CL2018002333A1 - Virus recombinante de la enfermedad de newcastle que expresa una proteína inmunomoduladora como adyuvante molecular. - Google Patents
Virus recombinante de la enfermedad de newcastle que expresa una proteína inmunomoduladora como adyuvante molecular.Info
- Publication number
- CL2018002333A1 CL2018002333A1 CL2018002333A CL2018002333A CL2018002333A1 CL 2018002333 A1 CL2018002333 A1 CL 2018002333A1 CL 2018002333 A CL2018002333 A CL 2018002333A CL 2018002333 A CL2018002333 A CL 2018002333A CL 2018002333 A1 CL2018002333 A1 CL 2018002333A1
- Authority
- CL
- Chile
- Prior art keywords
- newcastle disease
- expresses
- proposal
- post
- recombinant virus
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 208000010359 Newcastle Disease Diseases 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title abstract 2
- 239000002671 adjuvant Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000036755 cellular response Effects 0.000 abstract 1
- 230000008348 humoral response Effects 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/17—Newcastle disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A VIRUS DE LA ENFERMEDAD DE NEWCASTLE RECOMBINANTES (NDVR´S), QUE LLEVAN INSERTA UNA UNIDAD TRANSCRIPCIONAL AJENA A SU GENOMA, LA CUAL CODIFICA PARA LA SÍNTESIS DE PROTEÍNAS INMUNOMODULADORAS. ESTOS SISTEMAS OFRECEN EXCELENTES RESULTADOS DE PROTECCIÓN Y DISMINUYE SIGNIFICATIVAMENTE LA CARGA VIRAL EXCRETADA (POST-VACUNACIÓN Y POST-DESAFÍO) EN AVES INMUNIZADAS VARIAS SEMANAS DESPUÉS DE SER DESAFIADAS CON UNA CEPA VELOGÉNICA DEL VIRUS DE NEWCASTLE. ADICIONALMENTE, DICHAS VACUNAS PERMITEN LA PROTECCIÓN DE AVES CONTRA OTROS AGENTES PATÓGENOS DURANTE UN LARGO PERIODO DE TIEMPO YA QUE INDUCEN UN AUMENTO DE LOS NIVELES DE LAS PROTEÍNAS INMUNOMODULADORAS, LO QUE SE TRADUCE EN UNA POTENCIACIÓN DE LA RESPUESTA INMUNE DEL HOSPEDERO Y LA PROMOCIÓN DE UNA EFICIENTE RESPUESTA HUMORAL Y CELULAR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2016002399A MX2016002399A (es) | 2016-02-24 | 2016-02-24 | Virus recombinante de la enfermedad de newcastle que expresa una proteina inmunomoduladora como adyuvante molecular. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018002333A1 true CL2018002333A1 (es) | 2019-01-11 |
Family
ID=59685995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018002333A CL2018002333A1 (es) | 2016-02-24 | 2018-08-14 | Virus recombinante de la enfermedad de newcastle que expresa una proteína inmunomoduladora como adyuvante molecular. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190134188A1 (es) |
| CN (1) | CN109195613A (es) |
| CL (1) | CL2018002333A1 (es) |
| MX (1) | MX2016002399A (es) |
| PE (1) | PE20190222A1 (es) |
| WO (1) | WO2017145096A2 (es) |
-
2016
- 2016-02-24 MX MX2016002399A patent/MX2016002399A/es unknown
-
2017
- 2017-02-24 WO PCT/IB2017/051053 patent/WO2017145096A2/es active Application Filing
- 2017-02-24 CN CN201780025360.9A patent/CN109195613A/zh active Pending
- 2017-02-24 US US16/079,975 patent/US20190134188A1/en not_active Abandoned
- 2017-02-24 PE PE2018001566A patent/PE20190222A1/es unknown
-
2018
- 2018-08-14 CL CL2018002333A patent/CL2018002333A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190134188A1 (en) | 2019-05-09 |
| PE20190222A1 (es) | 2019-02-13 |
| WO2017145096A3 (es) | 2017-11-09 |
| WO2017145096A2 (es) | 2017-08-31 |
| MX2016002399A (es) | 2017-08-23 |
| CN109195613A (zh) | 2019-01-11 |
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