CN100392317C - Flow structure of controlling liquid continuously flowing in micro-pipeline - Google Patents

Flow structure of controlling liquid continuously flowing in micro-pipeline Download PDF

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CN100392317C
CN100392317C CN 200610065952 CN200610065952A CN100392317C CN 100392317 C CN100392317 C CN 100392317C CN 200610065952 CN200610065952 CN 200610065952 CN 200610065952 A CN200610065952 A CN 200610065952A CN 100392317 C CN100392317 C CN 100392317C
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flow
structure
flowing
controlling
liquid
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CN 200610065952
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CN1834528A (en )
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骋 周
官晓胜
京 程
胡玉明
旻 郭
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博奥生物有限公司;清华大学
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Abstract

本发明涉及一种控制液体在微管路中连续流动的流路结构,它包括一主微管道,一连通所述主微管道的辅微管道,其特征在于:在所述主微管道与所述辅微管道的汇合区域内设置有一阻流体。 The present invention relates to a liquid flow path structure in the micro-line continuous flow control, which includes a main micro-channel, a conduit communicating the main and auxiliary micro microchannels, characterized in that: said main duct and the micro in the confluence area of ​​said secondary micro-conduit is provided with a barrier fluid. 本发明在两微管道的汇合区域内设置了一阻流体,使自然存在的汇合区域的被动阀效应得到了有效的增强,使第一股液体到达汇合区域的阻流体,而第二股液体未到达之前,可以暂时停止流动,并通过及时撤除第一股液体的驱动力,实现第二股液体到达阻流体后两股液体的无气泡融合。 The present invention is provided in a region of confluence of two micro-channel resistance of a fluid, so that the passive valve effect naturally occurring confluence area has been effectively increased, so that the liquid reaches the first stream of fluid barrier confluence region, while the second strand is not liquid prior to arrival can temporarily stop the flow, and timely removal of fluid driving forces of the first, second stream to achieve bubble-free liquid reaches the two liquids bluff after fusion. 本发明在利用被动阀效应的同时,无需对微细管道的尺寸做出任何改动和表面处理,因此最大限度地降低了微加工的复杂性和难度,本发明可以广泛用于各种液体在微细管路中的流动控制中。 The present invention while utilizing passive valve effect, without making any changes to the size and the surface treatment of fine pipes, thus minimizing the complexity and difficulty of the micromachining, the present invention can be widely used in various liquid microcapillary control of the flow path.

Description

一种控制液体在微管路中连续流动的流路结构 One kind of the liquid flow path structure in the micro-line continuous flow control

技术领域 FIELD

本发明涉及一种流路结构,特别是关于一种控制液体在微管路中连续流动的流路结构。 The present invention relates to a flow path structure, in particular, it relates to a flow path structure in the micro fluid control line continuous flow. 背景技术 Background technique

目前,全世界都在积极研发被称之为"微型全分析系统"或者"芯片实验室"的縮微集成化的分析设备。 At present, the world is actively developing called "micro total analysis systems" or "lab on a chip" integrated analysis of microfilm equipment. 这些设备主要用于对微量的液体样品进行各种自动化的操作,包括将多种分离的样品分别引入系统,然后让它们接触并产生预期的相互作用,直到最后对结果进行检测分析并转换为人们可以理解的各种信号。 These devices are mainly used for small amount of liquid sample a variety of automated operation, including a plurality of isolated samples were introduced into the system, and then exposed them to produce the desired interaction, until the final results of the analysis detects and converts it It is understood that the various signals.

在微型化的系统里,让分别流动的液体样品相互融合是让它们产生相互作用的必要条件,融合的一般形式为:将它们从各自的管道里驱动到一个汇合区域, 以形成一个共同的下游流动。 In the miniaturized system, respectively, so that the liquid sample flow merging them is a necessary condition for generation of interaction, generally in the form of fusion: drive them from their respective pipes to a confluence region, to form a common downstream flow. 在实际情况中,由于它们的流阻或者驱动力不能做到完全匹配,往往是其中的一股液体比另一股稍早一点到达管道相汇处,这样就导致被夹在这两股液体中间的空气被携带进下游的流动中。 In reality, due to their flow resistance or the driving force can not be completely match, often a flow of fluid which reaches earlier than the other shares that the phase exchange pipe, thus resulting in the two streams is sandwiched intermediate liquid air is carried into the downstream flow. 这对许多下游功能的实现会产生不利的影响,因为通常希望被进一步处理的液体混合物是一均匀的液相介质而不掺杂有空气相在里面。 This will adversely affect the realization of many functions downstream, as generally desired for further processing the liquid mixture is a homogeneous liquid phase medium is not doped with the inside air.

为了解决这个问题,人们设计了一种疏水性通气孔的结构。 To solve this problem, we designed the structure of a hydrophobic vent. 通气孔设在紧邻汇合区域的上游位置,可以开在其中任何一条液体管道上,也可以在两条液体管道上各开一个,直接和大气相连。 Vent hole is provided in a position immediately upstream of the confluence area, which can start in any of a liquid conduit, may be on both the opening and a liquid pipe, and is directly connected to the atmosphere. 通气孔的内表面作了疏水性处理,这样在液体流向汇合区域的过程中,管道内的气体可以从通气孔旨由排出。 The inner surface of the vent made hydrophobic treatment, so that the process liquid to the merging region, the gas is discharged from the vent duct may be formed purpose. 这种原理真正实现起来,还需要能够及时将通气孔关闭,否则,在许多利用压力作为液体驱动力的情况下, 一旦液体完全流过通气孔,通气孔便成为了漏气孔。 This principle realize it, but also timely to vent closed, otherwise, in many cases using the liquid pressure as the driving force, once the liquid completely flow through the vent, vent has become the leak hole. 因此, 一般来说, 疏水性通气孔的结构还必须结合一个反馈控制系统才能使用。 Thus, in general, the hydrophobic vent structure to be combined with a feedback control system to use.

另一条途径则是利用所谓的被动阀效应,从一开始就避免在管道内形成气泡。 Another way is to use a so-called passive valve effect, from the outset to avoid the formation of bubbles within the conduit. 被动阀效应是指通过将微细管道与汇合区域连接处的末端尺寸縮小,使得流至该处的液体必须克服一个反向的表面张力,才能进入汇合区域之内。 Passive valve effect is connected by terminal size reduction at the fine region and merging pipe, so that the liquid flows to the premises must overcome the surface tension of a counter, to merge into the area. 如果能够利用这种效应将第一种液体暂时性地停留在管道汇合区域之外,然后让第二种液体流进汇合区域,那么两者的液头就能够完美的融合。 If you can take advantage of this effect will be the first liquid temporarily stay in the confluence area outside the pipe, then let the second liquid flow into the confluence region, the head of both the liquid can be the perfect fusion. 但是,这种被动阀效应是有一定阈值的,液体主要用来克服管道流阻而形成的背压不能超过该阈值。 However, the passive valve effect is a certain threshold value, the liquid is mainly used to overcome the flow resistance of the pipeline formed by the back pressure does not exceed the threshold value. 为了做到这一点,第一种液体的驱动力必须及时的撤除或者被重新分配,这个动作通常可 To do this, the first driving force to be required to remove the liquid or be reassigned, this action typically

以通过一个对液体流动的反馈控制来实现;另外,当管道汇合区域完全润湿后, Through a feedback control of the fluid flow; additionally, when confluent pipe completely wetted area,

该结构的被动阀效应基本消失,而要使两股液体的液尾也能够很好地实现融合, 就必须至少为每一路液体配备一个传感器用于实时地检测它们的位置,并反馈到控制系统以采取相应的动作。 Passive valve effect of the structure disappeared, and the tail was to make the two liquids to achieve a good convergence can be, at least for each channel must be equipped with a liquid sensor for detecting their position in real time and fed back to the control system to take appropriate action. 因此, 一个类似于疏水性通气孔设计方案的反馈控制仍然是必需的,但是利用被动阀原理的优势是省却了真正的阀的使用,以及对表面的改性处理。 Therefore, a similar feedback control hydrophobic vent design is still required, but to take advantage of passive valve principle is to dispense with the use of real valves, as well as modification of the surface. 发明内赛 Seneca invention

本发明的目的是提供一种控制液体在微管路中连续流动的流路结构,采用本发明结构不需要对管道表面做任何改性处理,也无需内置阀或外置阀,更无需对微细管道的尺寸做任何改动。 Object of the present invention is to provide a liquid flow path structure in the micro-line continuous flow control, using the structure of the present invention does not require any modification to the surface of the tube, and without external or built-in valves the valve, without the need for a more finely the size of the pipe to make any changes.

为实现上述目的,本发明采取以下技术方案: 一种控制液体在微管路中连续流动的流路结构,它包括一主微管道, 一连通所述主微管道的辅微管道,其特征在于:在所述主微管道与所述辅微管道的汇合区域内设置有一阻流体。 To achieve the above object, the present invention adopts the following technical solutions: A micro channel structure in the liquid line continuous flow control, which includes a main micro-channel, a conduit communicating the main and auxiliary micro microchannels, wherein : there is provided a barrier fluid in the confluence area of ​​the main duct and the secondary micro-micro-conduit.

在所述辅微管道上靠近所述汇合区域设置一旁通微管道。 On the secondary micro channels disposed adjacent to the confluence area bypass microchannel.

所述旁通微管道的另一端在所述主微管道的下游与其形成另一汇合区域,在所述另一汇合区域内也设置有一阻流体。 The other end of the bypass conduit downstream of said micro-micro main duct merge therewith forming another region, the another region is also provided with a confluence of a bluff body.

所述辅微管道为并联设置的多个,每一所述辅微管道与所述主微管道的汇合区域设置有一阻流体。 The plurality of secondary micro-channels arranged in parallel, each of said secondary micro confluence area of ​​the main duct is provided with a microchannel bluff.

各所述辅微管道的进口通过一公共微管道连通,所述公共微管道上设置有一液体进口。 Each of the secondary inlet micro-conduit communicates through a common micro-pipe, the upper conduit is provided with a common micro-liquid inlet.

在所述主微管道和辅微管道的汇合区域设置有反馈电路的传感器。 The sensor is provided with a feedback circuit in said main micro-channel and micro-pipe secondary merge area. 所述阻流体的截面形状为矩形或三角形。 The cross-sectional shape of the bluff body is rectangular or triangular.

本发明由于采取以上技术方案,其具有以下优点:1、本发明在两微管道的汇合区域内设置了一阻流体,使自然存在的汇合区域的被动阀效应得到了有效的增强,使第一股液体到达汇合区域的阻流体,而第二股液体未到达之前,可以暂时停止流动,并通过及时撤除第一股液体的驱动力,实现第二股液体到达阻流体后两股液体的无气泡融合的发明目的。 As a result of the present invention, the above technical solution, which has the following advantages: 1, the present invention is provided with a fluid barrier in the region of confluence of two micro-channel, so that the passive valve effect naturally occurring confluence area has been effectively increased, so that the first Unit bluff liquid reaches the confluence region, while the second stream does not arrive before the liquid may be temporarily stopped to flow, and timely removal of the first driving forces of the liquid, to achieve bubble-free liquid reaches the second strand of the two liquids post bluff the object of the invention is fused. 2、本发明在靠近汇合区域的辅微管道上设置了一旁通微管道,使第一股液体到达阻流体后,而第一股液体的驱动力没有撤除前的瞬间,液体可以进入旁通微管道,从而可以缓解阻流体处所承受的背压力, 使被动阀的作用更加可靠。 2, the present invention is in the area of ​​the secondary micro-pipe is provided near the confluence bypass microchannel, the first liquid barrier fluid reaches the stocks, immediately before the driving force of the first strand without removal of the liquid, the liquid may enter the bypass micro pipes, which could alleviate the back pressure of the barrier fluid receiving spaces, acting passive valve is more reliable. 3、本发明旁通微管道的设置不但可以实现两种液体分别从主、辅两微管道进入并无气泡地融合;而且还可以将主微管道作为排气管道, 通过阻流体的阻挡作用,在一条辅微管道内实现一种以上液体的无气泡融合,更 3, a bypass conduit of the present invention is not only micro may be implemented separately from the two liquids are primary, secondary pipe into the two micro-bubbles are not fused; but also as the main micro-pipe exhaust duct, the blocking action of the bluff body, implement one or more secondary liquid in a micro channel no bubbles fusion, more

可以将被气泡分成几段的一种液体中的气体排出,接合为一股连续流动的液体。 May be separated into gas bubbles in a liquid discharge passages, an engagement continuous liquid flow. 4、 本发明将辅微管道设置成并联的多条,同时在每一条辅微管道与主微管道的汇合区域内均设置一阻流体,从而可以方便地实现多种液体的无气泡融合。 4, the present invention is provided a plurality of secondary micro-channels in parallel, but are disposed in a fluid barrier region merging microchannels each secondary main microchannel, which can easily achieve a variety of bubble-free liquid fusion. 5、本发明将多条辅微管道的进口通过一具有进液口的公共微管道连通,并在各辅微管道与主微管道汇合处均设置一阻流体,且使最上游的阻流体的被动阀效应设置得最小, 从而可以实现一种液体的多路分配,省去重复地为每个单通道加液的繁琐操作。 5, the present invention is to import the plurality of microchannels through a secondary common micro channel having a liquid inlet communicating, and are provided with a barrier fluid in the main pipe and the secondary micro-micro confluence pipe, and that the most upstream of the bluff passive set the minimum valve effect, which can achieve demultiplexing of a liquid, eliminating the cumbersome operation is repeated for each single channel of dosing. 6、 本发明在利用被动阀效应的同时,无需对微细管道的尺寸做出任何改动和表面处理,因此最大限度地降低了微加工的复杂性和难度。 6, while utilizing the present invention the passive valve effect, without making any changes to the size and the surface treatment of fine pipes, thus minimizing the complexity and difficulty of the micromachining. 同时本发明还可以有效地减少反馈控制系统中传感器数量,并降低传感器安装位置的准确性和灵敏度要求。 The invention also effectively reduce the number of sensors in the feedback control system, and reduce the accuracy and sensitivity requirements of the sensor mounting position. 本发明可以广泛用于各种液体在微细管路中的流动控制中。 The present invention can be widely used in a variety of fluid flow control in the fine line.

附图说明 BRIEF DESCRIPTION

图1是本发明结构示意图图2是本发明阻流体的另一实施例图3〜7是本发明方法实施过程示意图图8是本发明具有旁微管道的结构示意图图9是本发明具有排气接合的结构示意图图IO是本发明具有多股液体融合的结构示意图图11是本发明具有液体分配的结构示意图具体实施方式 FIG 1 is a schematic structural diagram of the present invention, FIG. 2 is a diagram of another embodiment of the present invention bluff 3~7 are schematic process diagram of a method embodiment of the present invention 8 is a schematic diagram of the present invention having the structure next to the micro-duct 9 that the present invention has an exhaust engaging a schematic structural diagram of the present invention having a multi-IO is a schematic structural diagram of strands fused liquid 11 is a liquid having a dispensing structure of the present invention in a schematic DETAILED DESCRIPTION

下面结合附图和实施例对本发明进行详细的描述。 The present invention is described in detail below in conjunction with the accompanying drawings and embodiments.

实施例一: Example One:

如图1所示,本发明的结构包括一主微管道1, 一与主微管道1连通的辅微管 , Shown in Figure 1 of the present invention comprises a main micro microtubules auxiliary pipe 1, a main conduit 1 micro communication

道2,在辅微管道2与主微管道1的汇合区域设置一个阻流体3,其能够有效地减小流路面积,阻流体3的形状可以是长方形,也可以是三角形(如图2所示),还可以是其它形状。 Lane 2, the micro-pipe 2 and the secondary convergence region of the main pipe 1 is provided a micro-fluid barrier 3, which can be effectively reduced flow passage area, the shape of the bluff body 3 may be rectangular, or may be two triangles (FIG. shown), it may also be other shapes. 在主微管道1和辅微管道2的进口端分别设置有提供驱动力的驱动装置(图中未示出),驱动装置可以是专门为本发明融合管道设置的,也可以是系统中其它驱动装置产生的驱动力。 Drive means are provided (not shown), specifically for the drive means may be provided with a driving force in the main pipe 1 and the inlet end of the micro-micro-pipe secondary duct 2 of the present invention fused provided, the system may also be other drive driving force generating means. 如图1所示,在汇合区域还可以设置一个传感器4,用于监控液体的流入和流出。 1, the merging region 4 may also be provided a sensor for monitoring the inflow and outflow of liquid.

上述结构的制作可以采用通常制作芯片的方法,先在基片上制作出形成微管道l、 2的凹槽和阻流体3,然后通过基片-玻璃或塑料盖片的键合形成完整的主微管道1、辅微管道2和阻流体3。 Making the above-described configuration may be employed generally chip production method, first formed on the substrate the formed micro channels L, the groove and the bluff body 2 of 3, and then through the substrate - to form a complete primary micro bond glass or plastic cover sheet pipe 1, the secondary fluid microchannels 2 and 3 barrier. 传感器4的设置是为了自动控制液体的合并过程, 当然也可以通过人眼直接透过盖片观察和手动切换控制液体的流动。 4 is a sensor is provided for automatic control of the liquid merging process, of course, may be switched to control the flow of liquid through the eye directly through the cover sheet and manual observation. 传感器4可 Sensor 4 may

以采用各种现有技术的产品,比如采用红外传感器,在芯片的汇合区域上、下分 In various prior art products, such as infrared sensors, in the confluence area of ​​the chip, the sub

别设置一发射器和一接收器,当有液体通过时可以接收并传输信号,与传感器4 连接的反馈控制电路与现有技术相同。 Respectively provided with a transmitter and a receiver may receive and transmit signals, the same as the prior art circuit is connected to the feedback control when the sensor 4 through the liquid.

本发明两种液体的融合过程如下: Fusion process of the present invention, the following two liquids:

如图3所示,第一股液体在辅微管道2中正被驱动力驱动流向汇合区域。 3, the first stream of liquid is the driving force of the secondary flow merge region microchannel 2 CKS. 如图4所示,第一股液体到达汇合区域时,在被动阀效应和阻流体3的作用 As shown, the first stock liquid reaches the merging region 4, and the role of passive valve effect of the bluff 3

下,暂时停滞;同时由于液体部分进入了汇合区域,传感器4便会产生了一个相 Next, temporarily stalled; the same as the liquid portion into the merging region, the sensor will produce a phase 4

应的信号使得辅微管道2的驱动力被撤除。 Such that a signal corresponding to the driving force of the secondary micro-pipe 2 is removed.

如图5所示,第二股液体进入主微管道1,并到达汇合区域与第一股液体实现 As shown, the second stream into the main fluid micro-channels 15, and reaches the liquid merging region of the first strand to achieve

液头融合,使汇合区域完全被液体进占,被动阀作用消失;同样,此状态也能被 Fusion liquid discharge head so that a liquid merging region is completely occupy, passive valve effect disappears; similarly, this status can also be

设置在汇合区域的传感器4捕捉到。 Sensor 4 provided in the confluence area captured. 从这一时刻起,根据共同的下游汇合流动的 From that moment, according to a common merge downstream flow

目的,可以有至少三种不同的驱动两股液体的模式: Purpose, at least three different driving mode liquid two stocks:

(1) 如果希望得到一个并流(就像在基于扩散的分析设备里看到的那样), 这两股液体应该被同时驱动。 (1) and if you want to get a stream (as in the analysis device based on the diffusion's seen), these two liquids should be driven simultaneously.

(2) 如果希望得到一个混合均匀的下游,那么其中一个方法是以分时或时间 (2) If you want to give a mixed downstream, then one method is time division or

脉动的方式驱动两液体,也就是说,两股液体被交替以短促的时间脉冲形式驱动, 或者被连续驱动但相位相反。 Liquid driven two pulsation, that is, the two liquids are alternately driven in the form of short pulse time, or be continuously driven but opposite phase.

(3) 如果希望得到一个前后流,即一股液体正好全部紧跟在另一股的后面, (3) If you want to get a context flow, i.e. flow of fluid just all immediately behind another in the strand,

先将其中一股液体驱动至下游管道,直到其液尾到达汇合区域,然后再驱动另一股液体至下游管道。 Wherein the first downstream conduit to drive a flow of fluid, the liquid until it reaches the end of the merge area, then drives to another unit downstream liquid conduit.

对于并肩流和混合流,理想情况当然是希望两股液体同时在汇合区域收尾, 这样就不会在下游融合的流动中产生气泡或气体分段。 For flow and mixed flow side by side, it is of course desirable over two liquids simultaneously finishing the merging region, so that no bubbles or gas flow in the downstream segment of the fusion. 但实际很难做到,这需要两股流动在液体量、流阻以及各自的驱动力完全匹配的情况下才有可能实现,实际情况往往是其中一股的液尾先于另一股的液尾到达汇合区域。 However, the actual difficult to do, which requires two flows possible to achieve in the case where the amount of fluid flow resistance and the driving force of the respective exact match, wherein an actual situation is often a liquid solution prior to the end of another unit tail reaching confluence area. 对于前后流,一定是其中一股液体的全部先于另一股的全部在汇合区域收尾,这样才能形成前后流。 For before and after the flow, all of which must be the wave of the liquid before the ending all the other shares in the confluence area, the front and rear so as to form a flow.

如图6所示,这里描绘了这样一种情况,即假设第二股液体的尾部首先到达了汇合区域,该区域的传感器4检测到这一时刻,并给系统发出一个相应的信号关断第二股液体的驱动力,此时汇合区域因为阻流体3导致流路縮小,由此产生的毛细管的作用能够将第二股液体的液尾停留在汇合区域,从而保持与辅微管道2 中第一股液体的连续。 6, there is depicted a case where the tail is assumed that the second strand of the first fluid reaches the convergence region, the region of the sensor 4 detects this timing, and sends a corresponding signal to the shutdown of the system two driving forces liquid, the confluence region 3 as barrier fluid flow path leading to narrow, capillary action resulting solution can be a second stream of liquid remain in the confluence area of ​​the tail, so as to maintain the micro-pipe and the second auxiliary the continuous surge of liquid. 接下来的流程将会出现以下三种情况: The next process will be the following three conditions:

(1)如果融合的目的是为了形成一个前后流,那么第一股液体在辅微管道2 (1) If the object is fused to form a longitudinal stream, the first stream of liquid in the secondary micro-channels 2

中到达阻流体3后一直处于停顿状态,以等待图6所示的第二股液体液尾到达汇合区域。 3 after reaching the barrier fluid has been at a standstill, a second stream of liquid solution as shown in FIG. 6 to await the arrival confluence area.

(2) 如果融合的目的是为了形成一个混合流,那么在如图5和图6所示的步骤之间,两股液体被各自的驱动力交替切换驱动,根据图6中假设的第二股液体液尾刚刚被传感器4探测到,并且其驱动力被撤除,此时还未切换到驱动第一股液体,因此第一股液体仍暂时处于停顿状态。 (2) If the object is fused to form a mixed stream, between the steps shown in FIGS. 5 and 6, the two liquids are each alternately switching the drive force of the drive, it is assumed in FIG 6 according to the second strand liquid was tail just been detected by the sensor 4, and the driving force is removed, the drive will not have been switched to the first stream of liquid, the first liquid stocks remains temporarily at a standstill.

(3) 如果融合的目的是为了形成一个并肩流,则从图5所示的步骤幵始,两股液体一直被同时驱动,直至图6所假设那样,即第二股液体液尾首先刚刚到达汇合区域,并且其驱动力被撤除,此时第一股液体的液尾还未到达汇合区域,并且其驱动力也未被撤除。 (3) If the object is fused to form a side by side stream from the step shown in FIG. 5 starts its, the two liquids have to be driven simultaneously, until the assumption that FIG 6, i.e., the end of the second liquid in the liquid stocks just arrived first merging region, and the driving force is removed, the first stock solution at this time have not reached the end of the liquid merging region, and the driving force thereof is not removed.

前面所述的三种情况,如果是第一种和第二种,那么此时应重新启动对第一股液体的驱动,如果是第三种,那么只是继续维持对第一股液体的驱动。 Previously described three cases, if the first and second, then the time should be restarted on the first unit drives the liquid, if it is the third, but then continue to maintain the driving of the first stock liquid. 无论哪种情况,如图6所示辅微管道2中的第一股液体与第二股液体的液尾形成自然连接,而不会产生气泡。 Secondary micro channels illustrated in the first unit 2 is connected to a second liquid to form a natural liquid shares either case the end of the liquid, FIG. 6, without generating bubbles. 因此,如图7所示的最后一步中,通过对第一股液体的驱动将所有剩余的第一股液体全部推过汇合区域,以完成整个的融合过程,并形成了一个离开管道汇合区域的下游流动。 Thus, as shown in FIG. 7 in the last step, by driving the first liquid shares all remaining shares all the liquid is pushed through a first convergence zone, to complete the fusion process, and formed a confluent pipe leaving the area downstream flow.

实施例二: Example II:

如图8所示,本实施例包括一主微管道1和一辅微管道2,辅微管道2在接近与主微管道1的汇合区域时,分叉形成一旁通微管道5。 8, the present embodiment includes a main pipe 1 and a secondary micro microchannel 2, the secondary micro-pipe 2 when approaching confluence with the primary micro channel region 1, the bifurcation forming a bypass microchannel 5. 辅微管道2与主微管道1 在a点形成一汇合区域a,在汇合区域a内设置一阻流体3;旁通微管道5与主微管道1在b点形成另一汇合区域b,在该汇合区域b内设置一阻流体3',两股液体在汇合区域b汇合后,继续延伸形成一共同下游微管道6。 Secondary microchannel 2 and the main micro channel 1 at a point a is formed a confluence area, a bluff body disposed in the confluence area 3 a; micro bypass duct 5 and the main pipe 1 forming another micro region b at the merging point b, the a bluff body disposed within the confluence region b 3 ', the two liquids post-confluence region b confluent, continue extending downstream form a common micro channel 6.

本实施例的基本工作原理是:驱动第一股液体进入辅微管道2,当其被第一个阻流体3阻留在第一个汇合区域a的同时,仍能在旁通微管道5内继续流动,直到传感器4产生的信号使辅微管道2的驱动力完全撤除。 The basic working principle of this embodiment is that: the driving liquid into the first stream of secondary micro-channels 2, 3 when it is at the same time retaining a first fluid barrier a first region of confluence, still in the bypass microchannel 5 continues to flow until the signal generated in the sensor 4 so that the driving force of the secondary micro-pipe 2 is completely removed. 旁通微管道5的长度最好应使这股液体完全停住时并未到达与主微管道i的第二个汇合区域b,但即使液体到达了汇合区域b,设置在此处的阻流体3'也会保证液体能停住。 Preferably the micro length of the bypass pipe 5 should be such that it shares with a second liquid does not reach the confluence area of ​​the main microchannel b i is completely stopped, but even if the liquid has reached the confluence region b, provided here in the bluff 3 'will ensure that the liquid can be stopped. 接下来驱动主微管道1内的第二股液体进入第一个汇合区域a,这样就和第一股液体完成了第一次的液头合并,然后选择驱动其中任意一股液体或同时驱动两股液体,液体都会在主微管道1和旁通管道5中同时流动,因为被动阀效应在阻流体3被完全浸润后已经消失。 Next, a second liquid stocks driving the main microcontroller enters a first duct a confluence region a, and the first stream of liquid so that the liquid discharge head combined to complete the first time, and then select any of the driving flow of fluid or simultaneously driven two Unit liquid, while the liquid will flow in the main micro-channel and the bypass line 5 1, since the effect of the passive valve 3 is in the barrier fluid has disappeared completely wet. 主微管道1和旁通微管道5中的任何一股液体先到达汇合区域b 时,都会自动在阻流体3,的作用下暂停,待另一管道液体浸润阻流体3'后,自 After the main pipe 1 and a micro wave of any micro liquid bypass line 5 to zone B reaches confluence, are automatically suspended at 3, the bluff body effect, to be another pipe wetting liquid barrier fluid 3 ', from

动完成在汇合区域b的第二次的合并。 In moving to complete the merger merging the second region b. 在汇合区域b的自动融合是因为在相同背压的情况下,被动阀和阻流体3'的作用会使先到的液体暂停,而自动在阻力较小的管道中继续前进。 In automatic fusion confluence region b is the same as in the case of back pressure, and the role of passive barrier fluid valve 3 'is first to make a liquid suspension, automatically move the small conduit resistance. 当第二次合并过程完成后,第二个阻流体3'的被动阀效应也消失了,液体可自由通过共同下游微管道6。 When the merge process is completed after the second, the second bluff body 3 'passive valve effect also disappears, liquid is released through a common micro channel 6 downstream. 本实施例液体收尾时,在汇合区域a 的收尾过程与实施例一完全相同,而在汇合区域b的收尾将自动完成。 When ending the present embodiment example of the liquid, a region of confluence of a finishing process is the same as in Example, and finishing the merging region b will be done automatically.

本实施例是一种旁通结构的液体合并实例,其与实施例一直接利用阻流体结构实现液体合并有所不同,本实施例这种液体旁通结构中的两个阻流体3、 3'都只承受较低的旁通管道中的液体压力,因此其可靠性比实施例一更高。 The present embodiment is example of a combined liquid bypass structure, which embodiment a barrier fluid directly liquid were combined to achieve different structures, two such liquid bypass bluff embodiment according to the present embodiment in the structure 3, 3 ' only withstand low pressure fluid bypass conduit, and therefore a higher reliability than the embodiment.

实施例三 Third Embodiment

如图9所示,本实施例包括一主微管道1、 一辅微管道2和一从辅微管道2 分叉的旁通微管道7,主微管道1与辅微管道2的汇合区域设置有阻流体3。 9, the present embodiment includes a main micro pipe 1, a pipe 2 and a secondary micro-7, a main micro-pipe conduit 2 is provided from the secondary micro bifurcated bypass microchannel with secondary confluence area microchannel 2 there bluff 3. 本实施例中,主微管道1被作为排气管道,旁通微管道7作为融合管道,旁通管道7 的进口端十分靠近主微管道1与辅微管道2的汇合区域。 In this embodiment, the main pipe 1 is used as the micro exhaust duct, the bypass duct 7 as micro-terminal fusion inlet duct, the bypass duct 7 is close to the main pipe 1 and the micro confluence area of ​​the secondary microchannel 2.

本实施例具有排气接合功能,工作时,液体从辅微管道2进入,被阻流体3 阻挡停留的同时,自动进入旁通微管道7。 This embodiment has the exhaust junction function, operation, from the secondary liquid enters microchannel 2, 3 is a fluid barrier while the barrier to stay automatically pass into the micro channel 7. 此时在阻流体3与旁通微管道7进口之间的一小段管道内会停留部分液体,如果这一段管道太长,那么当液体液尾进入旁通微管道7内时,这部分液体将残留在这段管道内;如果旁通微管道7进口离阻流体3足够近,那么在表面张力的作用下,进入旁通微管道7的液尾能够将这段管道内的液体完全带入旁通微管道7内。 At this time in the micro channel 3 and the short-pass conduit between the inlet fluid barrier section 7 will stay liquid, if this section of pipe is too long, then the end of the liquid when the liquid enters the micro-pass duct 7, this portion of the liquid will be remaining in the length of tubing; if the bypass inlet micro channel 7 from the fluid barrier 3 close enough, then the surface tension of the liquid into the end of the bypass duct 7 micro possible liquid in the pipe completely into the next period 7 through the micro channel. 这样,如果液尾后面有气体继续过来(比如液体驱动力还未被撤除,)那么这些气体将顺利地从含有阻流体3的排气管 Thus, if the rear end of the liquid gas continues over (such as a liquid driving force has not yet been removed,) then the gas containing the barrier fluid smoothly from the exhaust pipe 3

道(主微管道1)排除,而不会因为这段管道内残留液体造成堵塞,使气体进入旁通微管道7。 Channel (main micro pipe 1) excluded, without causing clogging because this residual liquid inside the pipe, the gas entering the bypass microchannel 7. 由于已经进入旁通微管道7内的液尾不会被后来的气体推离开旁通微管道7的进口处,因此,如果再有一股液体流过来,那么新的液体的液头将和处于旁通微管道7进口处的液尾自动接合,形成连续流动的液体。 Since the bypass microchannel has entered the liquid 7 in the tail gas can not be subsequently pushed away from the inlet of the micro-pass duct 7, and therefore, if there was a flow of liquid over again, then a new liquid discharge head and the liquid in the bypass 7 at the inlet end of the liquid through the micro-channel automated bonding, forming a continuous liquid flow.

从以上描述可以看出,本实施例的同一排气旁通结构可被重复使用,在同一辅微管道2内可以先后注入两股或两股以上液体,不但可以将它们之间的气体排除,而且可以在旁通微管道7内实现液体无气泡的接合。 As can be seen from the above description, the same exhaust-bypass structure of the present embodiment may be reused in the same co-injection micro channel 2 may have two or more shares or two liquids, not only the gas between them can be excluded, and engagement can be achieved without bubble liquid in the bypass microchannel 7. 本实施例还可以将一股产生了气泡并导致分段的液体中的气泡去除,将被分段的液体重新接合起来。 This embodiment also may lead to an air bubble, and the bubble generated in the liquid segment is removed, the liquid will be re-joined segments.

实施例四 Fourth Embodiment

如图10所示,本实施例包括一主微管道l,多个辅微管道2,在各辅微管道2 与主微管道1的汇合区域分别设置一阻流体3。 , The present embodiment includes a main microchannel 10 l, the plurality of secondary micro channels 2, 3 provided with a barrier fluid in the microchannel 2 and the secondary region of the main micro confluence pipe 1, respectively.

本实施例具有将多种液体融合的功能,工作时分别从每一辅微管道2中进入 The present embodiment has a function of a plurality of liquids fusion, respectively, into the work from each of the secondary micro channels 2

一股液体,在阻流体3的作用下都暂停在辅微管道2的出口,然后驱动主微管道l 中的液体,使其依次浸润每一阻流体3,使其失去被动阀效应,进而通过上述的各种流动方式,实现多种液体的融合。 Drawing a liquid, under the action of the bluff body 3 are suspended at the outlet of the secondary micro channel 2, then the main microcontroller driving the liquid in the pipe l, so that each of the bluff 3 sequentially infiltration, loss passive valve effect, and further by various flow described above, to achieve more fusion liquids. 实施例五 Fifth Embodiment

如图ll所示,本实施例包括一主微管道l,多个辅微管道2,在各辅微管道2 与主微管道1的汇合区域分别设置一阻流体3,在各辅微管道2的进口连接一公共微管道8,公共微管道8上设置有一液体进口。 As shown in FIG ll, the present embodiment includes a main micro-channel L, a plurality of secondary micro-channel 2, in each of the microchannel 2 and the secondary region of the main micro confluence pipe 1 are provided a bluff body 3, in the secondary microchannel 2 connected to a common inlet micro-conduit 8, the common micro-pipe 8 is provided with a liquid inlet. 在各汇合区域中的阻流体3,可以通过其尺寸的大小、形状、或者离各自辅微管道2出口的远近所产生的大小不一的被动阀效应,选择让液体率先突破那个阻流体3,比如图中显示的是最上游的阻流体3',与其它阻流体3相比其尺寸最小。 Fluid resistance in the confluence area 3, the size can be the size, shape, or the sizes of the respective distance from the passive valve effect secondary outlet microchannel 2 generated by selecting the first to break so that the liquid barrier fluid 3, such as shown in FIG. 3 is the most upstream bluff ', compared with other bluff body 3 is smallest size.

本实施例的应用场合是并行多通道生物试验,如果试剂相同则可以省去依次为每一个通道加样的繁琐过程。 Applications of the present embodiment is a parallel multi-channel test organisms, the same can be omitted if the agent were loaded in each lane tedious process. 工作时,进入公共微管道8的液体,自动分配进入每一辅微管道2,可以利用每个辅微管道2与主微管道1汇合区域的阻流体3 实现液体自动分配,并在各汇合区域阻流体3处短暂停留。 In operation, fluid enters the common micro-conduit 8 automatically dispensed into each auxiliary microchannels 2, the fluid resistance may be utilized for each secondary duct 2 with a micro confluence area of ​​the main pipeline 3 micro achieve automatic liquid dispensing, and in the confluence area bluff at 3 short stay. 由于最上游的阻流体3' 的被动阀效果最差,因此在同样驱动压力下,液体最先从该阻流体3'处突破,并一路将各阻流体3浸润,使其失去被动阀效应,进而将流过各辅微管道2的液体融合在一起,作为废液排出流路。 Since most upstream bluff 3 'passive valve worst, so at the same driving pressure, the liquid from the first bluff body 3' at the break, and 3 all the way to the respective barrier fluid infiltration, loss passive valve effect, Further flowing through each secondary liquid microchannel 2 together as a waste liquid flow passage.

Claims (10)

  1. 1、一种控制液体在微管路中连续流动的流路结构,它包括一主微管道,一连通所述主微管道的辅微管道,其特征在于:在所述主微管道与所述辅微管道的汇合区域内设置有一阻流体。 1. A liquid flow path structure in the micro-line continuous flow control, which includes a main micro-channel, a conduit communicating the main and auxiliary micro microchannels, wherein: said main conduit and said at micro the confluence area of ​​the secondary conduit is provided with a micro-fluid-barrier.
  2. 2、 如权利要求1所述是一种控制液体在微管路中连续流动的流路结构,其特征在于:在所述辅微管道上靠近所述汇合区域设置一旁通微管道。 2, according to claim 1 is a liquid flow path structure in the micro-line continuous flow control, characterized in that: in said secondary micro channels disposed adjacent to the confluence area bypass microchannel.
  3. 3、 如权利要求2所述是一种控制液体在微管路中连续流动的流路结构,其特征在于:所述旁通微管道的另一端在所述主微管道的下游与所述主微管道形成另一汇合区域,在所述另一汇合区域内也设置有一阻流体。 3, as claimed in claim 2 is a structure of the liquid in the micro channel continuous flow control line, characterized in that: the other end of the bypass conduit downstream of said micro main conduit in said main micro forming another microchannel confluence region, the further region merging is also provided with a barrier fluid.
  4. 4、 一种控制液体在微管路中连续流动的流路结构,它包括一主微管道,连通所述主微管道的辅微管道,其特征在于:所述辅微管道为并联设置的多个,每一所述辅微管道与所述主微管道的汇合区域设置有一阻流体。 4. A liquid flow path structure in the micro-line continuous flow control, comprising a main micro microchannel secondary conduit, the conduit communicating said master microcontroller, wherein: said plurality of secondary micro-channels arranged in parallel a merge area of ​​each of the secondary conduit and the primary micro-micro-conduit is provided with a barrier fluid.
  5. 5、 如权利要求4所述是一种控制液体在微管路中连续流动的流路结构,其特征在于:各所述辅微管道的进口通过一公共微管道连通,所述公共微管道上设置有一液体进口。 5, as claimed in claim 4 is a structure of the liquid in the micro channel continuous flow control line, wherein: each of the secondary inlet conduit by a common micro-micro-conduit communication on the common micro channel provided with a liquid inlet.
  6. 6、 如权利要求1或2或3或4或5所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:在所述主微管道和辅微管道的汇合区域设置有反馈电路的传感器。 6, the flow path structure as claimed in controlling the liquid 1 or 2 or 3 or 4 or 5, wherein the micro-line continuous flow, characterized in that: in the confluence area of ​​the main duct and the secondary micro-micro-conduit the sensor is provided with a feedback circuit.
  7. 7、 如权利要求1或2或3或4或5所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:所述阻流体的截面形状为矩形。 7, as claimed in controlling the liquid flow path structure 1 or 2 or 3 or 4 or 5, wherein the micro-line continuous flow, characterized in that: the cross-sectional shape of the fluid barrier is rectangular.
  8. 8、 如权利要求6所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:所述阻流体的截面形状为矩形。 8, the flow path structure as claimed in claim 6 for controlling the liquid in the micro-line continuous flow, characterized in that: the cross-sectional shape of the fluid barrier is rectangular.
  9. 9、 如权利要求1或2或3或4或5所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:所述阻流体的截面形状为三角形。 9. A method of controlling a liquid flow path structure 1 or 2 or 3 or 4 or 5 in a continuous flow micro-conduit claim, wherein: the cross-sectional shape of the fluid resistance is triangular.
  10. 10、 如权利要求6所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:所述阻流体的截面形状为三角形。 10, the flow path structure as claimed in claim 6 for controlling the liquid in the micro-line continuous flow, characterized in that: the cross-sectional shape of the fluid resistance is triangular.
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