CN100453182C - 用于从含有微粒的液体中分离液体组分的微结构的分离装置和方法 - Google Patents
用于从含有微粒的液体中分离液体组分的微结构的分离装置和方法 Download PDFInfo
- Publication number
- CN100453182C CN100453182C CNB2004100923056A CN200410092305A CN100453182C CN 100453182 C CN100453182 C CN 100453182C CN B2004100923056 A CNB2004100923056 A CN B2004100923056A CN 200410092305 A CN200410092305 A CN 200410092305A CN 100453182 C CN100453182 C CN 100453182C
- Authority
- CN
- China
- Prior art keywords
- section
- particulate
- separator
- micro
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 147
- 239000002245 particle Substances 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims description 42
- 238000000926 separation method Methods 0.000 title abstract description 24
- 230000033001 locomotion Effects 0.000 claims abstract description 19
- 238000005204 segregation Methods 0.000 claims description 150
- 150000001875 compounds Chemical class 0.000 claims description 101
- 238000005192 partition Methods 0.000 claims description 55
- 239000000463 material Substances 0.000 claims description 53
- 210000004027 cell Anatomy 0.000 claims description 26
- 230000000694 effects Effects 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 10
- 238000004458 analytical method Methods 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 230000002776 aggregation Effects 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- 238000005054 agglomeration Methods 0.000 claims description 4
- 230000000035 biogenic effect Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 239000012429 reaction media Substances 0.000 claims description 3
- 230000009286 beneficial effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- 238000005470 impregnation Methods 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000011534 incubation Methods 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 26
- 239000008280 blood Substances 0.000 description 25
- 210000002381 plasma Anatomy 0.000 description 20
- 239000000523 sample Substances 0.000 description 16
- 210000003743 erythrocyte Anatomy 0.000 description 11
- 238000005520 cutting process Methods 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000005452 bending Methods 0.000 description 5
- 238000011176 pooling Methods 0.000 description 5
- 210000000265 leukocyte Anatomy 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000000003 hoof Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 102000004856 Lectins Human genes 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 101710186708 Agglutinin Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 238000000879 optical micrograph Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- -1 this Chemical class 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/4316—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor the baffles being flat pieces of material, e.g. intermeshing, fixed to the wall or fixed on a central rod
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/4317—Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10352535.1 | 2003-11-07 | ||
| DE10352535A DE10352535A1 (de) | 2003-11-07 | 2003-11-07 | Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1628907A CN1628907A (zh) | 2005-06-22 |
| CN100453182C true CN100453182C (zh) | 2009-01-21 |
Family
ID=34428663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100923056A Expired - Fee Related CN100453182C (zh) | 2003-11-07 | 2004-11-08 | 用于从含有微粒的液体中分离液体组分的微结构的分离装置和方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20050106756A1 (https=) |
| EP (1) | EP1531003B1 (https=) |
| JP (1) | JP2005140790A (https=) |
| CN (1) | CN100453182C (https=) |
| DE (1) | DE10352535A1 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0329220D0 (en) * | 2003-12-17 | 2004-01-21 | Inverness Medical Switzerland | System |
| CA2620690A1 (en) * | 2005-08-31 | 2007-03-08 | Nissan Chemical Industries, Ltd. | Microchip for cell response evaluation |
| GB2430393A (en) * | 2005-09-23 | 2007-03-28 | Univ Aston | Micro Device for Automatic Spermatozoa Selection and Cell Sorting |
| CN101305279A (zh) * | 2005-11-09 | 2008-11-12 | 皇家飞利浦电子股份有限公司 | 用于测试流体的设备 |
| EP2017000B1 (en) * | 2007-07-11 | 2012-09-05 | Corning Incorporated | Process intensified microfluidic devices |
| BRPI0815698A2 (pt) | 2007-08-24 | 2017-06-13 | Advanced Liquid Logic Inc | manipulação de contas em um atuador de gotículas. |
| TW200920841A (en) * | 2007-09-25 | 2009-05-16 | Cytyc Corp | Microfluidic apparatus for manipulating imaging and analyzing cells of a cytological specimen |
| JP5231782B2 (ja) * | 2007-10-26 | 2013-07-10 | 学校法人常翔学園 | 固液分離機能を有する装置及びその製造方法 |
| BRPI0907148B1 (pt) * | 2008-02-27 | 2021-01-12 | Boehringer Ingelheim Microparts Gmbh | dispositivo para a separação do plasma |
| EP2172260A1 (en) * | 2008-09-29 | 2010-04-07 | Corning Incorporated | Multiple flow path microfluidic devices |
| EP2350652A2 (en) * | 2008-10-10 | 2011-08-03 | Cnrs-Dae | Cell sorting device |
| SG184592A1 (en) * | 2011-03-18 | 2012-10-30 | Univ Singapore | Isolating target cells from a biological fluid |
| JP5340419B2 (ja) * | 2009-12-25 | 2013-11-13 | 学校法人常翔学園 | 固液分離機能を有する装置、μ−ＴＡＳデバイス及び固液分離方法 |
| TWI600462B (zh) * | 2010-03-05 | 2017-10-01 | 愛克斯崔里斯科技有限公司 | 過濾器旁路技術 |
| ES2715828T3 (es) * | 2010-04-15 | 2019-06-06 | Cytogen Co Ltd | Dispositivo microfluídico y métodos para aislar dianas |
| ITTO20100068U1 (it) * | 2010-04-20 | 2011-10-21 | Eltek Spa | Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici |
| MX2013001750A (es) * | 2010-08-15 | 2013-06-05 | Gpb Scientific Llc | Separacion celular micro-fluidica en el ensayo de sangre. |
| KR101768123B1 (ko) | 2010-12-03 | 2017-08-16 | 삼성전자주식회사 | 수력학 필터, 이를 구비한 필터링 장치 및 이에 의한 필터링 방법 |
| WO2012162779A1 (en) | 2011-05-27 | 2012-12-06 | The University Of British Columbia | Microfluidic cell trap and assay apparatus for high-throughput analysis |
| KR101911435B1 (ko) | 2011-09-26 | 2018-10-25 | 삼성전자주식회사 | 유체 제어 장치, 이를 포함하는 필터 및 바이오칩 |
| KR101890743B1 (ko) * | 2011-10-05 | 2018-08-23 | 삼성전자주식회사 | 유체 제어 장치 및 이를 사용하는 유체 제어 방법 |
| DE102011122579A1 (de) * | 2011-12-29 | 2013-07-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zum Trennen von Suspensions- oder Kolloidbestandteilen und Vorrichtung zum Trennen von Suspensions- oder Kolloidbestandteilen |
| KR101517091B1 (ko) | 2012-05-10 | 2015-05-04 | 단국대학교 산학협력단 | 미세입자 분리장치 및 미세입자 분리수거방법 |
| US10058866B2 (en) * | 2013-03-13 | 2018-08-28 | Abbott Laboratories | Methods and apparatus to mitigate bubble formation in a liquid |
| USD962471S1 (en) | 2013-03-13 | 2022-08-30 | Abbott Laboratories | Reagent container |
| US9535082B2 (en) | 2013-03-13 | 2017-01-03 | Abbott Laboratories | Methods and apparatus to agitate a liquid |
| USD978375S1 (en) | 2013-03-13 | 2023-02-14 | Abbott Laboratories | Reagent container |
| WO2014144627A1 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Automated diagnostic analyzers having rear accessible track systems and related methods |
| TW201522618A (zh) * | 2013-11-06 | 2015-06-16 | Japan Science & Tech Agency | 動物細胞運動方向之控制基材、使用有該基材之細胞識別方法及細胞分離方法 |
| TWI670114B (zh) * | 2014-11-28 | 2019-09-01 | 日商東洋製罐集團控股股份有限公司 | 微細輸液結構體及分析裝置 |
| KR102360072B1 (ko) * | 2014-12-08 | 2022-02-08 | 삼성전자주식회사 | 미세입자 분리 장치 |
| KR101850852B1 (ko) | 2016-01-08 | 2018-04-23 | 재단법인차세대융합기술연구원 | 미세유체채널장치 및 이의 사용방법 |
| KR102593919B1 (ko) * | 2016-03-21 | 2023-10-27 | 주식회사 지노바이오 | 세포 포획 카트리지 |
| US10983745B2 (en) | 2016-06-13 | 2021-04-20 | Lg Electronics Inc. | Display device and display system including same |
| CN106311368B (zh) * | 2016-07-29 | 2018-06-15 | 大连理工大学 | 一种用于微量进样器的液滴无损脱离装置 |
| GB2577607B (en) * | 2018-09-28 | 2023-05-17 | Guangdong Acxel Micro & Nano Tech Co Ltd | Droplet actuation |
| EP3983127B1 (en) * | 2019-06-12 | 2025-04-23 | Siemens Healthcare Diagnostics, Inc. | Plasma separation and sample metering device and methods of use related thereto |
| DE102020004660B4 (de) * | 2020-07-31 | 2022-06-15 | Evorion Biotechnologies Gmbh | Vorrichtung zur sequentiellen Positionierung von Partikeln |
| JP7455339B2 (ja) * | 2020-09-29 | 2024-03-26 | Nok株式会社 | 白血球捕捉デバイス |
| WO2023144192A1 (de) * | 2022-01-25 | 2023-08-03 | Evorion Biotechnologies Gmbh | Vorrichtung zur sequentiellen positionierung von partikeln |
| EP4502568A4 (en) * | 2022-03-28 | 2026-04-08 | National Univ Corporation Ibaraki Univ | WHITE BLOOD CELL CAPTURE DEVICE |
| EP4543592A1 (en) * | 2022-06-23 | 2025-04-30 | Solventum Intellectual Properties Company | Methods and devices for removing particles from fluids |
| KR20250102032A (ko) * | 2022-10-03 | 2025-07-04 | 웨스트 파마수티컬 서비시즈, 인코포레이티드 | 미세유체 혼합 및/또는 분리기 |
| WO2025166149A1 (en) * | 2024-02-02 | 2025-08-07 | Life Technologies Corporation | Microfluidic devices |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837115A (en) * | 1993-06-08 | 1998-11-17 | British Technology Group Usa Inc. | Microlithographic array for macromolecule and cell fractionation |
| US6156270A (en) * | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US6319719B1 (en) * | 1999-10-28 | 2001-11-20 | Roche Diagnostics Corporation | Capillary hematocrit separation structure and method |
| US20020196435A1 (en) * | 2000-11-22 | 2002-12-26 | Cohen David Samuel | Apparatus and methods for separating agglutinants and disperse particles |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3827555A (en) * | 1973-03-05 | 1974-08-06 | Bio Physics Systems Inc | Particle sorter with segregation indicator |
| US4271119A (en) * | 1979-07-23 | 1981-06-02 | Eastman Kodak Company | Capillary transport device having connected transport zones |
| IT1212882B (it) * | 1983-07-29 | 1989-11-30 | Della Valle Francesco | Derivati basici della cumarina |
| US5135719A (en) * | 1986-10-29 | 1992-08-04 | Biotrack, Inc. | Blood separation device comprising a filter and a capillary flow pathway exiting the filter |
| US5726026A (en) * | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| US5304487A (en) * | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5885527A (en) * | 1992-05-21 | 1999-03-23 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membrances |
| US5905028A (en) * | 1994-05-17 | 1999-05-18 | Gamma Biologicals, Inc. | Method and apparatus useful for detecting bloodgroup antigens and antibodies |
| US5938923A (en) * | 1997-04-15 | 1999-08-17 | The Regents Of The University Of California | Microfabricated filter and capsule using a substrate sandwich |
| DE19733108C2 (de) * | 1997-07-31 | 1999-06-02 | Bartels Mikrotechnik Gmbh | Trennvorrichtung im submum Bereich |
| GB9800263D0 (en) * | 1998-01-08 | 1998-03-04 | Bio Diagnostics Ltd | A device for testing liquids |
| US6762059B2 (en) * | 1999-08-13 | 2004-07-13 | U.S. Genomics, Inc. | Methods and apparatuses for characterization of single polymers |
| US6451264B1 (en) * | 2000-01-28 | 2002-09-17 | Roche Diagnostics Corporation | Fluid flow control in curved capillary channels |
| US6919046B2 (en) * | 2001-06-07 | 2005-07-19 | Nanostream, Inc. | Microfluidic analytical devices and methods |
| US7456025B2 (en) * | 2001-08-28 | 2008-11-25 | Porex Corporation | Sintered polymer membrane for analyte detection device |
| US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
| US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US20040166551A1 (en) * | 2003-02-24 | 2004-08-26 | John Moulds | Detection of agglutination of assays |
-
2003
- 2003-11-07 DE DE10352535A patent/DE10352535A1/de not_active Withdrawn
-
2004
- 2004-11-02 EP EP04025985.5A patent/EP1531003B1/de not_active Expired - Lifetime
- 2004-11-08 JP JP2004324376A patent/JP2005140790A/ja not_active Ceased
- 2004-11-08 US US10/983,096 patent/US20050106756A1/en not_active Abandoned
- 2004-11-08 CN CNB2004100923056A patent/CN100453182C/zh not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6156270A (en) * | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US5837115A (en) * | 1993-06-08 | 1998-11-17 | British Technology Group Usa Inc. | Microlithographic array for macromolecule and cell fractionation |
| US6319719B1 (en) * | 1999-10-28 | 2001-11-20 | Roche Diagnostics Corporation | Capillary hematocrit separation structure and method |
| US20020196435A1 (en) * | 2000-11-22 | 2002-12-26 | Cohen David Samuel | Apparatus and methods for separating agglutinants and disperse particles |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1531003B1 (de) | 2016-08-17 |
| DE10352535A1 (de) | 2005-06-16 |
| JP2005140790A (ja) | 2005-06-02 |
| EP1531003A1 (de) | 2005-05-18 |
| CN1628907A (zh) | 2005-06-22 |
| US20050106756A1 (en) | 2005-05-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100453182C (zh) | 用于从含有微粒的液体中分离液体组分的微结构的分离装置和方法 | |
| US12427521B2 (en) | Sorting particles in a microfluidic device | |
| EP2040843B1 (en) | Apparatus for continuous particle separation | |
| JP5684224B2 (ja) | マイクロチャネルにおける粒子集束のためのシステムおよび方法 | |
| CN102695561B (zh) | 样品处理盒以及在离心力下处理和/或分析样品的方法 | |
| US20020160518A1 (en) | Microfluidic sedimentation | |
| WO2006076567A2 (en) | Microfluidic rare cell detection device | |
| KR20110088746A (ko) | 원심력기반의 미세유동장치 및 이를 이용한 유체시료 내 분석대상물질 검출방법 | |
| US20210187508A1 (en) | Systems and methods for particulate encapsulation in microdroplets | |
| US20180149574A1 (en) | Method of processing specimen and specimen processing apparatus | |
| Mane et al. | Microfluidic systems for isolation of white blood cells: from design to practical applications | |
| US20040147043A1 (en) | Microfluidic system for the manipulation and concentration of particles suspended in liquid | |
| JP7714318B2 (ja) | 分離デバイス | |
| Zhang et al. | On-chip sample preparations for point-of-care cellular analysis of blood | |
| Kersaudy-Kerhoas | Design, test and biological validation of microfluidic systems for blood plasma separation | |
| HK1194817B (en) | Systems and methods for particle focusing in microchannels | |
| HK1243669B (en) | Sorting particles in a microfluidic device | |
| HK1243765B (en) | Combined sorting and concentrating particles in a microfluidic device | |
| HK1129211B (en) | Apparatus for continuous particle separation | |
| HK1129211A (en) | Apparatus for continuous particle separation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090121 Termination date: 20091208 |