CL2021000973A1 - Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen. - Google Patents

Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen.

Info

Publication number
CL2021000973A1
CL2021000973A1 CL2021000973A CL2021000973A CL2021000973A1 CL 2021000973 A1 CL2021000973 A1 CL 2021000973A1 CL 2021000973 A CL2021000973 A CL 2021000973A CL 2021000973 A CL2021000973 A CL 2021000973A CL 2021000973 A1 CL2021000973 A1 CL 2021000973A1
Authority
CL
Chile
Prior art keywords
pyrimidonyl
preparation
pharmaceutical compositions
compositions containing
new amino
Prior art date
Application number
CL2021000973A
Other languages
English (en)
Inventor
András Kotschy
Olivier Geneste
James Brooke Murray
Didier Demarles
Csaba Wéber
Andrea Fiumana
Attila Vasas
Balázs Molnár
Árpád Kiss
Alba Macias
Lisa Ivanschitz
Kristóf Hegedüs
Péter Spránitz
Tibor SOÓS
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Publication of CL2021000973A1 publication Critical patent/CL2021000973A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuestos de fórmula (I): (I) en donde R1, R2, R3, R4, R5, n y Q son como se definen en la descripción. Medicamentos.
CL2021000973A 2018-10-19 2021-04-16 Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen. CL2021000973A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18306377 2018-10-19
EP19305936 2019-07-12

Publications (1)

Publication Number Publication Date
CL2021000973A1 true CL2021000973A1 (es) 2021-11-19

Family

ID=68234009

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021000973A CL2021000973A1 (es) 2018-10-19 2021-04-16 Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen.

Country Status (24)

Country Link
US (1) US20210355106A1 (es)
EP (1) EP3866930A1 (es)
JP (1) JP2022505122A (es)
KR (1) KR20210081371A (es)
CN (1) CN113038990A (es)
AU (1) AU2019360391A1 (es)
BR (1) BR112021006714A2 (es)
CA (1) CA3116089A1 (es)
CL (1) CL2021000973A1 (es)
CO (1) CO2021004553A2 (es)
CR (1) CR20210173A (es)
DO (1) DOP2021000063A (es)
EC (1) ECSP21024078A (es)
IL (1) IL282218A (es)
JO (1) JOP20210063A1 (es)
MA (1) MA53900A (es)
MX (1) MX2021004379A (es)
NI (1) NI202100024A (es)
PE (1) PE20211649A1 (es)
PH (1) PH12021550788A1 (es)
SG (1) SG11202103279RA (es)
TW (1) TW202028188A (es)
UY (1) UY38423A (es)
WO (1) WO2020079205A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11999698B2 (en) 2019-03-11 2024-06-04 Inflarx Gmbh Fused piperidinyl bicyclic and related compounds as modulators of C5a receptor

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021123051A1 (en) 2019-12-20 2021-06-24 Bayer Aktiengesellschaft Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof
CN114507163A (zh) * 2020-11-16 2022-05-17 尚科生物医药（上海）有限公司 一种制备2-氟-5-甲氧基苯磺酰氯的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10654849B2 (en) * 2016-06-10 2020-05-19 Les Laboratoires Servier (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
FR3052452B1 (fr) * 2016-06-10 2018-06-22 Les Laboratoires Servier Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB201617758D0 (en) * 2016-10-20 2016-12-07 Almac Discovery Limited Pharmaceutical compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11999698B2 (en) 2019-03-11 2024-06-04 Inflarx Gmbh Fused piperidinyl bicyclic and related compounds as modulators of C5a receptor

Also Published As

Publication number Publication date
CN113038990A (zh) 2021-06-25
MX2021004379A (es) 2021-06-04
SG11202103279RA (en) 2021-04-29
CO2021004553A2 (es) 2021-04-30
JP2022505122A (ja) 2022-01-14
ECSP21024078A (es) 2021-05-31
JOP20210063A1 (ar) 2023-01-30
KR20210081371A (ko) 2021-07-01
PH12021550788A1 (en) 2021-10-18
US20210355106A1 (en) 2021-11-18
IL282218A (en) 2021-05-31
AU2019360391A1 (en) 2021-05-13
PE20211649A1 (es) 2021-08-24
TW202028188A (zh) 2020-08-01
DOP2021000063A (es) 2021-08-31
CA3116089A1 (en) 2020-04-23
BR112021006714A2 (pt) 2021-07-27
WO2020079205A1 (en) 2020-04-23
CR20210173A (es) 2021-05-11
UY38423A (es) 2021-02-26
MA53900A (fr) 2022-01-26
EP3866930A1 (en) 2021-08-25
NI202100024A (es) 2021-08-24

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