CN100345553C - Manufacturing technique of acanthopanax root soft capsule - Google Patents
Manufacturing technique of acanthopanax root soft capsule Download PDFInfo
- Publication number
- CN100345553C CN100345553C CNB031115780A CN03111578A CN100345553C CN 100345553 C CN100345553 C CN 100345553C CN B031115780 A CNB031115780 A CN B031115780A CN 03111578 A CN03111578 A CN 03111578A CN 100345553 C CN100345553 C CN 100345553C
- Authority
- CN
- China
- Prior art keywords
- alcohol
- acanthopanax senticosus
- extracturm
- solution
- distilled water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 6
- 238000000034 method Methods 0.000 title description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 40
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003292 glue Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000012153 distilled water Substances 0.000 claims abstract description 12
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 11
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 108010010803 Gelatin Proteins 0.000 claims abstract description 6
- 229920000159 gelatin Polymers 0.000 claims abstract description 6
- 239000008273 gelatin Substances 0.000 claims abstract description 6
- 235000019322 gelatine Nutrition 0.000 claims abstract description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 6
- 238000010992 reflux Methods 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 20
- 239000002390 adhesive tape Substances 0.000 claims description 15
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 10
- YOBAEOGBNPPUQV-UHFFFAOYSA-N iron;trihydrate Chemical compound O.O.O.[Fe].[Fe] YOBAEOGBNPPUQV-UHFFFAOYSA-N 0.000 claims description 10
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 10
- 229910000831 Steel Inorganic materials 0.000 claims description 5
- 238000004026 adhesive bonding Methods 0.000 claims description 5
- 238000003556 assay Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000010419 fine particle Substances 0.000 claims description 5
- 239000007903 gelatin capsule Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 238000001802 infusion Methods 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 5
- 239000000155 melt Substances 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 238000005070 sampling Methods 0.000 claims description 5
- 239000010959 steel Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 6
- 239000006187 pill Substances 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 abstract description 2
- 241001632410 Eleutherococcus senticosus Species 0.000 abstract 7
- 239000000463 material Substances 0.000 abstract 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 abstract 3
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 abstract 3
- 238000001914 filtration Methods 0.000 abstract 2
- JAIFOOPJUZCBFA-UHFFFAOYSA-N C(C)O.C(C)OC(=O)C1=CC=C(O)C=C1 Chemical compound C(C)O.C(C)OC(=O)C1=CC=C(O)C=C1 JAIFOOPJUZCBFA-UHFFFAOYSA-N 0.000 abstract 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 abstract 1
- 238000009413 insulation Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 4
- 239000008279 sol Substances 0.000 description 4
- MBDOYVRWFFCFHM-SNAWJCMRSA-N (2E)-hexenal Chemical compound CCC\C=C\C=O MBDOYVRWFFCFHM-SNAWJCMRSA-N 0.000 description 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 2
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 2
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 229960004544 cortisone Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 229960002319 barbital Drugs 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 229960001076 chlorpromazine Drugs 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a production technology for preparing an acanthopanax senticosus soft capsule. Acanthopanax senticosus medicinal materials are soaked for 12 to 24 hours by 65 to 85 % of alcohol with the weight which is 5 to 8 times heavier than that of the acanthopanax senticosus medicinal materials; the reflux extraction of the acanthopanax senticosus medicinal materials and the alcohol is carried out for 10 to 15 hours, and the acanthopanax senticosus medicinal materials and the alcohol are filtrated; alcohol in a filtration solution is recovered, and the filtration solution is concentrated into extracturm for use; ethylparaben is dissolved in 90 to 99 % of alcohol; ferric oxide is put in distilled water with the weight which is 4 to 8 times heavier than that of the ferric oxide and ground into small particulates by a globe mill; gelatin, glycerol and distilled water are weighed and placed in a stainless jacketed pan for use; a ferric oxide serous solution and an ethylparaben ethanol alcohol solution are added to the extracturm under the condition of vacuum stirring, and the extracturm is uniformly melted; the melting extracturm is concentrated under reduced pressure until stated water content is achieved, and a vacuum pump is shut down; a glue solution is discharged and filtrated by a gauze bag, and the glue solution is placed in a heat insulation tank; a glue solution sample is taken, the water and the viscosity are measured, and after passing tests, the glue solution sample is retained for use; the pill preparation is carried out; the acanthopanax senticosus soft capsule produced through the present invention obtains large scale improvement, and the accurate curative effect of acanthopanax senticosus is maintained.
Description
Affiliated technical field
The present invention relates to a kind of production technology of Radix Et Caulis Acanthopanacis Senticosi soft capsule.
Background technology
At present, the finished medicines of market sale has Radix Et Caulis Acanthopanacis Senticosi tablet, and it is to adopt Radix Et Caulis Acanthopanacis Senticosi natural Chinese medicine plant, makes extractum through extraction, and granule is made in oven dry then, is the Radix Et Caulis Acanthopanacis Senticosi finished product behind the tabletting, and the above-mentioned practice, technology are comparatively backward, and human bioavailability is lower.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, a kind of soft capsule manufacturing technique method that can guarantee the good curative effect of Radix Et Caulis Acanthopanacis Senticosi medicine is provided.
In order to achieve the above object, the technical solution used in the present invention is:
The medicinal liquid preparation
A, the Radix Et Caulis Acanthopanacis Senticosi medical material was doubly measured the 65-85% soak with ethanol 12-24 hour with 5-8;
Filtered in b, reflux, extract, 10-15 hour;
C, filtrate recycling ethanol are condensed into extractum, and be standby.
Colloidal sol
D, ethyl hydroxybenzoate is dissolved in the ethanol of 90-99%;
In e, the distilled water that iron sesquioxide is doubly measured to 4-8, with ball mill grinding to fine particles;
F, take by weighing gelatin, glycerol, distilled water and put in the rustless steel jacketed pan, standby;
Under g, the vacuum stirring, add the iron sesquioxide serosity, ethyl hydroxybenzoate alcohol liquid melts evenly;
H, be evaporated to regulation moisture, close vacuum pump;
I, emit glue, filter, put in the heat-preserving container with gauze bag.
J, sampling and measuring moisture and viscosity, stand-by after the assay was approved.
Pill
K, glue are made adhesive tape through gluing cabinet, cooling drum;
L, medicinal liquid quantitatively inject between two layers of adhesive tape by the wedge infusion appliance;
M, nib flange make adhesive tape parcel medicinal liquid be pressed into soft gelatin capsule, promptly.
The advantage of invention is:
1, has replenishing QI to invigorate the spleen, the effect of tonifying the kidney for tranquilization.The central nervous system there is sedation, can prolongs the hexenal anesthesia duration, reduce the postanesthetic irritability of hexenal.On the electroencephalogram of rabbit, demonstrate the inhibitory action that can weaken chloral hydrate, barbital and chlorpromazine, and the central nervous system is had the tangible excitation of Radix Ginseng sample.Take to static and the rat of swimming after 15 minutes, do not see the cortisone hormones content in obvious increase epinephrine and the blood, but after 5 hours, then significantly increase the content of cortisone.Simultaneously can obviously increase the activity that cytotoxic T lymphocyte kills and wounds target cell, stimulate the effect of mouse boosting cell secreting leukocytes mesonium.
2, the Radix Et Caulis Acanthopanacis Senticosi soft capsule is adopted new technology, and the quality of the pharmaceutical preparations is greatly improved, and clinical application reduces greatly, has guaranteed to hold the definite curative effect of Radix Et Caulis Acanthopanacis Senticosi, and the Radix Et Caulis Acanthopanacis Senticosi soft capsule preparation is more stable, stores, transports convenient.This product is through toxicology test and stability experiment, and every index all meets the prescription of national drug quality management regulation.
The specific embodiment
Below embodiments of the invention are described in further detail.
Embodiment 1
The medicinal liquid preparation
A, with the Radix Et Caulis Acanthopanacis Senticosi medical material with 5 times of amount 65% soak with ethanol 12 hours;
B, reflux, extract, filtered in 10 hours;
C, filtrate recycling ethanol are condensed into extractum, and be standby.
Colloidal sol
A, ethyl hydroxybenzoate is dissolved in 90% the ethanol;
In b, the distilled water with iron sesquioxide to 4 times amount, with ball mill grinding to fine particles;
C, take by weighing gelatin, glycerol, distilled water and put in the rustless steel jacketed pan, standby;
Under d, the vacuum stirring, add the iron sesquioxide serosity, ethyl hydroxybenzoate alcohol liquid melts evenly;
E, be evaporated to regulation moisture, close vacuum pump;
F, emit glue, filter, put in the heat-preserving container with gauze bag.
G, sampling and measuring moisture and viscosity, stand-by after the assay was approved.
Pill
A, glue are made adhesive tape through gluing cabinet, cooling drum;
B, medicinal liquid quantitatively inject between two layers of adhesive tape by the wedge infusion appliance;
C, nib flange make adhesive tape parcel medicinal liquid be pressed into soft gelatin capsule, promptly.
Embodiment 2
The medicinal liquid preparation
A, with the Radix Et Caulis Acanthopanacis Senticosi medical material with 8 times of amount 85% soak with ethanol 24 hours;
B, reflux, extract, filtered in 15 hours;
C, filtrate recycling ethanol are condensed into extractum, and be standby.
Colloidal sol
A, ethyl hydroxybenzoate is dissolved in 99% the ethanol;
In b, the distilled water with iron sesquioxide to 8 times amount, with ball mill grinding to fine particles;
C, take by weighing gelatin, glycerol, distilled water and put in the rustless steel jacketed pan, standby;
Under d, the vacuum stirring, add the iron sesquioxide serosity, ethyl hydroxybenzoate alcohol liquid melts evenly;
E, be evaporated to regulation moisture, close vacuum pump;
F, emit glue, filter, put in the heat-preserving container with gauze bag.
G, sampling and measuring moisture and viscosity, stand-by after the assay was approved.
Pill
A, glue are made adhesive tape through gluing cabinet, cooling drum;
B, medicinal liquid quantitatively inject between two layers of adhesive tape by the wedge infusion appliance;
C, nib flange make adhesive tape parcel medicinal liquid be pressed into soft gelatin capsule, promptly.
Embodiment 3
The medicinal liquid preparation
A, with the Radix Et Caulis Acanthopanacis Senticosi medical material with 7 times of amount 75% soak with ethanol 20 hours;
B, reflux, extract, filtered in 12 hours;
C, filtrate recycling ethanol are condensed into extractum, and be standby.
Colloidal sol
A, ethyl hydroxybenzoate is dissolved in 95% the ethanol;
In b, the distilled water with iron sesquioxide to 6 times amount, with ball mill grinding to fine particles;
C, take by weighing gelatin, glycerol, distilled water and put in the rustless steel jacketed pan, standby;
Under d, the vacuum stirring, add the iron sesquioxide serosity, ethyl hydroxybenzoate alcohol liquid melts evenly;
E, be evaporated to regulation moisture, close vacuum pump;
F, emit glue, filter, put in the heat-preserving container with gauze bag.
G, sampling and measuring moisture and viscosity, stand-by after the assay was approved.
Pill
A, glue are made adhesive tape through gluing cabinet, cooling drum;
B, medicinal liquid quantitatively inject between two layers of adhesive tape by the wedge infusion appliance;
C, nib flange make adhesive tape parcel medicinal liquid be pressed into soft gelatin capsule, promptly.
Claims (1)
1. production technology of making the Radix Et Caulis Acanthopanacis Senticosi soft capsule is characterized in that:
The medicinal liquid preparation:
A. the Radix Et Caulis Acanthopanacis Senticosi medical material was doubly measured the 65-85% soak with ethanol 12-24 hour with 5-8;
B. filtered in reflux, extract, 10-15 hour;
C. filtrate recycling ethanol is condensed into extractum, and is standby;
D. ethyl hydroxybenzoate is dissolved in the ethanol of 90-99%;
E. in the distilled water that iron sesquioxide is doubly measured to 4-8, with ball mill grinding to fine particles;
F. take by weighing gelatin, glycerol, distilled water and put in the rustless steel jacketed pan, standby;
G. under the vacuum stirring, add the iron sesquioxide serosity, ethyl hydroxybenzoate alcohol liquid melts evenly;
H. be evaporated to regulation moisture, close vacuum pump;
I. emit glue, filter, put in the heat-preserving container with gauze bag;
J. sampling and measuring moisture and viscosity are stand-by after the assay was approved;
Pill
K. glue is made adhesive tape through gluing cabinet, cooling drum;
L. medicinal liquid quantitatively injects between two layers of adhesive tape by the wedge infusion appliance;
M. the nib flange makes adhesive tape parcel medicinal liquid be pressed into soft gelatin capsule, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031115780A CN100345553C (en) | 2003-04-28 | 2003-04-28 | Manufacturing technique of acanthopanax root soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031115780A CN100345553C (en) | 2003-04-28 | 2003-04-28 | Manufacturing technique of acanthopanax root soft capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1541661A CN1541661A (en) | 2004-11-03 |
| CN100345553C true CN100345553C (en) | 2007-10-31 |
Family
ID=34319803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031115780A Expired - Fee Related CN100345553C (en) | 2003-04-28 | 2003-04-28 | Manufacturing technique of acanthopanax root soft capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100345553C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102056630B (en) * | 2008-06-18 | 2013-03-13 | 株式会社资生堂 | Stabilizer for lymph vessel |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090169A (en) * | 1993-01-11 | 1994-08-03 | 佛山友联医药发展有限公司 | Yuyou pellet and preparation method thereof |
-
2003
- 2003-04-28 CN CNB031115780A patent/CN100345553C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090169A (en) * | 1993-01-11 | 1994-08-03 | 佛山友联医药发展有限公司 | Yuyou pellet and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1541661A (en) | 2004-11-03 |
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|---|---|---|---|
| C06 | Publication | ||
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
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Effective date of registration: 20090116 Address after: Taiping Road, Zhaodong city of Heilongjiang Province, No. 34 Heilongjiang Dilong pharmaceutical Limited by Share Ltd Patentee after: Heilongjiang Fuhe Huaxing Pharmaceutical Group Co., Ltd. Address before: Taiping Road, Zhaodong city of Heilongjiang Province, No. 34 Heilongjiang Dilong pharmaceutical Limited by Share Ltd Patentee before: Wu Guangyan |
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| ASS | Succession or assignment of patent right |
Owner name: HEILONGJIANG FUHEHUAXING PHARMACUETICAL GROUP CO., Free format text: FORMER OWNER: WU GUANGYAN Effective date: 20090116 |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20071031 Termination date: 20170428 |