CL2016000025A1 - Volasertib en combinación con azacitidina para el tratamiento de leucemia mieloide aguda y síndrome mielodisplásico. - Google Patents

Volasertib en combinación con azacitidina para el tratamiento de leucemia mieloide aguda y síndrome mielodisplásico.

Info

Publication number
CL2016000025A1
CL2016000025A1 CL2016000025A CL2016000025A CL2016000025A1 CL 2016000025 A1 CL2016000025 A1 CL 2016000025A1 CL 2016000025 A CL2016000025 A CL 2016000025A CL 2016000025 A CL2016000025 A CL 2016000025A CL 2016000025 A1 CL2016000025 A1 CL 2016000025A1
Authority
CL
Chile
Prior art keywords
volasertib
azacitidine
treatment
combination
myeloid leukemia
Prior art date
Application number
CL2016000025A
Other languages
English (en)
Inventor
Dorothea Rudolph
Verges Maria Del Roser Calvo
Tillmann Taube
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51228430&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016000025(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2016000025A1 publication Critical patent/CL2016000025A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CL2016000025A 2013-07-26 2016-01-07 Volasertib en combinación con azacitidina para el tratamiento de leucemia mieloide aguda y síndrome mielodisplásico. CL2016000025A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361858804P 2013-07-26 2013-07-26

Publications (1)

Publication Number Publication Date
CL2016000025A1 true CL2016000025A1 (es) 2016-09-30

Family

ID=51228430

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016000025A CL2016000025A1 (es) 2013-07-26 2016-01-07 Volasertib en combinación con azacitidina para el tratamiento de leucemia mieloide aguda y síndrome mielodisplásico.

Country Status (12)

Country Link
US (3) US20150031643A1 (es)
EP (1) EP3024488A1 (es)
JP (1) JP2016525531A (es)
KR (1) KR20160035067A (es)
CN (1) CN105407923A (es)
AU (1) AU2014295019A1 (es)
CA (1) CA2919296A1 (es)
CL (1) CL2016000025A1 (es)
EA (1) EA201600134A1 (es)
MX (1) MX2016001087A (es)
PH (1) PH12016500083A1 (es)
WO (1) WO2015011235A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3070878A1 (en) * 2017-08-01 2019-02-07 Deutsches Krebsforschungszentrum Combination of midh1 inhibitors and dna hypomethylating agents (hma)
CN111629725A (zh) * 2018-01-25 2020-09-04 勃林格殷格翰国际有限公司 急性骨髓性白血病的组合治疗

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060058311A1 (en) * 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US20060063735A1 (en) * 2004-09-17 2006-03-23 Supergen, Inc. Salts of 5-azacytidine
US20070117776A1 (en) * 2005-11-04 2007-05-24 John Lyons Low Dose Therapy Of DNA Methylation Inhibitors
US9358233B2 (en) * 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
GEP20196940B (en) * 2011-11-03 2019-01-10 Millennium Pharm Inc Administration d’un inhibiteur d’enzyme activant nedd8 et agent d’hypométhylation

Also Published As

Publication number Publication date
KR20160035067A (ko) 2016-03-30
US20170157158A1 (en) 2017-06-08
EP3024488A1 (en) 2016-06-01
JP2016525531A (ja) 2016-08-25
US20150031643A1 (en) 2015-01-29
MX2016001087A (es) 2016-04-20
EA201600134A1 (ru) 2016-07-29
CA2919296A1 (en) 2015-01-29
US20190240242A1 (en) 2019-08-08
WO2015011235A1 (en) 2015-01-29
CN105407923A (zh) 2016-03-16
PH12016500083A1 (en) 2016-04-18
AU2014295019A1 (en) 2015-12-17

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