of organic solvent, it is characterized in that:
1. used non-ionic surface active agent weight percentage is 10～90%; Used non-ionic surface active agent is in the mixture of mixture, alkylphenol polyoxyethylene and the triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer of castor oil polyoxyethylene ether and alkyl phenol formaldehyde resin polyoxyethylene ether and triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer weight percentage 4:1:1.5 and phenethyl phenol formaldehyde resin APEO weight percentage 1:4:0.5 any one group;
2. used anion surfactant weight percentage is 1～50%; Used anion surfactant is the mixture of calcium dodecyl benzene sulfonate and lauryl sodium sulfate weight percentage 15:1;
3. used cosurfactant weight percentage is 1～50%; Used cosurfactant is the mixture of isopropyl alcohol and octanol weight percentage 1:5;
4. used organic solvent weight percentage is 1～50%; Used organic solvent is the mixture of dimethylbenzene and methyl alcohol and cyclohexanone weight percentage 1:1:1.5.
2. the preparation method of farm chemical microemulsifying assistant composition according to claim 1, it is characterized in that at first non-ionic surface active agent, anion surfactant, cosurfactant, organic solvent accurately being taken by weighing by formula rate, fully mix to the regulation technical indicator in the adding blender.
3. the purposes of farm chemical microemulsifying assistant composition according to claim 1 is characterized in that being used for the preparation microemulsified of pyrethroid pesticide beta-cypermethrin, macrolides agricultural chemical compound Avermectin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100906239A CN100490643C (en) | 2004-11-10 | 2004-11-10 | Farm chemical microemulsifying assistant composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100906239A CN100490643C (en) | 2004-11-10 | 2004-11-10 | Farm chemical microemulsifying assistant composition |
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| Publication Number | Publication Date |
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| CN1771804A CN1771804A (en) | 2006-05-17 |
| CN100490643C true CN100490643C (en) | 2009-05-27 |
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| CNB2004100906239A Expired - Fee Related CN100490643C (en) | 2004-11-10 | 2004-11-10 | Farm chemical microemulsifying assistant composition |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1886560A1 (en) * | 2006-08-05 | 2008-02-13 | Bayer CropScience AG | New microemulsifiable concentrates |
| CN101589711B (en) * | 2009-07-09 | 2012-08-22 | 长兴德源环保助剂有限公司 | Thickening synergist composition for efficient pesticide avermectin oil |
| CN111513063B (en) * | 2020-05-14 | 2020-12-29 | 广东省科学院产业技术育成中心 | Insecticide additive and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107651A (en) * | 1994-12-27 | 1995-09-06 | 李学锋 | Insecticide composite microemulsion |
| CN1208559A (en) * | 1998-07-17 | 1999-02-24 | 唐睿 | Avermectin pesticide series microemulsion agent, and method for producing same |
| CN1257655A (en) * | 1999-12-17 | 2000-06-28 | 温沛宏 | Methomyl and cyfluthrin microemulsion as insecticide-miticide |
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- 2004-11-10 CN CNB2004100906239A patent/CN100490643C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107651A (en) * | 1994-12-27 | 1995-09-06 | 李学锋 | Insecticide composite microemulsion |
| CN1208559A (en) * | 1998-07-17 | 1999-02-24 | 唐睿 | Avermectin pesticide series microemulsion agent, and method for producing same |
| CN1257655A (en) * | 1999-12-17 | 2000-06-28 | 温沛宏 | Methomyl and cyfluthrin microemulsion as insecticide-miticide |
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| CN1771804A (en) | 2006-05-17 |
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Assignee: Shandong Cao Da Chemical Co., Ltd. Assignor: Institute of Plant Protection, Chinese Academy of Agricultural Sciences Contract record no.: 2011370000257 Denomination of invention: Farm chemical microemulsifying assistant composition Granted publication date: 20090527 License type: Exclusive License Open date: 20060517 Record date: 20110616 |
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Granted publication date: 20090527 Termination date: 20131110 |