CL2019003420A1 - Compositions and methods for decreasing the expression of tau, useful for treating diseases associated with tau. (divisional request 201801652) - Google Patents

Compositions and methods for decreasing the expression of tau, useful for treating diseases associated with tau. (divisional request 201801652)

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Publication number
CL2019003420A1
CL2019003420A1 CL2019003420A CL2019003420A CL2019003420A1 CL 2019003420 A1 CL2019003420 A1 CL 2019003420A1 CL 2019003420 A CL2019003420 A CL 2019003420A CL 2019003420 A CL2019003420 A CL 2019003420A CL 2019003420 A1 CL2019003420 A1 CL 2019003420A1
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Chile
Prior art keywords
tau
protein
compositions
methods
expression
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CL2019003420A
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Spanish (es)
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Ofengeim Manuela Polydoro
Jan Weiler
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Novartis Ag
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Publication of CL2019003420A1 publication Critical patent/CL2019003420A1/en

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Abstract

SE PROPORCIONAN EN ESTA SOLICITUD COMPOSICIONES Y MÉTODOS PARA DISMINUIR LA EXPRESIÓN DE PROTEÍNA Y ARNM TAU. ESTAS COMPOSICIONES Y MÉTODOS SON ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS RELACIONADOS CON TAU. PARTICULARMENTE, SE PROPORCIONAN EN LA PRESENTE SOLICITUD OLIGONUCLEÓTIDOS ANTISENTIDO QUE SE DIRIGEN A LA PROTEÍNA TAU ASOCIADA A MICROTÚBULO HUMANA (MAPT, CONFORME A SUS SIGLAS EN INGLÉS), COMPOSICIONES QUE COMPRENDEN LOS OLIGONUCLEÓTIDOS ANTISENTIDO, Y MÉTODOS PARA DISMINUIR LA EXPRESIÓN DE PROTEÍNA Y ARNM DE TAU USANDO ESTOS OLIGONUCLEÓTIDOS ANTISENTIDO. LAS COMPOSICIONES Y LOS MÉTODOS PROPORCIONADOS EN ESTE DOCUMENTO SON ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS A TAU.COMPOSITIONS AND METHODS TO DECREASE THE EXPRESSION OF PROTEIN AND TAU mRNA ARE PROVIDED IN THIS APPLICATION. THESE COMPOSITIONS AND METHODS ARE USEFUL IN THE TREATMENT OF TAU-RELATED DISEASES AND DISORDERS. PARTICULARLY, IN THIS APPLICATION, ANTI-SENSE OLIGONUCLEOTIDES ARE PROVIDED THAT TARGET THE TAU PROTEIN ASSOCIATED WITH THE HUMAN MICROTUBE (MAPT, ACCORDING TO ITS ACRONYMS IN ENGLISH), COMPOSITIONS THAT INCLUDE THE PROTEIN OF THE PROTEIN ASSOCIATED WITH THE HUMAN MICROTUBLE (MAPT, ACCORDING TO ITS ACRONYM IN ENGLISH), COMPOSITIONS THAT INCLUDE THE PROTEIN OF THE ANTI-PRINTED OLIGONUCLEOTIDE, AND THE EXPRESSED PROTEIN, AND THE EXPRESSED PROTEIN OF THE PROTEIN, AND THE EXPRESSION OF THE PROTEIN OF ANTI-PRINTED MISCELLANEOUS PROTEIN. TAU USING THESE ANTI-SENSE OLIGONUCLEOTIDES. THE COMPOSITIONS AND METHODS PROVIDED IN THIS DOCUMENT ARE USEFUL IN THE TREATMENT OF DISEASES ASSOCIATED WITH TAU.

CL2019003420A 2015-12-21 2019-11-25 Compositions and methods for decreasing the expression of tau, useful for treating diseases associated with tau. (divisional request 201801652) CL2019003420A1 (en)

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US201562270165P 2015-12-21 2015-12-21

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CL2018001652A CL2018001652A1 (en) 2015-12-21 2018-06-18 Compositions and methods to reduce tau expression
CL2019000149A CL2019000149A1 (en) 2015-12-21 2019-01-18 Compositions and methods to reduce the expression of tau, useful for treating diseases associated with tau. (divisional application 201801652)
CL2019003420A CL2019003420A1 (en) 2015-12-21 2019-11-25 Compositions and methods for decreasing the expression of tau, useful for treating diseases associated with tau. (divisional request 201801652)

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CL2018001652A CL2018001652A1 (en) 2015-12-21 2018-06-18 Compositions and methods to reduce tau expression
CL2019000149A CL2019000149A1 (en) 2015-12-21 2019-01-18 Compositions and methods to reduce the expression of tau, useful for treating diseases associated with tau. (divisional application 201801652)

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