CN100429499C - Apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial - Google Patents
Apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial Download PDFInfo
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- CN100429499C CN100429499C CNB2005100574806A CN200510057480A CN100429499C CN 100429499 C CN100429499 C CN 100429499C CN B2005100574806 A CNB2005100574806 A CN B2005100574806A CN 200510057480 A CN200510057480 A CN 200510057480A CN 100429499 C CN100429499 C CN 100429499C
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Abstract
The present invention relates to an apparatus for testing mechanical properties of membrane-like biomaterials with high sensitivity and small tension, which is composed of a pressure transmitter 1, a pressure box 2, a sample fixing ring 4, a sample carrier 5, a sealing pad 6, an upper faceplate 7a, a bearing faceplate 7b, a movable clamping plate 8, a top tight screw rod 10, a bearing 11, a dumbbell-shaped nut 12, a pressure regulating box 13, a pulley 14, a glass pipe 15, a lifting pull rope 16, a hose 17, a step motor 18, a data line conductor 19, a control line conductor 20 and a microcomputer 21. The present invention has simple and reasonable structure and can conveniently and accurately test tissue engineering products, such as skin, bones, blood vessels, muscle tendons, muscles, etc., soft tissue materials, etc., and testing values are all calculated by Pa; the present invention also has sensitive and convenient operation control, can sensitively reflect the continuous variation of a load, and can resist environmental interference, which guarantees the accuracy of testing data. The apparatus of the present invention provides an ideal mechanical property testing tool for the batch production and the quality control of tissue engineering biomaterials.
Description
One, technical field
The invention belongs to the strength characteristics of what, particularly a kind of solid material apparatus for testing mechanical that applies stable tension or pressure with mechanical stress test solid material.
Two, background technology
Along with the progress and the maturation of tissue engineering technique, the development of organization engineering skin is also maked rapid progress with application.Clinical for guaranteeing that organization engineering skin is applied to better, its biophysical properties, particularly biomechanical property should obtain paying much attention to.In order to quantize the biomechanical property of the membranaceous biomaterials of small tension receiving coil such as organization engineering skin, must develop a kind of device that can detect its mechanical property.
Be used for detecting the instrument of the mechanical property of soft tissue or bone at present, what can detect all is the biomechanical property of high-tension biomaterial (animal or human's isolated skin and soft tissue thereof, corpse), and detected value all calculates with MPa, belongs to the biomaterial testing machine in fact.Yet the biological organic material of many low-tensions, Yan Jiu tissue engineering product as organization engineering skin product, organizational project bone product, can not detect with this biomaterial testing machine especially in the last thirty years.
On April 22nd, 1992, Granted publication had a name to be called " biomaterial mechanical property testing device " Chinese utility model patent ZL91222000.7, it is mainly by body, crossbeam, plumbing arm, power and kinematic train thereof, formations such as tension force sensing and displacement digital display system and corresponding fixture.Plumbing arm and transmission rod can fall in the liquid, and sample is tried in given solution.Power and kinematic train thereof are moved crossbeam up and down, make the sample generation length and the tension variation that are clamped between two fixtures.The latter transfers electric signal input register system to by displacement digital display and power sensor-based system respectively, finishes the detection to the biomaterial mechanical characteristic.This device can be measured the mechanical property of some biomaterial really, and cost is low.But the hook-type fixture of this device and folder formula fixture can only fixedly be in ring-type and strip biomaterial in the nutrient solution, are not suitable for the fixing biomaterials such as organization engineering skin that break away from nutrient solution; Secondly, this matching requirements biomaterial is loaded in the interior solution of casing, and aptitude test when needing electromagnetism to be heated to water temperature satisfaction can not make test break away from nutrient solution; This device is to move up and down that physical property is elongated and shorten sample and measure tensile strength by leading screw, uses inconveniently, quantizes also not accurate enough.
Three, summary of the invention
Above-mentioned defective at prior art " biomaterial mechanical property testing device " existence, we are according to the fluid pressure principle, adopt indirect pressure application to load, propose meter and make the high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance that a kind of structure is different from prior art fully, make sample when detecting, can break away from nutrient solution, and do not need directly to elongate or shorten sample, can accurately detect product and other mechanical properties such as engineered skin, bone, blood vessel, tendon, muscle easily as mesenterium, manadesma, cardiac valves soft-tissue material etc.
The technical solution used in the present invention is as follows.
A kind of high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance includes frame, pressure unit, microcomputer, data conductor and pilot, it is characterized in that:
1) it also has forbay, sample set collar, load sample platform, packing washer, top panel, load-bearing panel, active clamped plate, fastening screw, bearing, dumbbell shape nut, pressure regulating box, pulley, glass tube, lifting stay cord, flexible pipe and stepper motor;
2) the suitable for reading and pressure unit of forbay is tightly connected, the center pit contraposition coupling of end opening and top panel, and be connected with the plate face seal at the bottom of the case, the bottom surface of plate has ring groove in the above, plate is arranged with the load sample platform that top is circular platform type in the above, load sample platform center has cylindrical hole, round platform stretches in the center pit of top panel, sample set collar and round platform coupling are nested, position, the corresponding load sample platform of plate ring groove deep bid upper surface has ring groove in the above, in ring groove, be placed with packing washer, have ring groove in load sample platform deep bid lower surface;
3) be arranged with the active clamped plate that is nested with framework pillar at the load sample platform, active clamped plate has conical central hole, and the upper surface is provided with the convex annular that is complementary with load sample platform deep bid lower surface ring groove;
4) the dumbbell shape nut passes the center pit of load-bearing panel and closes with the weight-bearing surface integrated circuit board, the dumbbell shape nut can be rotated, be provided with bearing between the lower nut head of dumbbell shape nut and the load-bearing panel, be welded with handle on the top nut head of dumbbell shape nut, fastening screw and the screwed connection of dumbbell shape nut, fastening screw top are a pot mouthful top shape and prop up active clamped plate;
5) pressure regulating box is arranged on the load-bearing panel, the pressure regulating box top is communicated with forbay, use soft pipe connection between pressure regulating box bottom and the glass tube, pulley is arranged on the above height and position in pressure regulating box top, lifting stay cord pile warp pulley one end links to each other with the glass tube tube head, other end solderless wrapped connection is connected with pilot between stepper motor and the microcomputer on the wheel disc of stepper motor, be connected with data conductor between pressure unit and the microcomputer.
High-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance of the present invention, before use, earlier glass tube is risen to the suitable height of high what pressure regulating box bottom by the lifting stay cord, in pressure regulating box, inject the clean water of certain liquid then, again film software sample to be detected is placed on the round platform mouth of load sample platform, putting the sample set collar collapses flat, rotate the dumbbell shape nut with spanner at last and promote fastening screw, the load sample platform is clamped between active clamped plate and top panel, make forbay-pressure regulating box total system be in sealing state.During detection, its principle of work is: microcomputer is after pilot sends steering order to stepper motor, driving the lifting stay cord by stepper motor slowly promotes glass tube, thereby make forbay pressure increasing and slowly increase with the pressure regulating box liquid level, realization evenly loads continuously to film sample to be detected, the pressure measurement data that the film sample that pressure unit is gathered is breakdown is returned to be fed to by data conductor and is carried out data processing in the microcomputer, and in time obtains showing and storage.
High-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance of the present invention, simple and reasonable, the sample clamping is simple and convenient, can be to the tissue engineering skin of low-tension, bone, blood vessel, tendon, product such as muscle and other are as mesenterium, manadesma, cardiac valves soft-tissue material etc. carries out convenience, detect accurately, detected value all calculates with Pa, operation control is quick convenient, sample can break away from nutrient solution when detecting, and do not need directly to elongate or shorten sample, it can reflect the continuous variation of load and the interference that can resist environment delicately, guarantees to detect the accurate of data.Apparatus of the present invention provide a kind of desirable mechanical property testing tool for the batch process and the quality control of engineered biomaterial.
Four, description of drawings
Accompanying drawing is the broken section structural representation of high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance of the present invention.
In the drawings, 1-pressure unit, 2-forbay, 3-sample, 4-sample set collar, 5-load sample platform, 6-packing washer, 7-frame, 7
a-top panel, 7
b-load-bearing panel, 8-active clamped plate, 9-handle, 10-fastening screw, 11-bearing, 12-dumbbell shape nut, 13-pressure regulating box, 14-pulley, 15-glass tube, 16-lifting stay cord, 17-flexible pipe, 18-stepper motor, 19-data conductor, 20 system leads, 21-microcomputer.
Five, embodiment
Further specify concrete structure and its principle of work when detecting of apparatus of the present invention below in conjunction with accompanying drawing.
A kind of high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance includes frame 7, pressure unit 1, microcomputer 21, data conductor 19 and pilot 20, it is characterized in that:
1) it also has forbay 2, sample set collar 4, load sample platform 5, packing washer 6, top panel 7
a, load-bearing panel 7
b, active clamped plate 8, fastening screw 10, bearing 11, dumbbell shape nut 12, pressure regulating box 13, pulley 14, glass tube 15, lifting stay cord 16, flexible pipe 17 and stepper motor 18;
2) the suitable for reading and pressure unit 1 of forbay 2 is tightly connected, end opening and top panel 7
aCenter pit contraposition coupling, and be connected with the plate face seal at the bottom of the case, plate 7 in the above
aThe bottom surface have ring groove, plate 7 in the above
aBeing arranged with top is the load sample platform 5 of circular platform type, and load sample platform 5 centers have cylindrical hole, and round platform stretches into top panel 7
aCenter pit in, sample set collar 4 is nested with the round platform coupling, plate 7 in the above
aPosition, ring groove corresponding load sample platform 5 deep bid upper surface has ring groove, is placed with packing washer 6 in ring groove, has ring groove in load sample platform 5 deep bid lower surfaces;
3) be arranged with the active clamped plate 8 that is nested with framework pillar at load sample platform 5, active clamped plate 8 has conical central hole, and the upper surface is provided with the convex annular that is complementary with load sample platform 5 deep bid lower surface ring grooves;
4) dumbbell shape nut 12 passes load-bearing panel 7
bCenter pit and with load-bearing panel 7
bEngaging can rotate dumbbell shape nut 12, the lower nut head of dumbbell shape nut 12 and load-bearing panel 7
bBetween be provided with bearing 11, the top nut head of dumbbell shape nut 12 is welded with handle 9, fastening screw 10 and 12 screwed connections of dumbbell shape nut, fastening screw 10 tops are a pot mouthful top shape and prop up active clamped plate 8;
5) pressure regulating box 13 is arranged on load-bearing panel 7
bOn, pressure regulating box 13 tops are communicated with forbay 2, be communicated with flexible pipe 17 between pressure regulating box 13 bottoms and the glass tube 15, pulley 14 is arranged on the above height and position in pressure regulating box 13 tops, lifting stay cord 16 pile warp pulleys 14 1 ends link to each other with glass tube 15 tube heads, other end solderless wrapped connection is connected with pilot 20 between stepper motor 18 and the microcomputer 21 on the wheel disc of stepper motor 18, be connected with data conductor 19 between pressure unit 1 and the microcomputer 21.
Its principle of work when detecting is: after injecting the clean water of certain liquid and device total system in advance tightened up sealing in pressure regulating box, microcomputer 21 sends steering order through 20 pairs of stepper motors 18 of pilot, driving lifting stay cord 16 by stepper motor 18 slowly promotes glass tube 15, thereby make forbay 2 pressure increasing and slowly increase with pressure regulating box 13 liquid levels, realization is to the even loading of film sample to be detected, the breakdown pressure measurement data of film sample that pressure unit 1 is gathered, return to be fed to by data conductor 19 and carry out data processing in the microcomputer 21, and in time obtain showing and storage.
Claims (1)
1, a kind of high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance includes frame (7), pressure unit (1), microcomputer (21), data conductor (19) and pilot (20), it is characterized in that:
1) it also has forbay (2), sample set collar (4), load sample platform (5), packing washer (6), top panel (7
a), load-bearing panel (7
b), active clamped plate (8), fastening screw (10), bearing (11), dumbbell shape nut (12), pressure regulating box (13), pulley (14), glass tube (15), lifting stay cord (16), flexible pipe (17) and stepper motor (18);
2) the suitable for reading and pressure unit (1) of forbay (2) is tightly connected, end opening and top panel (7
a) center pit contraposition coupling, and be connected with the plate face seal at the bottom of the case, plate (7 in the above
a) the bottom surface have ring groove, plate (7 in the above
a) being arranged with the load sample platform (5) that top is circular platform type, load sample platform (5) center has cylindrical hole, and round platform stretches into top panel (7
a) center pit in, sample set collar (4) and round platform coupling is nested, plate (7 in the above
a) position, the corresponding load sample platform of ring groove (5) deep bid upper surface has ring groove, is placed with packing washer (6) in ring groove, has ring groove in load sample platform (5) deep bid lower surface;
3) be arranged with the active clamped plate (8) that is nested with framework pillar at load sample platform (5), active clamped plate (8) has conical central hole, and the upper surface is provided with the convex annular that is complementary with load sample platform (5) deep bid lower surface ring groove;
4) dumbbell shape nut (12) passes load-bearing panel (7
b) center pit and with load-bearing panel (7
b) engaging, dumbbell shape nut (12) can be rotated, the lower nut head of dumbbell shape nut (12) and load-bearing panel (7
b) between be provided with bearing (11), the top nut head of dumbbell shape nut (12) is welded with handle (9), fastening screw (10) and dumbbell shape nut (12) screwed connection, fastening screw (10) top is a pot mouthful top shape and props up active clamped plate (8);
5) pressure regulating box (13) is arranged on load-bearing panel (7
b) on, pressure regulating box (13) top is communicated with forbay (2), be communicated with flexible pipe (17) bottom the pressure regulating box (13) with between the glass tube (15), pulley (14) is arranged on the above height and position in pressure regulating box (13) top, lifting stay cord (16) pile warp pulley (14) one ends link to each other with glass tube (15) tube head, other end solderless wrapped connection is on the wheel disc of stepper motor (18), be connected with pilot (20) between stepper motor (18) and the microcomputer (21), be connected with data conductor (19) between pressure unit (1) and the microcomputer (21).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100574806A CN100429499C (en) | 2005-12-29 | 2005-12-29 | Apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100574806A CN100429499C (en) | 2005-12-29 | 2005-12-29 | Apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial |
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| Publication Number | Publication Date |
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| CN1789958A CN1789958A (en) | 2006-06-21 |
| CN100429499C true CN100429499C (en) | 2008-10-29 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101158679B (en) * | 2007-11-23 | 2011-04-27 | 清华大学 | Extract and mechanical properties measurement method of bone trabecula and measurement mechanism |
| CN101487778B (en) * | 2009-02-13 | 2010-11-03 | 中国人民解放军第三军医大学野战外科研究所 | Biomechanics test device for skin soft tissue and its liquid loading test method |
| CN101666726B (en) * | 2009-09-24 | 2011-02-16 | 中国人民解放军第三军医大学第三附属医院 | Piston pressure-regulating high-sensitivity small-tension film-shaped biomaterial mechanic detector |
| CN101810514B (en) * | 2010-03-12 | 2011-09-14 | 中国人民解放军第三军医大学第一附属医院 | Skin stretching and fixing frame |
| CN104535415B (en) * | 2014-12-19 | 2017-02-22 | 大连理工大学 | Biological soft tissue mechanical property test clamping device and method based on vacuum adsorption |
| CN110301923B (en) * | 2019-07-01 | 2020-08-04 | 清华大学 | Bridge type mechanism micro-measurement system applied to muscle stretching mechanical property test |
| CN115235891B (en) * | 2022-07-13 | 2023-08-22 | 北京大学第三医院（北京大学第三临床医学院） | Tendon mechanical property measuring method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2102511U (en) * | 1991-11-07 | 1992-04-22 | 山东医科大学 | Measuring device of boilogical material mechanics |
| FR2806804A1 (en) * | 2000-03-22 | 2001-09-28 | Innothera Lab Sa | Measuring apparatus characterizing soft biomaterials, e.g. tissue in terms of force detected by sensor relative to linear displacement of sample applied by piston of computer controlled actuator |
| CN2852102Y (en) * | 2005-12-29 | 2006-12-27 | 中国人民解放军第三军医大学第三附属医院 | Apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial |
-
2005
- 2005-12-29 CN CNB2005100574806A patent/CN100429499C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2102511U (en) * | 1991-11-07 | 1992-04-22 | 山东医科大学 | Measuring device of boilogical material mechanics |
| FR2806804A1 (en) * | 2000-03-22 | 2001-09-28 | Innothera Lab Sa | Measuring apparatus characterizing soft biomaterials, e.g. tissue in terms of force detected by sensor relative to linear displacement of sample applied by piston of computer controlled actuator |
| CN2852102Y (en) * | 2005-12-29 | 2006-12-27 | 中国人民解放军第三军医大学第三附属医院 | Apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial |
Non-Patent Citations (2)
| Title |
|---|
| 组织工程皮肤生物力学性能及移植溃疡面的初步研究. 李伟. 第三军医大学硕士学位论文. 2004 * |
| 细胞力学实验方法研究：压力加载及改进的膜式张应变加载. 何辉. 四川大学硕士学位论文. 2005 * |
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