CN100352496C - Lugua polypeptides for injection and its preparing process - Google Patents
Lugua polypeptides for injection and its preparing process Download PDFInfo
- Publication number
- CN100352496C CN100352496C CNB2004100136027A CN200410013602A CN100352496C CN 100352496 C CN100352496 C CN 100352496C CN B2004100136027 A CNB2004100136027 A CN B2004100136027A CN 200410013602 A CN200410013602 A CN 200410013602A CN 100352496 C CN100352496 C CN 100352496C
- Authority
- CN
- China
- Prior art keywords
- injection
- weight
- polypeptide
- make
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 98
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 92
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 92
- 239000007924 injection Substances 0.000 title claims abstract description 42
- 238000002347 injection Methods 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title abstract description 6
- 239000000243 solution Substances 0.000 claims abstract description 85
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 30
- 238000002360 preparation method Methods 0.000 claims abstract description 23
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 14
- 241000282994 Cervidae Species 0.000 claims abstract description 9
- 244000241257 Cucumis melo Species 0.000 claims abstract description 9
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 claims abstract description 9
- 241000282985 Cervus Species 0.000 claims description 51
- 241000219112 Cucumis Species 0.000 claims description 47
- 235000010071 Cucumis prophetarum Nutrition 0.000 claims description 47
- 238000005516 engineering process Methods 0.000 claims description 26
- 239000000047 product Substances 0.000 claims description 25
- 239000006228 supernatant Substances 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 20
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 18
- 238000007731 hot pressing Methods 0.000 claims description 18
- 229930195725 Mannitol Natural products 0.000 claims description 16
- 239000000594 mannitol Substances 0.000 claims description 16
- 235000010355 mannitol Nutrition 0.000 claims description 16
- 238000000108 ultra-filtration Methods 0.000 claims description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 239000012528 membrane Substances 0.000 claims description 12
- 240000001592 Amaranthus caudatus Species 0.000 claims description 8
- 235000009328 Amaranthus caudatus Nutrition 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 8
- 235000012735 amaranth Nutrition 0.000 claims description 8
- 239000004178 amaranth Substances 0.000 claims description 8
- 239000003610 charcoal Substances 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 5
- 239000003651 drinking water Substances 0.000 claims description 4
- 235000020188 drinking water Nutrition 0.000 claims description 4
- 239000008174 sterile solution Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 abstract description 10
- 229930013930 alkaloid Natural products 0.000 abstract description 4
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract description 4
- 235000018553 tannin Nutrition 0.000 abstract description 4
- 229920001864 tannin Polymers 0.000 abstract description 4
- 239000001648 tannin Substances 0.000 abstract description 4
- 208000003455 anaphylaxis Diseases 0.000 abstract description 2
- 201000008482 osteoarthritis Diseases 0.000 abstract description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract description 2
- 241000353135 Psenopsis anomala Species 0.000 abstract 2
- 235000009847 Cucumis melo var cantalupensis Nutrition 0.000 abstract 1
- 206010017076 Fracture Diseases 0.000 abstract 1
- 206010033425 Pain in extremity Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 239000013049 sediment Substances 0.000 description 12
- 239000008215 water for injection Substances 0.000 description 9
- 238000010255 intramuscular injection Methods 0.000 description 7
- 239000007927 intramuscular injection Substances 0.000 description 7
- 238000012856 packing Methods 0.000 description 7
- 239000008354 sodium chloride injection Substances 0.000 description 7
- 239000008227 sterile water for injection Substances 0.000 description 7
- 210000003462 vein Anatomy 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 206010067484 Adverse reaction Diseases 0.000 description 3
- 230000006838 adverse reaction Effects 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000004409 osteocyte Anatomy 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 238000011179 visual inspection Methods 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000004097 bone metabolism Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010061363 Skeletal injury Diseases 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000035194 endochondral ossification Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- -1 phosphonium ion Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Images
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100136027A CN100352496C (en) | 2004-03-04 | 2004-03-04 | Lugua polypeptides for injection and its preparing process |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100136027A CN100352496C (en) | 2004-03-04 | 2004-03-04 | Lugua polypeptides for injection and its preparing process |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1579542A CN1579542A (en) | 2005-02-16 |
CN100352496C true CN100352496C (en) | 2007-12-05 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100136027A Expired - Lifetime CN100352496C (en) | 2004-03-04 | 2004-03-04 | Lugua polypeptides for injection and its preparing process |
Country Status (1)
Country | Link |
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CN (1) | CN100352496C (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100363019C (en) * | 2005-10-09 | 2008-01-23 | 黑龙江迪龙制药有限公司 | Cervus and cucumis polypeptide injection composition and preparing method |
CN100382842C (en) * | 2006-05-31 | 2008-04-23 | 哈尔滨吉尔生物科技有限公司 | Orally administered cervus and cucumis polypeptide composition and preparation method thereof |
CN103040910B (en) * | 2012-12-17 | 2015-03-11 | 海南圣欣医药科技有限公司 | Cervus and cucumis polypeptide liposome injection |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1470256A (en) * | 2002-07-26 | 2004-01-28 | 哈尔滨誉衡药业有限公司 | Medicinal composition for promoting bone-fracture healing and bone-joint injure repairing |
-
2004
- 2004-03-04 CN CNB2004100136027A patent/CN100352496C/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1470256A (en) * | 2002-07-26 | 2004-01-28 | 哈尔滨誉衡药业有限公司 | Medicinal composition for promoting bone-fracture healing and bone-joint injure repairing |
Non-Patent Citations (2)
Title |
---|
药剂学 470.479,人民卫生出版社 2002 * |
鹿瓜多肽注射液 哈尔滨誉衡药业有限公司.第36届全国新特药会议 2002 * |
Also Published As
Publication number | Publication date |
---|---|
CN1579542A (en) | 2005-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication | ||
CI01 | Publication of corrected invention patent application |
Correction item: Reject Correct: delete False: Wrong announcement Number: 18 Page: 956 Volume: 23 |
|
ERR | Gazette correction |
Free format text: CORRECT: REJECTION; FROM: WRONG PUBLICATION TO: DELETION |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Heilongjiang Jiang Shi Pharmaceutical Co.,Ltd. Assignor: Jiang Weishi Contract fulfillment period: 2008.8.18 to 2018.8.18 Contract record no.: 2008230000029 Denomination of invention: Lugua polypeptides for injection and its preparing process Granted publication date: 20071205 License type: Exclusive license Record date: 20081009 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.8.18 TO 2018.8.18; CHANGE OF CONTRACT Name of requester: HEILONGJIANG JIANGSHI PHARMACEUTICAL CO., LTD. Effective date: 20081009 |
|
ASS | Succession or assignment of patent right |
Owner name: JIANG XIN Free format text: FORMER OWNER: JIANG WEISHI Effective date: 20110607 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110607 Address after: 150069 No. 2 Weihai Road, cottage economic and Technological Development Zone, Harbin, Heilongjiang Patentee after: Jiang Xin Address before: 150069 No. 2 Weihai Road, cottage economic and Technological Development Zone, Harbin, Heilongjiang Patentee before: Jiang Weishi |
|
EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Heilongjiang Jiang Shi Pharmaceutical Co.,Ltd. Assignor: Jiang Weishi Contract record no.: 2008230000029 Date of cancellation: 20111124 |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170505 Address after: 150069 No. 2 Weihai Road, cottage economic and Technological Development Zone, Harbin, Heilongjiang Patentee after: Heilongjiang Jiang Shi Pharmaceutical Co.,Ltd. Address before: 150069 No. 2 Weihai Road, cottage economic and Technological Development Zone, Harbin, Heilongjiang Patentee before: Jiang Xin |
|
CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20071205 |