CN100374092C - Medicinal coating production for vascular stand and electrostatic spraying apparatus - Google Patents
Medicinal coating production for vascular stand and electrostatic spraying apparatus Download PDFInfo
- Publication number
- CN100374092C CN100374092C CNB2005100456689A CN200510045668A CN100374092C CN 100374092 C CN100374092 C CN 100374092C CN B2005100456689 A CNB2005100456689 A CN B2005100456689A CN 200510045668 A CN200510045668 A CN 200510045668A CN 100374092 C CN100374092 C CN 100374092C
- Authority
- CN
- China
- Prior art keywords
- coating
- pressure pump
- intravascular stent
- electrostatic
- paint
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The present invention relates to a preparation method for the medicine coating of a blood vessel bracket in the field of medical apparatuses and an electrostatic spraying device thereof, which comprises a blood vessel bracket and a medicine coating. The present invention is characterized in that the preparation method comprises the following preparation steps: firstly, cleaning and drying are carried out; secondly, medicine and a polymer carrier are mixed into paint according to the weight ratio which is from 1: 1 to 1: 100; thirdly, the blood vessel bracket is connected with the ground, the paint is pressurized and atomized at 0.4 to 7MPa by a high-pressure pump to form fog drips, the fog drips are energized by an electrostatic generator to carry charges, and the fog drips with charges is absorbed on the surface of the blood vessel bracket under the action of an electric field and high-pressure thrusting force; fourthly, the packaging is carried out after drying and sterilization. The electrostatic spraying device is characterized in that a power source is connected with a change-over valve and a high-pressure pump, and a material sucking valve of the high-pressure pump is connected with a paint container; a discharging valve of the high-pressure pump is arranged from a pressure accumulating filter and a paint conveying pipe to a nozzle of a spray gun, and the nozzle is connected with an electrostatic generator of which the voltage is from 1 to 60kV through a cable. The present invention has the advantages of uniform coating surface, controllable thickness, high utilizing rate of paint, and high preparation rate of coating.
Description
Technical field
The present invention relates to a kind of medicinal coating production and electrostatic spraying apparatus thereof of intravascular stent, or rather, is a kind of medication coat method and electrostatic spraying apparatus thereof that utilizes electrostatic spraying to prepare intravascular stent efficiently, belongs to medical instruments field.
Background technology
1987, Sigwart (Sigwart U, et al.Intravascular stents to preventocclusion and restenosis after transluminal angioplasty.N Engl J Med, 1987,316:701) wait, for treatment coronary heart disease provides good approach first with the coronary artery stent implant into body.But intravascular stent is implanted and is caused that in-stent restenosis has limited its curative effect to a great extent.To be blood vessel cause blood vessel injury to the reason of restenosis after the support expansion, thus thereby induction of vascular smooth muscle cell transition propagation and cause the generation of vascular restenosis to the inner membrance migration.Cardiovascular pharmacology discovers, multiple medicine can produce the obvious suppression effect to tunica intima and smooth muscle cell external, but the systemic administration poor effect, and its reason may be crossed low relevant with the body blood drug level that circulates.And active drug is transported to the blood vessel injury place by coating stent of medicine, will help the treatment of complication.
At present, medicine coating blood vessel support is at home and abroad all brought into use clinically.For example, U.S.Pat.No.6,099,562, U.S.Pat.No.5,879,697, U.S.Pat.No.5,092,877 and U.S.Pat.No.5,304,121 etc.
The medicinal coating production of intravascular stent mainly is dip-coating and spraying two big classes.Spraying is owing to its significant advantage---and the amount of efficient height, coating can be controlled and be widely used.But, because intravascular stent is tiny eyed structure, the dead angle that the common existence of traditional spraying technology can't be sprayed onto, the appearance surface coatings of intravascular stent is difficult to evenly, U.S.Pat.Nos.4 for example, 655,771 and 4,954,126, the coating on inner surface of intravascular stent tubular structure is just thin than external surface coating.In addition, traditional spraying method utilization efficiency of coatings is very low, and in fact, traditional spraying method has only 5% coating solution to be sprayed on rack surface, and remaining overwhelming majority has all been wasted.
Another spraying technology is exactly electrostatic spraying.Traditional electrostatic coating method is the surface earthing with medical apparatus and instruments, compressed air is with the nozzle flow mistake of very high flow velocity from spray gun, form parital vacuum around making nozzle, the air-flow that is compressed air when coating drinks up, when spraying into this vacuum space, by high-speed gas atomization, form droplet, droplet through with spray equipment that high voltage power supply links to each other after charged, the nozzle of spray equipment and the rack surface of ground connection formation electrostatic field, charged droplet in the effect deposit of electrostatic field at medical apparatus surface.For example, U.S.Pat.Nos, 5,824,049 and 6,096, the method for the employing electrostatic spraying described in 070 prepares bioactive materials at medical apparatus surface.The shortcoming of this conventional electrostatic spraying technology is: the pressure of gas is difficult to control, wants to obtain uniform coating at medical apparatus surface, and it is inevitable losing a large amount of coating.And U.S.Pat.No.6,669, a kind of improved electrostatic coating method of mentioning in 980 (Method forspray-coating medical devices), this method also is the surface earthing with medical apparatus and instruments, but the atomizing of coating is to be finished by simple static, and just coating is being subjected to the effect of high-voltage electrostatic field, the coating drop is split into tiny droplet, the voltage that applies is high more, and the cracking of electric field is strong more, and the effect of electrostatic atomization is good more.The shortcoming that this method exists is: 1. coating is difficult to realize the atomizing fully of coating merely by electrostatic atomization, and the coating condensation rate is low; 2. because the electrostatic repulsion between droplet can only form one deck thin layer on the intravascular stent surface, be difficult to reach the demand of medication coat thickness; 3. the formation of coating is fully by electrostatic absorption, and it is extremely slow that droplet arrives the superficial velocity of intravascular stent, has reduced the efficient of production of coatings.
Therefore, need a kind of medicinal coating production of intravascular stent, this method makes that the intravascular stent face coat is even, and thickness can be controlled and can reach requirement, utilization efficiency of coatings height, the efficient height of production of coatings.
Summary of the invention
Purpose of the present invention and task will overcome prior art and exist: 1. the coating condensation rate is low; 2. coating layer thickness does not reach requirement; 3. the inefficient deficiency of production of coatings, and providing a kind of coating even, thickness can reach instructions for use, the condensation rate of coating and utilization rate height, the medicinal coating production of the intravascular stent that production of coatings efficient is high and electrostatic spraying apparatus thereof, special proposition technical solution of the present invention.
Technical conceive of the present invention is to utilize high-pressure pump that coating is increased pressure, coating after the supercharging sprays rapidly from nozzle, the moment blood pressure lowering, violent expansion fog changes into superfine little droplet, and by electrostatic generator discharge and be with electric charge, under the combined effect of electric field gravitation and high pressure thrust, be adsorbed in the intravascular stent surface.
The invention provides a kind of medicinal coating production of intravascular stent, mainly comprise: intravascular stent 2 and by the coating 5 of polymer carrier materials and solvent and medicament mixed, by the medication coat of electrostatic spraying preparation, employed polymer carrier materials adopts a kind of in the above-mentioned random or block copolymer of polylactide, polycaprolactone, poly-(lactide-Acetic acid, hydroxy-, bimol. cyclic ester), poly-(lactide-caprolactone) or poly-(lactide-Acetic acid, hydroxy-, bimol. cyclic ester-caprolactone); Solvent adopts wherein a kind of of chloroform, dichloromethane, acetone, oxolane or dioxane; Medicine adopts wherein a kind of of rapamycin, paclitaxel, heparin, the full plain A of ring, dactinomycin, dexamethasone, the anti-agent of platelet receptor, the anti-hypertrophy of Chinese medicine or anticoagulation medicine, it is characterized in that: during electrostatic spraying, also apply supercharging release spraying by 7 pairs of coating 5 of high-pressure pump, pressure is 0.4～7MPa.
The step of production of coatings is:
The first step, the cleaning of intravascular stent
Place the ultrasonic concussion of acetone, ethanol and distilled water to clean respectively 15～20 minutes self-expanding intravascular stent or balloon expandable intravascular stent; 60～80 ℃ of dryings are 20～30 minutes in vacuum drying oven;
Second step, the preparation of coating
At room temperature, polymer carrier materials and the dissolving of its solvent are formed homogeneous solution, concentration range 1%～15% is mixed with coating with medicine dissolution again in above-mentioned solution, and the mass ratio of medicine and polymer carrier materials is 1: 1～1: 100;
The 3rd step, the preparation of medication coat
Adopt one or more intravascular stent series connection, the spacing of intravascular stent is 2～5cm, becomes electric neutrality through lead ground connection again; The coating for preparing is injected the container for paint of electrostatic spraying apparatus 4, container for paint 6 links to each other with high-pressure pump 7, high-pressure pump is with the coating supercharging, coating after the supercharging is delivered to nozzle 10 places of spray gun through being coated with material conveying tube 8, coating sprays rapidly from the nozzle that links to each other with electrostatic generator, the moment blood pressure lowering, violent expansion fog changes into superfine little droplet 13, and by electrostatic generator discharge and be with electric charge, between nozzle and intravascular stent, form electrostatic field, the distance of the two is 1～20cm, charged coating is adsorbed on the intravascular stent surfaces externally and internally under the combined effect of electric field gravitation and high pressure thrust, and forms the layer of even coating, the time of spraying is 5～30 seconds, and the thickness of coating is 1～100 μ m;
The 4th step, the dry and sterilization of medication coat
The preparation of the medication coat of intravascular stent finishes and is placed in the vacuum drying oven, 30～40 ℃ of dryings 48 hours, and with encapsulating behind the oxirane disinfection.
The medicinal coating production that the invention provides a kind of intravascular stent is further characterized in that: the medicine in the coating 5 adopts one or more composite uses.
The invention provides a kind of electrostatic spraying apparatus of medicinal coating production of intravascular stent, mainly comprise: spray gun 9, nozzle 10, container for paint 6, electrostatic generator 11 and cable 12, it is characterized in that: in electrostatic spraying apparatus 4, also be provided with the high-pressure pump 7 of working by power source 14, its spray gun 9 is to link to each other with container for paint 6 by high-pressure pump 7, the material sucking valve 21 of high-pressure pump links to each other with container for paint, and the bleeder valve 20 of high-pressure pump is by behind the pressure accumulation filter 23, again through being coated with material conveying tube 8 nozzle 10 to spray gun, nozzle is that the electrostatic generator 11 of 1～60kv links to each other by cable 12 and voltage; The power source of high-pressure pump is sent to power in the high-pressure pump through switching valve 15, drives high-pressure pump piston 18, and promotes plunger 19, applies for coating 5 to increase, the release force transformation, thereby makes high-pressure pump realize the turnover of control coating.
The invention provides a kind of electrostatic spraying apparatus of medicinal coating production of intravascular stent, it is further characterized in that: the power source 14 of high-pressure pump adopts compressed air source, or oil pressure source, or power supply, and the pressure of power source is 0.4～7Mpa.
When implementing technical solution of the present invention, the parameter that is adopted should be determined by following principle: when the size of cerebrovascular support less, the thinner thickness of medication coat, coating layer thickness should take off limit, and the time of the distance of voltage, nozzle and the support of the mass ratio of the concentration of polymer carrier materials, medicine and polymer carrier materials, high-pressure pump pressure, electrostatic generator and spraying is all taken off limit value; When the peripheral blood vessel stent size bigger, the thickness of medication coat is thicker relatively, coating layer thickness is answered capping, and equal capping value of the time of the distance of voltage, nozzle and the support of the mass ratio of polymer carrier materials concentration, medicine and polymer carrier materials, high-pressure pump pressure, electrostatic generator and spraying; When the coronary artery stent size between between the two above-mentioned, the thickness of coating is also between between the two above-mentioned, the intermediate value that the other technologies parameter provides according to the present invention; For realizing the functionalization of intravascular stent, optional majority layer coating.
Major advantage of the present invention is: 1. charged fine mist is deposited on the intravascular stent surface under electrostatic field, make coating even, and the thickness of coating may be controlled to 1～100 μ m, has reached instructions for use; 2. the coating atomizing is not to be finished by static merely, but make the coating atomizing fully by high-pressure pump and electrostatic combined effect, the coating condensation rate can be up to 100%, and, under the effect of Electrostatic Absorption, the utilization rate of coating is increased to of the present invention 70% by 5% of conventional spray paint, the utilization rate of coating has improved; 3. droplet has increased the speed that is deposited on rack surface under the combined effect of high pressure thrust and electrostatic attraction, and the time of finishing the preparation of each bracket coating has been improved the efficient of working greatly by 240～360 seconds to 5～30 seconds of the present invention of simple Electrostatic Absorption.
Description of drawings
Below in conjunction with accompanying drawing details of the present invention is described further:
Fig. 1 is the medication coat surface topography map that adopts the intravascular stent that the present invention obtains
Photo among the figure is a sinusoidal wave ductwork type coronary stent, behind method coating medication coat of the present invention, amplifies 100 times, observed blood vessel stent drug coating 1 local surfaces shape appearance figure with SZX-12 Olympus Stereo microscope.
Show also among the figure that intravascular stent face coat 1 is smooth, uniform.
Fig. 2 adopts overall structure view in the electrostatic spraying apparatus pressure process proposed by the invention
Electrostatic spraying apparatus 4 comprises: high-pressure pump 7, be coated with material conveying tube 8, spray gun 9, nozzle 10, electrostatic generator 11 and cable 12.
Show among the figure that intravascular stent 2 becomes electric neutrality through lead 3 ground connection; Coating 5 is contained in the container for paint 6, and container for paint 6 links to each other with spray gun 9 by high-pressure pump 7, after be coated with nozzle 10 places that material conveying tube 8 arrives spray guns 9, nozzle 10 passes through cable 12 and links to each other with electrostatic generator 11 coating 5 by high-pressure pump 7 superchargings.
Also show among the figure, send power through switching valve 15 by power source 14, switching valve A mouth 16 advances, switching valve B mouth 17 goes out, piston 18 is descended, promote plunger 19 and descend, at this moment, the material sucking valve 21 of high-pressure pump is closed, the bleeder valve 20 of high-pressure pump is opened, coating 5 after the pressurization enters from the bleeder valve of high-pressure pump, from high pressure coating outlet 22 outputs, through pressure accumulation filter 23 and nozzle 10 places that are coated with material conveying tube 8 arrival spray guns 9, ejection rapidly, the moment decompressional expansion is atomized into superfine little droplet 13, and is with electric charge by electrostatic generator 11 discharges, is adsorbed on intravascular stent 2 surfaces externally and internallies.When thin-line arrow represents that power source 14 effects descend piston, the direction of motion of power; Thick-line arrow is illustrated in piston and promotes down, and plunger 19 is to the direction of motion of coating 5 pressurizations; After dotted arrow was represented the coating pressurization, with bleeder valve 20 jack-up of high-pressure pump, coating entered pressure accumulation filter 23 by high pressure coating outlet 22, and through being coated with the direction that material conveying tube 8 enters spray gun 9, the structure in the frame of broken lines is represented electrostatic spraying apparatus 4 again.
Fig. 3 is Fig. 2 overall structure view in stress-relief process
Show among the figure, send power through switching valve 15 by power source 14, switching valve B mouth 17 advances, switching valve A mouth 16 goes out, piston 18 is risen, driving plunger 19 rises, at this moment, the material sucking valve 21 of high-pressure pump is opened, and the bleeder valve 20 of high-pressure pump cuts out, coating 5 in the container for paint 6 enters high-pressure pump 7 from the material sucking valve 21 of high-pressure pump, at this moment, the bleeder valve 20 of high-pressure pump cuts out, and does not have coating to enter pressure accumulation filter 23 by high pressure coating outlet 22, enter in the spray gun 9 through being coated with material conveying tube 8 again, promptly do not have droplet to form.When thin-line arrow represents that power source 14 effects are risen piston, the direction of motion of power; Thick-line arrow is illustrated in piston and drives down, the direction of motion of the release that plunger 19 makes progress; Dotted arrow represents that the coating 5 in the container for paint enters the direction of high-pressure pump through the material sucking valve 21 of high-pressure pump.
Fig. 4 is the cross sectional representation that adopts the present invention's coated with multiple layer medication coat on intravascular stent
Showing among the figure, intravascular stent 2, intravascular stent inner surface 25, intravascular stent outer surface 24, contain the coating 26 of thunder handkerchief enzyme element and contain the coating 27 of heparin, is that the present invention realizes the intravascular stent functionalization, and a specific embodiment of coated with multiple layer medication coat.
The specific embodiment
According to the needs of clinical pathological changes, determine the content of dispersion of support, and then the thickness of the ratio of definite medicine and carrier and coating.
For satisfy * * the hospital clinical demand, and the medicine coating blood vessel support of preparation fine size, adopt technical solution of the present invention, its preparation process is as follows: the first step places the ultrasonic concussion of acetone, ethanol and distilled water to clean respectively 15 minutes intravascular stent, dries 20 minutes for 80 ℃ in vacuum drying oven; Second step preparation coating, the ratio of medicine and polymer support is 1: 1 (mass ratio), and the concentration of polymer support in its solvent is 1%, and its Chinese medicine is that paclitaxel, polymer support are chloroform for gathering (lactide-Acetic acid, hydroxy-, bimol. cyclic ester) and solvent; The preparation of the 3rd step medication coat, high-pressure pump pressure is 0.4MPa, the voltage of electrostatic generator is 1kv, the distance of nozzle and support is 1cm, after the coating atomizing, on the surface of support, the time of spraying is 5 seconds to charged droplet in the combined effect deposit of high pressure thrust and electrostatic attraction; After the dry and sterilization blood vessel bracket coating preparation of the 4th step medication coat finishes, in vacuum drying oven, 30 ℃ of dryings 48 hours, solvent removal encapsulates with oxirane disinfection after the medication coat drying.Through JEOL JSM-5600LV scanning electronic microscope observation coating layer thickness is 1.04 μ m, and coating is even.
In Dalian * * hospital does the zoopery demand, and the drug eluting vascular support of preparation, its preparation process is as follows: the first step is selected (3.0 * 20cm) 32 on 316L rustless steel sacculus blood vessel dilating support for use, place the ultrasonic concussion of acetone, ethanol and distilled water to clean respectively 20 minutes intravascular stent, in vacuum drying oven, dried 25 minutes for 70 ℃; Second step preparation coating, the ratio of medicine and polymer support is 1: 10 (mass ratio), and the concentration of polymer support in its solvent is 5%, and its Chinese medicine is a thunder handkerchief enzyme element, and polymer support is an oxolane for gathering (lactide-Acetic acid, hydroxy-, bimol. cyclic ester) and solvent; The preparation of the 3rd step medication coat, with 32 intravascular stents in two batches, a collection of 16, each intravascular stent series connection spacing is 2cm in every batch, and high-pressure pump pressure is 1MPa, and the voltage of electrostatic generator is 25kv, the distance of nozzle and support is 10cm, after the coating atomizing, on the surface of support, the time of spraying is 10 seconds to charged droplet in the combined effect deposit of high pressure thrust and electrostatic attraction; After the dry and sterilization blood vessel bracket coating preparation of the 4th step medication coat finishes, in vacuum drying oven, 35 ℃ of dryings 48 hours, solvent removal; The 5th step was contained in the drug eluting vascular support for preparing on the sacculus transmission system in advance, with encapsulating after the oxirane high-temperature sterilization; The 6th step was 10.06 μ m through JEOL JSM-5600LV scanning electronic microscope observation coating layer thickness, after the zoopery check is qualified products by the drug eluting vascular support that the present invention prepares.
Embodiment 3
Be treatment peripheral blood vessel pathological changes, select NiTi marmem self-expanding intravascular stent, totally 10 its preparation processes are as follows: the first step places the ultrasonic concussion of acetone, ethanol and distilled water to clean respectively 20 minutes NiTi marmem self-expanding intravascular stent, dries 30 minutes for 60 ℃ in vacuum drying oven; Second step preparation coating, the ratio of medicine and polymer support is 1: 100 (mass ratio), and the concentration of polymer support in its solvent is 15%, and its Chinese medicine is that thunder handkerchief enzyme element, polymer support are that polylactide and solvent are dichloromethane; The preparation of the 3rd step medication coat, with 10 intravascular stent series connection spacings is 5cm, high-pressure pump pressure is 7MPa, the voltage of electrostatic generator is 60kv, the distance of nozzle and support is 20cm, after the coating atomizing, on the surface of support, the time of spraying is 30 seconds to charged droplet in the combined effect deposit of high pressure thrust and electrostatic attraction; After the dry and sterilization blood vessel bracket coating preparation of the 4th step medication coat finishes, in vacuum drying oven, 40 ℃ of dryings 48 hours, solvent removal; The 5th step will prepare the drug eluting vascular support encapsulate after with the oxirane high-temperature sterilization, it is qualified to be through JEOL JSM-5600LV scanning electronic microscope observation coating layer thickness that 99 μ m are confirmed to be product.
Embodiment 4
For realizing the functionalization of intravascular stent, prepared two-layer drug eluting vascular support by the present invention, its preparation process is as follows: the first step is selected 316L rustless steel sacculus blood vessel dilating support for use, place the ultrasonic concussion of acetone, ethanol and distilled water to clean respectively 20 minutes intravascular stent, in vacuum drying oven, dried 20 minutes for 80 ℃; Second step preparation coating, two kinds of coating have been prepared, first kind: the ratio of medicine and polymer support is 1: 50 (mass ratio), the concentration of polymer support in its solvent is 10%, its Chinese medicine is that thunder handkerchief enzyme element, polymer support are dioxane for gathering (lactide-Acetic acid, hydroxy-, bimol. cyclic ester) and solvent, second kind: the ratio of medicine and polymer support is 1: 50 (mass ratio), the concentration of polymer support in its solvent is 10%, and its Chinese medicine is that heparin, polymer support are dioxane for gathering (lactide-Acetic acid, hydroxy-, bimol. cyclic ester) and solvent; The preparation of the 3rd step medication coat, at first on intravascular stent, prepare the coating that contains the plain medicine of thunder handkerchief enzyme, high-pressure pump pressure is 5MPa, and the voltage of electrostatic generator is 40kv, and the distance of nozzle and support is 15cm, after the coating atomizing, on the surface of support, the time of spraying is 20 seconds to charged droplet in the combined effect deposit of high pressure thrust and electrostatic attraction, and then spraying one deck contains the coating of heparin, technological parameter is the same, obtains one deck uniform coating 27 on coating 26 surfaces; After the dry and sterilization blood vessel bracket coating preparation of the 4th step medication coat finishes, in vacuum drying oven, 40 ℃ of dryings 48 hours, solvent removal; The 5th step was contained in the drug eluting vascular support for preparing on the sacculus transmission system in advance, with encapsulating after the oxirane high-temperature sterilization; The 6th step, to inside and outside two-layer, interior layer thickness was 49.04 μ m through the JEOLJSM-5600LV scanning electronic microscope observation, and outer layer thickness is 50.01 μ m, after be sent to Beijing * * hospital inspection is qualified.
Claims (3)
1. the medicinal coating production of an intravascular stent, mainly comprise: intravascular stent [2] and by the coating [5] of polymer carrier materials and solvent and medicament mixed, by the medication coat of electrostatic spraying preparation, employed polymer carrier materials adopts a kind of in the above-mentioned random or block copolymer of polylactide, polycaprolactone, poly-(lactide-Acetic acid, hydroxy-, bimol. cyclic ester), poly-(lactide-caprolactone) or poly-(lactide-Acetic acid, hydroxy-, bimol. cyclic ester-caprolactone); Solvent adopts wherein a kind of of chloroform, dichloromethane, acetone, oxolane or dioxane; Medicine adopts wherein a kind of of rapamycin, paclitaxel, heparin, the full plain A of ring, dactinomycin, dexamethasone or the anti-agent of platelet receptor, it is characterized in that:
A), during electrostatic spraying, be coating [5] to be applied supercharging and release spraying by high-pressure pump [7], pressure is 0.4～7MPa;
B), the step of production of coatings is:
The first step, the cleaning of intravascular stent
Place the ultrasonic concussion of acetone, ethanol and distilled water to clean respectively 15～20 minutes intravascular stent; 60～80 ℃ of dryings are 20～30 minutes in vacuum drying oven;
Second step, the preparation of coating
At room temperature, polymer carrier materials and the dissolving of its solvent are formed homogeneous solution, concentration range 1%～15% is mixed with coating with medicine dissolution again in above-mentioned solution, and the mass ratio of medicine and polymer carrier materials is 1: 1～1: 100;
The 3rd step, the preparation of medication coat
Adopt one or more intravascular stent series connection, the spacing of intravascular stent is 2～5cm, becomes electric neutrality through lead ground connection again; The coating for preparing is injected the container for paint of electrostatic spraying apparatus [4], container for paint [6] links to each other with high-pressure pump [7], high-pressure pump is with the coating supercharging, coating after the supercharging is delivered to the nozzle [10] of spray gun and is located through being coated with material conveying tube [8], coating sprays rapidly from the nozzle that links to each other with electrostatic generator, the moment blood pressure lowering, violent expansion fog changes into superfine little droplet [13], and by electrostatic generator discharge and be with electric charge, between nozzle and intravascular stent, form electrostatic field, the distance of the two is 1～20cm, charged coating is adsorbed on the intravascular stent surfaces externally and internally under the combined effect of electric field gravitation and high pressure thrust, and forms the layer of even coating, the time of spraying is 5～30 seconds, and the thickness of coating is 1～100 μ m;
The 4th step, the dry and sterilization of medication coat
The preparation of the medication coat of intravascular stent finishes and is placed in the vacuum drying oven, 30～40 ℃ of dryings 48 hours, and with encapsulating behind the oxirane disinfection.
2. the electrostatic spraying apparatus of the medicinal coating production of an intravascular stent, mainly comprise: spray gun [9], nozzle [10], container for paint [6], electrostatic generator [11] and cable [12], it is characterized in that: in electrostatic spraying apparatus [4], also be provided with the high-pressure pump [7] of working by power source [14], its spray gun [9] links to each other with container for paint [6] by high-pressure pump [7], the material sucking valve of high-pressure pump [21] links to each other with container for paint, and the bleeder valve of high-pressure pump [20] is by behind the pressure accumulation filter [23], again through being coated with material conveying tube [8] to the nozzle [10] of spray gun, nozzle is that the electrostatic generator [11] of 1～60kv links to each other by cable [12] and voltage; The power source of high-pressure pump is sent to power in the high-pressure pump through switching valve [15], drives high-pressure pump piston [18], and promotes plunger [19], applies for coating [5] to increase, the release force transformation, thereby makes high-pressure pump realize the turnover of control coating.
3. the electrostatic spraying apparatus of the medicinal coating production of a kind of intravascular stent according to claim 2 is characterized in that: the power source of high-pressure pump [14] adopts compressed air source, and the pressure of power source is 0.4～7Mpa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100456689A CN100374092C (en) | 2005-01-14 | 2005-01-14 | Medicinal coating production for vascular stand and electrostatic spraying apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100456689A CN100374092C (en) | 2005-01-14 | 2005-01-14 | Medicinal coating production for vascular stand and electrostatic spraying apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1644184A CN1644184A (en) | 2005-07-27 |
| CN100374092C true CN100374092C (en) | 2008-03-12 |
Family
ID=34876389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100456689A Expired - Fee Related CN100374092C (en) | 2005-01-14 | 2005-01-14 | Medicinal coating production for vascular stand and electrostatic spraying apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100374092C (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070077435A1 (en) * | 2005-10-05 | 2007-04-05 | Schachter Deborah M | Process for coating a medical device |
| CN1799650B (en) * | 2005-12-30 | 2010-07-14 | 李文涛 | Method for preparing biodegradable drug-carried high molecular material stent |
| CN100371030C (en) * | 2006-01-20 | 2008-02-27 | 重庆大学 | Drug coating-spraying method for drug eluting stent and spraying apparatus therefor |
| EP3459572A1 (en) * | 2007-11-14 | 2019-03-27 | Biosensors International Group, Ltd. | Automated coating method |
| CN101337093B (en) * | 2008-08-07 | 2014-04-09 | 乐普（北京）医疗器械股份有限公司 | Preparation method of monoclonal antibody coating biology stand |
| US20110034992A1 (en) * | 2009-08-04 | 2011-02-10 | Papp John E | Stent and Method of Coating Same |
| US20110076312A1 (en) * | 2009-09-29 | 2011-03-31 | Ethicon, Inc. | Antimicrobial/antibacterial medical devices coated with traditional chinese medicines |
| SG11201402789TA (en) * | 2012-01-23 | 2014-09-26 | Cortronik GmbH | Device for coating a stent, corresponding coating method, and stent produced according to said method |
| CN102961788B (en) * | 2012-12-04 | 2015-08-12 | 东华大学 | A kind of heparin load aneurysm treatment overlay film frame and preparation method thereof |
| CN103566418B (en) * | 2013-08-13 | 2016-01-20 | 重庆大学 | A kind of preparation method of laminated coating drug eluting vascular support |
| CN103566414B (en) * | 2013-08-13 | 2016-01-13 | 重庆大学 | A kind of nucleocapsid structure receives particulate coatings intravascular stent and preparation method thereof |
| CN103705981B (en) * | 2013-10-10 | 2015-07-22 | 上海师范大学 | Quick preparation method of growth-factor-loading high-cell-load tissue engineering scaffold |
| CN104607339B (en) * | 2015-01-22 | 2017-01-04 | 上海理工大学 | Medicine spraying Z axis system |
| CN108309204A (en) * | 2017-01-16 | 2018-07-24 | 深圳市先赞科技有限公司 | Equipped with the endoscope using snake gelatine skin made of spraying process |
| CN106727273A (en) * | 2017-03-02 | 2017-05-31 | 李成国 | The manufacture method of soluble micropin |
| CN107485777B (en) * | 2017-09-06 | 2020-12-15 | 乐普（北京）医疗器械股份有限公司 | Preparation method of crystal-controllable drug balloon catheter |
| CN109793935B (en) * | 2019-01-16 | 2021-09-03 | 武汉杨森生物技术有限公司 | Preparation method of artificial blood vessel material, artificial blood vessel prepared by preparation method and application of artificial blood vessel material |
| CN110385327A (en) * | 2019-08-05 | 2019-10-29 | 魏东金 | A kind of nanometer film isolation oil gas inhibits system and nanometer film that oil gas suppressing method is isolated |
| CN115192130B (en) * | 2022-08-09 | 2023-06-02 | 惠州市顺美医疗科技有限公司 | Bolt taking bracket and production and manufacturing process thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003092909A1 (en) * | 2002-05-02 | 2003-11-13 | Labcoat Ltd. | Stent coating device |
| US6743462B1 (en) * | 2001-05-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
| CN1509774A (en) * | 2002-12-25 | 2004-07-07 | 中国科学院金属研究所 | Coating preparing method for medicine coating cardiovascular stand |
| US20040200729A1 (en) * | 2003-04-09 | 2004-10-14 | Scimed Life Systems, Inc. | Electrohydrodynamic coating fluid delivery apparatus and method |
-
2005
- 2005-01-14 CN CNB2005100456689A patent/CN100374092C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743462B1 (en) * | 2001-05-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
| WO2003092909A1 (en) * | 2002-05-02 | 2003-11-13 | Labcoat Ltd. | Stent coating device |
| CN1509774A (en) * | 2002-12-25 | 2004-07-07 | 中国科学院金属研究所 | Coating preparing method for medicine coating cardiovascular stand |
| US20040200729A1 (en) * | 2003-04-09 | 2004-10-14 | Scimed Life Systems, Inc. | Electrohydrodynamic coating fluid delivery apparatus and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1644184A (en) | 2005-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100374092C (en) | Medicinal coating production for vascular stand and electrostatic spraying apparatus | |
| CN103566414B (en) | A kind of nucleocapsid structure receives particulate coatings intravascular stent and preparation method thereof | |
| CN103566418B (en) | A kind of preparation method of laminated coating drug eluting vascular support | |
| Sabra et al. | Recent advances in electrospun nanofibers for some biomedical applications | |
| US8282982B2 (en) | Method and system for coating a surface of a medical device with a therapeutic agent and drug eluting medical devices made thereby | |
| CN101279111A (en) | Method for preparing blood vessel stent with polyester medicament eluting coating | |
| CN100371030C (en) | Drug coating-spraying method for drug eluting stent and spraying apparatus therefor | |
| AU2007271554B2 (en) | Manufacture, method, and use of active substance-releasing medical products for permanently keeping blood vessels open | |
| CN107206129A (en) | Medication coat medicine equipment | |
| CN101548916B (en) | A medical equipment carrying extracellular matrix and its production method | |
| CN101156968A (en) | Preparation method of shell core fibre tectorial membrana endovascular stent | |
| CN102166141B (en) | Process for preparing drug eluting stent | |
| CN103948975B (en) | A kind of targeted drug release gets involved class medical apparatus and instruments and preparation method thereof | |
| CN204840617U (en) | Novel medicine elution sacculus pipe | |
| CN101703428A (en) | Intravascular scaffold provided with anti-restenosis coating layer and preparation method thereof | |
| KR101161151B1 (en) | Coating method for stents or biomedical implants by electrospray | |
| CN201299672Y (en) | Support mandrel system for spray coating drug-coated stent | |
| CN105251060B (en) | A kind of method and products thereof preparing medicament controlled-release coating using vacuum cold spray technology | |
| CN101411899A (en) | Vascular undercoat stent | |
| KR20130119727A (en) | Drug eluting stent | |
| CN101411901B (en) | Method for preparing stent with coating in blood vessel | |
| CN100500113C (en) | Stainless steel cardiovascular bracket with pharmaceutical coating on surface and preparation method thereof | |
| CN112603593A (en) | Self-anastomotic artificial blood vessel stent and preparation method thereof | |
| US20190374686A1 (en) | Method for coating implant with active pharmaceutical ingredients | |
| CN105797207A (en) | Drug release carrier on metal substrate and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080312 Termination date: 20110114 |