CN100459881C - Application of edestin for preparing functional food with adjuvant therapy of lowering blood fat - Google Patents
Application of edestin for preparing functional food with adjuvant therapy of lowering blood fat Download PDFInfo
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- CN100459881C CN100459881C CNB2006101638725A CN200610163872A CN100459881C CN 100459881 C CN100459881 C CN 100459881C CN B2006101638725 A CNB2006101638725 A CN B2006101638725A CN 200610163872 A CN200610163872 A CN 200610163872A CN 100459881 C CN100459881 C CN 100459881C
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Abstract
An application of the hemp seed's globulin in preparing the functional food for stabilizing the contents of cholesterol, triglyceride and low-density lipoprotein (LDL) in blood and increasing the content of high-density lipoprotein in blood is disclosed.
Description
Technical field
The invention belongs to the fructus cannabis applied technical field, relate to the purposes of fructus cannabis globulin, more particularly, the present invention relates to the application of fructus cannabis globulin in the functional food of preparation blood-fat-decreasing.
Background technology
Fructus cannabis (FRUCTUS CANNABIS) is commonly called as Ma Ren, fiery pockmarks, hempseed, is the dry mature fruit of the sub-sativa L. of moraceae plants hemp Cannabis.Its nature and flavor are sweet, flat, return spleen, stomach, large intestine channel, are usually used in treating disease of digestive system, as the dry constipation of intestines, relax bowel, the contrary more than disease of waiting of vomitting.Put down in writing according to Compendium of Material Medica: the fructus cannabis tonifying middle-Jiao and Qi, the dry and hot pouring of sharp large intestine wind-heat knot, preventing or arresting vomiting is contrary etc.Health ministry is defended method prison and is sent out [2002] No. 51 files " Ministry of Public Health is about the notice of further standard healthy food material management ", fructus cannabis is listed in the article list of " be medicine be again food ".The Main Ingredients and Appearance of fructus cannabis has fructus cannabis oil (Hemp seeds oil), fructus cannabis (hemp seeds protein), starch and cellulose etc.
Fructus cannabis globulin (edestin) is the six poly-globulin (hexamericglobulin) that extract from fructus cannabis.Have 65% to be the fructus cannabis globulin in the contained albumen of fructus cannabis approximately, by the SDS-PAGE atlas analysis, this type of globulin only exists in moraceae plants hemp seed, so the fructus cannabis globulin is considered to constitute the main component of fructus cannabis cell DNA structure.At present, the fructus cannabis globulin products of selling on the market is mainly fructus cannabis globulin powder (custom is called for short " edestin "), and its purity reaches more than 90%.
In the prior art, the fructus cannabis globulin uses mainly as plant protein nutrition replenishers or hardening agent, the research of the relevant auxiliary antilipemic effect of carrying out at the fructus cannabis globulin, and Shang Weijian has relevant report.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of new purposes of fructus cannabis globulin is provided, be i.e. new application in the functional food preparation.
In fact, the present invention relates to the application of fructus cannabis globulin in the functional food of preparation blood-fat-decreasing.
In order to understand essence of the present invention better, below will be with the application experiment of fructus cannabis globulin powder and result the new purposes of naked light edestin in the functional food preparation field of blood-fat-decreasing.Similarly, the fructus cannabis globulin is made other regular dosage form all can reach same effect, difference only is the difference on the using dosage.
Application experiment---the effect of the blood of human body middle-high density lipoprotein (HDL) that significantly raises
1, uses A, B, three kinds of samples of C respectively in the experiment.A: blank sample dietary fiber 20g/d (protein content＜0.3%); B: positive control sample soyabean protein powder 20g/d (protein content 90%); C: laboratory sample be the fructus cannabis globulin powder produced of German SIGMA company (mark this shop: 060924), 20g/d (protein content 90%).
2, experimental subjects and laboratory sample use and arrange
With 33 male sex students is the research experimenter, 21.7 ± 2.8 years old experimenter's mean age, 173.6 ± 3.8 centimetres of heights, 66.5 ± 4.9 kilograms of body weight.Experiment is single blind cross-over experiment, promptly the experimenter do not understand the grouping or the purpose of edible sample.
The experimenter is divided into 3 groups at random, every group 11 people, the A group is the blank group, take dietary fiber, B organizes positive control group, takes soyabean protein powder, and the C group is experimental group, take fructus cannabis globulin powder, take every day 2 times, A sample 10g/ time after all reconstituting with the warm boiling water below 45 degrees centigrade, B sample 10g/ time, C sample 10g/ time.Taking a week is one-period, amounts to for 3 weeks.
3, blood sample test index: before gathering experiment respectively, the empty stomach venous blood in first weekend, second weekend, the 3rd early morning at weekend, measure blood fat (T-CHOL, triglycerides, low-density lipoprotein (LDL), HDL (HDL)).
4, blood sample method of testing: T-CHOL enzymic colorimetric; The triglycerides enzymic colorimetric; Low-density lipoprotein (LDL) is used the polyvinyl sulfuric acid precipitation method; HDL (HDL) phosphotungstic acid-magnesium precipitate method; Above-mentioned all reagent are all available from Zhongsheng Beikong Biological Science ﹠ Technology Co., Ltd., and instrument is the semi-automatic analyzer of EppendorfCOM-F-6124 type.
5, statistical method: experimental data is analyzed with the SAS8.1 statistical software, adopts the data analysis of duplicate measurements.All data are represented with means standard deviation.
6, result:
Experimental session divides measures total cholesterol level three times, equal indifference between three groups.Fructus cannabis globulin group total cholesterol level is stable tendency (seeing Table 1).
Table 1: the variation (mmol/L) of serum cholesterol concentration in experimenter's experiment
Experimental session divides measures triglyceride levels three times, significant difference all do not occur between three groups and between four time points, and edible fructus cannabis globulin is to not influence (seeing Table 2) of triglyceride levels
Table 2: the variation (mmol/L) of serum triglyceride concentration in experimenter's experiment
Experimental session divides measures low-density lipoprotein (LDL) level three times, significant difference all do not occur between three groups and between four time points, and edible fructus cannabis globulin is to the not influence of low-density lipoprotein (LDL) level.(seeing Table 3)
Table 3: the variation (mmol/L) of ldl concn in experimenter's experiment
Experimental session, edible fructus cannabis globulin is after three weeks, and the level of HDL (HDL) obviously increases, and compares with basic value difference (P＜0.05) to have occurred, and other two groups same variation (seeing Table 4) then do not occur.
Table 4: the experimenter tests the variation (mmol/L) of middle-high density lipoprotein (HDL) concentration
*: represent that this organizes this time result and compare with this group basic value, significant difference is arranged, P＜0.05
Experimental result shows, the fructus cannabis globulin is in stablizing blood of human body in T-CHOL, triglycerides and low-density lipoprotein (LDL) level, can significantly increase the level of HDL (HDL), edible fructus cannabis globulin is after three weeks, the level of HDL (HDL) improves 8.5% than this group basic value, compare blank group and improve 13.3%, compare control group and improve 9.4%.
Lipoprotein in the human serum is divided into low-density lipoprotein (LDL) and HDL (HDL), both content ratios are one to two, the both has vital task: low-density lipoprotein (LDL) is transported to body tissue to cholesterol from liver, when the low-density lipoprotein in the blood (LDL) too high levels, the cholesterol that it carries just accumulates on blood and the arterial wall, cause diseases such as high fat of blood, artery sclerosis easily, so LDL-C (LDL-C) is called as " bad cholesterol ".HDL (HDL) is then played the part of street cleaner role, its cholesterol that perienchyma is unnecessary is sent liver recirculation back to, or excrete external with the form of cholic acid, cholesterol hoard in the blood and vascular wall on chance just reduce, so HDL-C (HDL-C) is called " good cholesterol ".This shows, improve HDL (HDL) level and can reach the purpose of regulating and reducing blood fat.Therefore, the fructus cannabis globulin can be used in the functional food of preparation blood-fat-decreasing.
As application of the present invention, also can be with the fructus cannabis globulin as active component, technology is used separately or adds to be prepared in the compound to supply human edible various multi-form functional food routinely.As oral agents, tablet, pulvis, capsule, microcapsules, soft capsule, food additives, nutrition fortifier, baking goods, beverage, for dairy products, ice cream etc.
Wherein, the extraction of fructus cannabis globulin can utilize the fructus cannabis globulin to be insoluble in the pure water, but is dissolved in the characteristics in the sodium-chloride water solution, and the sodium chloride solution with 2～10% extracts the fructus cannabis globulin from fructus cannabis.Also can use traditional " the molten acid of alkali is heavy " method or ethanol and other organic solvents under different condition, the fructus cannabis globulin to be extracted.Also comprise fructus cannabis is mixed the extraction of back to the fructus cannabis globulin with other raw materials.
With respect to prior art, the present invention has the following advantages:
1. the present invention has excavated the new purposes of fructus cannabis globulin, has opened up a new application;
2. directly taking the fructus cannabis globulin can be in stablizing blood of human body in T-CHOL, triglycerides and low-density lipoprotein (LDL) level, significantly increase the level of HDL (HDL), thereby play the effect of blood-fat-decreasing, effect is obvious;
3. raw material sources are abundant, preparation technology is simple, further be processed into can be for human edible various different food products forms for technology routinely, as oral agents, tablet, pulvis, capsule, microcapsules, soft capsule, food additives, nutrition fortifier, baking goods, beverage, for dairy products, ice cream etc.;
4. fructus cannabis globulin products safety non-toxic does not contain the excitant compositions such as stimulant, anesthetic, beta blocker, diuretics and hormone medicine of forbidding, has a good application prospect.
The specific embodiment
The present invention is described in further detail below in conjunction with embodiment, but they are not the qualification to content of the present invention.
Except as otherwise noted, the weighing among the embodiment is weight portion.
Embodiment 1
Utilize the fructus cannabis globulin to be insoluble in the pure water, but be dissolved in the characteristics in the sodium-chloride water solution, the sodium chloride solution with 2～10% extracts the fructus cannabis globulin from fructus cannabis.Adopt common process, further make fructus cannabis globulin sheet health food by following prescription:
50～80 parts in fructus cannabis globulin
10～40 parts of lactalbumins
5～10 parts of starch
0.5～1.5 part of vitamin E
0.1～0.5 part of ferric lactate
0.1～0.5 part of vitaminAD
0.1～0.5 part of lactose
0.001～0.005 part of dolomol
The accurate weighing of above component, by select materials, operations such as batch mixing, granulation, drying, compressing tablet, packing make fructus cannabis globulin sheet (500mg/ sheet) health food, suitable crowd: high fat of blood person.Eating method: each 6, every day 3 times.
Embodiment 2
Use traditional " the molten acid of alkali is heavy " method from fructus cannabis, to extract the fructus cannabis globulin.Adopt common process, further make fructus cannabis globulin powder by following prescription:
50～80 parts in fructus cannabis globulin
10～40 parts of lactalbumins
0.5～1.5 part of vitamin E
0.1～0.5 part of ferric lactate
0.1～0.5 part of vitaminAD
Flavorant is an amount of
The accurate weighing of above component, by select materials, batch mixing, tinning, operations such as packing make fructus cannabis globulin powder health food, suitable crowd: high fat of blood person.Eating method: get at every turn 1～2 spoon (about 16～32g), drink after reconstituting evenly with warm boiling water; Also can add in congee, soup, the milk edible.
Embodiment 3
Make fructus cannabis vegetable protein health drink by following prescription:
80～90 parts of pure water
3～10 parts in fructus cannabis globulin
3～10 parts of fructus cannabis oil
2～5 parts of cyclodextrines
0.5～1.5 part of emulsifying agent
0.1～0.5 part of stabilizing agent
0.1～0.5 part of lactose
1～5 part of sucrose
Flavorant is an amount of
The accurate weighing of above component, by select materials, batch mixing, size mixing, operation such as boiling, emulsification, filtration, homogeneous, can, sterilization, packing makes the fructus cannabis vegetable protein beverage.
Embodiment 4
Make person in middle and old age's Antilipemic health milk powder by following prescription:
65～75 parts of skimmed milk powders
15～25 parts in fructus cannabis globulin
5～10 parts of lactalbumins
0.1～0.5 part of lactose
1～5 part of vitamin E
0.1～0.5 part of ferrous lactate
0.1～0.5 part of FOS
0.1～0.5 part of mineral matter and trace element
Flavorant is an amount of
The accurate weighing of above component, by select materials, batch mixing, tinning, operations such as packing make person in middle and old age's Antilipemic health milk powder.
Claims (1)
1. the application of fructus cannabis globulin in the functional food of preparation blood-fat-decreasing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101638725A CN100459881C (en) | 2006-12-30 | 2006-12-30 | Application of edestin for preparing functional food with adjuvant therapy of lowering blood fat |
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| CNB2006101638725A CN100459881C (en) | 2006-12-30 | 2006-12-30 | Application of edestin for preparing functional food with adjuvant therapy of lowering blood fat |
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| CN100998413A CN100998413A (en) | 2007-07-18 |
| CN100459881C true CN100459881C (en) | 2009-02-11 |
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| CN111978385B (en) * | 2019-09-06 | 2022-04-19 | 云南汉盟制药有限公司 | Extraction method of edestin, product and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144065A (en) * | 1995-08-31 | 1997-03-05 | 戈振扬 | Hempseed protein drink and producing method thereof |
| CN1561829A (en) * | 2004-03-30 | 2005-01-12 | 云南工业用大麻实业有限公司 | Hemp seed protein powder and its preparing method and use |
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2006
- 2006-12-30 CN CNB2006101638725A patent/CN100459881C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144065A (en) * | 1995-08-31 | 1997-03-05 | 戈振扬 | Hempseed protein drink and producing method thereof |
| CN1561829A (en) * | 2004-03-30 | 2005-01-12 | 云南工业用大麻实业有限公司 | Hemp seed protein powder and its preparing method and use |
Non-Patent Citations (4)
| Title |
|---|
| 中药降脂研究现状. 楼锦英.浙江中医学院学报，第26卷第5期. 2002 |
| 中药降脂研究现状. 楼锦英.浙江中医学院学报，第26卷第5期. 2002 * |
| 火麻仁提取液对D半乳糖致衰模型小鼠学习记忆及代谢产物的影响. 骆静等.北京师范大学学报（自然科学版），第39卷第3期. 2003 |
| 火麻仁提取液对D半乳糖致衰模型小鼠学习记忆及代谢产物的影响. 骆静等.北京师范大学学报（自然科学版），第39卷第3期. 2003 * |
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