CN100432660C - Structure of electrochemical sensing test block and producing method thereof - Google Patents

Structure of electrochemical sensing test block and producing method thereof Download PDF

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CN100432660C
CN100432660C CN 200610009303 CN200610009303A CN100432660C CN 100432660 C CN100432660 C CN 100432660C CN 200610009303 CN200610009303 CN 200610009303 CN 200610009303 A CN200610009303 A CN 200610009303A CN 100432660 C CN100432660 C CN 100432660C
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electrode
metal
conductive
strip
sheet
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CN1811397A (en
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黄椿木
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黄椿木
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Abstract

本发明为一种抛弃式电化学式感测试片的结构及其制作方法,其结构包含:一绝缘薄片,其具有至少一通孔和至少一导电素材,其装设于该通孔中;一金属薄膜,盖覆于该导电素材上以合成一电极,且该电极具有一电极作用面及一电极衔接面,以利用该电极作用面产生一电极作用;以及至少一印刷导电条,其装设于该绝缘薄片上,并具有一导电条衔接端及一信号输出端,该导电条衔接端电连接至该电极衔接面,而该信号输出端则用以输出该电极作用产生的一量测信号。 The present invention is a structure and method for manufacturing a disposable electrochemical test strip, which structure comprises: an insulating sheet having at least one through hole and at least one conductive material, which is mounted in the through hole; a metal thin film the cover overlying the electrically conductive material to synthesize an electrode, and the electrode has an electrode and an electrode active surface mating face, with which to produce a surface electrode acting as electrodes; and at least one printed conductive strip, which is mounted on the the insulating sheet and having a terminal adapter and a signal output terminal of a conductive strip, the conductive strip is electrically connected to the terminal adapter engaging surface electrode, and the signal output terminal for outputting a measurement of the signal produced by action of the electrode.

Description

拋弃式电化学式感澜试片的结构及其制作方法 Disposable electrochemical sensing structure Lan and manufacturing method of the test piece

本申请是于2003年5月7日提交的申请号为03130909.7、发明名称为"拋弃式电化学式感测试片的结构及其制作方法"的分案申请。 Application No. This application is May 7, 2003 filed 03130909.7, entitled "structure and method for fabricating disposable electrochemical sensor strip," the divisional application.

(l)狀领域 (L) Field of shape

本发明为前申请的专利第92100279号的延续。 The present invention is a continuation Patent No. 92,100,279 before application. 该前专利为将塑胶导电复合材料以塑胶射出成型方式成型一感测试片的电极,而本发明延续该专利结构〈但已改变制造方法〉,以制造一种具有金属电极(Metal Electrode)的拋弃式感测试片。 The former patent the electrically conductive plastic composite material to an injection-molded plastic molded electrode of a test strip, the present invention is a continuation of the patent structure <changed but the production method> to produce a metal having an electrode (Metal Electrode) throw disposable test strip. 本发明为一种拋弃式电化学式感测试片(Electrochemical Sensor Strip)尤其是一 The present invention provides a disposable electrochemical test strip (Electrochemical Sensor Strip) a particular

种薄片式试片(Sheet Type Strip)的金属电极(Metal Electrode)的制造方法及其结构,其适用于测试一待测流体中某分析物的成分,如测试人体血液中的血糖、 The method of manufacturing a sheet-like test piece species (Sheet Type Strip) metal electrodes (Metal Electrode) and its structure, suitable for testing a component in a test fluid analyte, such as human blood glucose test,

尿酸的浓度。 The concentration of uric acid.

(2〉背聚技术 (2> back agglomeration techniques

一般使用贵金属为电化学感测器的电极材料可获得一高稳定与高再现性的检测品质,已是电化学领域的习知技术,但感测器上真正需要用到贵金属特性的只是电极的表面积而已,其他面积的贵金属材料是多余的,尤其对一拋弃式试片而言于电极面积以外的贵金属皆为浪费。 Typically a noble metal electrode material is an electrochemical sensor can be obtained a high quality and high stability and reproducibility of detection, is conventional in the art of electrochemical techniques, but really need to use the sensor characteristics of the noble metal electrodes only surface area of ​​it, the other area of ​​the noble metal material is unnecessary, particularly for a disposable test strip other than the noble metal electrode area are all wasted. 依本发明的目的为提供的金属电极,其除可应用于无化学干扰需求的惰性金属电极外,其亦可使用于具有直接催化功能的各种金属催化电极〈不限于惰性金属〉。 The metal electrode under this object of the invention to provide, in addition to which may be applied to an inert metal electrode needs no external chemical interference, which can also be used to direct various metal catalytic electrode having a catalytic function <limited to, inert metal>. 依本发明制成的拋弃式的电极及感测器,可适用于各式的电化学式检测电极、生物感测器、流体生化成分感测器(如污水、农药含量、重金属成分等检测试片)、各式居家医疗应用的检测试片(如血糖、尿酸、 胆固醇等检测试片)。 Under this electrode and the disposable sensor of the invention is made applicable to a variety of electrochemical detection electrodes, biosensors, biochemical components of fluid sensors (such as sewage, the content of pesticides, heavy metals and other detection test sheet), a variety of test strip home medical applications (e.g., glucose, uric acid, cholesterol test strip).

电化学感籌器(Electrochemical Sensor)的原理,于数十年来已被成熟应用 Principle to raise an electrochemical sense (Electrochemical Sensor), and has been for decades mature application

于各种流体的生化成分检测上,而在一实验室或专业的检验室中的一电化学检测的装备,因不同检验功能需求可有不同的配备。 On the detection of various biochemical components of the fluid, and an electrochemical detection equipment in a laboratory or in a professional laboratory, due to the different functional requirements can test different equipment. 请参阅第一图,其显示出一电化学检测装置10的最基本架构为: See the first graph, which shows the basic architecture of an electrochemical detection apparatus 10 is as follows:

1. 容置一待测流体11的一承装容器12,以为电化学的一量测区域13。 1. receiving a fluid to be measured 11 a holding container 12, that an electrochemical measurement region 13.

2. —化学试剂(Reagent) 14,用于与待测流体ll的一分析物产生一化学作用, 并产生一电性参数的输出信号,此电性参数的输出值与待测流体ii的该分析物的生化成分有关。 2. - the output signal Chemicals (Reagent) 14, a fluid to be measured with the analyte for a chemical reaction generating ll, and generating an electrical parameter output value of the fluid to be measured ii This electrical parameters of the about the biochemical composition of the analyte. 例如待测流体ii为人的血液,分析物为血醣的浓度,则此化学试剂14基本上为会为一葡萄糖氧化酶及其他复合物。 Ii fluid to be measured, for example, human blood, the concentration of the analyte is glucose, chemical reagents 14 This will provide a substantially glucose oxidase and other compounds.

3. 二至三个测试电极,如标号15是指一对电极(Counter Electrode) ,16 是一工作电极(Working Electrode) , 17是一参考电极(Reference Electrode), 用于将一电化学作用所需的一工作电压由一计量器18引接至化学反应容器12,并将待测流体11的该分析物经一电化学作用后的该电性参数输出信号电流,引接至计量器18作一数值分析及显示。 3. tests two to three electrodes, such as reference numeral 15 refers to a pair of electrodes (Counter Electrode), 16 is a working electrode (Working Electrode), 17 is a reference electrode (Reference Electrode), for the action of an electrochemical an operating voltage required by the connection of a meter 18 to a chemical reactor vessel 12, and the electrical parameters of the test output signal currents of the analyte fluid 11 after an electrochemical effect, connection of the gauge to make a value of 18 analysis and display.

4. 电化学计量器18,用于提供该电化学作用所需的工作电压(或电流),并量取该电化学作用后的该电性参数的输出信号电流(或电压),作成一记录与该数值分析及显示测试资料。 The output signal current of the electrical parameters of the electrochemical 4. gauge 18 for providing the desired effect of the electrochemical voltage (or current), and the amount of the electrochemically active (or voltage), creating a record analysis and display of test data and the value.

其中的测试电极15,16,17可只使用二个电极,其为对电极(Counter Electrode)与工作电极(WorkingElectrode)。 Wherein the test electrodes may be only two electrodes 16, 17, which is a pair of electrodes (Counter Electrode) working electrode (WorkingElectrode). 或可使用三个电极,除工作电极与对电极外,另一为参考电极(ReferenceElectrode)。 Or three electrodes may be used, in addition to the working electrode and the counter electrode and the other as a reference electrode (ReferenceElectrode). 或可再加上第四个以上的侦测电极(Detecting Electrode),因电化学作用需求不同可调配不同电极数目。 Plus the first or four or more detection electrodes (Detecting Electrode), because of the different needs of electrochemical action may deploy different number of electrodes.

除了电极数目的不同外,因不同的电极功能(如counter electrode相对于working electrode的不同)与感测器化学反应成分的不同,各电极材质的选用有非常大的变化。 In addition to the different number of electrodes, because the different functions of the electrode (e.g., counter electrode with respect to various working electrode) is different from the chemical reaction of the sensor component, the electrodes have a very large selection of materials change. 实验室通用的电极材料如下,其中对电极15(Counter Electrode) 材料只要是导电的材质即可,但导电电阻越低越好,如铜棒、银棒、镍棒、石墨棒或以碳胶或银胶印刷成形的导电膜电极。 General Laboratory electrode material follows, wherein the counter electrode 15 (Counter Electrode) as long as the material is electrically conductive material can be, but the conductive resistance as low as possible, such as copper, silver rod, Nickel bars, rods or graphite or carbon paste printing conductive silver paste electrode film formed. 当然金、白金等贵金属也可用于当对电极材料,只是材料成本高。 Of course gold, platinum and other precious metals may also be used as electrode material, but the high cost of materials. 其中参考电极17(Reference Electrode)的材质最常用为一银/氯化银修正电极(ModifiedElectrode) 171,因氯化银的电化学工作电位非常稳定,因而被广泛地用为参考电极。 Wherein the reference electrode 17 (Reference Electrode) The material most commonly used is a silver / silver chloride electrode correction (ModifiedElectrode) 171, due to the work of the electrochemical potential of silver chloride is very stable, which is widely used as the reference electrode.

其中工作电极16(WorkingElectrode)的电极材料的选用更为复杂,其有两大方向,第一类为利用电子转移媒介物的修正工作电极(Electron-Transfer Mediator Modified Working Electrode),第二类为金属催化电极(Metal-Catalyzed Electrode)。 Wherein the working electrode material selection electrode 16 (WorkingElectrode) is more complex, which has two direction, the first category is the use of the correction electron transfer mediator to the working electrode (Electron-Transfer Mediator Modified Working Electrode), a second type of metal catalyst electrode (Metal-catalyzed electrode). 其于第一类电子转移媒介物的电极上固化(immobilized) 一层化学试剂,于该化学试剂中含有一种酶(Enzyme)如葡萄糖氧化酶(Glucose oxidase)及一氧化还原反应电子媒介物(Redox Mediator),如广泛用于血糖试片的媒介物(Madiator)之一为次血盐(potassium ferricyanide),酶与待测分析物经 Which electron transfer mediator immobilized on the electrode of a first type (Immobilized) a layer of a chemical reagent comprising an enzyme (Enzyme) in which a chemical reagent such as glucose oxidase (Glucose oxidase) and an electron-transfer mediator redox reaction ( Redox Mediator), widely used in vehicles such as blood glucose test strip (Madiator) times the blood of one salt (potassium ferricyanide), and analyte to be measured enzymatically

化学反应后衍生(或消耗)某一新化学成分(如产生11202),再利用该电子媒介物与H202的氧化还原过程中所释放出的电子而产生一电性信号,并经由电极输出其电性量测参数,此类的工作电极的目的只作为传导功用,不具有化学催化功能,但其选用电极材料须不可与待测流体11或化学试剂14产生一自我化学作用而干扰量测准确性。 Derived (or consuming) chemical reaction a new chemical composition (e.g., generating 11,202), a redox recycling vehicle and the electronic H202 during the release of electrons to produce an electrical signal, and an output electrode electrically via measurement of parameters such purposes only working electrode as a conducting function, the catalytic function does not have a chemical, but the choice of electrode material must not generate a chemical reaction self interference measurement accuracy of fluid to be measured 11 or 14 Chemicals .

此无化学干扰的电极材料必须为一惰性导电材料, 一般为惰性金属贵金属(Noble Metal)(如金、白金、钯、铑等金属)或含碳材质的电极,如碳膜印刷电极(Carbon Base Screen Printing Electrode)、石墨棒(Graphite Bar)。 This electrode material without chemical interference must be an inert conductive material, typically an inert noble metal (Noble Metal) (such as gold, platinum, palladium and rhodium metal) electrode or a carbonaceous material, such as a printed carbon electrode (Carbon Base Screen Printing Electrode), graphite rod (graphite bar). 因碳与惰性金属在低温下不会起化学作用,故不会产生化学干扰。 Inert metal by carbon at low temperatures without chemical reaction, chemical interference is not generated. 因贵金属成本高,故此类电子转移媒介物的修正工作电极(Electron-Transfer Mediator Modified Working Electrode)的工作电极一般皆选用碳电极。 Because of the high cost of noble metals, so the correction of the working electrode (Electron-Transfer Mediator Modified Working Electrode) an electron transfer mediator such electrodes are generally covered with carbon working electrode.

至于第二类的金属催化电极(Metal-Catalyzed Electrode),其选用的工作电极材料会与化学试剂或分析物或其衍生物直接产生电化学作用,而有直接催化作用或对分析物具有单一选择性的功能,因此不需于化学试剂中再添加电子转移媒介物(Mediator)。 As the metal catalyst electrode (Metal-Catalyzed Electrode) The second category, the choice of working electrode material may produce chemical or analyte or derivative thereof direct electrochemical action, while having a single selection or the direct catalytic analyte sexual function, eliminating the need to add a chemical agent in the electron transfer mediator (Mediator). 此具有直接催化作用的电极材料, 一般为含有金属成分的金属电极,第一类电极只要是无化学干扰的导电电极即可适合任何分析物,但此类具有直接催化作用的电极,需与待分析物及化学试剂彼此具有匹配性的材料才能有催化功用,故不同分析物需选用不同的金属电极材料,此类的电极材料不限于惰性金属, 其材质如铜、钛、镍、金、白金、钯、铑…等金属(如铑电极对11202有极佳的直接催化作用)。 This has direct catalytic electrode material, typically a metal electrode containing a metal component, a first conductive type electrode is the electrode as long as no interference can be suitable for any chemical analyte, but such an electrode having a direct catalytic, it needs to be Chemicals analyte and another material having catalytic properties to match function, it is necessary to select different analytes different metal electrode material, the electrode material is not limited to such an inert metal, and the material such as copper, titanium, nickel, gold, platinum , palladium, rhodium, ... a metal (such as rhodium electrodes have excellent direct catalytic 11202). 上述电化学检测所用的电极,于第一类可用含碳电极或惰性金属电极, 而第二类可为各种金属电极并不限于惰性贵金属电极。 Electrode of the electrochemical detection is employed, can be used in the first carbonaceous electrode type or an inert metal electrode, and the second class of the noble metal is not limited to a variety of inert metal electrodes.

此两类所用的金属电极于传统的制作方法其材料与制程的两项成本皆高,尤其是惰性贵金属电极的成本更高,因而虽然其具有较好的品质稳定性却仍无法成为拋弃式居家医疗检测试的主流。 This two metal electrodes used in the conventional method for manufacturing two cost of the material and process are high, especially higher costs of the noble metal inert, which although still having a good quality can not be stable disposable mainstream of home medical detection test. 电化学式感测器于现今的最大使用量,为居家医疗应用的血糖、尿酸、胆固醇等拋弃式检测薄片,其绝大部分商品属于前述第一类为利用电子转移媒介物的修正工作电极(Electron-Transfer Mediator Modified Electrochemical sensors today to a maximum amount, blood glucose, uric acid, cholesterol and other disposable sheet detecting home medical applications, the vast majority of goods belonging to the first category using the modified working electrode as an electron transfer mediator ( Electron-Transfer Mediator Modified

Working Electrode),因此类电极可用碳膜印刷电极而获得较低成本,此类典型 Working Electrode), and therefore a printed carbon-based electrodes may be electrodes to obtain a low cost, such typical

实例如为美国的第5, 985, 116号专利。 As examples of U.S. 5, 985, 116 patent.

如图2所示为美国专利第5,997,817号,该专利的商品化产品以两条相同尺 FIG U.S. Patent No. 5,997,817 is shown in Figure 2, the commercialization of patented products of two identical feet

寸且皆被覆〈Coating〉 一层贵金属钯的金属条201与202以胶固定于绝缘薄片203 上以作为其感测器的金属电极,该感测器的工作电极204 〈Working Electrode〉、 对电极205 (Counter Electrode〉、电极引接线206与207 〈Lead〉、信号输出端208与209 〈0utput Terminal》等全以相同的钯金属条成型,贵金属钯的耗材较大, 但其真正需要用到贵金属钯材质特性的只有工作电极204及对电极205此两小段, 余者只要导电即可,其不需用到贵金属钯的特性。 Inch and are coated <Coating> palladium noble metal layer strips 201 and 202 to the insulating adhesive sheet is fixed to the metal electrode 203 as its sensor, the working electrode of the sensor 204 <Working Electrode>, electrode 205 (Counter electrode>, electrode lead wire 206 and 207 <lead>, a signal output terminal 208 and 209 <0utput terminal "and the like in the same full palladium metal strip forming the noble metal palladium supplies large, but it really needs to use a noble metal only the working electrode 204 and the electrode 205 of these two pieces, as long as I is conductive, it need not use the noble metal palladium, palladium characteristic material properties.

图3所示为欧洲第EP1,098,000号专利,其为另一金属电极的制造方式,其预先塑胶射出成型一绝缘薄片301,其绝缘薄片上具有由凹部〈Recess〉与分隔岛〈Island〉 306所围成的电极图案〈Pattern〉 302及电极引接线〈Lead〉 303及输出端304与305的位置,利用金属沉淀法(Metallic D印osits〉将金属蒸发后沉淀于塑胶绝缘薄片上,因沉淀的金属层会覆盖于整片绝缘薄片的表面,需再一次加工移除分隔岛上的金属层,只留下该金属电极图案、电极引接线及输出端。该方法的加工成本高,且只适合全部电极材质为同一种金属的情况。 Figure 3 shows the European Patent No. EP1,098,000, which is another way of manufacturing a metal electrode, a plastic injection molding in advance insulating sheet 301 having a recess <Recess> island partition <Island insulating sheet > 306 surrounded by electrode pattern <pattern> 302 and the position of the electrode lead wire <lead> 303 and an output terminal 304 and 305, a metal precipitation (metallic D printing osits> metal after the vapor deposition on the plastic insulating sheet, due to the precipitated metal layer may cover the entire surface of the sheet on the insulating sheet, to be processed again to remove the metal layer island separated, leaving only the metal electrode pattern, an electrode lead terminal and an output terminal high processing costs of the process, and only for the case where all the electrodes made of the same metal.

为了降低拋弃式感测器试片的金属电极的制作成本,以克服浪费贵金属材料的问题,就需要有一种拋弃式电化学式感测试片的结构及制作方法,除了有效解决先前金属电极的浪费贵金属材料的缺点外,亦能使得感测器上各不同的金属电极可以预先分别在各不同的镀槽内进行一种大量制造及亦可预先大量修正(Modify)完成电极的修正层后再组装至一绝缘薄片上,其可縮短一具有金属电极感测试片的制造工时。 In order to reduce the manufacturing cost of the metal electrode of the disposable test strip sensor, to overcome the problem of wasting precious metal materials, we need to have the structure and method for manufacturing a disposable electrochemical test strip, in addition to an effective solution to the previous metal electrode disadvantage of wasting precious metal outer material, also such various sensors on the metal electrode may be one of a number are previously manufactured and also a large number of pre-correction (the Modify) at various plating tank after completion of the correction electrode layer assembled to an insulating sheet on which manufacturing steps can be reduced with a metallic electrode test strip.

(3)发明内容 (3) Disclosure of the Invention

本发明的目的为提供一低成本的拋弃式的电化学试片的金属电极的制作方法与结构,可大大地将贵金属的使用量降低而降低成本。 The method of making a metal electrode structure and purpose of the present invention to provide a low-cost disposable electrochemical test strip, can greatly reduce the amount of noble metal used to reduce costs.

本发明的主要目的为利用一金属薄膜的形成于一导电素材上,以降低金属电极的贵金属的使用量。 The main object of the present invention is the use of a metal thin film is formed on a conductive material, in order to reduce the amount of noble metal electrodes. 本发明的另一目的是预先大量制造好一金属电极及修正好(Modify)该电极后,再将该金属电极装设于一绝缘薄片的一通孔内,以大幅縮短制作该拋弃式感测试片所需的时间。 After a further object of the present invention is good for producing a large number of pre-metal electrode and the good correction (the Modify) of the electrode, and then the metal electrode is mounted in a through hole of an insulating sheet, in order to significantly reduce the fabrication of the disposable sensing test the time required sheet.

本发明的再一目的是使用一金属电极装设于绝缘薄片的一通孔内,该通孔面积即为该电极的作用表面积,于大量生产时可获得一精确稳定的电极面积, 因感测器量侧信号大小与电极面积成正比,故本发明可使电化学式感测器量测信号的再现性准确度(Reproducibility)能大幅提升。 A further object of the present invention is the use of a metal electrode is mounted in a through hole of the insulating sheet, the through hole is the area of ​​effect of the surface area of ​​the electrode, obtained a precise and stable electrode area to mass production, because the amount of sensors side signal magnitude proportional to the electrode area, so that the present invention allows accurate reproducibility (reproducibility) electrochemical sensors capable of measuring the signal significantly improved.

本发明的又一目的是运用一绝缘薄片上的一卡榫,以径行卡固该绝缘薄片 A further object of the present invention is the use of a tenon on a insulating sheet, fastened to the diameter line of the insulating sheet

上于一量测仪表上。 A measurement on the instrument.

本发明为一种拋弃式电化学式感测试片(Electrochemical Sensor Strip)的结构及其制作方法,其结构包含一绝缘薄片,其具有至少一通孔,至少一导电素材(Conductive Raw Material),其装设于该通孔中, 一金属薄膜,盖覆于该导电素材上以合成一电极,且该电极具有一电极作用面及一电极衔接面,以利用该电极作用面产生一电极作用,以及至少一印刷导电条,其装设于该绝缘薄片上, 并具有一导电条衔接端及一信号输出端,该导电条衔接端电连接至该电极衔接 The present invention provides a disposable electrochemical test strip (Electrochemical Sensor Strip) structure and manufacturing method, the structure comprising an insulating sheet having at least one through hole, at least one conductive material (Conductive Raw Material), which means disposed in the through hole, a metal thin film, a cover overlying the electrically conductive material to synthesize an electrode, and the electrode having an electrode active surface and an electrode engaging surface, to use the electrode active surface to produce an electrode effect, and at least printing a conductive strip, which is mounted on the insulating sheet, and a conductive strip having a butt end and a signal output terminal, the conductive strip is electrically connected to the joint end of the electrode adapter

面,而该信号输出端则用以输出该电极作用产生的一量测信号。 Surface, and the signal output terminal for outputting a measurement of the signal generated by the effect electrode.

较佳者,该感测试片的导电素材是为一金属,而与该金属薄膜合成一金属电极。 It is preferred, the electrically conductive material of the test strip is a metal, a metal electrode and the metal thin film synthesis.

较佳者,该感测试片还包括一种化学试剂,其设置于该电极作用面上,用以检测一流体样本中的某分析物,该化学试剂即与该流体样本的一成分反应, 进而产生一量测信号,并经该信号输出端以输出该量测信号。 Preferably person, the sensor strip further comprises a chemical agent, which is disposed on the active surface of the electrode, for detecting an analyte in a fluid sample, i.e., the chemical agent to react with a component of the fluid sample, and then generate a measuring signal, via the signal output terminal and to output the measurement signal.

当然,该感测试片的电极是可以于该通孔中形成一电极面积,以传递该量测信号。 Of course, the electrodes of the sensor strip may be formed is a through hole to the electrode area in order to transfer the measuring signal.

较佳者,本发明可以一塑胶射出装置、 一冲压成形装置或一电脑钻孔装置成形该绝缘薄片上的通孔。 Are preferred, the present invention may be a plastic injection molding apparatus, a press forming apparatus or a computer drilling device through holes formed in the insulating sheet.

较佳者,本发明可以先以该塑胶射出装置完成该绝缘薄片上的通孔后,再以一机械加工装置将该电极置入该通孔中。 After are preferred, the present invention may be prior to the completion of the plastic injection device through hole on the insulating sheet, and then to the a machining device into the through hole electrode.

较佳者,本发明可以预先将电极置入一塑胶射出模具中,再注入一塑胶材料于该塑胶射出模具以成形该绝缘薄片,其同时将该电极以「塑胶射出包住J于该通孔中。 Are preferred, the present invention electrode may be previously placed in a plastic injection mold, and then injecting a plastic material in the plastic injection molding to mold the insulating sheet, while the electrodes which "plastic injection to enclose the through hole J in.

当然,该感测试片还包括一绝缘层,用以覆盖于该印刷导电条上。 Of course, the sensor strip further includes an insulation layer for covering the printed conductive strips. 较佳者,该感测试片的金属薄膜的材质是为一黄金、白金、铑、钯、钌、 铱、银、铜、镍、钛、铬、铁或铝。 Are preferred, the metal thin film material of the test strip is one of gold, platinum, rhodium, palladium, ruthenium, iridium, silver, copper, nickel, titanium, chromium, iron or aluminum.

较佳者,该感测试片的导电素材的材质是为一导电金属、 一含碳导电材料或一导电被覆处理的塑胶材质。 Are preferred, the material of the conductive material of the test strip is a conductive metal, a carbonaceous conductive material or an electrically conductive plastic material coating treatment.

当然,该感测试片的金属薄膜可以利用一电镀、 一浸镀、 一金属沉淀或一喷金属漆装置以覆盖于导电素材上,且该电镀装置承装有一镀液,而该镀液具有一金属离子,以形成该金属薄膜。 Of course, the metal thin film test strip may utilize an electroplating, a dip coating, a metal precipitation apparatus or a spray metallic paint to cover on the conductive material, and the supporting means is provided with a plating bath, and the bath having a metal ion to form the metal thin film.

当然,该感测试片的导电素材可以为圆形、矩形或环形,且具有0.2~3.0mm 的厚度,较佳者为0.5mm。 Of course, the sensor strip conductive material may be circular, rectangular or circular, and has a thickness of 0.2 ~ 3.0mm, preferably those of 0.5mm.

较佳者,该感测试片的金属薄膜是为一薄金属片,并利用一印金属裔装置以覆盖于该导电素材上。 Preferably person, the sensor strip metal thin film is a thin metal sheet using a metal plate to cover descent device on the conductive material.

按照另一种可实施的观点看,本发明的一种拋弃式电化学式感测试片,其包含一绝缘薄片,其具有至少一通孔,至少一导电素材,其装设于该通孔中, 以及一金属薄膜,盖覆于该导电素材上以合成一电极,且该电极具有一电极作用面及一信号输出端,以利用该电极作用面产生一电极作用,该信号输出端则用以输出该电极作用产生的一量测信号。 See view according to an alternative embodiment of a disposable electrochemical test strip according to the present invention, which comprises an insulating sheet having at least one through hole, at least one conductive material, which is mounted in the through hole, and a metal thin film, a cover overlying the electrically conductive material to synthesize an electrode, and the electrode having an electrode active surface, and a signal output terminal, with which to produce a surface electrode acting as electrodes, the signal output terminal for outputting the the amount of a sensing signal generated as an electrode.

较佳者,该感测试片还包括一金属薄条,其装设于该绝缘薄片上,且该金属薄片具有一电极衔接孔,以衔接该电极的一铆接凸点。 Preferably person, the sensor strip further comprises a thin metal strip, which is mounted on the insulating sheet, and the metal foil electrodes having a convergence aperture to link up with a caulking the bump electrode.

从另外一个角度看,本发明的一种拋弃式电化学式感测试片,其包含一绝缘薄片,其具有至少一凹部,至少一金属电极,其装设于该凹部中,且该金属电极具有一电极作用面及一信号输出端,以利用该电极作用面产生一电极作用,该信号输出端则用以输出该电极作用产生的一量测信号。 From another perspective a disposable electrochemical test strip according to the present invention, which comprises an insulating sheet having at least one recess, at least one metal electrode, which is mounted in the recess, and the metal electrode having an effect electrode surface and a signal output terminal, with which to produce a surface electrode acting as electrodes, the signal output terminal for outputting a measurement of the signal generated by the effect electrode.

当然,该感测试片还可以包括一导电条,且该导电条是与该金属电极为一体成型,以置于该绝缘薄片的该凹部内。 Of course, the sensor strip may further comprise a conductive strip and the conductive strip is integrally formed with the metal electrode to be placed in the concave portion of the insulating sheet.

当然,该感测试片还可以包括一修正层,其固化于该金属电极上,以形成—修正电极。 Of course, the sensor strip may further comprise a correction layer, which is cured on the metal electrode to form a - correction electrode.

较佳者,该薄片是包含有一对电极及一工作电极的金属电极,其分别设置于该绝缘薄片的二通孔中,产生该电极作用。 Preferably those, the sheet comprising a pair of electrodes is a metal electrode and a working electrode, which are disposed on the insulating sheet of the two through holes, the electrodes generating effect.

较佳者,该薄片是包含有一对电极、 一工作电极及一参考电极的金属电极, 其分别设置于该绝缘薄片的三通孔中,产生该电极作用。 Preferably those, the sheet comprising a pair of electrodes, a working electrode and a reference electrode of metal electrodes, respectively provided in the three-way hole in the insulating sheet, the electrodes generating effect.

当然,该感测试片的工作电极具有一"u"形截面,以装设于该绝缘薄片的一"u"形凹部上。 Of course, the working electrodes of the sensor strip having a "u" shaped cross-section, mounted on to a "u" shaped recessed portion of the insulating sheet.

当然,该感测试片可包含一对电极及一工作电极,而该对电极是以印刷一导电膏于该绝缘薄片上所形成的的一印刷电极,而该工作电极则装设于该绝缘薄片上的该通孔中的一金属电极。 Of course, the sensor strip may include a working electrode and a pair of electrodes, which electrodes are printed on a printing a conductive paste on the insulating sheet is formed, and the working electrode is mounted on the insulating sheet a metal electrode of the through hole in the.

当然,该感测试片包含一对电极、 一参考电极及一工作电极,而该对电极及该参考电极均是印刷一导电裔于该绝缘薄片上所形成的一印刷电极,而该工作电极则装设于该绝缘薄片上的该通孔中的一金属电极。 Of course, the sensor strip comprising a pair of electrodes, a reference electrode and a working electrode and the counter electrode and the reference electrode are printed on a printed electrode of a conductive descent on the insulating sheet is formed, and the working electrode is a metal electrode mounted on the insulating sheet in the through hole.

当然,该感测试片还可以包括一金属薄膜,且该金属薄膜与该金属电极为一体成型。 Of course, the sensor strip may further comprise a metal thin film, and the metal film and the metal electrode is integrally formed.

如按照另一个应用的观点来看,本发明的一种拋弃式电化学式感测试片, 其包含一绝缘薄片,其具有至少一通孔,至少一金属电极,其装设于该通孔中, 且该金属电极具有一电极作用面及一电极衔接面,以利用该电极作用面产生一电极作用,以及至少一印刷导电条,其装设于该绝缘薄片上,并具有一导电条衔接端及一信号输出端,该导电条衔接端电连接至该电极衔接面,而该信号输出端则用以输出该电极作用产生的一量测信号。 If, according to another perspective view of the application of a disposable electrochemical test strip according to the present invention, which comprises an insulating sheet having at least one through hole, at least one metal electrode, which is mounted in the through hole, and the metal electrode has an electrode and an electrode active surface mating face, with which to produce a surface electrode acting as electrodes, and at least one printed conductive strip, which is mounted on the insulating sheet, and a conductive strip having a butt end and a signal output terminal, the conductive strip is electrically connected to the terminal adapter engaging surface electrode, and the signal output terminal for outputting a measurement of the signal produced by action of the electrode.

较佳者,该感测试片的金属电极是为一铜电极。 Are preferred, the metal electrode of the test strip is a copper electrode.

若是从另一个相当的层面来看,本发明的一种拋弃式电化学式感测试片, 其包含一绝缘薄片,其具有至少一通孔,以及至少一金属电极,其装设于该通孔中,且该金属电极具有一电极作用面及一信号输出端,以利用该电极作用面产生一电极作用,该信号输出端则用以输出该电极作用产生的一量测信号。 If the equivalent from another perspective a disposable electrochemical test strip according to the present invention, which comprises an insulating sheet having at least one through-hole, and at least one metal electrode, which is mounted in the through hole , and the metal electrode having an electrode active surface, and a signal output terminal, with which to produce a surface electrode acting as electrodes, the signal output terminal for outputting a measurement of the signal generated by the effect electrode.

较佳者,该感测试片还包括一导电条,且该导电条是与该金属电极为一体成型,以置于该绝缘薄片的一凹部内。 Preferably person, the sensor strip further comprises a conductive strip, and the conductive strip is integrally formed with the metal electrode disposed within a recess in the insulating sheet.

当然,该感测试片包含一对电极、一参考电极、 一工作电极、 一流体测试凹部及一覆盖层,而该对电极及该参考电极均是以印刷一导电膏于该覆盖层上所形成的一印刷电极,而该工作电极则装设于该绝缘薄片上的该通孔中的一金属电极。 Of course, the sensor strip comprising a pair of electrodes, a reference electrode, a working electrode, a fluid test recess portion and a cover layer, and the pair of electrodes and the reference electrode are by printing a conductive paste is formed on the cover layer a printed electrode, and the working electrode is mounted on the insulating sheet is a metallic electrode in the through hole.

当然,该感测试片的绝缘薄片可以具有三通孔,以容纳三电极,且该绝缘薄片具有一卡榫,以置放该薄片于一量测仪表上,该卡榫即被固定于该量测仪表的一卡槽内。 Of course, the insulating sheet may have a sensor strip tee holes to accommodate three electrodes, and the insulating sheet having a tenon, the sheet to be placed on a measuring instrument, i.e. the tenon is fixed to the amount of a measuring instrument within the slot.

较佳者,该感测试片的各该电极具有一信号输出接点,以连接该量测仪表的一信号衔接点。 It is preferred, each of the electrodes of the sensor strip having a signal output contact, connected to a signal point of convergence of the measuring instrument.

从另外一个技术型态来看,本发明的一种拋弃式电化学式感测试片的制造方法,其包括如下步骤:提供一绝缘薄片,其具有至少二凹部,制备一导电素材组,其具有至少一第一及一第二导电素材,至少修正完成该第一导电素材, From another point of view technical patterns A method of manufacturing a disposable electrochemical test strip of the present invention, comprising the steps of: providing an insulating sheet having at least two recesses, the preparation of an electrically conductive material group having at least a first and a second conductive material, the corrected at least the first conductive material,

以形成一修正电极,以及置放该修正电极及该第二导电素材于该二凹部,以形成该拋弃式化学感测试片。 To form a modified electrode placement and the correction electrode and the second conductive material to the two recessed portions, to form the disposable chemical test strip.

较佳者,该感测试片还包括一电镀程序,是于该第一导电素材形成一金属薄膜,以获致该修正电极。 Preferably person, the sensor strip further comprises an electroplating process is formed on the first conductive material a metal thin film, to obtain the correction electrode actuator.

较佳者,该感测试片还包括一化学试剂的固化程序,以获致一酶电极。 Preferably person, the sensor strip further comprises a curing process a chemical agent, to obtain an enzyme electrode actuator.

较佳者,该感测试片还包括一印刷程序,用以印刷至少一导电条以形成至少一信号输出端,并电连接该电极的输出信号至该信号输出端。 Preferably person, the sensor strip further comprises a printing process for printing at least one conductive strip to form at least one signal output terminal, and is electrically connected to the electrode output signal to the signal output terminal.

本发明为一拋弃式检测薄片金属电极的制造方法与结构,其包含适用于第一类电子转移媒介修正电极用的无化学干扰的惰性金属电极及第二的类金属催化电极(不限于惰性金属)。 The present invention is a method and structure for producing a disposable sheet metal detection electrodes comprising a first electrode of inert metal suitable for electronic transfer media with no correction electrode and the second chemical interference of the catalytic metal electrodes (not limited to an inert metal). 具有金属电极的拋弃式感测器的专利发明已非常多,其主要要求为可获得较佳的品质稳定性。 Patent invention disposable sensor having a metal electrode is very large, the main requirements for the preferred quality stability can be obtained. 本发明提供了一种低成本的金属电极的制作方法与结构,其不仅可应用于无化学干扰需求的惰性金属电极, 或具有直接催化功能的各种金属催化电极,更因本发明的金属电极制作成本极低,故其同时可适合参考电极及对电极的制作。 The present invention provides a method for manufacturing the metal electrode structure and a low cost, which can be applied not only to an inert metal electrode needs no chemical interference, or with a direct catalytic function of various metal catalytic electrode, but due to the metal electrode of the present invention. low production costs, which while it may be adapted to produce the reference electrode and the counter electrode.

另本发明的电极结构,可获得一非常精确的电极工作面积,因电化学式感测器的量测电流与电极工作面积成正比,故本发明可使电化学式感测器量测信 Another electrode structure of the present invention obtained a very precise working electrode area, due to the sensing current proportional to the amount of the electrochemical sensor electrode working area, so that the present invention allows electrochemical sensor measurement channel

号的再现性准确度(Reprodudbility)大幅提升。 No. reproducibility accuracy (Reprodudbility) increased dramatically.

本发明经由上述构想的解说,即能观察到所运用的拋弃式电化学式感测试片的结构及制作方法,确实能利用一金属薄膜的形成于一导电素材上,以降低金属电极的贵金属的使用量,并具有使用一金属电极的装设于绝缘薄片的一通孔内,以大幅缩短制作该拋弃式感测试片所需的时间的特色。 Contemplated by the present invention illustrated above, i.e., it can be observed the structure and method of manufacturing disposable electrochemical test strip of the use, surely capable of forming a metal thin film on a conductive material, to reduce the noble metal electrode the amount and having a through-hole mounted to the insulating sheet using a metal electrode, in order to significantly shorten the time required for the production characteristics of the disposable sensor strip.

为了易于说明,本发明可藉由下述的较佳实施例及图示而得到一更加清楚的了解。 For ease of illustration, the present invention may be illustrated by the preferred embodiment and the following embodiments to obtain a clearer understanding.

(4)附圉说明 (4) Description attached yuzhen

图1是先前技术的电化学检测装置的立体示意图; FIG 1 is a perspective schematic view of the previous art of electrochemical detection means;

图2是另一先前技术的拋弃式金属电极感测器的立体分解正面示意图; FIG 2 is a schematic perspective view of another prior disposable metal electrode sensor technology decomposition front;

图3是另一先前技术以金属沉淀法制造的拋弃式金属电极感测器的立体示意 FIG 3 is a schematic perspective view of the disposable sensor further metal electrode prior art made of metal precipitation

图; Figure;

图4 (a) - (d)是本发明的电化学式薄片感测器单电极的结构的较佳实施例的立体正面示意图、立体背面示意图、立体分解正面示意图及一导电素材披覆一金属薄膜的立体示意图; FIG. 4 (a) - a front schematic perspective view (d) shows the structure of a single electrode electrochemical sensor sheet of the present invention a preferred embodiment, the back perspective schematic perspective view of a conductive material and a metal thin film coated exploded front a perspective schematic view;

图5(a)-(b)是本发明的电化学式薄片感测器单电极的结构的另一较佳实施例的立体正面示意图及立体分解正面示意图; FIG 5 (a) - (b) are a perspective view and a front perspective schematic view of another embodiment of the structure of a single electrode electrochemical sensor sheet of the present invention is an exploded view of the preferred embodiment of a front;

图6 (a) - (c)是本发明的电化学式薄片感测器单电极的结构的另一较佳实施例的立体正面示意图、立体背面示意图及立体分解背面示意图; FIG 6 (a) - (c) are a front perspective view of another configuration of a single-electrode electrochemical sensor sheet of the present invention, the preferred embodiment of a schematic, perspective and schematic exploded perspective schematic view of the back of the back surface;

图7(a)-(b)是本发明的电化学式薄片感测器单电极的结构的另一较佳实施例的立体爆开正面示意图及立体爆开背面示意图; FIG. 7 (a) - (b) is a front perspective view of another configuration of a burst sheet electrochemical sensor electrode of the invention a single preferred embodiment of a schematic diagram and a schematic perspective rear surface burst;

图8 (a) - (b)是本发明的一单电极的修正电极的结构立体正面示意图与立体正面分解示意图; FIG 8 (a) - (b) is a correction electrode of one electrode structure of the present invention is a front perspective view and a schematic perspective exploded view of the front;

图9是组合本发明的单电极与修正电极后的应用实例的立体正面示意图; 9 is a perspective schematic front view showing an example of application of the combination of single electrode and correction electrode according to the present invention;

图10 (a) - (b)是本发明的电化学式薄片感测器双电极的结构的另一较佳实施例的立体正面示意图及立体正面分解示意图; FIG. 10 (a) - (b) is a front perspective view and a schematic front perspective view of another embodiment of the structure of a two-electrode electrochemical sensor webs preferred embodiment of the present invention, an exploded view;

图11 (a) - (b)是本发明的电化学式薄片感测器三电极的结构的另一较佳实施例的立体正面示意图及立体正面分解示意图; FIG 11 (a) - (b) is a front perspective view and a schematic front perspective view of another configuration of a sheet electrochemical three-electrode sensor according to the present invention in an exploded schematic view of the preferred embodiment;

图12为本发明一片三电极检测薄片的应用实例的立体正面示意图; FIG 12 detects a three-electrode sheet front perspective schematic view of an application example of the present invention;

图13 (a) - (d)是本发明的具有毛细通道(适用于检测微量流体样品)的薄片感测ll的一较佳实施例的立体正面示意图、立体背面示意图、立体正面分解示意图及一导龟素材修正上一金属薄膜的立体示意图;图14为本发明检测薄片与一量测仪表组合的应用实例的立体正面示意图; FIG 13 (a) - (d) are a front perspective schematic view of a preferred embodiment of the sensing ll sheet having a capillary channel (for detecting micro-fluid sample) of the present invention, schematic perspective back side, front perspective and exploded view of a turtle guide material on a metal thin film correction schematic perspective view; FIG. 14 is a schematic view and a perspective front sheet detecting application example of a combination measuring instrument of the present invention;

图15 (a) - (c)是本发明的电化学式薄片感测器另一个三电极的结构的另一较佳实施例的立体正面示意图、立体正面分解示意图及立体背面分解示意图: FIG 15 (a) - (c) are a front perspective schematic view of another configuration of the electrochemical sensor according to the present invention, the sheet electrode of the other three preferred embodiments, an exploded schematic perspective view and a front perspective exploded view of the back side:

图16 (a) - (c)是本发明的电化学式薄片感测器另一个三电极的结构的另一较佳实施例的立体正面示意图、立体正面分解示意图及立体背面分解示意图; FIG 16 (a) - (c) are a front perspective view of another configuration of the electrochemical sensor according to the present invention, a sheet electrode of another preferred embodiment of three schematic, perspective and exploded view of a front perspective exploded view of the back surface;

图17 (a) - (b)是本发明的具有毛细通道(适用于检测微量流体样品)的薄片感测器的一较佳实施例的立体背面示意图及立体正面分解示意图;以及 FIG 17 (a) - a front perspective schematic view and a perspective rear surface (b) is a sensor having a capillary channel sheet (for detecting micro-fluid sample) of the present invention, a preferred embodiment of an exploded view; and

图18 (a) - (d)是本发明的薄片感测器的另一较佳实施例的立体正面示意图、 立体正面分解示意图、立体背面示意图及本发明实施例接至一量测仪表的组合的立体正面示意图。 FIG. 18 (a) - (d) are a front perspective schematic view of another preferred sheet sensor of the present embodiment of the invention, a front perspective exploded embodiment is connected to a measuring instrument of a combination of a schematic embodiment, the present invention and a schematic perspective rear surface a perspective schematic front view.

(5)具体实施方式 (5) DETAILED DESCRIPTION

请参阅图4 (a) - (c),是为一单电极检测薄片,显示出本发明的一种拋弃式电化学式感测试片的结构,其包含一绝缘薄片40K亦可称为一绝缘基材), 其具有至少一通孔402,至少一导电素材403,其装设于通孔402中, 一金属薄膜404,盖覆于导电素材403上以合成一电极411,且电极411具有一电极作用面409及一电极衔接面408,以利用电极作用面409产生一电极作用(即作为一电极之用),以及至少一印刷导电条410,其装设于绝缘薄片401上, 并具有一导电条衔接端405及一信号输出端406,导电条衔接端405电连接至电极衔接面408,而信号输出端406则用以输出该电极作用产生的一量测信号。 See FIG. 4 (a) - (c), the detection electrode is a single sheet, showing structure of a disposable electrochemical test strip of the present invention, which includes an insulation sheet may also be referred to as an insulating 40K substrate), having at least one through-hole 402, at least one conductive material 403, which is mounted in the through-hole 402, a metal thin film 404, the cover 403 overlying the electrically conductive material to synthesize an electrode 411, and electrode 411 having an electrode and an electrode active surface 409 engaging surface 408 to surface 409 using an electrode acting as an electrode to generate a (i.e. using as electrodes a), and at least one printed conductive strip 410, which is mounted on the insulating sheet 401 and having a conductivity Article joint end 405 and a signal output terminal 406, the conductive strip 405 is electrically connected to the terminal adapter engaging surface electrode 408, and the signal output terminal 406 for outputting a measurement signal produced by this electrode effect.

该感测试片的导电素材403可为一种金属,而与金属薄膜404合成一金属电极411。 The test strip of conductive material 403 may be a metal, the metal thin film 404 and a metal electrode 411 synthesis. 该感测试片还包括一种化学试剂414,其设置于金属电极411的电极作用面409上以形成一酶电极413,用以检测一流体样本中的某分析物,化学试剂414即与该流体样本的一成分反应,进而产生一量测信号,并经信号输出端406以输出该量测信号。 The test strip further comprises a chemical agent 414, 409 disposed on the metal electrodes 411 acting surface 413 to form an enzyme electrode for detecting an analyte in a fluid sample, i.e. a chemical reagent with the fluid 414 a sample of the reaction components, thereby generating a measuring signal, via the signal output terminal 406 and to output the measurement signal. 该感测试片的电极411可以于通孔402中形成一电极面积412,以传递该量测信号。 The sensor strip 411 of electrodes 412 may be formed in the area of ​​a through hole electrode 402 to transmit the measuring signal. 亦即绝缘薄片401至少具有一通孔402, 一金属薄膜404覆盖于一导电素材403上合成为一金属电极411,置放金属电极411于通孔402中形成紧配,通孔402紧紧包住金属电极411的侧面使其只露出一电极作用面409与电极接面408,以利用该电极作用面409产生一电极作用。 I.e. insulating sheet 401 having at least one through hole 402, a metal thin film 404 covering the conductive material on a synthetic 403 is a metal electrode 411, 411 disposed in the through hole 402 with a tight metal electrodes, the through-hole 402 tightly wrap the sides of the metal electrode 411 is exposed to only one surface of the electrode 409 and the electrode acting surface 408 to surface 409 with which an electrode acting as an electrode to generate a.

以及印刷一导电条410于绝缘薄片401上,并具有一导电条衔接端405及一信号输出端406,导电条衔接端405电连接至电极衔接面408,而信号输出端406则用以输出该电极作用产生的一量测信号。 And printing a conductive strip 410 on the insulating sheet 401, and a conductive strip having a joint end 405 and a signal output terminal 406, the conductive strip 405 is electrically connected to the terminal adapter engaging surface electrode 408, and the signal output terminal 406 for outputting the a measured amount of signal produced as an electrode. 一绝缘层407被覆于绝缘薄片401的背面只露出印刷导电条410的信号输出端406,其用于隔离待测流体与电极作用面409以外的任何导电部位接触,以免影响检测准确度。 An insulating layer 407 covering the back surface of the insulating sheet 401 is exposed only to the printed conductive strips 410 a signal output terminal 406 for isolating the fluid to be measured and any electrode action surface 409 in contact with the conductive portion other than to affect the detection accuracy.

本实施例的最终电极材料为该金属薄膜404,其材质可为黄金、白金、铑、 钯、钌、银、铜、镍、钛、铝、铁、等。 Final electrode material of the present embodiment that the metal thin film 404, which may be made of gold, platinum, rhodium, palladium, ruthenium, silver, copper, nickel, titanium, aluminum, iron, and the like. 导电素材403的选用需利于与金属薄膜404能紧密结合为一体,其材质可为任何导电金属或任何含碳导电材料或经导电被覆处理的塑胶材质。 Conductive material 403 needs to facilitate selection of the metal thin film 404 can be closely combined into one, which may be made of any electrically conductive metal or any carbon-containing conductive material or coating treatment by a conductive plastic material.

金属薄膜404被覆于导电素材上的方法可为电镀、浸镀、金属沉淀法、喷金属漆等。 Covering the metal thin film 404 on the conductive material in the process may be electroplating, immersion plating, metal precipitation, spray metallic paint and the like. 导电素材403可先置入通孔后再被覆金属薄膜404,导电素材403 亦可先被覆金属薄膜404后再置入通孔402中。 First conductive material 403 may be inserted through hole 404 and then coated with a metal thin film, a conductive material 403 may also be first coated with a metal thin film 404 and then into the through hole 402. 本实施例的最佳流程为先将导电素材403以大量电镀的方式(亦即将许多颗导电素材403置放于同一镀槽内) 镀上贵金属薄膜404后再置入通孔402中。 Preferred embodiment of the process of the present embodiment first conductive material 403 is electroplated with plenty manner (i.e., the many conductive particles 403 is placed in the same material plating bath) and then coated with a noble metal thin film 404 into the through hole 402. 导电素材403的材质是为铜或其合金,如黄铜、无氧铜、青铜、磷铜、洋白铜、铍铜,该铜金属易于成型各电极形状,且又具有导电性适合以电镀等程序上修正金属薄膜404。 Conductive material 403 is made of copper or an alloy thereof, such as brass, oxygen-free copper, bronze, phosphor bronze, copper-beryllium copper, the copper metal forming each electrode is easy to shape, and because a conductive plating or the like adapted to program on the metal thin film 404 corrected. 导电素材403 的材质可为含碳塑胶导电复合材料,以塑胶射出成型方式成型该含碳导电素材403的形状,此含碳塑胶导电复合材料具有导电性适合于电镀等程序上修正该金属薄膜。 The conductive material 403 may be a carbon-containing material a conductive plastic composite material, injection-molded plastic to the shape of the molded carbonaceous conductive material 403, the carbonaceous conductive plastic composite material having a metal thin film on the correction of the conductive plating or the like is suitable for the program.

目前"塑胶电镀"己为一种非常成熟的现有技术,其可以一般塑胶材质射出成型的方式成型该非导电的塑胶素材403的形状,于塑胶素材上再被覆一层导电层即可进行金属膜404的电镀, 一般可在原塑胶素材上先镀上一层镍作为底层后再镀上所要的上层金属薄膜404。 Currently "plastic plating" is already a very mature prior art, which can generally be made of plastic material molded by injection molding the shape of the non-conductive embodiment of the plastic material 403, then coating material on the plastic layer of the metal conductive layer can be carried out plating film 404, and can be first coated with a layer of nickel metal thin film as an upper layer on the underlayer 404 and then be plated on the original plastic material. 印刷导电条410的印刷导电膏材料可为一种含碳、银、铜、镍、铝、金、不锈钢之任一或其混合的导电胶。 Printing a conductive paste printed conductive strips 410 may be a material containing carbon, conductive paste of any of silver, copper, nickel, aluminum, gold, stainless steel, or a mixture. 绝缘薄片401的材质可采用一种聚氯乙烯PVC(polyvinyl chloride)、聚丙烯PP (polypropylene)、聚碳酸酯PC (polycarbonate)、聚对苯二甲酸亚丁烯基酯PBT(polybutylene Ter印hthalate)、聚对苯二甲酸乙二醇酯PET (polyethylene Ter印hthalate)、聚氧化亚苯PPO (modified polyphenlene oxide)或丙烯丁二烯苯乙烯树脂ABS(acrylonitrile butadiene stytene)等塑胶树脂。 Sheet insulating material 401 may employ one kind of polyvinyl chloride PVC (polyvinyl chloride), polypropylene PP (polypropylene), polycarbonate PC (polycarbonate), poly butenylene ester PBT (polybutylene Ter printing hthalate), polyethylene terephthalate PET (polyethylene Ter printing hthalate), poly phenylene oxide PPO (modified polyphenlene oxide) resin or acrylic butadiene styrene ABS (acrylonitrile butadiene stytene) and other plastic resins. 绝缘薄片401的厚度可为0.2mm-3. Omm。 The thickness of the insulating sheet 401 may be 0.2mm-3. Omm. 导电素材403可为圆形、矩形或环形,其厚度可比绝缘薄片401的厚度少O.OOmm-0.15腿。 Conductive material 403 may be circular, rectangular or annular, insulating sheet having a thickness less than the thickness of the legs 401 O.OOmm-0.15. 覆盖于电极411的金属薄膜404 可为黄金,而覆盖于411电极的金属薄膜404可以改为银,并经处理一层氯化银层后以形成一银/氯化银参考电极。 Covering the metal electrode 411 may be a gold thin film 404, the metal thin film 411 covering the electrode 404 can be changed to silver, a layer of silver chloride and treated to form a layer of the silver / silver chloride reference electrode. 且覆盖于电极411的金属薄膜404亦可为白金,或覆盖于电极411的金属薄膜404可为铑金属。 Covering the metal thin film electrode 411 and the metal thin film 404 may also be platinum, or 404 to cover the electrode 411 may be a rhodium metal. 覆盖于电极411的金属薄膜404可为钯金属,覆盖于电极411的金属薄膜404可为钌金属。 Covering the metal electrode 411 may be a palladium metal thin film 404, the electrode 411 covering the metal thin film 404 may be a ruthenium metal. 当然, 电极411的导电素材403可为铜金属且该覆盖的金属薄膜404亦为铜金属,意即此电极411为一纯铜金属电极。 Of course, the metal thin film electrode 411 conductive material 403 may be copper and the metallic cover 404 is also of copper, which means that this metal electrode 411 is a copper electrode.

绝缘薄片401上的通孔402,可以通过一塑胶射出装置、 一冲压成形装置或一电脑钻孔装置于绝缘薄片401上成形。 The through hole 402 in the insulating sheet 401 may be emitted by a plastic device, a press forming apparatus or a computer drilling apparatus 401 formed on the insulating sheet. 如釆用将电极411置于通孔402中的方式,可以先以该塑胶射出装置、该冲压成形装置或该电脑钻孔装置成形通孔402于绝缘薄片401上后,再以一机械加工装置将电极411置入该通孔中并 As will preclude the use of the electrode 411 is placed through hole 402 in such a manner, it is possible first to the plastic injection means, the press forming apparatus or the computer drilling device through holes 402 formed on the insulating sheet 401, and then to a machining device the electrode 411 into the through hole and

形成紧配。 A tight distribution. 另外,可改成以「塑胶射出包住」方式,预先将电极置入一塑胶射出模具中,再注入一塑胶材料于该塑胶射出模具以成形该绝缘薄片,并同时将 Furthermore, it can be changed to "wrap plastic injection" mode, advance the electrode into a plastic injection mold, and then injecting a plastic material in the plastic injection molding to mold the insulating sheet, and simultaneously

该电极包住于该通孔中。 The electrode to enclose the through hole.

请参阅图5 (a) - (b),是为一单电极检测薄片, 一绝缘薄片501至少具有一通孔502, 一导电素材503置放于通孔502中形成紧配,一金属薄膜504 覆盖于导电素材503的顶面509上合成为一金属电极(此时的导电素材503是一种金属或含碳塑胶导电复合材料),该金属电极具有一电极作用面504与电极衔接面508,以利用电极作用面504产生一电极作用,以及印刷一导电条510 于绝缘薄片501上,并具有一导电条衔接端505及一信号输出端506,导电条衔接端505电连接至电极衔接面508,而信号输出端506则用以输出该电极作用产生的一量测信号,标号507表示一绝缘层。 Refer to FIG. 5 (a) - (b), is a single electrode detecting sheet, an insulating sheet 501 having at least one through-hole 502, a conductive material 503 placed in the through hole 502 is formed in a tight fit, a thin metal film 504 covering 509 on the top surface 503 of the conductive material is a synthetic metal electrode (in this case a conductive material 503 is a metal or a conductive plastic composite material containing carbon), the metal electrode having an electrode active surface 504 engaging surface 508 of the electrode to using the electrode active surface 504 to produce an electrode effect, and printing a conductive strip 510 on the insulating sheet 501 and having a conductive strip joint end 505 and a signal output terminal 506, the conductive strip butted ends 505 electrically connected to the electrode mating face 508, and the signal output terminal 506 for outputting a measurement signal generated by the electrode effect, reference numeral 507 denotes an insulating layer. 金属薄膜504的被覆于导电素材503上的方法可为电镀、浸镀、金属沉淀法、喷金属漆或印金属膏等。 Coating the metal thin film 504 on the conductive material in the process 503 may be electroplating, immersion plating, metal precipitation, spray metallic paint or printing metal paste.

如按照另一种可实施的观点来看,图4中的印刷导电条410是可以被取代的,请参阅图6 (a) - (c),是为一单电极检测薄片,图6的实施例以一金属薄条606代替图4实施例的印刷金属条410,该金属薄条606具有一信号输出端608与一导电条衔接孔607,该导电条孔607电连接至一金属电极603上的一铆接凸点604以输出该电极的量测信号,而标号605是指电极作用面。 According to another point of view as the view may implement a printed conductive strips 410 in FIG. 4 may be substituted, see FIG. 6 (a) - (c), the detection electrode is a single sheet, the embodiment of FIG. 6 Example in a thin metal strip 606 in place of the printed metal strip embodiment of FIG 4410, the thin metal strip 606 has a signal output terminal 608 and a conductive strip engagement hole 607, the conductive strip hole 607 is electrically connected to the a metal electrode 603 the bump 604 to a caulking output signal of the measuring electrode, and reference numeral 605 refers to an electrode active surface. 电极为一纯镍金属电极,该电极亦可以为一纯铁金属电极。 A metal electrode of pure nickel electrodes, which may think that an iron metal electrode.

若是从另外一个角度来看,图4中的导电素材403可以改为一种纯金属的导电素材,以形成一金属电极,而且具有一凹部以涵盖通孔及金属导电条,请参阅图7 (a) - (b),是为一单电极检测薄片,图7的实施例以一体成型的金属条703代替图6实施例的金属薄条606与金属电极603,金属条703具有一电极工作面704、电极引接线705及信号输出端706 (此金属片703可以一塑胶导电材料射出成形装置或金属冲压装置将电极工作面704、电极引接线705 及信号输出端706 —体成形而得,是与图4的印刷导电条410的方式不同), 绝缘薄片701具有一通孔702与一凹部707 (recess)以置放金属片703并形成紧配。 If From another perspective, the conductive material in FIG. 4 to the conductive material 403 may be a pure metal to form a metal electrode, and has a recess to cover the through hole and a conductive metal strips, see FIG. 7 ( a) - (b), the detection electrode is a single sheet, the embodiment of FIG. 7 integrally formed metal strip 703 instead of the thin metal strip of FIG embodiment of the metal electrode 603 and 6606, a metal strip 703 having electrodes face 704, electrode lead wire 705 and a signal output terminal 706 (the metal sheet 703 may be a conductive plastic material or a metal stamping device emitting means forming the electrode face 704, electrode lead wire 705 and a signal output terminal 706 - form obtained by molding, is Unlike the embodiment of FIG. 4 printed conductive strips 410), the insulating sheet 701 has a through hole 702 with a recess 707 (recess) disposed in the metal sheet 703 and form a tight fit. 而覆盖一层金属薄膜(图上没显示)于金属条703上的程序,可于先覆盖该金属薄膜于金属条703上后才置入绝缘薄片701的通孔702中,亦可先将金属条703置入绝缘薄片701的通孔702后再覆盖该金属薄膜。 To cover the metal thin film layer (not indicated on FIG.) To program the metal strip 703 may cover the first metal thin film on the metal strip after the insulating sheet 701 into through holes 702 703, the metal may first Article 703 into the through-hole 701 of the insulating sheet 702 and then covering the metal thin film.

请参阅图8 (a) - (b),是为一修正电极的示意图,依图4至图7所完成的金属电极,适切的选用导电素材与金属薄膜材质已可适用于工作电极(Working Electrode)或对电极(Counter Electrode),而于电化学感测器应用中可经特定的制作程序于电极802上固化一修正层(Modified Layer)801,以将纯电极802修正(Modify)成特定用途的修正电极(Modified Electrode)。 See FIG. 8 (a) - (b), is a schematic diagram of a correction electrode, a metal electrode according to FIGS. 4 to 7 completed, relevance selection conductive material and a metal thin film is applied to the working electrode (Working electrode) or counter (Counter electrode), and the electrochemical sensor applications a curable correction layer (Modified layer) 801 to the electrode 802 by a specific production process, to a pure correction electrode 802 (the Modify) into specific the use of the correction electrode (Modified electrode). 例如:将镀有银金属膜的金属电极802经浸入于氯化钾溶液的电化学作用或印刷方式使银层与氯产生化学结合而形成一银/氯化银参考电极(Ag/AgCl Reference Electrode)。 For example: a metallic electrode 802 plated with silver-metal film is immersed in potassium chloride solution or electrochemical action of printing the silver layer chemically combined with chlorine to form a silver / silver chloride reference electrode (Ag / AgCl Reference Electrode ).

或是固化((i國bilized、 coated) 一层化学试剂(Reagent)414于图4的金属电极411上,化学试剂414包含一酶催化剂(Enzyme)、 一酸碱值缓冲剂 Or curing ((I States bilized, coated) a layer of a chemical agent (Reagent) 414 to the metal electrode 411 of FIG. 4, a chemical agent 414 comprises an enzyme catalyst (Enzyme), a pH buffer

(PH Buffer)、 一界面活性剂(Surfactant/Surface Active Agent)、 一氧化还原反应电子媒介物(Redox Mediator)、 一亲水性的高分子聚合物 (PH Buffer), a surfactant (Surfactant / Surface Active Agent), an electron-transfer mediator redox reaction (Redox Mediator), a hydrophilic polymer

(Hydrophilic Ploymer Compound)等混合的复合物,以形成一酶电极(Enzyme Electrode)413。 (Hydrophilic Ploymer Compound) like complex was mixed to form an enzyme electrode (Enzyme Electrode) 413.

酶电极413上的化学试剂414用以与一待测流体中的某分析物产生化学反应并产生一电性信号,经由电极411输出该电性量测信号至一电化学分析仪表18 (详见图9),以计算出该分析物的浓度。 Chemicals enzyme electrode on 413,414 to generate a chemical reaction with the fluid to be measured in an analyte and generating an electrical signal, an output electrode 411 via the electrical measurement signal to an electrochemical analysis instrument 18 (see FIG. 9) to calculate the concentration of the analyte. 如上的酶电极413的化学试剂(Reagent)4H中含有一氧化还原反应电子媒介物(Redox Mediator),其为一电子转移媒介物的修正工作电极(Electron-Transfer Mediator Modified Working Electrode)。 The enzyme electrode as the chemical agent 413 (Reagent) comprising an electron-transfer mediator redox reaction (Redox Mediator) in 4H, transferred vehicles correcting the working electrode (Electron-Transfer Mediator Modified Working Electrode) is an electronic. 如上所述的酶电极413,若将化学试剂(Reagent)414 中的该氧化还原反应电子媒介物(Redox Mediator)弃除,并匹配性的选择一金属薄膜电极材料,将可以作为一金属催化电极(Metal-Catalyzed Electrode),例如一白金金属催化电极。 Enzyme electrodes 413 as described above, if the chemical reagent (Reagent) the oxidation-reduction reaction of the electron-transfer mediator 414 (Redox Mediator) was discarded, and a choice of matching metal thin film electrode material, the electrode can be used as a metal catalyst (metal-catalyzed electrode), such as a platinum metal catalyst electrodes.

如上所述的酶电极413,化学试剂414中的酶可具有一葡萄糖氧化酶(Glucose Oxidase),以为测试一人体的全血(Whole Blood),而获得对该流体样本的一分析结果,该分析结果即为该人血中的一血醣浓度。 413 enzyme electrode described above, chemical agent 414 may have an enzyme glucose oxidase (Glucose Oxidase), that a human whole blood test (Whole Blood), to obtain a fluid sample to the analysis result, the analysis the result is a blood glucose concentration in human blood. 如上所述的酶电极413,化学试剂414中的酶可改为具有一尿素氧化酵,以为测试一人体的 413 as described above enzyme electrode, an enzyme chemical agent 414 may instead have a urea oxide yeast, that a human test

全血,而分析该人血中的一尿酸浓度。 Whole blood, and an analysis of the uric acid concentration in human blood. 如上所述的酶电极413,化学试剂414 中的酶可具有一胆固醇氧化酶,以为测试一人体的全血,而分析该人血中的一胆固醇浓度。 413 as described above enzyme electrode, an enzyme chemical agent 414 may have a cholesterol oxidase, a whole blood test that a human body, and an analysis of the cholesterol concentration in human blood.

请参阅图9,是为结合本发明的三片拋弃式测试薄片以代替图1传统电极的应用实例,各电极的导电素材可为任一导电材料经各自修正一层金属薄膜以形成一特定电极,如一黄金薄膜对电极(Counter Electrode)409、 一银薄膜参考电极802及一银/氯化银(Ag/AgCl)修正层801组成的参考电极(Ag/AgCl Reference Electrode)及一白金薄膜电极修正成一含有化学试剂层414的酶工作电极(Enzyme Electrode)413等三片拋弃式测试薄片以代替图1传统电极的应用实例。 Please refer to FIG. 9, showing an application example of the present invention in conjunction with three disposable test sheet in place of a conventional electrode pattern, electrically conductive material of the electrodes may be any electrically conductive material is a metal thin film layer are each corrected to a particular form electrode, the reference electrode (Ag / AgCl reference electrode) 409 such as a gold film, a silver thin film 802, and a reference electrode of silver / silver chloride (Ag / AgCl) electrode correction layer 801 (Counter electrode) consisting of a platinum film and electrode examples of correction to apply a chemical agent containing the enzyme working electrode layer 414 (enzyme electrode) 413 and other three disposable test sheet of FIG. 1 in place of a conventional electrode.

如按照另一个应用的观点来看,图7中的凹部707可以改成只有通孔而不涵盖金属导电条,请参阅图10 (a) - (b),是为一片两电极检测薄片的实施例,图10的实施例为于一绝缘薄片1001上具有一矩形的通孔1002及一环形的通孔1003, 一环形对电极(Counter Electrode)金属电极1006以及一矩形工作电极(Working Electrode)金属电极1004分别置放于通孔1003,1002中以形成紧配,两导电条衔接端1007置于绝缘薄片的下方,该二导电条各具有一信号输出端1008并与金属电极1004,1006具有电连接,以为输出该电极作用的该量测信号; 一化学试剂1005固化于工作电极1004上,用以与一待测流体中的某分析物产生化学反应并产生一电性信号,经由电极1004,1006与导电条 As another point of view according to the application point of view, the recess 707 may be changed only in FIG. 7 does not cover the through-hole conductive metal strips, see FIG. 10 (a) - (b), two electrodes for detecting an embodiment of a sheet embodiment, the embodiment of FIG. 10 having a rectangular through hole in the insulating sheet 10,011,002 and via a ring 1003, a ring of electrodes (Counter electrode) a metal electrode 1006, and a rectangular working electrode (working electrode) metal electrodes were placed in the through-hole 1004 to form a tight fit 1003,1002, two end adapters conductive strip 1007 disposed below the insulating sheet, the two conductive strips each having a signal output terminal 1008 and 1004, having a metal electrode electrically connection, that the output of the measuring electrode acting signal; a chemical agent 1005 immobilized on the working electrode 1004 to generate a chemical reaction with the fluid to be measured in an analyte and generating an electrical signal, via the electrode 1004, the conductive strip 1006

1107及输出端1008,输出该电性量测信号至电化学测试仪表18。 1008 1107 and an output terminal, the output of the electrical measurement signal to an electrochemical test meter 18.

请参阅图11 (a) - (b),是为本发明三电极检测薄片的实施例,于一绝缘薄片1101上具有三个通孔1102, 一对电极(Counter Electrode) 1105、 一工 See FIG. 11 (a) - (b), the detection electrode is a sheet according to a third embodiment of the present invention having three through holes on a insulating sheet 11,011,102, a pair of electrodes (Counter Electrode) 1105, a work

作电极(Working Electrode) 1103及一参考电极(Reference Electrode) 1104 分别置放于通孔1102中以形成紧配,三导电条1108置于绝缘薄片1101的下方,其各具有一信号输出端1109并与各金属电极1103, 1104, 1105具有电连接, 以为输出该电极作用的该量测信号, 一氯化银修正层1107置于参考电极1104 上,以修正电极1104成为一氯化银参考电极(Ag/AgCl Reference Electrode), 一化学试剂1106固化于工作电极1103上,用以与一待测流体中的某分析物产生化学反应并产生一电性信号,经由电极1103与导电条输出端1109,输出该电性量测信号至电化学测试仪表18。 As an electrode (Working Electrode) 1103, and a reference electrode (Reference Electrode) 1104 are placed in the through-hole 1102 to form a tight fit, a third conductive strip 1108 disposed below the insulating sheet 1101, each having a signal output terminal 1109 and and each of the metal electrodes 1103, 1104, 1105 has an electrical connection, that the output of the measuring electrode acting signal, a correction layer of silver chloride on the reference electrode 1107 is placed 1104, 1104 in order to become a correction electrode silver chloride reference electrode ( Ag / AgCl Reference electrode), a chemical agent 1106 immobilized on the working electrode 1103 to generate a chemical reaction with the fluid to be measured in an analyte and generating an electrical signal, an output terminal 1109 via the electrode 1103 and the conductive strip, the electrical output signals to the electrochemical measurement test instrument 18.

请参阅图12,是为本发明一片三电极检测薄片的应用实例,使用图11实施例完成的一拋弃式三电极检测薄片以代替图1的传统电极使用例。 Please refer to FIG. 12, an application example is a three-electrode sheet of the present invention, detection, detection of a disposable three-electrode sheet of FIG. 11 patients completed the embodiment of FIG. 1 in place of conventional electrodes used in Example.

请参阅图13(a)-(c),是为本发明一片具有毛细流动通道的三电极检测薄片的应用实例,于图4至图12的实施例,其适合测试中大量的流体样品,用于小量流体的检测薄片(如测试人体的血液中的拋弃式血糖测试薄片只用数P 1的血量), 一般于电极检测薄片上附有一结构,用于吸附小量待测流体,并使的完全布满于全部电极上,若有部分电极未被待测流体覆盖,则会造成检测错误。 See FIG. 13 (a) - (c), is an application example of a three-electrode sheet having a detection capillary flow passage of the present invention, the embodiment of FIG. 4 to FIG. 12, which is suitable for a large fluid sample testing, with sheet to detecting small amounts of fluid (e.g., blood glucose test sheet disposable testing human blood in the blood only a number P 1), is generally attached to the electrode detecting sheet a structure for adsorbing a small amount of fluid to be measured, and completely covered on all the electrodes, any part of the fluid to be measured is not covered with the electrode, it will result in a detection error. 此吸附结构一般具有一毛细通道入口1308、 一毛细流动通道1314及一毛细对流气孔1309,毛细通道通1314通常亦为该流体的一量测区域。 This structure generally has a suction inlet 1308, a capillary flow passage 1314 and a convection air vent capillary channel 1309, 1314 is typically also through a capillary channel for measuring a fluid region.

当该待测流体碰到毛细通道入口1308,毛细通道1314利用一种毛细现象会自动吸附该流体至布满该量测区域后即自动停止不会再吸。 When the fluid to be measured across the capillary channel inlet 1308, 1314 capillary channel utilizes a capillary phenomenon of the fluid will automatically snap to the covered measurement region will not stop automatically after the suction. 图13至图18的实施例皆为适用于检测小量流体的检测薄片实施例,图13为一用于检测小量流体的一拋弃式三电极检测薄片的实施例, 一绝缘薄片1301其上具有一流体量测凹部1314 (即毛细流动通道1314),流体量测凹部1314的底面具有一化学试剂置放凹部1306,用于置放一化学试剂1307并使其产生一均匀厚度的涂布,于试剂1307置放凹部1306的底面具有三个通孔1302,通孔1302用于置放一工作电极1303、 一对电极1305及一参考电极1304。 EXAMPLES 13 to 18 are all adapted to detect a small amount of fluid is detected sheet, 13 is a disposable three-electrode sheet detector for detecting a small amount of fluid to FIG embodiment, an insulating sheet 1301 which measuring fluid having a recessed portion 1314 (i.e., the capillary flow path 1314), a bottom surface measuring fluid having a recessed portion 1314 Chemicals disposed recess 1306, 1307 for placing a chemical agent, and to produce a uniform coating thickness , 1307 disposed in the reagent of the bottom of the recess 1306 having three through holes 1302, 1302 through hole 1303 for placing a working electrode, a pair of electrodes 1305 and 1304 a reference electrode. 三电极1303, 1304, 1305于三通孔1302中形成紧配,各电极1303, 1304,1305是由一导电素材1313经各自覆盖一金属薄膜1315后(详见图13(d)),各形成一金属电极1303, 1304,1305,各电极1303, 1304, 1305各具有一电极作用面与一电极衔接面,以利用该电极作用面产生--电极作用,三导电条1311置放于绝缘薄片1301的底面,各导电条1311各具有一导电条衔接端及各一信号输出端1312,各该导电条1311的衔接端各与该电极衔接面具有电连接,以为利用信号输出端1312输出一电极量测信号;流体量测凹部1314上具有一流体入口1308及一毛细对流气孔1309, 一覆盖层1310置于流体量测凹部1314的上方以组成一完整的毛细现象的吸附结构。 After (see FIG. 13 (d)) three electrodes 1303, 1304, 1305 arranged for a tight tee hole 1302, the electrodes 1303, 1304, 1305, 1313 is composed of a conductive material are each covered by a thin metal film 1315 are each formed a metal electrode 1303, 1304, 1305, the electrodes 1303, 1304, 1305 each having an electrode active surface with an engaging surface electrode, to produce by using the electrode active surface - as an electrode, a third conductive strip 1311 is placed in the insulating sheet 1301 the bottom surface, each of the conductive strips 1311 each have a conductive strip and each end of the adapter a signal output terminal 1312, each of the conductive strips each having a butt end 1311 is electrically connected to the electrode engaging surface, that by using a signal output terminal 1312 outputs the amount of electrode sensing signal; 1308 having a fluid inlet and a fluid convection hole 1309 measuring recess portion 1314, an upper layer 1310 positioned in the fluid measuring portion 1314 of the recess to form a complete cover of the capillary attraction structure. 于绝缘薄片1301的上方具有二抵顶凸块1316、 1317,以抵顶覆盖层1310,并利用抵顶凸块1316,1317 以隔离该流体样本与覆盖层1310上的一黏胶。 Above the insulating sheet 1301 has two abutting projections 1316, 1317, 1310 to abut against the covering layer, and the abutting projections 1316,1317 using a glue to isolate the fluid sample on the cover layer 1310.

该化学试剂1307置放于三电极1303, 1304, 1305的顶面,用于与该待测流体中的某分析物产生化学作用并产生一电性信号,该电性信号大小与该分析物的浓度有一比例关系,经由电极1303,1304,1305输出该电性信号至信号输出端1312并接至仪表18,用以计算出该分析物的参数,各电极1303,1304, 1305 的导电素材1315可为任一导电材料。 The chemical agents placed in a three-electrode 1307 1303, 1304, 1305 of the top surface, for chemical reaction with the fluid to be measured in an analyte and generating an electrical signal, the electrical signal with the magnitude of the analyte there is a proportional relationship between the concentration of, 1303,1304,1305 output via the electrode to the electrical signal and the signal output terminal 1312 connected to the instrument 18, for calculating the parameters of the analyte, each of the conductive electrode material 1303, 1304, 1305 1315 may is any conductive material. 而覆盖于工作电极1303的金属薄膜1315 可为黄金。 1303 to cover the working electrode 1315 may be a metal thin film of gold. 覆盖于参考电极1304的金属薄膜1315可为银,并经处理一层氯化银层后以形成一银/氯化银参考电极。 A metal thin film covering the reference electrode may be silver 13,151,304, and the treated layer of the silver chloride layer was formed to a silver / silver chloride reference electrode. 覆盖于该对电极1305的金属薄膜1315 可为白金。 Covering the metal thin film 1315 may be a platinum electrode 1305.

覆盖于该工作电极1303的金属薄膜1315可以改为一铑金属,覆盖于该工作电极1303的金属薄膜1315可为钯金属,覆盖于该工作电极1303的金属薄膜1315可为钌金属,工作电极1303的导电素材1313可为铜金属,且该覆盖的金属薄膜1315亦可为铜金属,意即此电极可为一铜原素材与覆盖的金属薄膜1315彼此为一体成型。 Covering the metal thin film of the working electrode 1315 to 1303 may be a rhodium metal, covering the working electrode 1303 may be thin metal film 1315 as palladium metal, a metal covering the working electrode may be a thin film 13151303 ruthenium metal, the working electrode 1303 1313 may be a conductive copper material, and the cover 1315 may also be a metal thin film of copper metal, which means that this may be a copper electrode raw material covering the metal thin film 1315 is formed integrally with each other.

请参阅图14,是为本发明图13至图17的检测薄片实施例与一电化学仪表的组合应用, 一电化学量测仪表1401具一插入口1402,插入口1402用于引入一薄片式电化学检测薄片1301,该待测流体由毛细通道入口1308吸入薄片中。 Please refer to FIG. 14, an application example is a combination with an electrochemical detection instrument of the present invention, the sheet of FIG. 13 to FIG. 17 embodiment, an electrochemical measurement instrument 1401 is inserted into a port 1402, an insertion opening for introducing a sheet-1402 electrochemical detection sheet 1301, 1308 of the fluid to be measured sucked by the capillary channel inlet sheet. 量测仪表1401用于提供一电化学作用所需的工作电压至各电极,并接收由电极输出的量测信号,经计算量测信号后显示一信息。 1401 measuring instrument for providing a desired voltage to each of the electrochemically active electrodes, and receives the measurement signal outputted from the electrodes, the measured signal is calculated after displaying a message. 请参阅图15(a)-(c),是为本发明另一片具有毛细流动通道的三电极检测薄片的应用实例,本实施例结合本发明精神的金属电极用于工作电极1505,利 See FIG. 15 (a) - (c), is another example of three-electrode sheet having an application sheet detection capillary flow passage of the present invention, the metal electrode of the present embodiment in conjunction with the spirit of the present invention for the working electrode 1505, Lee

用该金属电极的金属薄膜可得到好的工作电极性能,另本发明于通孔1503中形成工作电极1506可得到一非常精确的的作用面积,大大地提高感测器的品 Good performance can be obtained with a working electrode of the metal thin film metal electrode, the working electrode 1506 to obtain a very precise role in the area of ​​the other through hole 1503 formed in the present invention, greatly improved product sensor

质再现性。 Qualitative reproducibility. 而于对电极1515与参考电极1512,其电极材质与电极作用面积并 In 1515 and the counter electrode and the reference electrode 1512, the electrode material and the electrode active area and

不需如工作电极1505那样的精确需求,故对电极1515与参考电极1512可用 The working electrode 1505 need not as precise needs, it can be used for the reference electrode 1515 and the electrode 1512

传统印刷电极方式生产以降低成本。 Traditional printing electrode system to reduce cost of production.

一绝缘薄片1501上具有一电极作用面通孔1503及一电极衔接面通孔1504 且此二通孔于底部1502相连以形成一nr形凹部1502, ; 一"IT形电极片1505 (即具有一"ir形截面)置放于该"IT形凹部1502中并形成紧配,〃U"形电极片1505上具有一电极作用面1506及一电极衔接面1507,以利用电极作用面1506 产生一工作电极作用, 一第一印刷导电条1508印刷于绝缘薄片1501上并覆盖于电极衔接面1507上,第一印刷导电条1508具有一导电条衔接端1509及一工作电极输出端1510,导电条衔接端1509与电极衔接面1507有电连接,以输出该电极量测信号至工作电极输出端1510。 Having an electrode active surface a through hole on an insulating sheet 15,011,503 and an electrode adapter surface of the through-hole 1504 and this two through holes at the bottom of 1502 are joined to form a nr-shaped recess 1502,; an "IT shaped electrode sheet 1505 (i.e., having a "IR-shaped cross section) placed in the" 1502 and IT-shaped recess with a tight, 〃U "action surface having an electrode formed on the electrode pad 15051506 engaging surface and an electrode 1507, using electrodes to produce a working action surface 1506 as an electrode, a first printed conductive strips printed on the insulation sheet 1508 and cover 1501 to the electrode engaging surface 1507, a first conductive strip 1508 having a printed conductive strip adapter 1509 and a working electrode output terminal 1510, terminal adapters conductive strip engaging surface 1509 and the electrode 1507 electrically connected to the signal output of the measuring electrode to the working electrode output terminal 1510.

—第二印刷导电条1514及一第三印刷导电条1511与第一印刷导电条1508 同时印刷于绝缘薄片1501,第二印刷导电条1514具有一对电极输出端1516及一第二电极端1515以为一对电极1515,第三印刷导电条1511具有一参考电极输出端1513及一第三电极端1512,其作为一参考电极1512,参考电极1512 经一银/氯化银修正层1518的修正后已成为一氯化银参考电极; 一绝缘层1519 具有一〃C"形开口1520并覆盖于三导电条1508,1511,1514的上方只露出电极作用面1506与电极输出端1510, 一覆盖层1521上具有一毛细对流气孔1522 并覆盖于〃C"形开口1520的上方以形成一完整的毛细吸附结构。 - printing a second conductive strip 1514 and a third conductive strip printed with a first printing conductive strip 1511 1508 1501 while the insulating sheet is printed, printing a second conductive strip 1514 having a pair of output terminal electrodes 1516 and 1515 that a second electrical terminal a pair of electrodes 1515, 1511 of the third conductive strip having a printed reference electrode output terminal 1513, and a third electrical terminal 1512, which serves as a reference electrode 1512, reference electrode 1512 has been amended after a silver / silver chloride correction layer 1518 into a silver chloride reference electrode; 1519 having an insulating layer on a 〃C "shaped opening 1520 and a third conductive strip covers only the exposed upper electrode 1508,1511,1514 action surface 1506 and the output terminal electrode 1510, a cover layer 1521 convection having a hole in the cover 1522 and 〃C "shaped opening 1520 upward to form a complete capillary suction structure. 本结构利用该"U"形凹部1502与该"IT形电极片1505的配合,可使衔接该工作电极的该第一印刷导电条1508可与该第二及第三印刷导电条1511,1514同一次印刷于绝缘薄片上的同一面,因而可省掉一次印刷程序。 This structure utilizes the "U" 1502 to the "IT-shaped recess mating shaped electrode sheet 1505 allows the first printed conductive link one of the working electrode 1508 may be printed with the second and third conductive strips 1511,1514 same prints on the same side of the insulating sheet, a printing process thus omitted.

一化学试剂1517置放于工作电极1505的顶面,用于与该待测流体中的某分析物产生化学作用并产生一电性信号,并经由电极1505输出该电性信号至信号输出端1510。 A chemical agent 1517 is placed on the top surface of the working electrode 1505, a chemical reaction with the fluid to be measured in an analyte and generating an electrical signal via the electrode 1505 and outputs the signal to the electrical signal output terminal 1510 . 三印刷导电条1508,1511,1514的材料可为一含碳导电裔或银育,而标号1523是表示一流体入口。 1508,1511,1514 three printed conductive strip material may be silver or a carbon-containing conductive American Fertility, and reference numeral 1523 shows a fluid inlet.

若是从另一个相当的层面来看,图10中的印刷导电条1006是可以被改成一体成型的导电条或取消不用的,请参阅图16(a)-(c),是为本发明另一片具有毛细流动通道的三电极检测薄片的应用实例,本实施例的三电极的电极作用端、电极引接线及电极输出端皆为一体成型的导电片, 一绝缘薄片1601具有一第一面1602及一第二面1603,于第二面1603上具有一第一凹部1604及一通孔1605 (详见图16(c)),通孔1605与该第一面1602相通; 一体成型的一第一导电条1606置放于第一凹部1604中并形成紧配,第一导电条1606具有一第一电极输出端1608及一第一电极端1607,以利用第一电极端1607产生一工作电极1607的功用。 If the equivalent from another perspective, the printed conductive strip 1006 in FIG. 10 may be integrally formed into conductive strips cancel or not, see FIG. 16 (a) - (c), another of the present invention is examples of application of a three-electrode sheet detected having a capillary flow passage, a three-electrode embodiment of an electrode acting end of the present embodiment, the electrode lead wire and the electrode output terminal are all integrally formed conductive sheet, an insulation sheet having a first side 1602 1601 and a second surface 1603 having a recessed portion 1604, and a first through hole 1605 (see FIG. 16 (c)), the through-hole 1605 communicating with the first face 1602 to 1603 on the second surface; a first integrally molded the conductive strip 1606 is placed in the first recessed portion 1604 and form a tight fit, the first conductive strip 1606 having a first output terminal electrode 1608 and a first electrode terminal 1607, terminal 1607 to generate electricity using a first working electrode 1607 function.

又于绝缘薄片1601的第一面1602上具有一第二凹部1611及一第三凹部1610, 一体成型的一第二导电条1616置放于第二凹部1611中并形成紧配,第二导电条1616上具有一第二信号输出端1618及一第二电极端1617,俾利用第二电极端1617产生一对电极1617,而一体成型的一第三导电条1612置放于第三凹部1610中并形成紧配,第三导电条1612上具有一第三信号输出端1614 及一第三电极端1613,以利用第三电极端1613产生一参考电极1613的功用, 参考电极1613经一银/氯化银修正层1615的修正后已成为一氯化银参考电极, —绝缘层1619具有一"C"形开口1620并覆盖于二导电条1614,1618的上方, 只露出电极作用面1607与电极输出端1608。 Also has a second recess portion 1611 and a third recess portion 1610 on the first surface 1602 of the insulating sheet 1601, a second conductive strip 1616 is formed integrally placed in the second recess portion 1611 and a tight fitting, the second conductive strip having a second signal output terminal 1618 and a second electrode terminal 1617 on the 1616, 1617 to serve with the second electrical terminal 1617 generates a pair of electrodes, and a third conductive strip 1612 is disposed in the integrally molded recess portion 1610 and the third forming a tight fit, on the third conductive strip 1612 having a third signal output terminal 1614 and a third electrical terminal 1613, terminal 1613 in order to generate electricity using a third function of a reference electrode 1613, reference electrode 1613 via a silver / chloride correcting the corrected silver layer 1615 has become a silver chloride reference electrode, - an insulating layer 1607 and the electrode 1619 having an output terminal "C" shaped opening 1620 and covers 1614,1618 above two conductive strips, and only the exposed surface of the electrode acting 1608.

一覆盖层1621上具有一毛细对流气孔1622并覆盖于"C"形开口1620的上方,以形成一完整的毛细吸附结构, 一化学试剂1609置放于工作电极1607的 A convection cover having a hole on the cover layer to 16,211,622 and a "C" above the opening 1620 to form a complete capillary suction structure, a chemical agent 1609 disposed in the working electrode 1607

顶面,用于与待测流体中的某分析物产生化学作用并产生一电性信号,并经由电极1607输出该电性信号至信号输出端1608,而标号1623是表示一流体入口。 A top surface for generating a fluid to be measured in a chemical reaction of the analyte and generating an electrical signal, and outputs the electrical signal to the signal output terminal 1608 via the electrode 1607, and reference numeral 1623 shows a fluid inlet. 请参阅图17(a)-(b),是为本发明另一片具有毛细流动通道的三电极检测薄片的应用实例,本发明实施例为图16实施例的修改,该图16将对电极1617 及参考电极1613以传统印刷电极方式印刷于绝缘薄片1601上,其中参考电极1613需经一银/氯化银的修正过程,因参考电极1613与工作电极1607同样皆附在同一绝缘薄片1601上,而怕于执行该银/氯化银的修正过程中会污染到工作电极1607,故本实施例将对电极1617与参考电极1613改为印刷于覆盖层1716上,于制作该银/氯化银的修正过程时,此覆盖层1716与依附工作电极 See FIG. 17 (a) - (b), is another example of three-electrode sheet having an application sheet detection capillary flow passage of the present invention, embodiments of the present invention is a modification of the embodiment in FIG. 16, the counter electrode 1617 in FIG. 16 the reference electrode 1613 and an electrode printed in a conventional manner on an insulating sheet 1601 is printed, wherein the reference electrode 1613 is subject to the correction procedure of a silver / silver chloride reference electrode due to the working electrode 1613 and 1607 are attached to the same 1601 on the same insulating sheet, to execute the correction process for the fear of the silver / silver chloride will contaminate the working electrode 1607, so the electrode of the present embodiment will embodiment 1613 to 1617 and the reference electrode printed on the cover layer 1716, the production of the silver / silver chloride when the correction process, the capping layer 1716 and the working electrode attachment

1707的绝缘薄片1701是分离的,故工作电极1707不会被制作该银/氯化银的 1707 1701 insulating sheet is separated, the working electrode 1707 is not made of the silver / silver chloride

修正过程而会污染。 The revision process will pollute.

一绝缘薄片1701其上具有一流体量测凹部1702,流体量测凹部1702的底 An insulating sheet having thereon 1701 1702, a bottom fluid measuring portion 1702 is a recessed measuring fluid recess

面具有一化学试剂置放凹部1703,用于置放一化学试剂1708,于试剂置放凹 Chemicals having a surface disposed recess 1703, 1708 for placing a chemical reagent, is placed in the reagent recess

部1703的底面具有一个通孔1704,通孔用于置放一第一电极1707,第一电极 A bottom surface portion 1703 has a through hole 1704, through-holes for placing a first electrode 1707, a first electrode

1707于通孔1704中形成紧配,第一电极1707是由一导电素材覆盖一金属薄膜 1707 tightly fits in the through hole formed in 1704, the first electrode 1707 is covered with a metal thin film of an electrically conductive material

后形成一金属电极1707,第一电极1707具有一第一电极作用面与一第一电极 After forming a metal electrode 1707, a first electrode having a first electrode 1707 and a first electrode active surface

衔接面,以利用第一电极作用面产生一工作电极1707的作用,一第一导电条 Engaging surface, to a first electrode surface utilizing an effect of a working electrode 1707, a first conductive strips

1718置放于绝缘薄片1701的底面,第一导电条1718具有一导电条衔接端1719 1718 placed in the bottom surface of the insulating sheet 1701, conductive strips 1718 having a first end of a conductive strip adapter 1719

及一信号输出端1720。 And a signal output terminal 1720.

第一导电条1718的衔接端1719与该第一电极衔接面具有电连接,以为利用信号输出端1720输出一工作电极量测信号,流体量测凹部1702上具有一流体入口1705及一毛细对流气孔1706, 一覆盖层1716置于流体量测凹部1702 的上方以组成一完整的毛细现象的吸附结构。 A first conductive strip 1719 having a butt end 1718 is electrically connected to the first electrode engaging surface, that using the signal output terminal 1720 outputs a signal measuring the working electrode having a fluid inlet hole 1705 and a convection in the fluid measuring portion recessed 1702 1706, a capping layer 1716 disposed over the fluid measuring portion 1702 of the recess to form a complete attraction structure capillary phenomenon. 覆盖层1716上印刷一第二导电条1709及一第三导电条1713,第二印刷导电条1709具有一对电极输出端1711 及一第二电极端1710以为一对电极1710,第三印刷导电条1713具有一参考电极输出端1715及一第三电极端1714以为一参考电极1714,参考电极1714经一银/氯化银修正层1712的修正后,以合成为一氯化银参考电极。 Printing a second conductive strips 1709 and a third conductive layer on the cover strip 17161713 second printing conductive strip 1709 having a pair of electrodes and a second output terminal 1711 is electrically terminal 1710 that a pair of electrodes 1710, a third printed conductive strip 1713 has a reference electrode output terminal 1715 and a terminal 1714 that a third electrical reference electrode 1714, reference electrode 1714 after correction by a correction layer 1712 of silver / silver chloride, to synthesize a silver chloride reference electrode.

一化学试剂1708置放于工作电极1707的顶面,用于与该待测流体中的某分析物产生化学作用并产生一电性信号,并经由电极1707输出该电性信号至信号输出端1720,而标号1717是表示一"(T形开口。 A chemical agent 1708 is placed on the top surface of the working electrode 1707, a chemical reaction with the fluid to be measured in an analyte and generating an electrical signal, and outputs the electrical signal to the signal output terminal 1720 via the electrodes 1707 , and reference numeral 1717 is a "(T-shaped opening.

请参阅图18(a)-(c),是为本发明另一片三电极检测薄片的应用实例,本实施例直接利用金属电极的背面为信号输出端,此金属信号输出端直接连接至量测仪表的输入衔接端点, 一绝缘薄片1801 (即绝缘基材)其上具有一流体量测凹部1802,流体量测凹部1802的底面具有三通孔1803、 1804及1805,三电极扁、翻及1810置放于三通孔1803,1804,1805中并形成紧配,各电 See FIG. 18 (a) - (c), is an example of another application of the present three-electrode sheet of the present invention detects the sheet, the back of the present embodiment, the metal electrode is directly used as a signal output terminal, the metal terminal is directly connected to the signal output measurement input adapter end of the instrument, an insulating sheet 1801 (i.e., insulating substrate) having thereon a fluid measurement concave portion 1802, a bottom surface of the fluid measuring recessed portion 1802 having a three-way apertures 1803, 1804 and 1805, a three-electrode flat, turn and 1810 1803,1804,1805 placed in the hole and the three-way with a tight, each of the electrical

极1808, 1809, 1810具有一电极信号输出面1813及电极作用面1811,以利用电极作用面1811产生一电极功用, 一化学试剂1814置放于电极作用面1811的上方。 Pole 1808, 1809, 1810 having a surface 1813 and a signal output electrode action surface electrode 1811, using electrodes to generate an action surface electrode 1811 function, a chemical agent 1814 is placed above the electrode action surface 1811.

一网状薄片1815置于化学试剂1814的上方以保护化学试剂1814及滤除 A mesh sheet 1815 disposed above the chemical reagents 1814 and 1814 in order to protect the chemical agent was filtered off

该待测流体中的杂物, 一覆盖层1816覆盖于网状薄片1815与绝缘薄片1801 上,覆盖层1816具有一开口1817以为该待测流体的输入口。 The debris in the fluid to be measured, a cover layer covers the mesh sheet 1816 1815 1801 with the insulating sheet, the cover layer 1816 has an opening 1817 that is the input port of the fluid to be measured. 于绝缘薄片1801 An insulating sheet 1801

的两侧各具有一卡条1806及1807 (即卡榫),卡条1806, 1807用于将本发明实施例的薄片1801滑入如图18(d)的一量测仪表1820的二插入卡槽1821中形成定位功能。 Sides each having a clip strip 1806 and 1807 (i.e. tenon), clip bar 1806, 1807 is inserted into the card sheet 1801 for two embodiments of the present invention, the slide in FIG. 18 (d) is a measuring instrument 1820 the groove 1821 is formed in positioning. 薄片1801插入卡槽1821后感测试片1801的信号输出接点1813 与量测仪表1820的输入信号衔接点1822直接接触,即可完成信号传输,而不需用到导电条1006,其中标号1818表示一薄片底面。 After the sheet 1801 into the slot 1821 test strip 1801 to the signal output contact 1813 and measurement instrument 1820 is the convergence point of the input signal 1822 in direct contact, to complete the signal transmission, without the need to use conductive strip 1006, wherein reference numeral 1818 denotes a the bottom surface of the sheet.

按照本发明所制成的抛弃式感测器的金属电极若作为工作电极(Working Electrode)使用,其可适用于"第一类电子转移媒介物的修正工作电极(electron-transfer mediator modified working electrode)"与"第二类的金属催化电极(metal-catalyzed electrode)"。 The metal electrode of the disposable sensor of the present invention is made if as a working electrode (Working Electrode), which is applicable to the "first correction type electron transfer mediator working electrode (electron-transfer mediator modified working electrode) "and" a second catalytic electrode type metal (metal-catalyzed electrode) ". 于第一类金属电极只要是无化学干扰的惰性金属(noble Metal)即可,其并不限何种贵金属电极(如黄金、白金、钯、铑等皆可),本发明于此类电极的架构使用一贵金属膜404被覆于一导电素材403上以合成一金属电极411,并置入该金属电极411于一绝缘薄片401的一通孔402中,其可降低贵金属的使用量、縮减金属电极的制作工时、并可使感测器获得一稳定精确的电极面积而得到好品质的检测再现性(R印roducibility)。 A first metal electrode of inert metal as long as it is without chemical interference (noble Metal) to which the noble metal which is not limited (e.g., gold, platinum, palladium, rhodium, etc. can), the present invention is to such an electrode 404 architecture uses a noble metal film coated on a conductive material 403 to synthesize a metal electrode 411, and the metal electrode 411 placed on an insulating sheet in a through hole 402,401, it may reduce the amount of noble metal used, reduction of the metal electrode the manufacturing time, and can obtain a stable and accurate sensor electrode area be detected with good reproducibility and quality (R printed roducibility). 至于适用第二类的金属催化电极,其选用的工作电极材料需直接参与电化学催化作用(不需于化学试剂中再添加电子转移媒介物), 其材质需与化学试剂及待测分析物具有化学匹配性,适应不同化学架构需用不同金属材质,其可为各种金属电极并不限于惰性贵金属材料,例如铜电极可作为检测&02的工作电极(Working Electrode)。 As the metal catalyst suitable for the second type of electrode, a working electrode material which is selected for an electrochemical directly involved in catalysis (no need to add a chemical agent in the electron transfer mediator), which is a material for an analyte to be detected with a chemical agent and having chemical matching, to adapt to different architectures need to use different chemical metal material, which may be a noble metal is not limited to an inert electrode material for a variety of metals, such as copper electrode as the working electrode 02 is detected & (working electrode). 当使用的金属电极的材质不贵时,本发明的结构可直接选用该导电素材403与该金属电极411所需相同的材质,可省去被覆该金属膜404的程序,此时应用本发明的结构与方法仍可縮减金属电极的制作工时、并可使感测器获得一稳定精确的电极面积而得到好品质的检测再现性,其于电极的结构与制程上与先前技术的拋弃式金属电极的方法结构相较仍得到非常大的改善。 When the material of the metal electrode is not expensive to use, structure of the present invention can be directly used with the conductive material 403 of the same material as a desired metal electrode 411, the program may be omitted coated metal film 404, in which case application of the present invention structure and method of manufacturing steps can still reduce the metal electrode and the sensor can get a stable and accurate detection electrode area to obtain good quality reproduction, in which the disposable electrode structure and process and prior art methods metal electrode structure compared to still get a very big improvement.

若是从另外一个技术型态来看图13,本发明的一种拋弃式电化学式感测试片的制造方法,其包括如下步骤提供一绝缘薄片1301,其具有至少二凹部(通孔)1302,制备一导电素材组,其具有至少一第一及一第二导电素材(即电极1313的原素材),至少修正完成该第一导电素材,以形成一修正电极1315(1315 可为电镀上一白金薄膜以作为一工作电极、电镀上一银/氯化银层以作为一参考电极),以及置放修正电极1315及该第二导电素材于二凹部1302,以形成 If A method of manufacturing a disposable electrochemical test strip of the present invention, there is provided an insulating sheet 1301 comprising the steps of a technical patterns from another point of view in FIG. 13, which has at least two recesses (vias) 1302, preparation of a set of electrically conductive material, having at least a first and a second conductive material (i.e., the original electrode material 1313), the corrected at least the first conductive material to form a correction electrode 1315 (1315 may be a platinum plating film as a working electrode, electroplating a silver / silver chloride layer was used as a reference electrode), and the placement of the compensating electrode 1315 and the second conductive material 1302 in the two recessed portions to form

该拋弃式化学感测试片。 The disposable chemical test strip. 该感测试片还包括一电镀程序,是于该第一导电素材形成一金属薄膜,以获致该修正电极1315。 The sensor strip further comprises an electroplating process, a metal thin film is formed on the first conductive material, to the correction electrodes 1315 attainable. 该感测试片还包括一化学试剂的固化程序,以获致一酶电极。 The test strip further comprises a curing process a chemical agent, to obtain an activated enzyme electrode.

本发明是根据不浪费贵金属材料的原则来设计本发明的结构与制造方法。 The present invention is to design the structure and the manufacturing method of the present invention is based on the principle of not wasting precious metals. 本发明使用一低价的导电素材403 (如圆柱型铜粒,其直径1. 5mm、厚度0. 5mm) 以利于电镀一层惰性贵金属薄膜(如电镀白金、镀膜厚O. 025-5 "m)形成一贵金属电极411,将电极411置入一绝缘薄片401的通孔402中并形成紧配,使电极411被绝缘薄片401包住后只露出一电极作用面409及一电极衔接面408, 以利用电极作用面409产生一电极作用,以及再印刷一导电条410衔接于电极411的衔接面408,以作为电极411的导引线410及输出端406。此结构使用的贵金属材料只是电镀薄膜层404,又只限用于通孔402中的电极面积412,这样可将贵金属的使用量降至最低,且其可一次电镀数百万粒电极411后,再机械加工置入绝缘薄片401的通孔402中,故可大量降低此贵金属电极的材料与制程成本。 The present invention uses a low electrically conductive material 403 (e.g., cylindrical copper particles having a diameter of 1. 5mm, a thickness of 0. 5mm) to facilitate the plating layer of inert noble metal thin film (such as electric rhodium, film thickness O. 025-5 "m ) forming a noble metal electrode 411, the electrode 411 into a via 402 through an insulating sheet 401 and is formed with a tight, the electrode 411 is exposed only after the insulating sheet 401 encloses an electrode action surface 409 engaging surface 408, and an electrode, engaging surface 408 to surface 409 using an electrode acting as electrodes to generate a, and then printing a conductive strip adapter 410 to the electrode 411, and an output terminal 410 as a guide wire 406. the electrode 411 of this structure used in the noble metal material plated film only layer 404, and only an electrode area of ​​the through holes 402 412, so that the amount of noble metal can be minimized, and it may be a number of one million electrode after plating 411, and then machined into the insulating sheet 401 the through hole 402, it can significantly reduce the cost of this material and process of the noble metal.

另本发明的电极411置于绝缘薄片401的通孔402中形成紧配,绝缘薄片401紧紧包住电极411的侧面只露出一电极作用面409及一电极衔接面408, 又印刷导电条410衔接于电极411的衔接面408以为电极411的导引线410及输出端406,其与电极作用面409无直接接触,使电极作用面409的面积完全独立且由通孔402面积决定,而可获得一非常精确的电极面积412,因电化学式感测器的量测电流与电极面积412成正比,故本发明可使电化学式感测器量测信号的再现性准确度(R印roducibility)大幅提升。 Another side electrode 411 of the present invention is placed in the through hole 401 of the insulating sheet 402 is formed with a tight, insulating sheet 401 tightly wrap the electrode 411 is exposed only to an electrode 409 and an electrode active surface engaging surface 408, and a printed conductive strips 410 area of ​​engagement in the engaging surface 411 of the electrode 408 of the electrode 411 that guide wire 410 and an output terminal 406 and the electrode 409 without direct contact with the action surface, the electrode surface 409 acting completely independently and is determined by the area of ​​the through hole 402, but may obtaining a very precise area of ​​the electrode 412, by electrochemical measurement current sensor 412 is proportional to the electrode area, so that the present invention allows accurate reproducibility (R printed roducibility) electrochemical sensors measuring the signal significantly upgrade.

本发明可用塑胶射出方式成形感测器绝缘薄片401上的电极通孔402,于相同的塑胶射出程序可将感测器所需要的其他机构一次成形,如将待测流体入口1308,流体毛细流动通道凹槽1314,毛细对流气孔1309,化学试剂1307的置放凹部1306,抵顶凸块1316等多种结构一次成形,不但可减少元件组装数目以降低成本,更可降低多元件的组装误差。 Embodiment of the present invention can be used plastic injection molding on the sensor electrode via an insulating sheet 401 402 emits the same program may be a molded plastic bodies other sensors required, as will be measured fluid inlet 1308, in fluid capillary flow passage recess 1314, 1309 convection hole, placing recess portion 1307 Chemicals 1306, 1316 bump abuts against a variety of structures other primary molding, not only the number of assembly components can be reduced to reduce costs, but also reduce assembly error of a multi-element.

综上所述,本发明确实能以一崭新的方式,藉由利用一金属薄膜的形成于一导电素材上,以降低金属电极的贵金属的使用量,并且所运用的金属电极的 In summary, the present invention is actually capable of a new way by using a metal thin film is formed on a conductive material, in order to reduce the amount of noble metal electrode and a metal electrode by the use of the

装设于绝缘薄片的一通孔内,能大幅縮短制作该拋弃式感测试片所需的时间, 而极适合工业上的生产。 Mounted to a through hole of the insulating sheet, can significantly shorten the time required for making the disposable test strip, and is very suitable for industrial production on.

Claims (3)

1.一种抛弃式电化学式感测试片的制造方法,其特征在于,包括如下步骤: 提供一绝缘薄片,其具有至少二通孔; 制备一导电素材组,其具有至少一第一及一第二导电素材; 至少修正完成该第一导电素材,以形成一修正电极;以及置放该修正电极及该第二导电素材于该二通孔,并于该绝缘薄片上分别配置一导电条于每一通孔,使该导电条其一端连接于该修正电极或该第二导电素材,而其另一端提供信号输出,以形成该抛弃式化学感测试片。 1. A method for manufacturing disposable electrochemical test strip, the method comprising the steps of: providing an insulating sheet having at least two through holes; Preparation of a set of electrically conductive material, having at least a first and a second second conductive material; at least a first electrically conductive material of the correction is completed, to form a correction electrode; and placing the correction electrode and the second conductive material to the two through holes, and the insulating sheet on a conductive strip are arranged in each a through-hole, so that the conductive strip having one end connected to the correction electrode or the second conductive material, and the other end to provide an output signal, to form the disposable chemical test strip.
2. 如权利要求l所述的方法,其特征在于: 该至少修正完成该第一导电素材,以形成该修正电极的步骤包括:一电镀程序,用于在该第一导电素材上电镀一金属薄膜,以获致该修正电极, 且该修正电极为一金属薄膜电极;及/或一化学试剂固化程序,用于在该电极上固化一化学试剂以获致该修正电极, 且该修正电极为一酶电极。 2. A method as claimed in claim l, wherein: at least a first conductive material to complete the correction, the correction to the step of forming an electrode comprising: a plating process for plating the first conductive material a metal film, to obtain actuation of the correction electrode, and the correction electrode is a thin film metal electrode; and / or a chemical agent curing process for curing a chemical agent on the electrode to obtain actuation of the correction electrode, and the correction electrode is an enzyme electrode.
3. 如权利要求l所述的方法,其特征在于,还包括:一印刷程序,用以印刷该导电条以形成至少一信号输出端,并电连接该修正电极的输出信号至该信号输出端。 3. The method according to claim l, characterized in that, further comprising: a printing process for printing the conductive strips to form at least one signal output terminal, and an output signal is electrically connected to the correction electrode is to the signal output terminal .
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