CN100392317C - Flow structure of controlling liquid continuously flowing in micro-pipeline - Google Patents

Flow structure of controlling liquid continuously flowing in micro-pipeline Download PDF

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CN100392317C
CN100392317C CN 200610065952 CN200610065952A CN100392317C CN 100392317 C CN100392317 C CN 100392317C CN 200610065952 CN200610065952 CN 200610065952 CN 200610065952 A CN200610065952 A CN 200610065952A CN 100392317 C CN100392317 C CN 100392317C
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micro
liquid
channel
secondary
main
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CN 200610065952
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CN1834528A (en
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骋 周
官晓胜
京 程
胡玉明
旻 郭
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博奥生物有限公司;清华大学
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Abstract

本发明涉及一种控制液体在微管路中连续流动的流路结构,它包括一主微管道,一连通所述主微管道的辅微管道,其特征在于:在所述主微管道与所述辅微管道的汇合区域内设置有一阻流体。 The present invention relates to a channel structure of the liquid in the micro-line continuous flow control, which includes a main micro-channel, a communication with the main microchannel secondary micro channels, wherein: said main micro-conduit and the at the confluence area of ​​said secondary micro-conduit is provided with a barrier fluid. 本发明在两微管道的汇合区域内设置了一阻流体,使自然存在的汇合区域的被动阀效应得到了有效的增强,使第一股液体到达汇合区域的阻流体,而第二股液体未到达之前,可以暂时停止流动,并通过及时撤除第一股液体的驱动力,实现第二股液体到达阻流体后两股液体的无气泡融合。 The present invention is provided in the confluence area two micro-conduit of a barrier fluid, so that the passive valve effect confluence area naturally occurring been effectively increased, so that the first unit the liquid reaches the barrier fluid confluence region, while the second stream of liquid is not prior to arrival can temporarily stop the flow, and timely removal of the first driving forces of the liquid, to achieve a second stream of liquid reaches the bubble-free two liquids after bluff fusion. 本发明在利用被动阀效应的同时,无需对微细管道的尺寸做出任何改动和表面处理,因此最大限度地降低了微加工的复杂性和难度,本发明可以广泛用于各种液体在微细管路中的流动控制中。 The present invention using a passive valve effect at the same time, without the need for fine pipe size to make any changes and surface treatment, and therefore minimize the micromachining of the complexity and difficulty of the present invention can be widely used in a variety of liquid in the fine tube the flow passage in the control.

Description

一种控制液体在微管路中连续流动的流路结构 With a fluid passage structure of the liquid in the micro-line continuous flow control

技术领域 FIELD

本发明涉及一种流路结构,特别是关于一种控制液体在微管路中连续流动的流路结构。 The present invention relates to a channel structure, especially the flow path structure relates to a control liquid in the micro-line continuous flow. 背景技术 Background technique

目前,全世界都在积极研发被称之为"微型全分析系统"或者"芯片实验室"的縮微集成化的分析设备。 At present, the world is actively developing called "micro total analysis systems" or "lab on a chip" miniature integrated analysis equipment. 这些设备主要用于对微量的液体样品进行各种自动化的操作,包括将多种分离的样品分别引入系统,然后让它们接触并产生预期的相互作用,直到最后对结果进行检测分析并转换为人们可以理解的各种信号。 These devices are mainly used for small amount of liquid sample a variety of automated operation, including a plurality of isolated samples were introduced into the system, and then exposed them and produce the expected interactions until the final results were detected and analyzed and converted people It is understood that the various signals.

在微型化的系统里,让分别流动的液体样品相互融合是让它们产生相互作用的必要条件,融合的一般形式为:将它们从各自的管道里驱动到一个汇合区域, 以形成一个共同的下游流动。 In the miniaturized system, so that the liquid sample flow, respectively mutual integration is to make them generate the necessary conditions of interaction, generally in the form of fusion to: They are driven from their respective pipes to a merging region to form a common downstream flow. 在实际情况中,由于它们的流阻或者驱动力不能做到完全匹配,往往是其中的一股液体比另一股稍早一点到达管道相汇处,这样就导致被夹在这两股液体中间的空气被携带进下游的流动中。 In reality, due to their flow resistance or the driving force can not be completely match, often where the flow of fluid than the other shares arrive a little earlier pipeline phase exchange office, thus leading to being caught in these two intermediate liquid air is carried into the flow downstream. 这对许多下游功能的实现会产生不利的影响,因为通常希望被进一步处理的液体混合物是一均匀的液相介质而不掺杂有空气相在里面。 This will adversely affect the achievement of many downstream functions, as is generally desired liquid mixture is further processed in a homogeneous liquid medium without doped air phase inside.

为了解决这个问题,人们设计了一种疏水性通气孔的结构。 To solve this problem, we designed the structure of a hydrophobic vent. 通气孔设在紧邻汇合区域的上游位置,可以开在其中任何一条液体管道上,也可以在两条液体管道上各开一个,直接和大气相连。 Vent hole provided in close proximity to the confluence region upstream position, you can start in any of a liquid conduit, may be the opening and one on the two liquid conduits, and connected to the atmosphere directly. 通气孔的内表面作了疏水性处理,这样在液体流向汇合区域的过程中,管道内的气体可以从通气孔旨由排出。 The inner surface of the vent made hydrophobic treatment, so that the liquid flows merge process areas, the gas in the conduit may be formed is discharged from the vent purpose. 这种原理真正实现起来,还需要能够及时将通气孔关闭,否则,在许多利用压力作为液体驱动力的情况下, 一旦液体完全流过通气孔,通气孔便成为了漏气孔。 This principle realize it, but also timely to vent closed, otherwise, many using pressure as a liquid driving force of circumstances, once the liquid completely flow through the vent, vent has become the leak hole. 因此, 一般来说, 疏水性通气孔的结构还必须结合一个反馈控制系统才能使用。 Thus, in general, the structure of the hydrophobic vent to be combined with a feedback control system to use.

另一条途径则是利用所谓的被动阀效应,从一开始就避免在管道内形成气泡。 Another way is to use a so-called passive valve effect, from the outset to avoid the formation of bubbles within the conduit. 被动阀效应是指通过将微细管道与汇合区域连接处的末端尺寸縮小,使得流至该处的液体必须克服一个反向的表面张力,才能进入汇合区域之内。 Passive valve effect refers to the end of the size at the connection area is reduced to a fine pipe and the convergence, so that to the fluid thereat must overcome a reverse surface tension, before entering the convergence area. 如果能够利用这种效应将第一种液体暂时性地停留在管道汇合区域之外,然后让第二种液体流进汇合区域,那么两者的液头就能够完美的融合。 If you can take advantage of this effect will be the first liquid temporary stay outside the pipeline confluence area, and then let the second liquid flow into the confluence region, the liquid head between the two can be the perfect fusion. 但是,这种被动阀效应是有一定阈值的,液体主要用来克服管道流阻而形成的背压不能超过该阈值。 However, the passive valve effect is a certain threshold value, the liquid is mainly used to overcome the duct flow resistance formed by the back pressure does not exceed the threshold value. 为了做到这一点,第一种液体的驱动力必须及时的撤除或者被重新分配,这个动作通常可 To do this, the first driving force of the liquid to be required to remove or be reassigned, this action typically

以通过一个对液体流动的反馈控制来实现;另外,当管道汇合区域完全润湿后, Through a feedback control of the fluid flow; additionally, when the rear duct confluence area completely wetted,

该结构的被动阀效应基本消失,而要使两股液体的液尾也能够很好地实现融合, 就必须至少为每一路液体配备一个传感器用于实时地检测它们的位置,并反馈到控制系统以采取相应的动作。 Passive valve effect of the structure disappeared, and was the tail to make the two liquids it is possible to achieve a good fusion, it is necessary at least for each path of the liquid is equipped with a sensor for detecting their position in real time and fed back to the control system to take appropriate action. 因此, 一个类似于疏水性通气孔设计方案的反馈控制仍然是必需的,但是利用被动阀原理的优势是省却了真正的阀的使用,以及对表面的改性处理。 Therefore, a similar feedback control hydrophobic vent design is still required, but to take advantage of passive valve principle is to save the real use of the valve, as well as modification of the surface. 发明内赛 Seneca invention

本发明的目的是提供一种控制液体在微管路中连续流动的流路结构,采用本发明结构不需要对管道表面做任何改性处理,也无需内置阀或外置阀,更无需对微细管道的尺寸做任何改动。 Object of the present invention is to provide a flow passage structure of the liquid in the micro-line continuous flow control, using the structure of the present invention does not require any modification to the surface of the tube, and without the built-in valves or external valves, and more without the need for a fine the size of the pipe to make any changes.

为实现上述目的,本发明采取以下技术方案: 一种控制液体在微管路中连续流动的流路结构,它包括一主微管道, 一连通所述主微管道的辅微管道,其特征在于:在所述主微管道与所述辅微管道的汇合区域内设置有一阻流体。 To achieve the above object, the present invention adopts the following technical solutions: A flow path structure of liquid in the micro-line continuous flow control, which includes a main micro-channel, a communication with the main microchannel secondary micro channels, wherein : is provided with a barrier fluid in the confluence area of ​​the main micro channel and the secondary micro-conduit.

在所述辅微管道上靠近所述汇合区域设置一旁通微管道。 On the secondary micro-duct near the merging region disposed side through micro-channels.

所述旁通微管道的另一端在所述主微管道的下游与其形成另一汇合区域,在所述另一汇合区域内也设置有一阻流体。 The other end of the bypass microchannel downstream of the main micro-conduit therewith further convergence region, on the other merging region is also provided with a barrier fluid.

所述辅微管道为并联设置的多个,每一所述辅微管道与所述主微管道的汇合区域设置有一阻流体。 A plurality of said secondary micro-channels is arranged in parallel, confluence area of ​​each of the secondary micro-channels of the main micro-conduit is provided with a barrier fluid.

各所述辅微管道的进口通过一公共微管道连通,所述公共微管道上设置有一液体进口。 Each of the secondary micro-channel imports through a common micro-channel connectivity, the common micro-pipe is provided with a liquid inlet.

在所述主微管道和辅微管道的汇合区域设置有反馈电路的传感器。 Sensor is provided with a feedback circuit in said main micro-channel and the confluent area of ​​the secondary micro-conduit. 所述阻流体的截面形状为矩形或三角形。 The cross-sectional shape of the bluff body is rectangular or triangular.

本发明由于采取以上技术方案,其具有以下优点:1、本发明在两微管道的汇合区域内设置了一阻流体,使自然存在的汇合区域的被动阀效应得到了有效的增强,使第一股液体到达汇合区域的阻流体,而第二股液体未到达之前,可以暂时停止流动,并通过及时撤除第一股液体的驱动力,实现第二股液体到达阻流体后两股液体的无气泡融合的发明目的。 As a result of the present invention, the above technical solution, which has the following advantages: 1, the present invention is provided with a fluid barrier in the region of confluence of two micro-channel, so that the passive valve effect naturally occurring confluence area has been effectively increased, so that the first shares liquid reaches the confluence area of ​​the bluff, the second shares liquid does not arrive before, you can temporarily stop the flow, and timely removal of the first stock liquid driving force, to achieve a second stream of liquid to reach the bluff after the two liquids free of bubbles fusion object of the invention. 2、本发明在靠近汇合区域的辅微管道上设置了一旁通微管道,使第一股液体到达阻流体后,而第一股液体的驱动力没有撤除前的瞬间,液体可以进入旁通微管道,从而可以缓解阻流体处所承受的背压力, 使被动阀的作用更加可靠。 2, the present invention is on the secondary microchannel near confluence area is provided bypass microchannel the first stream of liquid after the barrier fluid reaches, momentarily before the driving force of the first unit the liquid is not removed, the liquid may enter the bypass micro pipes, which could alleviate the back pressure of the barrier fluid receiving spaces, acting passive valve is more reliable. 3、本发明旁通微管道的设置不但可以实现两种液体分别从主、辅两微管道进入并无气泡地融合;而且还可以将主微管道作为排气管道, 通过阻流体的阻挡作用,在一条辅微管道内实现一种以上液体的无气泡融合,更 3, the bypass microchannel of the present invention can not only two liquids separately from the main and auxiliary two micro-pipe enters no air bubbles fusion; but also the main micro channel as an exhaust duct, the blocking action of the bluff body, to achieve one or more of the liquid in a secondary micro channels no bubbles fusion, more

可以将被气泡分成几段的一种液体中的气体排出,接合为一股连续流动的液体。 It may be bubbles into gas a liquid paragraphs is discharged, engaging a liquid surge continuous flow. 4、 本发明将辅微管道设置成并联的多条,同时在每一条辅微管道与主微管道的汇合区域内均设置一阻流体,从而可以方便地实现多种液体的无气泡融合。 4, the present invention is the secondary micro channels arranged plurality in parallel, but are provided with a barrier fluid in the confluence area each of the secondary micro-channels of the main microchannel, which can easily achieve bubble-free more liquids fusion. 5、本发明将多条辅微管道的进口通过一具有进液口的公共微管道连通,并在各辅微管道与主微管道汇合处均设置一阻流体,且使最上游的阻流体的被动阀效应设置得最小, 从而可以实现一种液体的多路分配,省去重复地为每个单通道加液的繁琐操作。 5, the present invention is to import the plurality of secondary micro-channels by having a common micro channel inlet port communicates, and are provided with a barrier fluid in the secondary microchannel main microchannel junction, and that the barrier fluid most upstream of the passive valve effect set to be the minimum, thereby enabling multi-channel distribution of a liquid, eliminating the cumbersome operation is repeated for each single channel plus liquid. 6、 本发明在利用被动阀效应的同时,无需对微细管道的尺寸做出任何改动和表面处理,因此最大限度地降低了微加工的复杂性和难度。 6, the present invention while utilizing passive valve effect, without making any modifications and surface treatment of the size of the fine conduit, thus minimizing the complexity and difficulty micromachining. 同时本发明还可以有效地减少反馈控制系统中传感器数量,并降低传感器安装位置的准确性和灵敏度要求。 The invention also effectively reduce the number of feedback control system sensors, and reduce the accuracy and sensitivity requirements of the sensor mounting position. 本发明可以广泛用于各种液体在微细管路中的流动控制中。 The present invention can be widely used in a variety of fluid flow control in the fine line in.

附图说明 BRIEF DESCRIPTION

图1是本发明结构示意图图2是本发明阻流体的另一实施例图3〜7是本发明方法实施过程示意图图8是本发明具有旁微管道的结构示意图图9是本发明具有排气接合的结构示意图图IO是本发明具有多股液体融合的结构示意图图11是本发明具有液体分配的结构示意图具体实施方式 FIG 1 is a schematic structural diagram of the present invention 2 is an illustration of another bluff body of the present invention 3~7 is a process diagram of the method of the present invention embodiment 8 of the present invention having a structural diagram next to the micro-duct 9 that the present invention has an exhaust structural schematic view of the engagement IO is the present invention having a multi-strand schematic structural diagram of a liquid fusion 11 that the present invention is the structure of a liquid dispensing schematic DETAILED DESCRIPTION

下面结合附图和实施例对本发明进行详细的描述。 The present invention is described in detail with the drawings and embodiments below in conjunction.

实施例一: Example One:

如图1所示,本发明的结构包括一主微管道1, 一与主微管道1连通的辅微管 , Shown in Figure 1 of the present invention include adjuvants microtubules a main micro pipe 1, a main microchannel 1 communication

道2,在辅微管道2与主微管道1的汇合区域设置一个阻流体3,其能够有效地减小流路面积,阻流体3的形状可以是长方形,也可以是三角形(如图2所示),还可以是其它形状。 Track 2, in the secondary micro-pipe 2 and the merging region of the main micro-channel 1 is provided a bluff body 3, which can be effectively reduced flow passage area, the shape of the bluff body 3 may be rectangular, or may be two triangles (FIG. shown), it may also be other shapes. 在主微管道1和辅微管道2的进口端分别设置有提供驱动力的驱动装置(图中未示出),驱动装置可以是专门为本发明融合管道设置的,也可以是系统中其它驱动装置产生的驱动力。 Are provided driving means (not shown), the drive means may be specially present there providing a driving force of the main micro-channel 1 and the inlet end of the auxiliary microchannel 2 of the inventive fusion pipe disposed, or may be the system other drive driving force generating means. 如图1所示,在汇合区域还可以设置一个传感器4,用于监控液体的流入和流出。 1, in the confluence area may also be provided a sensor 4 for the inflow and outflow monitoring liquid.

上述结构的制作可以采用通常制作芯片的方法,先在基片上制作出形成微管道l、 2的凹槽和阻流体3,然后通过基片-玻璃或塑料盖片的键合形成完整的主微管道1、辅微管道2和阻流体3。 Making the above-described configuration may be employed generally chip production method, first formed on the substrate the formed micro channels L, the groove and the bluff body 2 of 3, and then through the substrate - to form a complete primary micro bond glass or plastic cover sheet pipe 1, the secondary micro-channel 2 and blocking the fluid 3. 传感器4的设置是为了自动控制液体的合并过程, 当然也可以通过人眼直接透过盖片观察和手动切换控制液体的流动。 Sensor 4 is arranged to automatically control the combined process fluids, of course, may be switched to control the flow of fluid through the eye directly through the cover sheet was observed and manually. 传感器4可 Sensor 4 may

以采用各种现有技术的产品,比如采用红外传感器,在芯片的汇合区域上、下分 In various prior art products, such as infrared sensors, in the confluence area of ​​the chip, the sub

别设置一发射器和一接收器,当有液体通过时可以接收并传输信号,与传感器4 连接的反馈控制电路与现有技术相同。 Respectively provided with a transmitter and a receiver may receive and transmit signals, the same circuit with the prior art and the feedback sensor connected to the fourth control when a liquid passes through.

本发明两种液体的融合过程如下: Fusion of the two liquids of the present invention are as follows:

如图3所示,第一股液体在辅微管道2中正被驱动力驱动流向汇合区域。 3, the first stream of liquid is the driving force of the flow of the merge area in the secondary microchannel 2 CKS. 如图4所示,第一股液体到达汇合区域时,在被动阀效应和阻流体3的作用 As shown, the first stock liquid reaches the merging region 4 acting on the passive valve effect and bluff 3

下,暂时停滞;同时由于液体部分进入了汇合区域,传感器4便会产生了一个相 Next, temporarily stalled; the same as the liquid portion into the merging region, the sensor 4 will produce a phase

应的信号使得辅微管道2的驱动力被撤除。 It is a signal such that the secondary micro channels driving force 2 is removed.

如图5所示,第二股液体进入主微管道1,并到达汇合区域与第一股液体实现 As shown, the second stream of liquid into the main micro-channels 15, and reaches the merging area and first strand liquid to achieve

液头融合,使汇合区域完全被液体进占,被动阀作用消失;同样,此状态也能被 Liquid discharge head integration of the confluence region is completely liquid into account, a passive valve effect disappears; similarly, this status can also be

设置在汇合区域的传感器4捕捉到。 A sensor disposed at a confluence area 4 captured. 从这一时刻起,根据共同的下游汇合流动的 From that moment, according to a common merge downstream flow

目的,可以有至少三种不同的驱动两股液体的模式: Purpose, at least three different driving bifurcated mode liquid:

(1) 如果希望得到一个并流(就像在基于扩散的分析设备里看到的那样), 这两股液体应该被同时驱动。 (1) If you want to get a parallel flow (as in the analysis device based on the diffusion's seen), these two liquids should be driven simultaneously.

(2) 如果希望得到一个混合均匀的下游,那么其中一个方法是以分时或时间 (2) If you want to give a mixed downstream, then one method is time-division or time

脉动的方式驱动两液体,也就是说,两股液体被交替以短促的时间脉冲形式驱动, 或者被连续驱动但相位相反。 Pulsation driven two liquids, i.e., the two liquids are alternately driven in short time pulse form, or driven continuously but opposite phase.

(3) 如果希望得到一个前后流,即一股液体正好全部紧跟在另一股的后面, (3) If you want to get a context flow, i.e. flow of fluid just all immediately behind another strand in,

先将其中一股液体驱动至下游管道,直到其液尾到达汇合区域,然后再驱动另一股液体至下游管道。 First wherein the flow of fluid driven to a downstream pipe, until it was tail reaches the merging area and then drives the other shares the liquid to the downstream pipe.

对于并肩流和混合流,理想情况当然是希望两股液体同时在汇合区域收尾, 这样就不会在下游融合的流动中产生气泡或气体分段。 For alongside stream and a mixed stream, over the course, it is desirable two liquids simultaneously at confluence area finishing, so that no bubbles or gas segments flow downstream of the fusion of. 但实际很难做到,这需要两股流动在液体量、流阻以及各自的驱动力完全匹配的情况下才有可能实现,实际情况往往是其中一股的液尾先于另一股的液尾到达汇合区域。 However, the actual difficult to achieve, which requires two flows possible to achieve in the case where the amount of fluid flow resistance and the respective driving force of an exact match, reality is often where an liquid tail prior to liquid another Unit tail reaching confluence area. 对于前后流,一定是其中一股液体的全部先于另一股的全部在汇合区域收尾,这样才能形成前后流。 For before and after the flow must be where all of an liquid prior to all other stocks ending in the confluence area, the front and rear so as to form a flow.

如图6所示,这里描绘了这样一种情况,即假设第二股液体的尾部首先到达了汇合区域,该区域的传感器4检测到这一时刻,并给系统发出一个相应的信号关断第二股液体的驱动力,此时汇合区域因为阻流体3导致流路縮小,由此产生的毛细管的作用能够将第二股液体的液尾停留在汇合区域,从而保持与辅微管道2 中第一股液体的连续。 6, there is depicted a case, which assumes the tail of the second share of the liquid first reaches the merging area sensor of the area 4 is detected prior to this time, and sends a corresponding signal shutdown of the system two driving forces liquid, the confluence region because of the bluff body 3 leads to passage out, capillary action thus produced can be liquid second strand liquids tail remain in the confluence area, thereby maintaining the secondary micro-conduit 2 a surge of liquid continuously. 接下来的流程将会出现以下三种情况: The next process will be the following three conditions:

(1)如果融合的目的是为了形成一个前后流,那么第一股液体在辅微管道2 (1) If the purpose of convergence to form a longitudinal stream, the first stream of liquid in the secondary micro-channels 2

中到达阻流体3后一直处于停顿状态,以等待图6所示的第二股液体液尾到达汇合区域。 In reaching the bluff body 3 has been at a standstill, a second stream of liquid was shown to wait FIG. 6 reaches the merging area.

(2) 如果融合的目的是为了形成一个混合流,那么在如图5和图6所示的步骤之间,两股液体被各自的驱动力交替切换驱动,根据图6中假设的第二股液体液尾刚刚被传感器4探测到,并且其驱动力被撤除,此时还未切换到驱动第一股液体,因此第一股液体仍暂时处于停顿状态。 (2) If the purpose of convergence to form a mixed stream, between the steps shown in FIGS. 5 and 6, the two liquids are each driving force alternately switching the drive, it is assumed in accordance with FIG. 6 Unit II liquid was tail just by sensor 4 detected, and the driving force is removed, will not have been switched to the driving first stream liquid, the first stock liquid remains temporarily at a standstill.

(3) 如果融合的目的是为了形成一个并肩流,则从图5所示的步骤幵始,两股液体一直被同时驱动,直至图6所假设那样,即第二股液体液尾首先刚刚到达汇合区域,并且其驱动力被撤除,此时第一股液体的液尾还未到达汇合区域,并且其驱动力也未被撤除。 (3) If the purpose of convergence to form a side by side flow, the step from FIG. 5 starts its, the two liquids have to be driven simultaneously, until 6 assumed above, i.e. a second stream of liquid solution tail first just arrived merging region, and the driving force is removed, then the first strand was end of the liquid has not reached confluence region, and the driving force is not removed.

前面所述的三种情况,如果是第一种和第二种,那么此时应重新启动对第一股液体的驱动,如果是第三种,那么只是继续维持对第一股液体的驱动。 In front of the three cases, if the first and second, then the time should be restarted for the first unit of the liquid drive, if it is the third, then just continue to maintain the first stock liquid drive. 无论哪种情况,如图6所示辅微管道2中的第一股液体与第二股液体的液尾形成自然连接,而不会产生气泡。 Illustrated secondary micro channels 2 first stream of liquid formed naturally connected to the second stream of fluid tail liquid either case, as shown in FIG 6, without generating bubbles. 因此,如图7所示的最后一步中,通过对第一股液体的驱动将所有剩余的第一股液体全部推过汇合区域,以完成整个的融合过程,并形成了一个离开管道汇合区域的下游流动。 Thus, as shown in FIG. 7 the last step, by the first unit driving the liquid will all the remaining first share all the liquid is pushed through the convergence zone to complete the fusion process, and forms a leaving conduit confluence area downstream flow.

实施例二: Example II:

如图8所示,本实施例包括一主微管道1和一辅微管道2,辅微管道2在接近与主微管道1的汇合区域时,分叉形成一旁通微管道5。 8, the present embodiment includes a main micro-channel 1 and a secondary microchannel 2, the secondary micro-pipe 2 when approaching the main micro channel confluence region 1, the bifurcation forming a bypass microchannel 5. 辅微管道2与主微管道1 在a点形成一汇合区域a,在汇合区域a内设置一阻流体3;旁通微管道5与主微管道1在b点形成另一汇合区域b,在该汇合区域b内设置一阻流体3',两股液体在汇合区域b汇合后,继续延伸形成一共同下游微管道6。 Secondary micro-pipe 2 and the main micro channel 1 at a point forming a confluence region a, provided with a barrier fluid 3 in the confluence area a; bypass micro-pipe 5 and the main micro channel 1 forming another confluence region b at the point b, the provided with a barrier fluid in the confluence area b 3 ', the two liquids post-confluence region b confluence, continues to extend form a common downstream microchannel 6.

本实施例的基本工作原理是:驱动第一股液体进入辅微管道2,当其被第一个阻流体3阻留在第一个汇合区域a的同时,仍能在旁通微管道5内继续流动,直到传感器4产生的信号使辅微管道2的驱动力完全撤除。 The basic principle of the present embodiment is: driving the first unit the liquid enters the secondary micro-channels 2, when at the same time it is 3 retention of a barrier fluid in a first confluence region a, still in the bypass microchannel 5 continues to flow until the signal generated in the sensor 4 so that the secondary micro channels driving force 2 is completely removed. 旁通微管道5的长度最好应使这股液体完全停住时并未到达与主微管道i的第二个汇合区域b,但即使液体到达了汇合区域b,设置在此处的阻流体3'也会保证液体能停住。 The best length of the bypass microchannel 5 should be such that it shares the liquid does not reach the second confluence area of ​​the main micro-channel i, b is completely stopped, but even if the liquid has reached the confluence region b, provided barrier fluid herein 3 'will ensure that the liquid can be stopped. 接下来驱动主微管道1内的第二股液体进入第一个汇合区域a,这样就和第一股液体完成了第一次的液头合并,然后选择驱动其中任意一股液体或同时驱动两股液体,液体都会在主微管道1和旁通管道5中同时流动,因为被动阀效应在阻流体3被完全浸润后已经消失。 Second stream of liquid subsequent driving of the main micro-duct 1 into the first confluence region a, so that the first share of liquid complete liquid discharge head combined first, and then select the drive in which any flow of fluid or simultaneously driven two Unit liquid, the liquid will flow simultaneously in the main micro-channel 1 and the bypass line 5, since the passive valve effect in the barrier fluid 3 is completely wet has disappeared. 主微管道1和旁通微管道5中的任何一股液体先到达汇合区域b 时,都会自动在阻流体3,的作用下暂停,待另一管道液体浸润阻流体3'后,自 After the master micro-channel 1 and any surge of the liquid bypass micro-conduit 5 before reaching the confluence region B, are automatically suspended at 3, the effect of the bluff body, be another pipe the liquid wetting the bluff body 3 ', from

动完成在汇合区域b的第二次的合并。 Done automatically combined at a merging region b of the second time. 在汇合区域b的自动融合是因为在相同背压的情况下,被动阀和阻流体3'的作用会使先到的液体暂停,而自动在阻力较小的管道中继续前进。 The merging region b automated fusion is because at the same back pressure, the role of passive valves and bluff body 3 'will first come in liquid suspension, automatically move in less resistance conduit. 当第二次合并过程完成后,第二个阻流体3'的被动阀效应也消失了,液体可自由通过共同下游微管道6。 When combined second process is complete, the second bluff body 3 'passive valve effect also disappears, liquid is released through a common downstream microchannel 6. 本实施例液体收尾时,在汇合区域a 的收尾过程与实施例一完全相同,而在汇合区域b的收尾将自动完成。 When the example of the liquid ending the present embodiment, confluence area a finishing process of the first embodiment is identical, and the merging region b finishing will be done automatically.

本实施例是一种旁通结构的液体合并实例,其与实施例一直接利用阻流体结构实现液体合并有所不同,本实施例这种液体旁通结构中的两个阻流体3、 3'都只承受较低的旁通管道中的液体压力,因此其可靠性比实施例一更高。 The present embodiment is a liquid consolidated example of a bypass structure, which embodiment a direct use of the bluff body structure to achieve liquor were different, two bluff example of such a liquid bypass structure in the present embodiment 3, 3 ' only withstand the pressure of the liquid low-pass conduit, so reliability a higher than Example.

实施例三 Third Embodiment

如图9所示,本实施例包括一主微管道1、 一辅微管道2和一从辅微管道2 分叉的旁通微管道7,主微管道1与辅微管道2的汇合区域设置有阻流体3。 9, the present embodiment includes a main micro-channel 1, a secondary micro-channel 2 and a 7, the main micro-pipe 1 is provided from the secondary microchannel 2 bifurcated bypass microchannel and confluence area secondary microchannel 2 there bluff 3. 本实施例中,主微管道1被作为排气管道,旁通微管道7作为融合管道,旁通管道7 的进口端十分靠近主微管道1与辅微管道2的汇合区域。 In this embodiment, the main microcontroller pipe 1 is used as an exhaust duct, the bypass micro-pipe 7 as the inlet end of the fusion conduit, the bypass duct 7 is very close to the main micro-pipe 1 and the confluence area secondary microchannel 2.

本实施例具有排气接合功能,工作时,液体从辅微管道2进入,被阻流体3 阻挡停留的同时,自动进入旁通微管道7。 This embodiment has the exhaust junction function, during operation, the liquid enters from the secondary micro-channel 2, the bluff body 3 barrier while visits to automatically enter the bypass microchannel 7. 此时在阻流体3与旁通微管道7进口之间的一小段管道内会停留部分液体,如果这一段管道太长,那么当液体液尾进入旁通微管道7内时,这部分液体将残留在这段管道内;如果旁通微管道7进口离阻流体3足够近,那么在表面张力的作用下,进入旁通微管道7的液尾能够将这段管道内的液体完全带入旁通微管道7内。 At this time in the 3 with the bypass microchannel short pipe between the inlet of the bluff body 7 will remain part of the liquid, if this section of pipe is too long, when the liquid in the liquid tail into 7 bypass microchannel, which part of the liquid will be remaining in the length of tubing; if the bypass microchannel 7 inlet from the bluff body 3 close enough, then under the action of surface tension, into the bypass micro-pipe was the end 7 of the liquid can be within the length of tubing fully into the next 7 the through micro channel. 这样,如果液尾后面有气体继续过来(比如液体驱动力还未被撤除,)那么这些气体将顺利地从含有阻流体3的排气管 Thus, if the latter was the tail gas continues over (such as a liquid driving force has not yet been removed,) then these gases smoothly from containing a barrier fluid exhaust pipe 3

道(主微管道1)排除,而不会因为这段管道内残留液体造成堵塞,使气体进入旁通微管道7。 Channel (main micro pipe 1) excluded, without causing clogging since the residual liquid within the length of tubing, the gas entering the bypass microchannel 7. 由于已经进入旁通微管道7内的液尾不会被后来的气体推离开旁通微管道7的进口处,因此,如果再有一股液体流过来,那么新的液体的液头将和处于旁通微管道7进口处的液尾自动接合,形成连续流动的液体。 Having entered the bypass microchannel liquid tail inside 7 will not be subsequently gas pushed away from the inlet of the bypass micro-conduit 7, and therefore, if the existence of a liquid flow over, then a new liquid discharge head of the liquid to and in the next liquid tail 7 at the inlet of the through microchannels automated bonding, to form a liquid continuous flow.

从以上描述可以看出,本实施例的同一排气旁通结构可被重复使用,在同一辅微管道2内可以先后注入两股或两股以上液体,不但可以将它们之间的气体排除,而且可以在旁通微管道7内实现液体无气泡的接合。 As can be seen from the above description, the same exhaust-bypass structure of the present embodiment may be reused in the same secondary micro channels 2 may be successively injected over more than two, or two liquids, not only the gas between them can be excluded, and can achieve bubble-free engagement of liquid in the bypass microchannel 7. 本实施例还可以将一股产生了气泡并导致分段的液体中的气泡去除,将被分段的液体重新接合起来。 The present embodiment may also be surge bubbles occur and cause bubbles segment liquid removal, to be segmented liquid re-joined.

实施例四 Fourth Embodiment

如图10所示,本实施例包括一主微管道l,多个辅微管道2,在各辅微管道2 与主微管道1的汇合区域分别设置一阻流体3。 , The present embodiment includes a main micro pipe l in FIG. 10, a plurality of secondary micro-channel 2, provided with a barrier fluid 3 in the secondary microchannel 2 and the merging region of the main micro-channel 1, respectively.

本实施例具有将多种液体融合的功能,工作时分别从每一辅微管道2中进入 The present embodiment has a function of a plurality of liquids integration, work respectively enters from each of the secondary micro channels 2

一股液体,在阻流体3的作用下都暂停在辅微管道2的出口,然后驱动主微管道l 中的液体,使其依次浸润每一阻流体3,使其失去被动阀效应,进而通过上述的各种流动方式,实现多种液体的融合。 Drawing a liquid, under the action of the bluff body 3 are suspended at the outlet of the secondary micro-channel 2, and then drives the liquid main microchannels l in that it successively infiltration of each bluff body 3, it lost passive valve effect, and further by the above-described various flow, to achieve more fusion liquids. 实施例五 Fifth Embodiment

如图ll所示,本实施例包括一主微管道l,多个辅微管道2,在各辅微管道2 与主微管道1的汇合区域分别设置一阻流体3,在各辅微管道2的进口连接一公共微管道8,公共微管道8上设置有一液体进口。 As shown in FIG ll, the present embodiment includes a main micro-channel L, a plurality of secondary micro-channel 2, in each of the secondary micro-pipe 2 and the merging region of the main micro-channel 1 are respectively provided with a barrier fluid 3, in the secondary microchannel 2 the inlet is connected to a common micro-conduit 8, the common micro-pipe 8 is provided with a liquid inlet. 在各汇合区域中的阻流体3,可以通过其尺寸的大小、形状、或者离各自辅微管道2出口的远近所产生的大小不一的被动阀效应,选择让液体率先突破那个阻流体3,比如图中显示的是最上游的阻流体3',与其它阻流体3相比其尺寸最小。 Barrier fluid in the confluence area 3, by the size of the size, shape, or the sizes of the passive valve effect from their proximity secondary microchannel 2 export generated, choose to let the liquid first to break through the barrier fluid 3, such as shown in the figures is a bluff body 3 most upstream ', compared with other bluff body 3 is smallest size.

本实施例的应用场合是并行多通道生物试验,如果试剂相同则可以省去依次为每一个通道加样的繁琐过程。 Applications of the present embodiment is a parallel multi-channel biological test, if the agent the same is omitted were loaded in each lane tedious process. 工作时,进入公共微管道8的液体,自动分配进入每一辅微管道2,可以利用每个辅微管道2与主微管道1汇合区域的阻流体3 实现液体自动分配,并在各汇合区域阻流体3处短暂停留。 In operation, the liquid entering the common micro-conduit 8 automatically dispensed into each of the secondary micro-conduit 2, may be utilized bluff each of the secondary micro-channels 2 and a merging region of the main microchannel 3 to achieve automatic liquid dispensing, and in the confluence area bluff at 3 short stay. 由于最上游的阻流体3' 的被动阀效果最差,因此在同样驱动压力下,液体最先从该阻流体3'处突破,并一路将各阻流体3浸润,使其失去被动阀效应,进而将流过各辅微管道2的液体融合在一起,作为废液排出流路。 Since the bluff most upstream of the 3 'passive valve worst, and therefore at the same driving pressure, the liquid first from the bluff body 3' to break at and along each of the bluff 3 infiltration, loss passive valve effect, Further flowing through each secondary microchannel liquid 2 together, as a waste liquid flow passage.

Claims (10)

1、一种控制液体在微管路中连续流动的流路结构,它包括一主微管道,一连通所述主微管道的辅微管道,其特征在于:在所述主微管道与所述辅微管道的汇合区域内设置有一阻流体。 A flow path structure of liquid in the micro-line continuous flow control, which includes a main micro-channel, a communication with the main microchannel secondary micro channels, wherein: said main micro-channel and said in the confluence area secondary micro-conduit is provided with a barrier fluid.
2、 如权利要求1所述是一种控制液体在微管路中连续流动的流路结构,其特征在于:在所述辅微管道上靠近所述汇合区域设置一旁通微管道。 2, according to claim 1 is a flow passage structure of the liquid in the micro-line continuous flow control, characterized in that: in the secondary micro-duct near the merging region disposed side through micro-channels.
3、 如权利要求2所述是一种控制液体在微管路中连续流动的流路结构,其特征在于:所述旁通微管道的另一端在所述主微管道的下游与所述主微管道形成另一汇合区域,在所述另一汇合区域内也设置有一阻流体。 3, as claimed in claim 2 is a flow passage structure of the liquid in the micro-line continuous flow control, characterized in that: the other end of the bypass microchannel downstream of the master in the master micro-conduit microchannel forming another confluence region, on the other merging region is also provided with a barrier fluid.
4、 一种控制液体在微管路中连续流动的流路结构,它包括一主微管道,连通所述主微管道的辅微管道,其特征在于:所述辅微管道为并联设置的多个,每一所述辅微管道与所述主微管道的汇合区域设置有一阻流体。 4. A method of controlling liquid in the micro-line continuous flow channel structure, which includes a main micro-channel, communication with the main micro-channel auxiliary micro-channel, wherein: the secondary micro-channels is provided in parallel multi a merge area of ​​each of the secondary micro-channels of the main micro-conduit is provided with a barrier fluid.
5、 如权利要求4所述是一种控制液体在微管路中连续流动的流路结构,其特征在于:各所述辅微管道的进口通过一公共微管道连通,所述公共微管道上设置有一液体进口。 5, as claimed in claim 4 is a flow passage structure of the liquid in the micro-line continuous flow control, wherein: inlet of each of the secondary micro-duct by a common micro channel communicating, on the common micro channel provided with a liquid inlet.
6、 如权利要求1或2或3或4或5所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:在所述主微管道和辅微管道的汇合区域设置有反馈电路的传感器。 6, as claimed in the flow path structure for controlling the liquid 1 or 2 or 3 or 4 or 5, wherein the micro-line continuous flow, characterized in that: in the confluence area of ​​the main micro-channel and the secondary micro-conduit sensor is provided with a feedback circuit.
7、 如权利要求1或2或3或4或5所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:所述阻流体的截面形状为矩形。 7, as claimed in the flow path structure for controlling the liquid 1 or 2 or 3 or 4 or 5, wherein the micro-line continuous flow, characterized in that: a cross-sectional shape of the fluid of the barrier is rectangular.
8、 如权利要求6所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:所述阻流体的截面形状为矩形。 8, as claimed in the flow channel structure of a control liquid of claim 6 in a micro-line continuous flow, characterized in that: a cross-sectional shape of the fluid of the barrier is rectangular.
9、 如权利要求1或2或3或4或5所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:所述阻流体的截面形状为三角形。 9, as claimed in claim 1 or 2 or 3 or 4 or 5 for controlling liquid in the micro-line continuous flow channel structure, wherein: the bluff-sectional shape of a triangle.
10、 如权利要求6所述的一种控制液体在微管路中连续流动的流路结构,其特征在于:所述阻流体的截面形状为三角形。 10, as claimed in the flow channel structure of a control liquid of claim 6 in a micro-line continuous flow, characterized in that: a cross-sectional shape of the fluid of the barrier is triangular.
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