CN100382792C - Water soluble microcapsule for medicine and its production process - Google Patents
Water soluble microcapsule for medicine and its production process Download PDFInfo
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- CN100382792C CN100382792C CNB2005100472037A CN200510047203A CN100382792C CN 100382792 C CN100382792 C CN 100382792C CN B2005100472037 A CNB2005100472037 A CN B2005100472037A CN 200510047203 A CN200510047203 A CN 200510047203A CN 100382792 C CN100382792 C CN 100382792C
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Abstract
The present invention discloses a medicinal water-soluble microcapsule. A mother pill is prepared by that adhesive is sprayed to the mixture of water-soluble starch and lactose powder which are mixed according to the ratio of 1:1. The adhesive is an aqueous solution of water-soluble starch and sodium carboxymethylcellulose, wherein the concentration of the water-soluble starch is from 20 to 30%, the concentration of the sodium carboxymethylcellulose is from 1 to 3%, and the coating is a hydroxypropyl methylcellulose alcohol solution with the concentration of 5 to 8%. The production method comprises the steps that the mixture of the water-soluble starch and the lactose powder which are mixed according to the ratio of 1:1 is placed on a fluidized bed, and the adhesive is cut and sprayed on the water-soluble starch to prepare the mother pill; medicinal materials are cut and sprayed on the mother pill to prepare a medicine loading layer; 10 to 80% of alcohol as a solvent is prepared into the hydroxypropyl methylcellulose alcohol solution with the concentration of 5 to 8%, and then cut and sprayed on the medicine loading layer. The microcapsule can be quickly and completely dissolved in the stomach, the pharmacodynamic action can be performed as soon as possible, and the medicinal utilization rate is high. The production technology ensures that the mother pill has regular shapes and uniform sizes, and the thicknesses of the medicine loading layer and the coating layer are uniform. Medicines can be furthest loaded, and the coating materials can be saved.
Description
Technical field:
The present invention relates to a kind of pill and production method, especially a kind ofly meet effective water soluble microcapsule for medicine of water dissolution and production.
Background technology:
Known medicinal microcapsule comprises female ball, drug-loaded layer from the inside to the outside and wraps by three-decker.Concrete manufacture method is that common starch is placed fluid bed, treat that the operation of coating equipment is normal after, more certain density common starch solution is pushed up spray (under last) equably on common starch, make female ball; A certain size female ball is packed in the coating bed, treat that the operation of coating equipment is normal, chemical agents such as antibiotic top is sprayed on female ball, reach required thickness (dose) and make drug-loaded layer; To pack in the coating bed by the granule that female ball, drug-loaded layer constitute again, treat that the operation of coating equipment is normal after, certain density common starch solution top is sprayed on outside the drug-loaded layer, form the bag tegillum.Existing medicinal microcapsule exists following shortcoming:
1. because female ball, bag by being made by common starch, make the water solublity weak effect of whole pill, and it is slow that clothes are gone into the microcapsule dissolution velocity of gastric, the pill that has even do not have abundant dissolving and just excrete directly causes the drug absorption effect bad, weak curative effect;
2. female ball, drug-loaded layer and bag are all adopted top spray form from top to bottom, consequently female ball out-of-shape, size inequality, drug-loaded layer and bag tegillum became uneven;
3. owing to do not have ideal protective agent in the drug-loaded layer, the survival period of active agents is short, and for this reason, the medicament in the existing drug-loaded layer can only be chemicalses such as antibiotic, can not the appendix probiotic bacteria, interferon or transfer factor.
Summary of the invention:
The present invention is in order to solve existing in prior technology water solublity weak effect, and technical problems such as out-of-shape provide that a kind of water solublity is effective, the uniform water soluble microcapsule for medicine of shape and production method.
Technical solution of the present invention is: a kind of water soluble microcapsule for medicine, be configured by female ball, drug-loaded layer and bag, it is characterized in that: described female ball is adhesive to be cut be sprayed onto on 1: 1 mixture of water soluble starch and lactose powder and make, adhesive is the aqueous solution of water soluble starch and sodium carboxymethyl cellulose, and wherein water soluble starch concentration is 20～30%, sodium carboxymethyl cellulose concentration is 1～3%; Bag is to be that to make concentration be 5～8% hydroxypropyl methylcellulose alcoholic solution to solvent with 10～80% alcoholic solution.
The concentration of water soluble starch is 25% in the described adhesive.
Described drug-loaded layer is the mixed liquor of probiotic bacteria, interferon or transfer factor and protection liquid, and protection liquid is the PBS solution that contains trehalose, and the concentration of extra large bath sugar is 1～3%.
A kind of production method of water soluble microcapsule for medicine is characterized in that comprising the steps:
A. water soluble starch is mixed with the lactose powder at 1: 1 and be placed on the fluid bed, adhesive cut on the mixture that is sprayed onto water soluble starch and lactose powder make female ball, adhesive is the aqueous solution of water soluble starch and sodium carboxymethyl cellulose, and wherein water soluble starch concentration is 20～30%, sodium carboxymethyl cellulose concentration is 1～3%;
B. drug material is cut be sprayed onto on female ball and made drug-loaded layer;
C. with 10～80% ethanol solvent as hydroxypropyl methylcellulose, make concentration and be 5～8% hydroxypropyl methylcellulose alcoholic solution, cut and be sprayed onto on the drug-loaded layer.
Described b step is made drug-loaded layer for probiotic bacteria, interferon or transfer factor are mixed with the PBS solution that contains trehalose to cut to be sprayed onto on female ball, the concentration of extra large bath sugar is 1～3%.
Female ball of the present invention is to adopt the effective water soluble starch of water solublity and 1: 1 mixture of lactose powder, and cut with adhesive and to be sprayed onto on water soluble starch, the milk-sugar mixture, bag is then adopted the hydroxypropyl methylcellulose alcoholic solution to cut spray, has good water solublity effect.After under the microcapsule water clothes, can dissolve rapidly and fully under one's belt, not only drug effect can be brought into play as early as possible, and the utilization rate height of medicine; Used production technology can guarantee female ball regular shape, size evenly, and drug-loaded layer and bag tegillum thickness are also very even, can carry the powder charge thing to greatest extent, save bag by materials; Medicine is mixed to cut to be sprayed onto on female ball and makes drug-loaded layer with protection liquid, can preserve medicine effectively, the prolong drug activity cycle, except that chemical drugss such as appendix antibiotic, all right appendix probiotic bacteria, interferon or transfer factor.
The specific embodiment:
Embodiment 1:
A. water soluble starch is mixed by 1: 1 with the lactose powder and be placed on the fluid bed, useful load is 65～75% of an equipment displacement volume, treat that the operation of coating equipment is normal, adhesive is installed by cutting spray (side spray), be sprayed onto equably on the powder body that is suspended in (fluidisation attitude) in the hot-air, by continuous adjustment technology parameter, make the powder body of fluidisation attitude constantly be condensed into small particle, reach the requirement of female ball gradually, adhesive is the aqueous solution of water soluble starch and sodium carboxymethyl cellulose, and wherein water soluble starch concentration is 20～30%, sodium carboxymethyl cellulose concentration is 1～3%;
B. female ball microgranule is packed in the coating bed, treat that the operation of coating equipment is normal, medicaments such as antibiotic by cutting spray apparatus, are cut equably to be sprayed onto and carried out coatedly, dry on the solid particle that is suspended in (fluidisation attitude) in the hot-air, so repeatedly, make drug-loaded layer;
C. with 10～80% ethanol solvent as hydroxypropyl methylcellulose, make concentration and be 5～8% hydroxypropyl methylcellulose alcoholic solution, promptly capsulating material is stand-by.To pack in the coating bed by the granule that female ball, drug-loaded layer constitute, useful load is 50～60% of a displacement volume, after treating that the operation of coating equipment is normal, capsulating material is installed by cutting spray (side spray), spray on the solid particle of fluidisation attitude, and continuous adjustment technology parameter, make that capsulating material evenly is coated on the solid particle, drying, form the medicinal soluble capsule.
Embodiment 2:
A. water soluble starch is mixed by 1: 1 with the lactose powder and be placed on the fluid bed, useful load is 65～75% of an equipment displacement volume, treat that the operation of coating equipment is normal, adhesive is installed by cutting spray (side spray), cut equably and be sprayed onto on the powder body that is suspended in (fluidisation attitude) in the hot-air, by continuous adjustment technology parameter, make the powder body of fluidisation attitude constantly be condensed into small particle, reach the requirement of female ball gradually, adhesive is the aqueous solution of water soluble starch and sodium carboxymethyl cellulose, and wherein water soluble starch concentration is 20～30%, sodium carboxymethyl cellulose concentration is 1～3%;
The concentration of b. getting extra large bath sugar is 1～3%, and pH value is 6.8～7.2, and ion concentration is that the PBS solution of 0.2mol/L is active agents protection liquid, mixes stand-by with probiotic bacteria, interferon or transfer factor; Female ball microgranule is packed in the coating bed, treat that the operation of coating equipment is normal, to be mixed with probiotic bacteria, interferon or the transfer factor of medicament protection liquid by cutting spray apparatus, cut equably be sprayed onto carry out on the solid particle that is suspended in (fluidisation attitude) in the hot-air coated, dry, so repeatedly, make drug-loaded layer;
C. with 10～80% ethanol solvent as hydroxypropyl methylcellulose, make concentration and be methylcellulose alcoholic solution in 5～8% the hydroxyl, promptly capsulating material is stand-by.To pack in the coating bed by the granule that female ball, drug-loaded layer constitute, useful load is 50～60% of a displacement volume, after treating that the operation of coating equipment is normal, capsulating material is installed by cutting spray (side spray), spray on the solid particle of fluidisation attitude, and continuous adjustment technology parameter, make that capsulating material evenly is coated on the solid particle, drying, form the medicinal soluble capsule.
Claims (5)
1. water soluble microcapsule for medicine, be configured by female ball, drug-loaded layer and bag, it is characterized in that: described female ball is adhesive to be cut be sprayed onto on 1: 1 mixture of water soluble starch and lactose powder and make, adhesive is the aqueous solution of water soluble starch and sodium carboxymethyl cellulose, and wherein water soluble starch concentration is 20～30%, sodium carboxymethyl cellulose concentration is 1～3%; Bag is that alcoholic solution with 10-80% is that concentration that solvent is made is 5～8% hydroxypropyl methylcellulose alcoholic solution.
2. water soluble microcapsule for medicine according to claim 1 is characterized in that: the concentration of water soluble starch is 25% in the described adhesive.
3. water soluble microcapsule for medicine according to claim 1 and 2 is characterized in that: described drug-loaded layer is the mixed liquor of probiotic bacteria, interferon or transfer factor and protection liquid, and protection liquid is the PBS solution that contains trehalose, and the concentration of extra large bath sugar is 1～3%.
4. the production method of a water soluble microcapsule for medicine as claimed in claim 1 is characterized in that comprising the steps:
A. water soluble starch is mixed with the lactose powder at 1: 1 and be placed on the fluid bed, adhesive cut on the mixture that is sprayed onto water soluble starch, lactose powder make female ball, adhesive is the aqueous solution of water soluble starch and sodium carboxymethyl cellulose, and wherein water soluble starch concentration is 20～30%, sodium carboxymethyl cellulose concentration is 1～3%;
B. drug material is cut be sprayed onto on female ball and made drug-loaded layer;
C. with 10～80% ethanol solvent as hydroxypropyl methylcellulose, make concentration and be 5～8% hydroxypropyl methylcellulose alcoholic solution, cut and be sprayed onto on the drug-loaded layer.
5. the production method of water soluble microcapsule for medicine according to claim 4, it is characterized in that: described b step is made drug-loaded layer for probiotic bacteria, interferon or transfer factor are mixed with the PBS solution that contains trehalose to cut to be sprayed onto on female ball, the concentration of extra large bath sugar is 1～3%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100472037A CN100382792C (en) | 2005-09-12 | 2005-09-12 | Water soluble microcapsule for medicine and its production process |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100472037A CN100382792C (en) | 2005-09-12 | 2005-09-12 | Water soluble microcapsule for medicine and its production process |
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| CN1739489A CN1739489A (en) | 2006-03-01 |
| CN100382792C true CN100382792C (en) | 2008-04-23 |
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| CNB2005100472037A Active CN100382792C (en) | 2005-09-12 | 2005-09-12 | Water soluble microcapsule for medicine and its production process |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114699512A (en) * | 2022-04-02 | 2022-07-05 | 贵州医科大学 | Parathyroid hormone sustained-release medicine and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5051304A (en) * | 1986-12-18 | 1991-09-24 | Societe Anonyme: Mero Rousselot Satia | Microcapsules based on gelatin and polysaccharides and process for obtaining same |
| WO1996038159A1 (en) * | 1995-06-02 | 1996-12-05 | Lafor Laboratories Limited | Micro-encapsulated lactobacilli for medical applications |
| WO1997019676A1 (en) * | 1995-11-24 | 1997-06-05 | Schering Aktiengesellschaft | Method of producing morphologically uniform microcapsules and microcapsules produced by this method |
| CN1569043A (en) * | 2003-07-17 | 2005-01-26 | 中国农业大学 | Coated micro capsule of lactic acid bacteria and its preparation |
| CN1613455A (en) * | 2003-11-04 | 2005-05-11 | 北京东方百信生物技术有限公司 | Targeting microorgan micro-capsules and their preparation |
-
2005
- 2005-09-12 CN CNB2005100472037A patent/CN100382792C/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5051304A (en) * | 1986-12-18 | 1991-09-24 | Societe Anonyme: Mero Rousselot Satia | Microcapsules based on gelatin and polysaccharides and process for obtaining same |
| WO1996038159A1 (en) * | 1995-06-02 | 1996-12-05 | Lafor Laboratories Limited | Micro-encapsulated lactobacilli for medical applications |
| WO1997019676A1 (en) * | 1995-11-24 | 1997-06-05 | Schering Aktiengesellschaft | Method of producing morphologically uniform microcapsules and microcapsules produced by this method |
| CN1569043A (en) * | 2003-07-17 | 2005-01-26 | 中国农业大学 | Coated micro capsule of lactic acid bacteria and its preparation |
| CN1613455A (en) * | 2003-11-04 | 2005-05-11 | 北京东方百信生物技术有限公司 | Targeting microorgan micro-capsules and their preparation |
Non-Patent Citations (2)
| Title |
|---|
| ENCAPSULATED MICROCAPSULES. G.P.D'ONOFRIO et al.International Journal of Pharmaceutics,No.2. 1979 * |
| 微胶囊技术及在食品添加剂中的应用. 袁俊杰等.中国食品添加剂，第2期. 1997 * |
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| CN1739489A (en) | 2006-03-01 |
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Effective date of registration: 20200527 Address after: 116000 No.9 Yingxu Road, Ganjingzi District, Dalian City, Liaoning Province Co-patentee after: JIANGSU SANYI BIOENGINEERING Co.,Ltd. Patentee after: DALIAN SANYI ANIMAL DRUG Co.,Ltd. Co-patentee after: SHANDONG HEZE SANYI BIO-ENGINEERING Co.,Ltd. Address before: 116036, No. 9, Xu Xu Road, Dalian hi tech park, Ganjingzi District, Liaoning Patentee before: DALIAN SANYI ANIMAL DRUG Co.,Ltd. |
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