CN100477994C - Meloxicam containing skin topical paste formulation - Google Patents
Meloxicam containing skin topical paste formulation Download PDFInfo
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- CN100477994C CN100477994C CNB2004100211225A CN200410021122A CN100477994C CN 100477994 C CN100477994 C CN 100477994C CN B2004100211225 A CNB2004100211225 A CN B2004100211225A CN 200410021122 A CN200410021122 A CN 200410021122A CN 100477994 C CN100477994 C CN 100477994C
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- patch
- meloxicam
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Abstract
The meloxicam plaster for local sticking to skin has medicine content in its adhering skeleton layer of 1-50 wt%, and consists of three parts, including lining layer, medicated adhering skeleton layer and anti-sticking layer. The preparation process includes dissolving pressure-sensitive glue in proper solvent, dissolving or dispersing the medicine in pressure-sensitive glue solution, painting the mixed solution onto the lining layer or anti-sticking layer, drying to volatilize solvent, covering anti-sticking layer or lining layer, and cutting into certain dosage. The meloxicam plaster is used mainly for treating osteoarthritis, rheumatoid arthritis, sciatica and other diseases and remitting the symptoms.
Description
Technical field:
The present invention relates to medical technical field, exactly it is a kind of local skin patch that contains meloxicam.
Background technology:
Meloxicam is a kind of enol acid non-steroid antiinflammatory drug, its chemistry 4-hydroxy-2-methyl-N-(5-methyl-2-thiazole) by name-2-hydrogen-1,2-benzothiazine-3-carboxamide-1,1 dioxide.Structural formula is as follows:
The easing pain and diminishing inflammation effect that the meloxicam tool is stronger has excellent curative to diseases such as osteoarthritis, rheumatoid arthritis, sciatica.Main dosage form has tablet, capsule, suppository, gel, injection at present.
Summary of the invention:
The purpose of this invention is to provide a kind of local skin patch that contains meloxicam.It has easy to use, and effective drug duration is long, the advantage of slow release.Meloxicam is used to prepare the local skin patch, and it is 1-50% that gluing casing play amount of solid is calculated the content of medicine in patch.Described patch is made up of following three parts: (1) backing layer; (2) the gluing casing play of pastille; (3) adherent layer.Backing layer can be non-woven fabrics, elastic force cloth, common cloth, paper, polychloroethylene film, polyethylene film, polypropylene screen, MULTILAYER COMPOSITE aluminium foil, polyethylene terephthalate.Adherent layer can be siliconised paper,, polyethylene film, polypropylene screen, polystyrene film, polycarbonate membrane, poly tetrafluoroethylene.Casing play can be Oppanol, silicone rubber, polyacrylate, acrylic resin.Can add plasticizer in the casing play of polymer, plasticizer is mineral oil, ethyl sebacate, diethyl phthalate, triethyl citrate, the mixture between them.Can add viscosifier in the casing play of polymer, viscosifier can be multicomponent organic acid, terpene resin, Colophonium and Foral, or the mixture between them.Can add the drug transdermal absorption enhancer in the casing play of polymer, the drug transdermal absorption enhancer can be oleic acid, laurocapram, Oleum menthae, eucalyptus oil, or the mixture between them.The content range of polymer backbone layer Chinese medicine is 1%-50%.
Processing technology is as follows: pressure-sensitive adhesive material is dissolved in the appropriate solvent, medicine dissolution or be dispersed in the pressure sensitive adhesive solution is coated on mixed solution on backing layer or the anti-glutinous layer with suitable technology the drying and volatilizing solvent then, cover anti-glutinous layer or backing layer, the cutting divided dose.
Advantage of the present invention is: meloxicam plaster is by sticking percutaneous drug delivery, medicine in the patch is by the diffusion of molecule, in vivo, enter skin under the promotion of outer drug level gradient, enter the systemic blood circulation by the blood capillary absorption, be transported to each diseased region, reach treatment concentration and bring into play curative effect; Or the medicine that absorbs through skin is directly spread by subcutaneous tissue and arrives diseased region or target site and play a role.Meloxicam plaster is mainly used in the alleviation of treatment of conditions such as osteoarthritis, rheumatoid arthritis, sciatica and symptom.Meloxicam plaster is a kind of novel drug-supplying system, has the advantage that other dosage forms can not be compared, and can reduce whole body blood drug level as the part with patch, reduces toxic and side effects; Improve the local organization drug level, help locating therapy, also have advantages such as long-acting, slow release simultaneously, have easy to use, advantage such as pollution clothes not.
The specific embodiment:
Embodiment 1: the method for making that with the Oppanol is the patch that contains meloxicam of skeleton; Get 100 parts in polyisobutylene and poly-isobutyl group butadiene mixture, be dissolved in 400 parts of chloroforms, add 5 parts of meloxicams, dissolving is uniformly dispersed, film, and solvent flashing, the combination backing layer, requirement cuts into the patch of suitable size according to dosage.
Embodiment 2: the method for making that with the acrylate pressure-sensitive adhesive is the patch that contains meloxicam of skeleton; Get solid content and be 100 parts of 30% pressure sensitive adhesives, add 5 parts of meloxicams, dissolving is uniformly dispersed, film, and solvent flashing, the combination backing layer requires to cut into the patch of suitable size according to dosage.
Embodiment 3: be that skeleton, laurocapram are the method for making of the patch that contains meloxicam of Percutaneous absorption enhancer with the polyacrylate pressure-sensitive; Get solid content and be 100 parts of 30% pressure sensitive adhesives, add 5 parts of meloxicams, 3 parts of laurocaprams, dissolving is uniformly dispersed, films, solvent flashing, the combination backing layer requires to cut into the patch of suitable size according to dosage.
Embodiment 4: with the polyacrylic resin pressure sensitive adhesive is the method for making that skeleton contains the patch of meloxicam; Get polyacrylic resin IV100 part, be dissolved in 200 parts the ethanol and acetone mixed solvent, add 5 parts of meloxicams, 30 parts of triethyl citrates, dissolving is uniformly dispersed, films, solvent flashing, the combination backing layer requires to cut into the patch of suitable size according to dosage.
Embodiment 5: with the polyacrylic resin pressure sensitive adhesive is the method for making that skeleton contains the patch of meloxicam; Get 100 parts of polyacrylic resin IV, be dissolved in 200 parts the ethanol and acetone mixed solvent, add 5 parts of meloxicams, 30 parts of triethyl citrates, 8 parts of succinic acid, dissolving is uniformly dispersed, and films, solvent flashing, the combination backing layer, requirement cuts into the patch of suitable size according to dosage.
Embodiment 6: with the polyacrylic resin pressure sensitive adhesive is the method for making that skeleton contains the patch of meloxicam; Get polyacrylic resin III100 part, be dissolved in 200 parts the ethanol and acetone mixed solvent, add 4 parts of meloxicams, 40 parts of triethyl citrates, dissolving is uniformly dispersed, and films, solvent flashing, the combination backing layer, requirement cuts into the patch of suitable size according to dosage.
Embodiment 7: with the polyacrylic resin pressure sensitive adhesive is the method for making that skeleton contains the patch of meloxicam; Get 100 parts of polyacrylic resin IV, be dissolved in 200 parts the ethanol and acetone mixed solvent, add 5 parts of meloxicams, 20 parts of triethyl citrates, 12 parts of ethyl sebacates, dissolving is uniformly dispersed, and films, solvent flashing, the combination backing layer, requirement cuts into the patch of suitable size according to dosage.
Claims (3)
1, a kind of local skin patch that contains meloxicam, described patch is made up of following three parts: (1) backing layer; (2) the gluing casing play of pastille; (3) adherent layer is characterized in that: get 100 parts of polyacrylic resin IV, be dissolved in 200 parts the ethanol and acetone mixed solvent, add 5 parts of meloxicams, 30 parts of triethyl citrates; Or get 100 parts of polyacrylic resin III, and be dissolved in 200 parts the ethanol and acetone mixed solvent, add 4 parts of meloxicams, 40 parts of triethyl citrates, dissolving is uniformly dispersed, films, solvent flashing, the combination backing layer cuts into patch.
2, a kind of local skin patch that contains meloxicam according to claim 1 is characterized in that: add viscosifier in the gluing casing play of pastille, viscosifier are a kind of in multicomponent organic acid, terpene resin, Colophonium and the Foral.
3, a kind of local skin patch that contains meloxicam according to claim 1, it is characterized in that: add the drug transdermal absorption enhancer in the gluing casing play of pastille, the drug transdermal absorption enhancer is a kind of in oleic acid, laurocapram, Oleum menthae, the eucalyptus oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100211225A CN100477994C (en) | 2004-02-09 | 2004-02-09 | Meloxicam containing skin topical paste formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100211225A CN100477994C (en) | 2004-02-09 | 2004-02-09 | Meloxicam containing skin topical paste formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1557320A CN1557320A (en) | 2004-12-29 |
| CN100477994C true CN100477994C (en) | 2009-04-15 |
Family
ID=34351933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100211225A Expired - Fee Related CN100477994C (en) | 2004-02-09 | 2004-02-09 | Meloxicam containing skin topical paste formulation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100477994C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1301709C (en) * | 2005-02-17 | 2007-02-28 | 西安东盛集团有限公司 | Skin plaster containing aceclofenac |
| CN106924223B (en) * | 2017-03-13 | 2021-11-12 | 沈阳药科大学 | Meloxicam patch and preparation method and application thereof |
-
2004
- 2004-02-09 CN CNB2004100211225A patent/CN100477994C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 美洛昔康贴剂的研究. 杨丽英等.沈阳药科大学硕士学位论文. 2002 |
| 美洛昔康贴剂的研究. 杨丽英等.沈阳药科大学硕士学位论文. 2002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1557320A (en) | 2004-12-29 |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090415 Termination date: 20180209 |
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| CF01 | Termination of patent right due to non-payment of annual fee |