CN100394979C - Medicine and food dual purpose Chinese medicinal product for preventing and treating lethargy and its manufacturing method - Google Patents

Abstract

The present invention relates to a traditional Chinese medicine product with medicine and food purposes for preventing and treating somnolence, and a preparation method thereof. The traditional Chinese medicine product is prepared from the traditional Chinese medicine raw materials with medicine and food purposes, such as wild jujube seed, fructus alpiniae oxyphyllae, hippophae rhamnoides fruit, ginger, chicory herb and matrimony vine; the product has no toxic or side effect and is mainly used for long-term prevention. The product has the advantages of low production cost, no environment pollution, good mouth feel, small dosage and positive effect, and the product is suitable for different people of different ages, is easily accepted by patients, and has wide service aspects because all medicine materials have official medicine and food purposes, positive efficacy and no toxic or side effect. The product has simple and uniform medication varieties and functions and flexible and various prescriptions, adapts to various patient conditions, appropriately selects medication, and widens the concrete content and the application range of identifying and curing the diseases with traditional Chinese medicines.

Description

The application of a kind of compositions in the medicine of preparation control hypersomnia

Chinese medicine and western modern medicine disease preventing and treating theory one significantly difference be that the former does not rest on analysis to the concrete cause of disease to pathological knowledge, show the nonantagonistic latter and then be antagonism, that is the former emphasizes is human body integral and the ability that how improves the antagonism disease from integral body, the latter then is that " sitting in the right seat " is as what microorganism, malnutrition or surplus, poisonous and harmful substance (comprising medicine) and effect etc. cause any disease, though theoretic dispute is very big, even opposition and antagonism, whom shows under a lot of situations whom does not persuade, mutual contradiction or do not have public opinion even, undisputable fact really but they can both be cured the disease and/or reach a cure, this also proved human to medicine especially in, cognitive level and ability between western modern medicine is mutual are also very limited, and arbitrarily in the dogmatize about, the western modern medicine theory who to whose mistake, can not declare that more which is right and which is wrong, because both sides do not have enough conclusive evidences to prove that the other side is wrong, so do not meet the view of science, so should advocate the pardon scientific research of promptly taking facts as the basis and deepen continuously progressively gets and improves relevant theoretical dispute clear with practice and argue, thereby in constantly enriching, the theoretical treasure-house of western modern medicine, make the two can both more effectively be human good health and a long life service, but not argue for arguement, even be negative arbitrarily even attack the other side, not science and responsible attitude and behavior because do like this by lack of evidence ground to argue, all be unfavorable for ensureing and developing human medical and health care system.

Though also reduce to some extent along with development, the various diseases of medical and health care system are corresponding, but this is not just can sleep without any anxiety, in fact various diseases still exist, there is no disappearance sign or trend, disease of the present invention is no exception, this type of disease takes place especially easily and bring out the key factor of other disease often and omen such as serious obesity and fatiguability, drowsiness etc., as untimely control, often easily stay in various degree nerve and sequela such as moral damage, so still should actively prevent and treat.In present this class disease of control, the Western medicine product substantially all are to lay particular stress on treatment, poison, side effect is just more common, in no matter the more important thing is, the all rare officinal food dual purpose product of Western medicine, this is to forbid unauthorized medicine to use food (comprising health product) in any form because consider all to make laws from drug safety in China and a lot of countries and regions, otherwise investigate civil and even criminal responsibility in accordance with the law, and that disease reaches the degree of essential treatment is very serious, say on the clinical meaning and increase the treatment difficulty greatly, let alone puted prevention first, even if also just can sell medicine as the U.S. because of the prescription drugs pharmacy that must the doctor prescribes in developed country and area, otherwise it is illegal, consumer then must pay expenses such as high prescription takes and surpass medicine valency itself outward, and nonprescription drugs, health food is that the dietotherapeutic product then need not prescription and expensive expense thereof, has alleviated consumer's financial burden greatly and made to buy to consume simple and direct and increase purchasing power, fulfill thereby making puts prevention first.Therefore unique legal effectively, economically feasible, to put prevention first, prevent and treat the scheme of taking into account just can only be screening, combination and design relevant new departure and new product in view of the above in legal dietotherapeutic medicine scope, because of such product could really accomplish good and cheap, consumer channel is unblocked, service group is extensive, its disease preventing and treating function and curative effect, safety and crowd's general applicability could also must gain public acceptance and serial relevant law such as state food health legislation is approved and protect.Total be exactly the present invention at prior art not enough, for one for solve an above-mentioned serial difficult problem the application of a kind of compositions in the medicine of preparation control hypersomnia that design of inventive concept, its health that adopts officinal promulgated by the ministries or commissions of the Central Government is eaten dual-purpose raw material of Chinese medicine and the property of medicine and main Chinese medicine principle and functional advantage and is described below.

Tired, living, the sleeplessness stir-fry of hypersomnia that sour jujube kernel acid, arresting sweating drive.Semen Ziziphi Spinosae sour in the mouth, property are put down, and the effect that has the arresting sweating of calming the nerves to remove deficiency and coldness can be controlled diseases such as heart beating uneasiness, incessant sweating due to debility, insomnia.Make with energy clearing gallbladder fire, can sleep Zhiduo County, restlessness of asrhenia type and insomnia disease must fry usefulness.1.5-3 part.

The hot temperature of Fructus Alpiniae Oxyphyllae, the QI invigorating of calming the nerves, incontinence of urine seminal emission, vomiting are all controlled.The Fructus Alpiniae Oxyphyllae acrid in the mouth is warm in nature, and tranquilizing mind, the kidney invigorating gas are controlled the enuresis or the frequent micturition and the seminal emission of kidney qi deficiency and coldness, again can warming the spleen, control the diseases such as nausea and vomiting of spleen-cold syndrome.1-3 part.

Be rich in multivitamin in the Fructus Hippophae, vitamin V C content be Fructus actinidiae chinensis 2-3 doubly, radioprotective, fatigue, aging, help digestion, be good for the stomach, calm the nerves, blood pressure lowering, treatment coronary heart disease, hypertension and chronic bronchitis etc., better effects is all arranged.1-2 part.

Rhizoma Zingiberis Recens gods warm in nature, unobstructed, phlegmatic cough vomiting, extremely spirit of appetizing.Rhizoma Zingiberis Recens acrid in the mouth, slightly warm in nature have refreshment, preventing or arresting vomiting, dispersing wind and cold effect, and the soldier of bad odor so faints and the vomiting of cold syndrome of the stomach in can controlling, and lung has cold-evil's abundant expectoration cough.In addition can also appetite stimulator, the effect of appetizing is good.1-2 part.

But Herba Cichorii is coffee surrogate, event refreshment, and antidiarrheal efficacy is arranged, and 9 kinds of essential amino acids content are higher than generally acknowledged lucerne place of the preeminent quality, and vitamin, carotene, calcium content enrich, and mouthfeel is good, utilization rate is high.

The sweet temperature of Fructus Lycii, add the smart marrow, the wind that makes eye bright, cloudy emerging sun mended and rise.Fructus Lycii sweet in the mouth, warm in nature has nourishing kidney to mend bone marrow, nourishing the liver to improve visual acuity and goes the wind effect, and it can yin nourishing, again can be supporing yang, so disease such as clinical impotence and seminal emission, the Yao Xi Acid that is usually used in insufficiency of kidney-YANG be soft also is used for the prosperous disease such as have a dizzy spell of deficiency of the kidney yin, liver-yang.2-4 part.

Product of the present invention is by legal dietotherapeutic Chinese crude drug Semen Ziziphi Spinosae 1.5-3 part, and Fructus Alpiniae Oxyphyllae 1-3 part, Fructus Hippophae 1-2 part, Rhizoma Zingiberis Recens 1-2 part, Herba Cichorii 2-3 part, Fructus Lycii 2-4 part are that raw material of Chinese medicine is formed.

The manufacture method of product of the present invention is as follows:

A. decoction pieces type Chinese crude drug Semen Ziziphi Spinosae 1.5-3 part, Fructus Alpiniae Oxyphyllae 1-3 part, Fructus Hippophae 1-2 part are on the waiting list in the choosing of raw material Chinese medicine, Rhizoma Zingiberis Recens 1-2 part, Herba Cichorii 2-3 part, Fructus Lycii 2-4 part joins in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;

Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (it is volume ratio that V/V divides), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;

C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;

D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;

E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the medicinal residues that discard behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed are the acyclic dirts of agricultural soil high-quality fertilizer of returning crop stocks to the field, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;

F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;

G. the preparation of product of the present invention is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, lactose is added Chinese medicine extraction liquid, is the solution dry matter content that concentration promotes and to be 35-40%, be spray dried into water content and get product below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Any shape such as the sheet of compacting (lactose is compression moulding very easily) one-tenth 0.2-0.4 gram, grain, ball as food, nutriment, health product and medicine, are advised oral every day 2-3 time, each 0.4-0.8 gram, need not the branch of crowd and dosage.

The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.

Embodiment:

1, drinks 1.5 parts of sheet type Chinese crude drug Semen Ziziphi Spinosaes, 1 part of Fructus Alpiniae Oxyphyllae, 1 part of Fructus Hippophae, 1 part in Rhizoma Zingiberis Recens, 2 parts of Herba Cichoriis, 2 parts of Fructus Lyciis are made compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.Be mainly used in the daily life health food that puts prevention first.

2, drink 2 parts of sheet type Chinese crude drug Semen Ziziphi Spinosaes, 2 parts of Fructus Alpiniae Oxyphyllae, 2 parts of Fructus Hippophaes, 1 part in Rhizoma Zingiberis Recens, 2 parts of Herba Cichoriis, 3 parts of Fructus Lyciis are made compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.Be mainly used in the light patient of the their early stage or the state of an illness.

3, drink 3 parts of sheet type Chinese crude drug Semen Ziziphi Spinosaes, 3 parts of Fructus Alpiniae Oxyphyllae, 2 parts of Fructus Hippophaes, 2 parts in Rhizoma Zingiberis Recens, 3 parts of Herba Cichoriis, 4 parts of Fructus Lyciis, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, the Any shape such as sheet, grain, ball that product of the present invention are pressed into 0.2-0.4 gram get product.Be mainly used in the long or heavier patient of the state of an illness of the course of disease.

Supplementary copy inventive principle and advantage are as follows:

1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high, and constitute most crowds with the acescencies of the little sweet and Fructus Hippophae of lactose etc., Fructus Lycii etc. and like the popular taste products of " acid is sour-sweet sweet " that eat and easily be accepted, so service face and service group are the most extensive, its society and economic benefit are also just apparent naturally.

2; the property of medicine of Chinese prescription medical material is for flat; temperature; tepor; be slightly cold and tremble with fear to take into account and alleviate the property of medicine and based on flat; to avoid cold side effect and the sequela such as colliding other new disease of too quickly generation controlled of calentura; this is to neuroprotective and psychiatric system and make its functional rehabilitation normally extremely important; also take into account the heart simultaneously; liver; lung; spleen; the protection of the function of kidney and coordination; demonstrated fully Chinese medicine primary disease (essence) dispirited (gas) anemia essence; the accent spirit of control; with QI and blood organic conception and advantage; make drug effect and function more comprehensive and mark; this double controlling; realized the high boundary that Chinese medicine property of medicine general inclination is slightly cold in the Pingliang and avoids too urgent and promote drug effect mutually; and because of the legal dietotherapeutic of all medical materials; effect certainly and do not have a toxic and side effects; be suitable for any crowd and serve wide, these just the present invention to the wide main advantages imbody of Chinese medicine adaptive surface.

3, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, and the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer has been opened up out Chinese medicine and debated disease and execute tool body content and range of application.

4, all medical materials all are conventional varieties and do not have hormone and toxic and side effects, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.

5, innovate organic and inorganic mixed solvent and extract at room temperature and reclaim organic solvent and recycle molten and water-soluble substances and energy-conservation joint (cooling) water of Extraction oil with being beneficial to synchronously high-quality and high recovery rate, again with inorganic solvent and room temperature and high temperature combined extractive technique, scheme and technology, ensured extraction overall process asepticize, can carry substantially many to the greatest extent be insoluble in water or be insoluble in oil material and significantly improve drug effect and extract quality and content, and extraction ratio height, with short production cycle, energy-saving and water-saving, product cost is low, do not have (organic solvent) and pollute, its serial comprehensive advantage is traditional decocting and single with organic solvent or water or some other is because of expensive, highly difficult, the product of receiving single (fact proved and the generally acknowledged both at home and abroad compound composition extract of Chinese medicine than single composition extract good effect, this was exactly the essence and the inherent feature place of Chinese medicine originally and was determined by it), recovery rate low and short-term even long duration are difficult to that so-called modern Chinese medicine extractive technique that penetration and promotion uses is difficult to mention in the same breath.

6, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, can significantly slow down the medicine slow release speed and avoid taking the very big and beyond affordability historic difficult problem of traditional decocting Chinese medicine dose because adopt lactose to replace the starch easily digested and assimilated and dextrin to make adsorbent, adhesive and filler, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.

More than these also are the great novelty and the practicality of the legal approval of Patent Law.

Test method, data and presentation of results: disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, product of the present invention is because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, and make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and please understand: different sexes allow keeping in Patent Law about situation, totally 20 of the patients at age, divide equally and be drug treatment group and placebo group, treatment group product of the present invention and usage and dosage control.The result is as follows: the treatment group is mitigate the disease in a week all, cure in January and rehabilitation, body constitution and mental status also be significantly improved, follow up a case by regular visits to March-in half a year steadily, none example of matched group is cured, the 7 routine state of an illness have increasing the weight of in various degree, the 3 routine state of an illness are unstable repeatedly.Prompting: steadily the persistent period can think healings, be product of the present invention effectively and remarkable.

To sum up state, raw material of the present invention, product and method belong to a total inventive concept, economic environmental protection good effect, be suitable for the crowd and market is all very wide, helpfulness and the degree of association are also very high.

Claims (1)

1. the compositions application in the medicine of preparation control hypersomnia is characterized in that said composition makes according to the following steps:

A. drink sheet type Chinese crude drug Semen Ziziphi Spinosae 1.5-3 part, Fructus Alpiniae Oxyphyllae 1-3 part, Fructus Hippophae 1-2 part, Rhizoma Zingiberis Recens 1-2 part, Herba Cichorii 2-3 part, Fructus Lycii 2-4 part joins in the nonmetallic surface container of belt stirrer, filter and water bath with thermostatic control heater;

Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage and adds the dilution of room temperature drinking water that to make alcohol concentration be that alcohol content is the organic and inorganic mixed solvent of 55-75%V/V;

C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating fumigators medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of vaporization of ethanol boiling point ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, used cooling water extracts water as preheating, and this uses the airtight f merge extractive liquid, that is equipped with of medicinal liquid, medicinal residues add the following d step and proceed to handle;

D. water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container soak at room temperature Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;

E. water is proceeded to increase temperature extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, increasing temperature boiling simultaneously slowly lowered the temperature about 20-30 minute to 60-70 ℃ after 3-5 minute naturally, the summer high temperature cooling suitably is aided with the room temperature water-cooled too slowly, cooling water reclaims incorporates the described preheating water of c into, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, 1000-3000 rev/min rotating speed is centrifugal, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;

F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;

G. the preparation of product is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, lactose is added Chinese medicine extraction liquid, is the solution dry matter content that concentration promotes and to be 35-40%, be spray dried into water content 3% below raw material, be pressed into sheet, grain, the ball that 0.2-0.4 restrains and get product.