CN100459957C - Medical neonate sub-low-temperature therapeutic equipment - Google Patents
Medical neonate sub-low-temperature therapeutic equipment Download PDFInfo
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- CN100459957C CN100459957C CNB2005100294788A CN200510029478A CN100459957C CN 100459957 C CN100459957 C CN 100459957C CN B2005100294788 A CNB2005100294788 A CN B2005100294788A CN 200510029478 A CN200510029478 A CN 200510029478A CN 100459957 C CN100459957 C CN 100459957C
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Abstract
The invention relates to an newborn sub-low-temperature therapeutic equipment, including a detached cooling hat and a freezing cycle system and each of them equipped with the measuring sensor units and the tutelar measuring units for life parameters which controlled by computers. Said freezing cycle system integrated with semiconductor refrigeration, calefaction technique, modulation technique for pulse width and intelligence arithmetic, the deviation of temperature is +-0.1DEG C, two-path cycle system and mixed adjusting technique with cold and hot water to keep the temperature of the newborn baby in stable level of sub-low-temperature. The measuring sensor units contain the temperature of baby and the cooling hat, and the tutelar measuring units for life parameters contain the tutelar parameters of the rhythm of the heart, the pulse, the blood pressure and the oxygen saturation. The apparatus also provides a simple operating system for doctors.
Description
Technical field
This utility model relates to a kind of medical neonate cooling sub-low-temperature therapeutic equipment, and reasonable in design, the advanced technology, temperature control that relates to clinical use or rather accurately, the cranium brain cooling of good cooling effect uses therapeutic instrument, belongs to field of medical instruments.
Background technology
Over past ten years, clinical medicine domain has had more the mechanism of neonate thermoregulation and cold injury understands in depth, and the warming idea of traditional neonate is re-recognized, and studies show that, the body temperature of FTNB appropriateness reduces can not cause cold injury.Studies confirm that, excessively warming if the neonate that seriously suffocates gives, can increase the weight of the brain injury degree after the brain temperature rise; Low 2～4 ℃ of opposite brain temperature drop can alleviate the back hypoxic-ischemic brain damage degree of seriously suffocating, and improves long-term prognosis.Nearest 5 years, successively 3 clinical multicenter study have been carried out in countries such as New Zealand, the U.S. and China, finish substantially in the recent period, the result all confirms, the back hypoxic-ischemic brain damage neonate that suffocates carries out the Head cooling treatment as early as possible after life, the brain relaxing the bowels with purgatives of warm nature falls 2～4 ℃, can alleviate the brain injury degree, reduces the generation of sequela at a specified future date such as cerebral palsy, mentally disabled, epilepsy.Thus, temperature reduces by 2～4 ℃ inferior low temperature (MildHypothermia) treatment (Hypoxic ischemic braindamage, HIBD) using value in is gradually by clinical approval and popularization at the anoxia neonatorum ischemic brain injury.
Though; craniocerebral injury has neuroprotective to inferior low temperature to neonate; but key technologies such as suitable temperature, lasting time, the inferior cryogenic method of enforcement are all not definite fully; up to the present; still do not have the patent application that is exclusively used in neonate sub-low-temperature therapeutic equipment, the heat sink report that is used for the neonate sub-low-temperature treatment is also very few.Clinically to physical cooling methods such as the many uses of neonate brain disorder person wardrobe cranium cooling ice bags, brain temperature fluctuation range is big, should not control, and is difficult to reach therapeutic effect at present; Also have part unit's sub-low-temperature therapeutic equipment of attempting be grown up to be used for the neonate clinical treatment, its instrument parameters setting, neonate vital sign parameter are difficult to obtain synchronous monitoring and regulation and control, have danger greatly.We design the patent application of the medical sub-low-temperature therapeutic equipment of neonate that is exclusively used in the neonate Head cooling jointly in conjunction with the special technology personnel of neonatological medicine domain expert and cooling instrument production aspect for this reason.
Summary of the invention
The object of the present invention is to provide a kind of medical neonate sub-low-temperature therapeutic equipment, be applicable to the neonatal clinical medicine treatment of the back hypoxic-ischemic brain damage that seriously suffocates.
Medical neonate sub-low-temperature therapeutic equipment provided by the invention is made up of dismountable cooling hat and cooling cycle system, they contain measurement sensing unit and life parameters monitoring measuring unit respectively, control by main control computer, measure sensing unit and comprise by parameters such as human body temperature, ice cap temperature, life parameters monitoring measuring unit comprises by the rhythm of the heart, pulse, blood pressure, oxygen saturation, nasopharyngeal temperature etc. and shows vital sign.
The present invention is in conjunction with semiconductor refrigerating technology, pulse modulation technique (PWM) and INTELLIGENT PID CONTROL ALGORITHM technology, regulate and control the neonate temperature accurately and fast, implement mild hypothermia therapy anoxia neonatorum ischemic brain injury, reach the purpose of neonate vital sign parameter synchronous detecting and regulation and control, have characteristics such as fluctuation range is little, reliable, good reproducibility.
Described cooling cycle system integrating semiconductor refrigeration and heating technique, PWM and PID intelligent algorithm adopt the two-way blood circulation, utilize cold and hot current mixing regulating and controlling temperature.
Its core technology design has:
(1) adopts the two-way blood circulation; utilize cold and hot current mixing regulating and controlling temperature: because neonate thermoregulation ability is poor more than the adult; if use the adult to use instrument; to preset the cooling target temperature and place 34 ℃; when neonate body temperature drops to 34 ℃; monitor message feedback back machine down; but cooling hat (blanket) water temperature is low; neonatal body temperature still continues to descend; body temperature descended to hanging down and may cause the neonate cold injury; adopt the two-way blood circulation; utilize cold and hot current mixing regulating and controlling temperature technology can overcome this shortcoming, 0.5 ℃ the time, machine can start heating facility below body temperature is reduced to preset temperature; change cooling hat (blanket) water temperature, be in metastable inferior low temperature level with regulation and control neonate body temperature.
(2) be equipped with neonate physiology, dissect the vital sign monitoring and the inferior low temperature implementation system that are complementary: the neonatal vital sign of back hypoxic ischemic encephalopathy that seriously suffocates is extremely unstable, during implementing mild hypothermia therapy, it is of crucial importance that strict monitoring its vital sign (rhythm of the heart, pulse, blood pressure, oxygen saturation) and inferior low temperature are implemented temperature (nasopharyngeal temperature, rectal temperature).This apparatus preparation multiple tracks neonate vital signs monitors adopts liquid crystal display, the menu in Chinese operation; The temperature sensor of monitoring neonatal nasopharyngeal temperature simultaneously is Pt100 (φ 1.5mm), directly inserts in the neonate nostril, and its body temperature situation of change of actual response can not cause the neonate airway obstruction simultaneously.The default inferior low temperature implementation condition of instrument is: 34 ℃ of human bodies, and 5 ℃ of water temperatures, 15 ℃/hour of cooling rates, alarm temperature threshold value ± 1.0 ℃, other also comprise multiple warning systems such as watermark threshold, cooling rate threshold value and sign parameter threshold.
Described Pt100 is a platinum resistance 100, is a kind of critesistor, measures the degree of accuracy height between human body 25-45 ℃, and does not have obvious temperature error.
(3) managing the hardware that matches with neonatal intensive care unit (NICU) is equipped with: more and more many discovers, long-term noise exposure, and may there be negative effect in neonatal nervous system development.This instrument is abandoned the freon refrigeration Compressor Technology for this reason, adopts commercially available Tecl-1274 type semiconductor refrigerating assembly, super quiet circulating pump technology, reduces noise greatly, makes the noise≤40db of whole therapeutic instrument.Cause situations such as nosocomial infection lowly, easily in view of the neonatal immunity defence capability, this instrument adopts disposable cooling hat or blanket, cross infection with keeping off infection property disease, cooling hat is equipped with different model, be applicable to different big or small neonates, one of the applicant---Children's Hospital, Fudan University is in application utility model patent in 2002.(the patent No.: 02266745.8)
(4) be adapted to medical personnel's easy operating system: directly enter Auto-Sensing Mode after the start, System self-test main frame, pick off, keying demonstration, electro-mechanical actuator etc., provide status information after normal, and change over to automatically and preset mode of operation, the inferior low temperature implementation condition that machine is preset automatically comprises given human body temperature, ice cap temperature, cooling rate and warning limit etc.Be equipped with the manual adjustments pattern simultaneously, can every mild hypothermia therapy implementation condition manually be set according to the neonate concrete condition.If the undesired warnings/maintenance mode that changes over to automatically of System self-test, and demonstration malfunction and fault mode, system is in safe work state, forbids refrigeration system work.This instrument has a hardware clock simultaneously, accurately memory open, between the stopping time.Interchangeability adds water, changes water operation simplification fast.
It is easy to use to the invention provides the medical sub-low-temperature therapeutic equipment of neonate, at first, cooling hat is connected with the cooling instrument main frame, cooling hat is placed the neonate head, select the headgear of different size for use according to the size of neonate head, open cooling instrument, set the cooling temperature, connect each vital signs parameter simultaneously, this instrument can be reduced to predefined temperature with the neonate head temperature in 30 minutes.Compact conformation of the present invention, low, the dependable performance of cost, and the neonatal cooling therapeutic of simple to operate and applicable different sizes.
Instrument parameters index explanation: 8～37 ℃ of water temperature span of control, deviation ± 0.2 ℃, human body temperature is to be standard with the monitoring nasopharyngeal temperature, human body temperature certainty of measurement ± 0.1 ℃, cooling hat temperature measurement accuracy ± 0.2 ℃, total noise of centrifuge＜40db.Cooling rate〉15 ℃/h, power consumption≤800w.Main frame MTBF〉10000h, these cooling instrument overall dimensions: 440 x, 330 x 830cm.
Description of drawings
The medical sub-low-temperature therapeutic equipment block diagram of system of Fig. 1 neonate provided by the invention.
Fig. 2 is system's described cooling rate controllability solution block diagram shown in Figure 1.
Fig. 3 refrigeration, heating two-way blood circulation block diagram.
Fig. 4 controlling models block diagram of lowering the temperature.
Fig. 5 therapeutic instrument operator scheme provided by the invention flow chart.
The specific embodiment
Further illustrating substantive distinguishing features of the present invention and obvious improvement, but the present invention absolutely not only is confined to embodiment below in conjunction with accompanying drawing.
Medical neonate sub-low-temperature therapeutic equipment of the present invention, it is made up of cooling hat and cooling cycle system, and the latter is integrated by semiconductor refrigerating, heating technique, PWM and pid algorithm technology and forms.Described cooling hat or blanket are to be used by PVC material system, the cooling hat temperature measurement accuracy reaches ± and 0.2 ℃, sub-low-temperature therapeutic equipment is regulated and control neonate body temperature fast and is in metastable level, the regulating and controlling temperature deviation is ± 0.1 ℃, and in use by life parameters monitoring unit by the strict monitoring of vital signs such as the rhythm of the heart, pulse, blood pressure, oxygen saturation, nasopharyngeal temperature, rectal temperature, neonatal nasopharyngeal temperature is by Φ 1.5mmPt100 temperature sensor measurement.
As shown in Figure 1, after the location parameter collection of temperature sensor, at first carry out electrical signal conversion, feed back to main control computer then, carry out date processing, handle the back signal and be divided into two-way, one of input display monitoring unit, carry out data show, two input master control electric motor units, the control of freezing circulates, and with control ice cap (blanket) temperature, synchronous signal continues to feed back to the mensuration sensing unit, to form closed loop control, guarantee Instrument measuring precision.
And for example shown in Figure 4, after the required value of human body temperature or set-point are set, machine is at first measured actual human body temperature and ice cap temperature, and compare with setting or set-point, send into then among 16 the CPU, carry out date processing, simultaneously in conjunction with the threshold value parameter, information is sent among the power amplifier executor, and output signal is divided into two-way, one of input motor electromechanical units carry out kind of refrigeration cycle running control, two data feed back in H (S) and revise immediately, and this process information passed in the master cpu, form closed circuit, with the temperature and the certainty of measurement of the quiescent point that guarantees machine.H among the figure (S) is the transfer function commonly used in the industry automatic control.
Whole therapeutic instrument can change the neonate sub-low-temperature mode of operation that presets automatically over to, the inferior low temperature implementation condition that machine is preset automatically.After start, directly enter Auto-Sensing Mode, System self-test main frame, pick off, keying show, electro-mechanical actuator, provide status information after normal, and change over to automatically and preset mode of operation, the inferior low temperature implementation condition that machine is preset automatically comprises given human body temperature, ice cap temperature, cooling rate and warning limit; Be equipped with the manual adjustments pattern simultaneously,, every mild hypothermia therapy implementation condition be set manually according to the neonate concrete condition; If the undesired warning/maintenance mode that changes over to automatically of System self-test, and show malfunction and fault mode.
Claims (5)
1. medical neonate sub-low-temperature therapeutic equipment, it is made up of detachable cooling hat and cooling cycle system; And contain sensing unit and the life parameters monitoring measuring unit of measuring human body and ice cap temperature respectively, it is characterized in that:
1. described life parameters monitoring measuring unit shows the monitored parameters of the vital sign that includes the rhythm of the heart, pulse, blood pressure and oxygen saturation, and adopts liquid crystal display;
2. described cooling cycle system adopts the two-way blood circulation, utilizes hot and cold water mixing regulating and controlling temperature technology, is in metastable inferior low temperature level with regulation and control neonate body temperature;
3. control by main control computer.
2. by the described medical neonate sub-low-temperature therapeutic equipment of claim 1, it is characterized in that described cooling cycle system is integrating semiconductor refrigeration, heating technique, pulse modulation technology and intelligent algorithm, regulating and controlling temperature deviation ± 0.1 ℃.
3. by the described medical neonate sub-low-temperature therapeutic equipment of claim 1, it is characterized in that described human body temperature is is standard with the monitoring nasopharyngeal temperature, the temperature sensor of use is directly inserted in the neonate nostril.
4. by the described medical neonate sub-low-temperature therapeutic equipment of claim 1, it is characterized in that the inferior low temperature implementation condition of presetting is 34 ℃ of human bodies, 5 ℃ of water temperatures, cooling rate are 15 ℃/hour, and the alarm temperature threshold value is ± 1.0 ℃.
5. by the described medical neonate sub-low-temperature therapeutic equipment of claim 1, the operating system that it is characterized in that described main control computer directly enters Auto-Sensing Mode after start, System self-test main frame, pick off, keying show, electro-mechanical actuator, provide status information after normal, and change over to automatically and preset mode of operation, the inferior low temperature implementation condition that machine is preset automatically comprises given human body temperature, ice cap temperature, cooling rate and warning limit; Be equipped with the manual adjustments pattern simultaneously,, every mild hypothermia therapy implementation condition be set manually according to the neonate concrete condition; If the undesired warning/maintenance mode that changes over to automatically of System self-test, and show malfunction and fault mode.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100294788A CN100459957C (en) | 2005-09-07 | 2005-09-07 | Medical neonate sub-low-temperature therapeutic equipment |
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| CNB2005100294788A CN100459957C (en) | 2005-09-07 | 2005-09-07 | Medical neonate sub-low-temperature therapeutic equipment |
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| CN1927140A CN1927140A (en) | 2007-03-14 |
| CN100459957C true CN100459957C (en) | 2009-02-11 |
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| CNB2005100294788A Expired - Fee Related CN100459957C (en) | 2005-09-07 | 2005-09-07 | Medical neonate sub-low-temperature therapeutic equipment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108814803A (en) * | 2018-06-14 | 2018-11-16 | 中国医学科学院生物医学工程研究所 | A kind of body temperature regulation method, apparatus, equipment and storage medium |
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| CN104434445A (en) * | 2013-09-22 | 2015-03-25 | 深圳市科曼医疗设备有限公司 | Infant incubator and temperature control method thereof |
| CN104546277B (en) * | 2014-12-31 | 2016-11-09 | 潍坊豪泰医疗科技有限公司 | Autompulse cold compress system |
| CN104586564A (en) * | 2015-02-10 | 2015-05-06 | 中国人民解放军第三军医大学第二附属医院 | Intelligent multifunctional ice cap |
| CN104856795B (en) * | 2015-04-18 | 2017-04-12 | 深圳市前海安测信息技术有限公司 | Human body temperature monitoring and controlling device for network hospital |
| CN105640691B (en) * | 2015-12-29 | 2019-02-01 | 浙江大学 | A kind of rat cranio-cerebral hypothermia experiment porch and temprature control method |
| CN105708667A (en) * | 2016-01-20 | 2016-06-29 | 广州奥迈医疗科技有限公司 | Body temperature regulation device used in in-vitro counterpulsation treatment |
| CN105596161A (en) * | 2016-01-27 | 2016-05-25 | 卢雯 | Multifunctional water bed |
| CN106691666A (en) * | 2017-01-20 | 2017-05-24 | 菅天孜 | Wearable cooling garment with vital sign monitoring function |
| CN111481335A (en) * | 2019-01-28 | 2020-08-04 | 深圳市科曼医疗设备有限公司 | Human body temperature adjusting method and device and sub-hypothermia treatment equipment |
| CN110236773B (en) * | 2019-06-12 | 2021-03-23 | 深圳市科曼医疗设备有限公司 | Many plug-ins inferior low temperature therapeutic instrument |
| CN114159222A (en) * | 2022-02-14 | 2022-03-11 | 江苏省人民医院（南京医科大学第一附属医院） | Brain temperature data processing system based on brain temperature monitoring |
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