CN100411801C

CN100411801C - High speed laser-beam drilling machine for tablet

Info

Publication number: CN100411801C
Application number: CNB2006100964407A
Authority: CN
Inventors: 梅林�; 王新; 杨志刚; 朱万兵; 颜明光
Original assignee: Ruichi Electronic Technology Engineering Industry Co Ltd Nanjing
Current assignee: Ruichi Electronic Technology Engineering Industry Co Ltd Nanjing
Priority date: 2006-09-26
Filing date: 2006-09-26
Publication date: 2008-08-20
Anticipated expiration: 2026-09-26
Also published as: CN1927519A

Abstract

The invention related to a high speed laser-beam drilling machine for tablets belonging to pharmaceutic accoutrement technology field. The device includes laser generator located at framework, optical conduction device and transport unit. The optical conduction device is at least consist of vibrating lens with its launching angle changing between the first position and the second position and two stationary mirrors, the laser emitted by laser generator shoots to the side of medicine on transport unit by direct reflex optical path when vibrating lens is at the first position; the laser emitted by laser generator shoots to the other side of medicine on transport unit by circuitous reflex optical path formed by vibrating lens and the two reflecting mirrors when vibrating lens is at the second position. With this equipment, slotting on two sides of the tablets continuously and precisely can be realized just by changing the direction of beam path and the adjusting the size of laser beam and position, so the production quality and efficiency has been improved greatly, the cost of equipment has been decreased greatly as well.

Description

High speed laser-beam drilling machine for tablet

Technical field

The present invention relates to a kind of laser-beam drilling machine, especially a kind of high-rate laser puncher that is used for the controlled-release pharmaceutical tablet suitability for industrialized production belongs to the pharmaceutical equipment technical field.

Background technology

Controlled release drug is a kind of slowly-releasing Formulation that is surrounded by pellicle on the surface.Usually need on pellicle, to get the release micropore, thereby after preparation is taken, moisture in the body fluid can pass pellicle and enter the preparation inner core, expansion is dissolved after making inner core absorb hydrone, produce osmotic pressure, force medicine slowly to discharge and diffuse into human body, reach the purpose that stable control discharges medicine, so the release micropore above the pellicle be most important for the release quality of osmotic pump preparation by the release micropore of having got on the pellicle.

Experimental results show that, the rate of release of controlled release drug is directly proportional with the area that discharges micropore. for required suitable release micropore size in determining to produce by batch, need under lab to utilize in advance laser-beam drilling machine, by changing the focus point position and method such as the power that punches obtains the controlled-release pharmaceutical tablet in different apertures, as test specimen, finally determine to produce required suitable release micropore size by drug test again.

Retrieval is found, Chinese patent 99103576.3 " laser borer for high-speed osmotic pump ", 02283653.5 " a kind of two-chamber osmotic pump controlled-release tablet laser-beam drilling machine " and 03270284.1 " full-automatic two-chamber osmotic pump controlled-release tablet laser-beam drilling machine " discloses the laser-beam drilling machine of three kinds of controlled-release pharmaceutical tablets respectively. when requiring appointment in tablet is two-sided simultaneously to punch, need by mechanical device upset tablet, therefore not only make mechanism's complexity of puncher, and influence operating efficiency.

Summary of the invention

The problem to be solved in the present invention is: at the defective that above-mentioned prior art exists, proposes a kind ofly to need not the high speed laser-beam drilling machine for tablet that switching mechanism can realize that to controlled-release pharmaceutical tablet the appointment in two-sided is simultaneously punched, thereby simplify the internal structure of an organization the raising work efficiency.

In order to address the above problem, the technical solution used in the present invention is: a kind of high speed laser-beam drilling machine for tablet, comprise the laser generator, light conduction device and the conveying device that are placed on the frame, its improvements are, described smooth conduction device is made up of galvanometer and two groups of stationary mirrors that the angle of departure can change between first and second position at least, when described galvanometer was in primary importance, described laser generator emitted laser was mapped to the one side of medicine on the conveying device through the direct reflected light path of galvanometer; When described galvanometer was in the second place, described laser generator emitted laser was mapped to the another side of medicine on the conveying device through the circuitous reflected light path of galvanometer and two speculums formation.

Like this, as long as the angle of appropriate regulation galvanometer, can realize very easily that to medicine the appointment in two-sided is simultaneously punched. owing to need not switching mechanism, so machine construction obviously simplifies, and helps guaranteeing drilling quality, raises the efficiency.

In a word, after adopting high speed laser-beam drilling machine for tablet of the present invention, medicine need not turn-over in course of conveying can realize that to it appointment in two-sided simultaneously punches, medicine is able to continuous carrying by beat, production efficiency height, drilling quality are good, machine construction obtains simplifying and reducing equipment cost, therefore compared with prior art, has outstanding substantive distinguishing features and obvious improvement.

Description of drawings

Fig. 1 is the system authority schematic diagram of the embodiment of the invention one.

Fig. 2 is the vertical view of Fig. 1.

Fig. 3 is the light path system figure of Fig. 1 embodiment one.

Fig. 4 be the embodiment of the invention two overlook the system authority schematic diagram.

Fig. 5 is the light path system figure of Fig. 4 embodiment two.

Below in conjunction with accompanying drawing the utility model is further described.

The specific embodiment

Embodiment one

The high speed laser-beam drilling machine for tablet of present embodiment such as Fig. 1, shown in 2 and 3, comprise laser generator 1, the light path conduction device, vibratory feed and frame 50, the top, horizontal of frame 50 is covered installing plate 51 is housed, laser generator 1 is loaded on the installing plate 51 with arranging by priority with the light path conduction device that its exit is right after. and laser generator 1 exchanges radio frequency closed type laser instrument or dc laser device for the carbon dioxide water-cooled, its power bracket is 100W-250W, the time adjustable range of its emission laser beam is that 0-15000 μ s. light path conduction device comprises beam expanding lens 2, spectroscope 3, galvanometer 5 and stationary mirror 6,7 reach upward focus lamp 8, following focus lamp 9, beam expanding lens 2 is right after the exit at laser generator 1, beam expanding lens 2 is spaced with spectroscope 3 coaxial priorities, spectroscope 3, galvanometer 5 and stationary mirror 6,7 and

focus lamp

8,9 form the certain included angle positioned opposite each other, described spectroscope 3, galvanometer 5 and stationary mirror 6,7 reach upward focus lamp 8, following focus lamp 9 is installed in respectively in separately the microscope base, described microscope base is respectively spectroscope base 10, galvanometer seat 15 and fixation

reflex microscope base

11,12 and focus on

microscope base

13,14, lens barrel 16 by sealing between these microscope bases, 17,18,19 and 20 link, speculum 6 and 7 all adopts 100% speculum, the multiplication factor adjustable extent of beam expanding lens 2 is 1-10 times, last focus lamp 8 and following focus lamp 9 positions symmetry also are equipped with the dial that can regulate focus point. and vibratory feed is mainly by vibrating disk 21, spiral slide 22 and straight slideway 23 connect and compose and are loaded on the installing plate 51, straight slideway 23 passes between last focus lamp 8 and following focus lamp 9. and import one side at straight slideway 23 is provided with RGB sensor 24 (three-primary colours resolution sensor), import one side of the straight slideway 23 after RGB sensor 24 is provided with acquisition sensor 25, side at the spectroscope 3 in laser generator 1 exit is provided with laser power detection module 4, is provided with optics or image leak detection sensor 26. in outlet one side of straight slideway 23

When using the high speed laser-beam drilling machine for tablet of present embodiment, tablet 100 is put into vibrating disk 21, tablet 100 is in the vibration effect lower edge spiral slide 22 and straight slideway 23 motions of vibrating disk, during the straight slideway of Swertia Tablet 100 by between

focus lamp

8,9, passing, the RGB sensor 24 that is positioned at straight slideway 23 imports one side detects the positive and negative of tablet 100 earlier, produce signal and the driving machine by electric control gear control galvanometer 5 thus, make galvanometer 15 deflections or motionless; Then acquisition sensor 25 detects tablet 100 and arrives and produce signal behind the desired locations and give off laser beam by electric control gear control laser instrument 1, laser beam arrives spectroscope 3 (also can do up the effect dwindled to laser after beam expanding lens 2 upsets) through beam expanding lens 2 earlier through certain amplification with after improving, laser beam is through spectroscope 3 beam split, wherein 2% laser beam reflexes to the light logical attenuation of laser power detection module 4 in order to detection laser beam, and then the generation power by electric control gear control and regulation laser generator 1, remaining 98% laser beam transmission is crossed spectroscope 3 and is arrived galvanometers 5; This moment, laser beam formed two kinds of reflected light paths respectively: if a RGB sensor 24 that is positioned at tablet 100 1 sides detects tablet 100 is positive, galvanometer 5 not deflections are in primary importance, laser beam reflexes to down focus lamp 9 through galvanometer 5, and the punching to tablet 100 surperficial pellicles is finished on the surface that is mapped to tablet 100 after down focus lamp 9 focuses on; Two, if what RGB sensor 24 detected is the reverse side of tablet, galvanometer 5 is in the second place with angle [alpha] of deflection, laser beam reflexes to fixation reflex eyeglass 6 and 7 successively through galvanometer 5, behind secondary reflection, arrive and go up focus lamp 8, the punching to tablet 100 surperficial pellicles is finished on the surface that is mapped to tablet 100 again after last focus lamp 8 focuses on. when the tablet 100 of having beaten the hole continues to proceed to the exit of straight slideway 23, the optics of straight slideway 23 outlets one side or the punching of 26 pairs of tablets 100 of image leak detection sensor are hunted leak, and the tablet 100 of finishing punching is sent to the packing point; 100 quilts of tablet of not finishing punching pass on sends vibrating disk 21 toward temporary point back to more again after check, perhaps directly send vibrating disk 21. back to

Embodiment two

The high speed laser-beam drilling machine for tablet of present embodiment is shown in Figure 4 and 5, its basic structure is identical with embodiment one with function, different is that the stationary mirror in the light path conduction device is adjusted, change two fixation reflex eyeglasses 6 and 7 into four

fixation reflex eyeglasses

27,28,29 and 30, corresponding microscope base is 31,32,33 and 34, changing thus and forming new sealing lens barrel is 35,36,37,38,39 and 40,

stationary mirror

27,28,29 and 30 also all adopt 100% speculum. like this after laser beam arrives galvanometer 5, if it is positive that RGB sensor 24 detects tablet 100, then galvanometer 5 not deflections are in primary importance, and the process of laser beam behind galvanometer 5 is identical with embodiment one; If what RGB sensor 24 detected is the reverse side of tablet, galvanometer 5 is in the 3rd position with angle beta of deflection, laser beam reflexes to

stationary mirror

27,28,29 and 30 successively behind galvanometer 5, behind four secondary reflections, arrive to go up focus lamp 8, after the focusing of last focus lamp 8, play the punching of finishing on the surface of controlled-release pharmaceutical tablet 100 tablet 100 surperficial pellicles.

Be not difficult to analogize by above-mentioned two embodiment, many arbitrarily groups that high speed laser-beam drilling machine for tablet of the present invention can carry out stationary mirror wherein more than two groups change combination, the angle of reflection of corresponding galvanometer can have multiple angles forming different change locations, thereby the control laser beam forms forward and reverse light path and finishes punching to the controlled-release pharmaceutical tablet positive and negative.

Experiment shows, adopt high speed laser-beam drilling machine for tablet of the present invention, compare existing controlled-release pharmaceutical tablet laser-beam drilling machine, changed original inflexible hole knockout, by direction and the diameter that changes laser beam flexiblely, can lightly accurately finish the two-sided punching of tablet at a high speed, therefore not only improve drilling quality and production efficiency greatly, and can simplify the mechanism of laser-beam drilling machine and reduce equipment cost.

The foregoing description that the present invention is not limited to illustrate as an example can have other distortion on the structure. and all employings are equal to the technical scheme of replacement or equivalent transformation formation, all drop on the protection domain of requirement of the present invention.

Claims

1. high speed laser-beam drilling machine for tablet, comprise the laser generator, light conduction device and the conveying device that are placed on the frame, it is characterized in that: described smooth conduction device is made up of galvanometer and two groups of stationary mirrors that the angle of departure can change between first and second position at least, when described galvanometer was in primary importance, described laser generator emitted laser was mapped to the one side of medicine on the conveying device through the direct reflected light path of galvanometer; When described galvanometer was in the second place, described laser generator emitted laser was mapped to the another side of medicine on the conveying device through the circuitous reflected light path of galvanometer and described two groups of stationary mirrors formation.

2. high speed laser-beam drilling machine for tablet according to claim 1 is characterized in that: the exit of described laser generator is provided with beam expanding lens, and the multiplication factor adjustable extent of described beam expanding lens is 1-10 times.

3. high speed laser-beam drilling machine for tablet according to claim 2 is characterized in that: described smooth conduction device also contains is located at front and the symmetrical two groups of focus lamps that are positioned at the conveying device both sides that reflected light path arrives medicine on the conveying device.

4. high speed laser-beam drilling machine for tablet according to claim 3 is characterized in that: described stationary mirror all adopts 100% speculum.

5. high speed laser-beam drilling machine for tablet according to claim 4 is characterized in that: described smooth conduction device also contains spectroscope, and the laser that described laser generator sends arrives the reflection of spectroscope generation 2% and 98% transmission.

6. high speed laser-beam drilling machine for tablet according to claim 5, it is characterized in that: described beam expanding lens is spaced with the coaxial priority of spectroscope, described spectroscope, galvanometer, stationary mirror and focus lamp form the certain included angle positioned opposite each other, and be installed in respectively in separately the microscope base, the lens barrel by sealing between the described microscope base links.

7. high speed laser-beam drilling machine for tablet according to claim 6, it is characterized in that: described conveying device is a vibratory feed, described vibratory feed mainly connects and composes and is loaded on the frame by vibrating disk, spiral slide and straight slideway, and described straight slideway passes between described two groups of focus lamps.

8. high speed laser-beam drilling machine for tablet according to claim 7, it is characterized in that: import one side of described straight slideway is provided with RGB sensor and acquisition sensor successively, export a side and be provided with optics or image leak detection sensor, a described spectroscopical side is provided with the laser power detection module.

9. high speed laser-beam drilling machine for tablet according to claim 8, it is characterized in that: described laser generator is that the carbon dioxide water-cooled exchanges radio frequency closed type laser instrument or dc laser device, its power bracket is 100W-250W, and the time adjustable range of its emission laser beam is 0-15000 μ s.