CN100488468C - Fixing device for experiment of pain and heat senses stimulus - Google Patents
Fixing device for experiment of pain and heat senses stimulus Download PDFInfo
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- CN100488468C CN100488468C CNB2006100375027A CN200610037502A CN100488468C CN 100488468 C CN100488468 C CN 100488468C CN B2006100375027 A CNB2006100375027 A CN B2006100375027A CN 200610037502 A CN200610037502 A CN 200610037502A CN 100488468 C CN100488468 C CN 100488468C
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Abstract
A fixing apparatus for the remotely controlled pain sense/warmth sense experiment of rat or mouse in functional nuclear magnetic resonance imaging environment is composed of animal fixer, coil fixer, beater for pain sense, and stimulating box for wormth sense.
Description
Technical field
The present invention relates to a kind of zoopery fixture, especially a kind of pain sense of heat stimulation test fixture that is applicable to clear-headed large and small experimental mouse under the medical function magnetic resonance device functional magnetic resonance resonance radiography experimental situation.
Background technology
The zoopery fixture is an experiment equipment commonly used in the biomedical boundary, is used for laboratory animal is fixed so that get operations such as blood, perfusion, injection, sense of heat stimulation, pain stimulus.Chinese patent description CN2696315Y (bulletin on May 4th, 2005) discloses a kind of fixture that is used for animal, this device is the operating platform of flat-faced tube, or combine the vertical operating board that forms with supporter by this operating platform, operating platform comprise fixing head and on chute and the holder on the chute, chute is trapezoidal or the protruding sample of other shapes or the chute of depressed, holder comprises moving slider and fixed connection apparatus, and supporter is the supporter of adjustable-height or level altitude.This device is suitable for for a long time fixing animal.But this apparatus function is single, only plays the fixedly effect of animal, simultaneously owing to the restriction of material, can not satisfy the needs of some particular experiment environment such as functional magnetic resonance resonance radiography experimental situation.
For many years, medical science and Neuroscience Research worker expectation biology utilize the function magnetic resonance device, zoologize the central nervous system to different stimulated on every side, and to reaction all kinds of and the relevant medicine of central nervous system.But, do not comprise at present fixing on the market and the pain sense of heat stimulates and is the zoopery holder of one, and more existing fixtures can not be used under functional magnetic resonance resonates the radiography experimental situation because of the restriction of manufactured materials. therefore, the research worker has to that low coverage is liftoff operates in the process of experiment. health is subjected to the infringement of function magnetic resonance device high-intensity magnetic field easily. simultaneously. under functional magnetic resonance resonance radiography experimental situation fixing clear-headed animal relatively difficulty exist damage to stimulate to cause experiment effect poor, purpose is difficult for realizing.
Summary of the invention
Purpose of the present invention is exactly in order to overcome at present the above-mentioned shortcoming of zoopery holder on the market, clear-headed large and small Mus pain sense of heat stimulation test fixture under a kind of functional magnetic resonance resonance radiography experimental situation to be provided.
The present invention is achieved in that
Pain sense of heat stimulation test fixture provided by the invention comprises that animal holder, coil holders, pain sensation beating device, the sense of heat stimulate case; The animal holder body frame stimulates case to connect into an integral body animal holder and coil holders, pain sensation beating device, the sense of heat by link.
In such scheme:
Coil holders is installed in an end of animal holder body frame, and pain sensation beating device is vertically set on the animal holder body frame, and the sense of heat stimulates case to be connected with the animal holder body frame, is positioned at the below of pain sensation beating device.
The making material selection of whole device is the pmma material that is applicable under the functional magnetic resonance resonance radiography experimental situation.
Link between each ingredient of whole device is a nylon screw.
Animal holder among the present invention is made up of animal holder body frame, the headstock, body folder, Mus tail fixed mount, head-clamp, head pressure, neck folder, body pressing plate and breathing supporting plate; The headstock, body folder, Mus tail fixed mount are successively set on the animal holder body frame at a certain distance; The headstock divides left and right sides two parts, is installed in animal holder body frame both sides respectively, and the headstock has head-clamp, a pressure, neck presss from both sides and breathe supporting plate, and a pressure chute is arranged on the headstock, and a pressure can press chute to move up and down along head; Head-clamp divides left and right sides two parts, connects the headstock respectively, is arranged on the nearer side of off-line circle holder, and left and right sides two parts of head-clamp can be by promoting in the middle of two side direction of animal holder body frame; The neck folder connects the headstock, is arranged on the nearer side of stripped folder of the headstock: breathe supporting plate and be connected in the middle of the headstock, be attached on the animal holder body frame surface: body
Branch left and right sides two parts are installed in two lateral body platen covers of animal holder body frame respectively on the body folder
Under adjust the position.
Mus tail fixed mount comprises that the rat tail fixes
With the mouse tail fixed mount, do not put both sides respectively at pain sensation beating device.
Pain sensation beating device among the present invention comprises
Hit device body frame tail holder tail guide hole, upper slide bar drop shot. upper slide bar. drop shot vertically is located on the beating device body frame. and upper slide bar is stretched to upper slide bar and drop shot than the high rubber band of drop shot.
The beating device body frame of pain sensation beating device has two different fixed positions on the animal holder body frame. according to the bodily form of experimental mouse, is fixed on mice beating device fixing threaded hole or the rat beating device fixing threaded hole with screw.
The upper slide bar of pain sensation beating device, drop shot link at a distance with traditional thread binding thing.
The sense of heat among the present invention stimulates the case water temperature in 0～70 ℃ of scope.
Advantage of the present invention is: (1) collection animal is fixed and reaches pain stimulus, sense of heat stimulation test device is an one, realizes multinomial functions such as animal is fixed, sense of heat stimulation, pain stimulus on same device.(2) the elite pmma material and the nylon material of functional magnetic resonance resonance radiography experimental situation of being applicable to made, and meets the requirement of functional magnetic resonance resonance radiography experimental situation and all kinds of Related Experimental Study.(3) adopt distant control, solved the infringement that high-intensity magnetic field may exist experimental implementation person.(4) on an agent structure, solve the clear-headed fixed problem of large and small Mus not damaged.
Description of drawings
Describe embodiments of the present invention in detail below in conjunction with the drawings and specific embodiments.
Figure 1 shows that the overall structure sketch map of apparatus of the present invention.
Figure 2 shows that the vertical view of the mice head-clamp in the embodiment of the invention.
Figure 3 shows that the left view that the head in the embodiment of the invention is pressed.
Figure 4 shows that the left view of the mouse carotid folder in the embodiment of the invention.
Figure 5 shows that the vertical view of the mouse breathing supporting plate in the embodiment of the invention.
Figure 6 shows that the left view of the mice body pressing plate in the embodiment of the invention.
The specific embodiment
The invention will be further described below in conjunction with accompanying drawing. and present embodiment is experimental subject with the mice, carries out the experiment of medical function magnetic resonance device functional magnetic resonance resonance radiography. except that also will using functional magnetic resonance resonance radiography, this fixing device for experiment tests necessary coil in the experiment
See also Fig. 1, the pain sense of heat stimulation test fixture of present embodiment comprises animal holder. coil holders 1. pain sensation beating devices, the sense of heat stimulate case 12: animal holder body frame 2 stimulates case 12 to connect into an integral body animal holder and coil holders 1, pain sensation beating device, the sense of heat by link, coil holders 1 is installed in an end of animal holder body frame 2, pain sensation beating device is vertically set on the animal holder body frame 2, the sense of heat stimulates case 12 to be connected with animal holder body frame 2, is positioned at the below of pain sensation beating device.It is the elite pmma material that is applicable to functional magnetic resonance resonance radiography experimental situation that whole device is made the material selection, and the coupling part is a nylon screw.All parts are made through selection, cutting, polishing, polishing, rotary-cut, thermoplastic, technology such as bonding.Wherein, animal holder is made up of animal holder body frame 2, the headstock 3, body folder 5, mouse tail fixed mount 6, rat tail fixed mount 11, head-clamp 19, head pressure 20, neck folder, body pressing plate 18 and breathing supporting plate, and the headstock 3, body folder 5, mouse tail fixed mount 6, rat tail fixed mount 11 are successively set on the animal holder body frame 2 at a certain distance.Head presses 20 heads that are placed on the headstock to press in the chute 4, can move up and down; Head-clamp 19 be installed in the headstock 3 from the nearer side of animal fixed mount 1, the neck folder being connected the nearer sides of the folder 5 of exsomatizing on the headstock 3, head-clamp 19 can be by promoting in the middle of two side direction of animal holder body frame 2; Breathe supporting plate and be connected in the middle of the headstock 3, be attached on the animal holder body frame surface 2; Body pressing plate 18 is placed on the body folder 5, can adjust the position up and down.Beating device body frame 10 is fixed on the animal holder body frame 2 by mice beating device fixing threaded hole 14, and rubber band 7 has two, is stretched to upper slide bar 8 and drop shot 9 respectively.The sense of heat that the sense of heat stimulates case 12 usefulness screws to be fixed on pain sensation beating device right side stimulates on the case fixing hole.
Fig. 2 is the vertical view of mice head-clamp 19 in the present embodiment, mice head-clamp 19 is used for fixing mouse head in experiment, prevent mouse head move left and right in experiment, mice head-clamp 19 mainly is made of vertical two faces, one side is a cambered surface, contact with mouse head in the experiment, be used to clamp mouse head, cambered surface can be avoided the damage of mouse head is stimulated, another side is the plane of band dead slot, passes dead slot fall frame with screw and connects, and the plane can be moved along dead slot during use, adjust the position of head-clamp 19, mouse head is fixed on centre.
Fig. 3 is the left view of head pressure 20 in the present embodiment, in the experiment, head presses 20 to put into head pressure chute 4, after adjusting the position up and down, screw the screw that head is pressed 20 two ends, the labour contractor presses 20 to be fixed on the headstock 3, after mouse head is fixed on centre with head-clamp 19, the backspin head is pressed the screw at 20 middle parts, makes the plane of screw lower end push down mouse head, thereby prevents that mouse head from moving up and down.
Fig. 4 is the neck folder sketch map of mice in the present embodiment, the neck folder is the rectangle lucite sheet of band supporting plate, there is the square hole in central authorities, there is dead slot the left and right sides, the neck folder connects through dead slot fall frame 3 with screw, in the experiment, press down neck folder, the mice cervical region is stuck in the square hole, prevents mice cervical region move left and right along the dead slot direction.
Fig. 5 is the mouse breathing supporting plate vertical view in the embodiment of the invention, and breathing supporting plate is rectangle lucite sheet, and thickness is 3 millimeters, and there is the frustum type groove centre, in experiment. the frustum type groove is inserted by the throat of mice, and can smooth and easy experimental mouse respiration channel.
Fig. 6 is mice body pressing plate 18 left views in the embodiment of the invention, and body pressing plate 18 is a plane, and respectively there is strip piece both sides, and screw is connected on the body folder 5 by the screw in the strip piece, and body pressing plate 18 is adjusted the position up and down according to Mus body size.
In experimentation, at first shallow degree anesthetized mice, mouse web portion is inserted its head in the headstock 3 earlier down during placement, presses down the neck folder, and screw is tightened; By promoting head-clamp 19 in the middle of 2 liang of side direction of body frame, make mouse head be positioned at the position, center, the screw that is tightened, and mouse head is placed on above the mouse breathing supporting plate; The mice body is inserted body folder 5, adjust screwing screw behind body pressing plate 18 positions and fix; Mouse tail is imported the uropore of mouse tail fixed mount 6, fixedly afterbody; Functional magnetic resonance resonated, and the head of the coil that radiography experiment must use is inserted in the headstock 3, neck clamp circle supporting plate top, the body of coil is inserted in coil holders 1 upper groove, press the coil of chute 4 push-down heads pressure 20 to press along head, the screw that is tightened, mice fixedly finishes like this.When carrying out the pain stimulus experiment, mouse tail is imported in the Mus tail entrance hole 13 of pain sensation beating device.Research worker is fastened upper slide bar 8 and drop shot 9 with two lines respectively during experiment, firmly slide bar is extracted from pain sensation beating device a long way off. the 7 instantaneous contractions of rubber bar, impact on mouse tail, and make experimental mouse produce the pain sensation.When carrying out sense of heat stimulation test, the mouse tail entry guide hole 13 that mouse tail is imported on the animal holder body frame 2 enters thermo aesthesia stimulation case 12.The water temperature of experiment can be selected in 0～70 ℃ of scope, and the water of 50 degree water temperatures is adopted in this experiment, and earlier water being poured into thermo aesthesia before the experiment stimulates case 12, thermal stimulus case 12 is fixed on the animal holder body frame again.
The temperature of rat, pain stimulus experimental procedure are the same. just the parts of experiment are correspondingly changed into head-clamp 19, the neck folder that is applicable to rat. breathe supporting plate, body pressing plate 18 and rat tail fixed mount 11, hit on the rat beating device fixing threaded hole 17 that frame body frame 10 is fixed on the animal holder body frame 2. the Mus tail by the rat tail fixedly guide hole 11 fix.When carrying out sense of heat stimulation test. rat tails enters the sense of heat by rat tail entry guide hole 15 stimulates case 12.
The present invention is not limited to the above-mentioned specific embodiment, building block of the present invention also has other malformations. and for example the arcwall face of head-clamp can change taper surface into, the square sky of neck folder can change arch door shape, arc etc. into, and these shapes equally also can reach the effect of fixing experimental mouse and very little to the experimental mouse body-stimulating.So long as the variation of the identical planform of function all falls into protection scope of the present invention.The present invention can design other embodiments in conjunction with concrete applicable cases according to described technical scheme.
Claims (3)
1. pain sense of heat stimulation test fixture, it comprises that animal holder, coil holders (1), pain sensation beating device, the sense of heat stimulate case (12); Animal holder body frame (2) stimulates case (12) to connect into an integral body animal holder and coil holders (1), pain sensation beating device, the sense of heat by link; Described animal holder is the mouse holder, comprises animal holder body frame (2), the headstock (3), body folder (5), Mus tail fixed mount, head-clamp (19), head pressure (20), neck folder, body pressing plate (18) and breathes supporting plate; The headstock (3), body folder (5), Mus tail fixed mount are successively set on the animal holder body frame (2) at a certain distance; The headstock (3) divides left and right sides two parts, be installed in animal holder body frame (2) both sides respectively, the headstock (3) is pressed (20), neck folder and is breathed supporting plate with head-clamp (19), head, has head to press chute (4) on the headstock (3), and head presses (20) to press chute (4) to move up and down along head; Head-clamp (19) divides left and right sides two parts, connects the headstock (3) respectively, is arranged on the nearer side of off-line circle holder (1), and left and right sides two parts of head-clamp (19) can be by promoting in the middle of two side direction of animal holder body frame (2); The neck folder connects the headstock (3), is arranged on the nearer side of stripped folder (5) of the headstock (3); Breathe supporting plate and be connected in the middle of the headstock (3), pasting on animal holder body frame (2) surface; Body folder (5) divides left and right sides two parts, is installed in the both sides of animal holder body frame (2) respectively, on body pressing plate (18) the Gai Zaiti folder (5), can adjust the position up and down.
2. pain sense of heat stimulation test fixture according to claim 1 is characterized in that described Mus tail fixed mount comprises rat tail fixed mount (11) and mouse tail fixed mount (6), is separately positioned on the both sides of pain sensation beating device.
3. pain sense of heat stimulation test fixture according to claim 1, it is characterized in that described pain sensation beating device comprises beating device body frame (10), tail holder, tail guide hole, upper slide bar (8), drop shot (9), upper slide bar (8), drop shot (9) vertically are located on the beating device body frame (10), upper slide bar (8) is than drop shot (9) height, and rubber band (7) is stretched to upper slide bar (8) and drop shot (9); Described upper slide bar (8), drop shot (9) link at a distance with traditional thread binding thing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100375027A CN100488468C (en) | 2006-09-05 | 2006-09-05 | Fixing device for experiment of pain and heat senses stimulus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100375027A CN100488468C (en) | 2006-09-05 | 2006-09-05 | Fixing device for experiment of pain and heat senses stimulus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1915186A CN1915186A (en) | 2007-02-21 |
| CN100488468C true CN100488468C (en) | 2009-05-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100375027A Expired - Fee Related CN100488468C (en) | 2006-09-05 | 2006-09-05 | Fixing device for experiment of pain and heat senses stimulus |
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| CN (1) | CN100488468C (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101390746B (en) * | 2008-11-14 | 2010-06-02 | 河北医科大学第一医院 | Elastic vertical compression type pain quantitative determination instrument |
| CN101721260B (en) * | 2009-12-22 | 2011-03-16 | 中国人民解放军第三军医大学第一附属医院 | Adjustable scalding frame for producing scalding model |
| CN103892932A (en) * | 2014-02-25 | 2014-07-02 | 曲林涛 | Fixing device for magnetic resonance examination on laboratory mouse and application method thereof |
| CN104095614B (en) * | 2014-07-10 | 2017-01-25 | 中国人民解放军第四军医大学 | Rat balance based multifunctional pain threshold measuring apparatus and method |
| CN104257438A (en) * | 2014-09-29 | 2015-01-07 | 嘉兴博康生物科技有限公司 | Animal injury fixing clamp |
| CN109549747B (en) * | 2018-12-20 | 2023-06-06 | 深圳市智屏微科技有限公司 | Suspension fixing device and equipment for poultry |
| CN110522415B (en) * | 2019-08-19 | 2022-08-23 | 中山大学 | Animal pain testing system and testing method thereof |
| CN110403578A (en) * | 2019-08-30 | 2019-11-05 | 福建医科大学 | A kind of heat conducting device measuring skin flap of rats nerve recovery |
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2006
- 2006-09-05 CN CNB2006100375027A patent/CN100488468C/en not_active Expired - Fee Related
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| CN1915186A (en) | 2007-02-21 |
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