CL2015001814A1 - Composición que comprende al menos un macrólido antibiótico útil para tratar enfermedad genética neurodegenerativa o del neurodesarrollo asociada con una mutación sin sentido; método para tratar dicha enfermedad; método para identificar macrólido antibiótico; ácido nucleíco útil para identificar macrólido antibiótico; vector; y célula hospedadora. - Google Patents
Composición que comprende al menos un macrólido antibiótico útil para tratar enfermedad genética neurodegenerativa o del neurodesarrollo asociada con una mutación sin sentido; método para tratar dicha enfermedad; método para identificar macrólido antibiótico; ácido nucleíco útil para identificar macrólido antibiótico; vector; y célula hospedadora.Info
- Publication number
- CL2015001814A1 CL2015001814A1 CL2015001814A CL2015001814A CL2015001814A1 CL 2015001814 A1 CL2015001814 A1 CL 2015001814A1 CL 2015001814 A CL2015001814 A CL 2015001814A CL 2015001814 A CL2015001814 A CL 2015001814A CL 2015001814 A1 CL2015001814 A1 CL 2015001814A1
- Authority
- CL
- Chile
- Prior art keywords
- antibiotic macrolide
- useful
- macrolide
- neurodevelopmental
- treat
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261745651P | 2012-12-24 | 2012-12-24 | |
US201361762900P | 2013-02-10 | 2013-02-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015001814A1 true CL2015001814A1 (es) | 2015-10-23 |
Family
ID=49956287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015001814A CL2015001814A1 (es) | 2012-12-24 | 2015-06-23 | Composición que comprende al menos un macrólido antibiótico útil para tratar enfermedad genética neurodegenerativa o del neurodesarrollo asociada con una mutación sin sentido; método para tratar dicha enfermedad; método para identificar macrólido antibiótico; ácido nucleíco útil para identificar macrólido antibiótico; vector; y célula hospedadora. |
Country Status (16)
Country | Link |
---|---|
US (1) | US10987370B2 (es) |
EP (1) | EP2934548A2 (es) |
JP (1) | JP2016503051A (es) |
KR (1) | KR20150098675A (es) |
AU (1) | AU2013368805A1 (es) |
BR (1) | BR112015015075A2 (es) |
CA (1) | CA2894992A1 (es) |
CL (1) | CL2015001814A1 (es) |
CR (1) | CR20150381A (es) |
EA (1) | EA201500699A1 (es) |
IL (1) | IL239467A0 (es) |
MD (1) | MD20150056A2 (es) |
MX (1) | MX2015008146A (es) |
PE (1) | PE20151296A1 (es) |
SG (1) | SG11201504933WA (es) |
WO (1) | WO2014102778A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2014102778A2 (en) | 2012-12-24 | 2014-07-03 | Ramot At Tel-Aviv University Ltd. | Agents for treating genetic diseases resulting from nonsense mutations, and methods for identifying the same |
WO2015192198A1 (en) * | 2014-06-19 | 2015-12-23 | The Hospital For Sick Children | Treatment of peroxisome biogenesis disorder |
WO2015198329A1 (en) | 2014-06-25 | 2015-12-30 | Bio Blast Pharma Ltd. | Injectable formulations for intrathecal administration of antibiotic agents |
WO2017010382A1 (ja) * | 2015-07-14 | 2017-01-19 | 国立大学法人大阪大学 | 筋強直性ジストロフィー治療薬 |
CA3005434A1 (en) | 2015-11-16 | 2017-05-26 | Ohio State Innovation Foundation | Methods and compositions for treating disorders and diseases using survival motor neuron (smn) protein |
US11213537B2 (en) | 2017-09-18 | 2022-01-04 | Friedrich Miescher Institute For Biomedical Research | Inhibition of autism spectrum disorder using ribosomal read-through compounds |
WO2023235380A1 (en) * | 2022-06-01 | 2023-12-07 | Zikani Therapeutics, Inc. | Macrolides for treating genetic diseases |
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US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
IT1176332B (it) | 1984-06-27 | 1987-08-18 | Erba Farmitalia | Procedimento per al preparazione di peptidi |
CA2127578A1 (en) | 1993-07-08 | 1995-01-09 | Keiichi Ajito | 16-membered macrolide derivatives and process for producing the same |
AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
WO2000071557A1 (en) | 1999-05-24 | 2000-11-30 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
US6458538B1 (en) | 1999-12-14 | 2002-10-01 | Ptc Therapeutics, Inc. | Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay |
US6455680B1 (en) | 2000-12-21 | 2002-09-24 | Abbott Laboratories | Methods utilizing aryl thioimines in synthesis of erythromycin derivatives |
US20030013692A1 (en) | 2001-01-19 | 2003-01-16 | Gullans Steven R. | Methods of treating neurological disorders |
CA2490062A1 (en) * | 2002-05-23 | 2003-12-04 | Activbiotics, Inc. | Methods of treating bacterial infections and diseases associated therewith |
US7291461B2 (en) | 2002-06-21 | 2007-11-06 | Ptc Therapeutics, Inc. | Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay |
US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
US7786151B2 (en) * | 2004-01-09 | 2010-08-31 | Kinopharma, Inc. | Therapeutic composition of treating abnormal splicing caused by the excessive kinase induction |
US20070072815A1 (en) * | 2004-05-04 | 2007-03-29 | Kmiec Eric B | Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration |
WO2005118610A2 (en) * | 2004-06-01 | 2005-12-15 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
EP3121176A1 (en) * | 2004-06-08 | 2017-01-25 | Families of Spinal Muscular Atrophy | 2,4-diaminoquinazolines for the treatment of spinal muscular atrophy |
US20060018921A1 (en) * | 2004-07-16 | 2006-01-26 | Baylor College Of Medicine | Histone deacetylase inhibitors and cognitive applications |
CA2595159A1 (en) * | 2005-01-13 | 2006-07-20 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
US20080221150A1 (en) | 2005-08-13 | 2008-09-11 | Shacka John J | Prevention of Neurodegeneration by Macrolide Antibiotics |
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US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
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EP2600865B1 (en) | 2010-08-05 | 2018-11-14 | Université de Lille | Compound useful for the treatment of nonsense-mutation-mediated diseases and pharmaceutical composition comprising said compound |
EP3702460A1 (en) * | 2010-11-12 | 2020-09-02 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
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EP2797592B1 (en) * | 2011-12-30 | 2019-08-28 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
EP2809322B9 (en) * | 2012-01-26 | 2019-10-30 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
SG10201609188WA (en) * | 2012-02-10 | 2016-12-29 | Ptc Therapeutics Inc | Compounds for treating spinal muscular atrophy |
WO2013130689A1 (en) * | 2012-03-01 | 2013-09-06 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
US9914722B2 (en) * | 2012-03-23 | 2018-03-13 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
WO2014044972A1 (fr) * | 2012-09-19 | 2014-03-27 | Centre National De La Recherche Scientifique - Cnrs - | Traitement des neuronopathies motrices |
WO2014102778A2 (en) | 2012-12-24 | 2014-07-03 | Ramot At Tel-Aviv University Ltd. | Agents for treating genetic diseases resulting from nonsense mutations, and methods for identifying the same |
-
2013
- 2013-12-24 WO PCT/IL2013/051058 patent/WO2014102778A2/en active Application Filing
- 2013-12-24 EP EP13821190.9A patent/EP2934548A2/en not_active Withdrawn
- 2013-12-24 CA CA2894992A patent/CA2894992A1/en not_active Abandoned
- 2013-12-24 EA EA201500699A patent/EA201500699A1/ru unknown
- 2013-12-24 BR BR112015015075A patent/BR112015015075A2/pt not_active IP Right Cessation
- 2013-12-24 KR KR1020157020037A patent/KR20150098675A/ko not_active Application Discontinuation
- 2013-12-24 SG SG11201504933WA patent/SG11201504933WA/en unknown
- 2013-12-24 AU AU2013368805A patent/AU2013368805A1/en not_active Abandoned
- 2013-12-24 JP JP2015548887A patent/JP2016503051A/ja active Pending
- 2013-12-24 MD MDA20150056A patent/MD20150056A2/ro not_active Application Discontinuation
- 2013-12-24 MX MX2015008146A patent/MX2015008146A/es unknown
- 2013-12-24 US US14/652,368 patent/US10987370B2/en active Active
- 2013-12-24 PE PE2015001190A patent/PE20151296A1/es not_active Application Discontinuation
-
2015
- 2015-06-17 IL IL239467A patent/IL239467A0/en unknown
- 2015-06-23 CL CL2015001814A patent/CL2015001814A1/es unknown
- 2015-07-20 CR CR20150381A patent/CR20150381A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL239467A0 (en) | 2015-07-30 |
US20150328247A1 (en) | 2015-11-19 |
JP2016503051A (ja) | 2016-02-01 |
AU2013368805A1 (en) | 2015-08-13 |
WO2014102778A2 (en) | 2014-07-03 |
SG11201504933WA (en) | 2015-07-30 |
MD20150056A2 (ro) | 2015-09-30 |
CR20150381A (es) | 2015-09-09 |
US10987370B2 (en) | 2021-04-27 |
BR112015015075A2 (pt) | 2019-01-15 |
WO2014102778A3 (en) | 2014-08-21 |
CA2894992A1 (en) | 2014-07-03 |
PE20151296A1 (es) | 2015-10-15 |
MX2015008146A (es) | 2016-01-20 |
KR20150098675A (ko) | 2015-08-28 |
EP2934548A2 (en) | 2015-10-28 |
EA201500699A1 (ru) | 2015-12-30 |
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