CL2013000085A1 - Sal cristalina de (s)-3-[(s)-1-(4-clorofenoxi)-2-metilpropil]pirrolidina y acido clorhidrico en una relacion molar 1:1; composicion farmaceutica; proceso de preparacion; y su uso para el tratamiento del dolor, un trastorno depresivo, un trastorno afectivo, obesidad, entre otras. - Google Patents
Sal cristalina de (s)-3-[(s)-1-(4-clorofenoxi)-2-metilpropil]pirrolidina y acido clorhidrico en una relacion molar 1:1; composicion farmaceutica; proceso de preparacion; y su uso para el tratamiento del dolor, un trastorno depresivo, un trastorno afectivo, obesidad, entre otras.Info
- Publication number
- CL2013000085A1 CL2013000085A1 CL2013000085A CL2013000085A CL2013000085A1 CL 2013000085 A1 CL2013000085 A1 CL 2013000085A1 CL 2013000085 A CL2013000085 A CL 2013000085A CL 2013000085 A CL2013000085 A CL 2013000085A CL 2013000085 A1 CL2013000085 A1 CL 2013000085A1
- Authority
- CL
- Chile
- Prior art keywords
- chlorophenoxy
- methylpropyl
- pyrrolidine
- obesity
- pain
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 4
- LZLQEDMHCMNYFK-FZMZJTMJSA-N (3s)-3-[(1s)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine Chemical compound O([C@@H](C(C)C)[C@@H]1CNCC1)C1=CC=C(Cl)C=C1 LZLQEDMHCMNYFK-FZMZJTMJSA-N 0.000 title abstract 2
- 208000017194 Affective disease Diseases 0.000 title abstract 2
- 208000020401 Depressive disease Diseases 0.000 title abstract 2
- 208000019022 Mood disease Diseases 0.000 title abstract 2
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36277310P | 2010-07-09 | 2010-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013000085A1 true CL2013000085A1 (es) | 2013-03-15 |
Family
ID=44510052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013000085A CL2013000085A1 (es) | 2010-07-09 | 2013-01-09 | Sal cristalina de (s)-3-[(s)-1-(4-clorofenoxi)-2-metilpropil]pirrolidina y acido clorhidrico en una relacion molar 1:1; composicion farmaceutica; proceso de preparacion; y su uso para el tratamiento del dolor, un trastorno depresivo, un trastorno afectivo, obesidad, entre otras. |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8163794B2 (enExample) |
| EP (1) | EP2590941A1 (enExample) |
| JP (2) | JP5823512B2 (enExample) |
| KR (1) | KR20130041916A (enExample) |
| CN (1) | CN103038211B (enExample) |
| AR (1) | AR083512A1 (enExample) |
| AU (1) | AU2011276416B2 (enExample) |
| BR (1) | BR112013000602A2 (enExample) |
| CA (1) | CA2803090A1 (enExample) |
| CL (1) | CL2013000085A1 (enExample) |
| CO (1) | CO6680604A2 (enExample) |
| IL (1) | IL223584A0 (enExample) |
| MX (1) | MX2013000334A (enExample) |
| NZ (1) | NZ605490A (enExample) |
| PH (1) | PH12013500051A1 (enExample) |
| RU (1) | RU2013105479A (enExample) |
| SG (1) | SG186789A1 (enExample) |
| TW (1) | TW201206882A (enExample) |
| WO (1) | WO2012006205A1 (enExample) |
| ZA (1) | ZA201300154B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102471258A (zh) * | 2009-07-13 | 2012-05-23 | 施万制药 | 3-苯氧基甲基吡咯烷化合物 |
| AU2011276416B2 (en) * | 2010-07-09 | 2015-04-02 | Theravance Biopharma R&D Ip, Llc | Crystalline form of a 3-phenoxymethylpyrrolidine compound |
| US11013340B2 (en) | 2018-05-23 | 2021-05-25 | L&P Property Management Company | Pocketed spring assembly having dimensionally stabilizing substrate |
| US12369722B2 (en) | 2018-05-23 | 2025-07-29 | L&P Property Management Company | Method of disassembling pocketed spring assembly with dimensionally stabilizing substrate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020151712A1 (en) | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| DE60119047D1 (de) * | 2000-08-31 | 2006-06-01 | Pfizer | Phenoxyphenylheterozyklen als Serotonin-Wiederaufnahmehemmer |
| WO2005092835A1 (en) * | 2004-03-05 | 2005-10-06 | Eli Lilly And Company | Pharmaceutical compounds |
| CA2661187A1 (en) * | 2006-08-23 | 2008-02-28 | Pfizer Products Inc. | Piperidine derivatives |
| EP2155668A2 (en) * | 2007-06-08 | 2010-02-24 | Arena Pharmaceuticals, Inc. | Crystalline forms of (r)-1-{2-ý4'- (3-methoxy-propane-1- sulfonyl)-biphenyl-4-yl¨-ethyl}-2-methyl-pyrrolidine, and compositions, and methods related thereto |
| JP5405571B2 (ja) * | 2008-07-24 | 2014-02-05 | セラヴァンス， インコーポレーテッド | ３−（フェノキシフェニルメチル）ピロリジン化合物 |
| US20100267743A1 (en) * | 2009-04-15 | 2010-10-21 | Stangeland Eric L | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| CN102471258A (zh) | 2009-07-13 | 2012-05-23 | 施万制药 | 3-苯氧基甲基吡咯烷化合物 |
| AU2011276416B2 (en) * | 2010-07-09 | 2015-04-02 | Theravance Biopharma R&D Ip, Llc | Crystalline form of a 3-phenoxymethylpyrrolidine compound |
-
2011
- 2011-06-30 AU AU2011276416A patent/AU2011276416B2/en not_active Ceased
- 2011-06-30 KR KR1020137001583A patent/KR20130041916A/ko not_active Withdrawn
- 2011-06-30 NZ NZ605490A patent/NZ605490A/en not_active IP Right Cessation
- 2011-06-30 JP JP2013518688A patent/JP5823512B2/ja not_active Expired - Fee Related
- 2011-06-30 WO PCT/US2011/042518 patent/WO2012006205A1/en not_active Ceased
- 2011-06-30 CA CA2803090A patent/CA2803090A1/en not_active Abandoned
- 2011-06-30 SG SG2012094348A patent/SG186789A1/en unknown
- 2011-06-30 MX MX2013000334A patent/MX2013000334A/es active IP Right Grant
- 2011-06-30 US US13/173,204 patent/US8163794B2/en not_active Expired - Fee Related
- 2011-06-30 EP EP11738521.1A patent/EP2590941A1/en not_active Withdrawn
- 2011-06-30 CN CN201180033815.4A patent/CN103038211B/zh not_active Expired - Fee Related
- 2011-06-30 BR BR112013000602A patent/BR112013000602A2/pt not_active IP Right Cessation
- 2011-06-30 RU RU2013105479/04A patent/RU2013105479A/ru not_active Application Discontinuation
- 2011-06-30 PH PH1/2013/500051A patent/PH12013500051A1/en unknown
- 2011-07-07 AR ARP110102429A patent/AR083512A1/es unknown
- 2011-07-08 TW TW100124302A patent/TW201206882A/zh unknown
-
2012
- 2012-03-20 US US13/424,561 patent/US8383669B2/en not_active Expired - Fee Related
- 2012-12-12 IL IL223584A patent/IL223584A0/en unknown
- 2012-12-19 US US13/720,385 patent/US8791151B2/en not_active Expired - Fee Related
-
2013
- 2013-01-07 ZA ZA2013/00154A patent/ZA201300154B/en unknown
- 2013-01-09 CL CL2013000085A patent/CL2013000085A1/es unknown
- 2013-01-09 CO CO13003305A patent/CO6680604A2/es not_active Application Discontinuation
-
2014
- 2014-06-24 US US14/313,422 patent/US9120746B2/en not_active Expired - Fee Related
-
2015
- 2015-03-26 JP JP2015063809A patent/JP2015120752A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2803090A1 (en) | 2012-01-12 |
| AR083512A1 (es) | 2013-03-06 |
| PH12013500051A1 (en) | 2017-10-25 |
| NZ605490A (en) | 2014-10-31 |
| JP5823512B2 (ja) | 2015-11-25 |
| AU2011276416A1 (en) | 2013-02-14 |
| JP2015120752A (ja) | 2015-07-02 |
| RU2013105479A (ru) | 2014-08-20 |
| CN103038211B (zh) | 2015-04-15 |
| BR112013000602A2 (pt) | 2016-07-05 |
| ZA201300154B (en) | 2013-09-25 |
| TW201206882A (en) | 2012-02-16 |
| US20120178790A1 (en) | 2012-07-12 |
| US20140018407A1 (en) | 2014-01-16 |
| US9120746B2 (en) | 2015-09-01 |
| US8791151B2 (en) | 2014-07-29 |
| CO6680604A2 (es) | 2013-05-31 |
| AU2011276416B2 (en) | 2015-04-02 |
| KR20130041916A (ko) | 2013-04-25 |
| JP2013532170A (ja) | 2013-08-15 |
| IL223584A0 (en) | 2013-03-05 |
| MX2013000334A (es) | 2013-02-26 |
| CN103038211A (zh) | 2013-04-10 |
| SG186789A1 (en) | 2013-02-28 |
| US8383669B2 (en) | 2013-02-26 |
| US20120010265A1 (en) | 2012-01-12 |
| US20150080450A1 (en) | 2015-03-19 |
| WO2012006205A1 (en) | 2012-01-12 |
| US8163794B2 (en) | 2012-04-24 |
| EP2590941A1 (en) | 2013-05-15 |
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