CL2008002700A1 - Composicion farmaceutica que comprende 2-(2,4-difluoro-fenil)-6-[1-(2,6-difluoro-fenil)-ureido]-nicotinamida; envase farmaceutico; util en el tratamiento de artritis reumatoidea. - Google Patents

Composicion farmaceutica que comprende 2-(2,4-difluoro-fenil)-6-[1-(2,6-difluoro-fenil)-ureido]-nicotinamida; envase farmaceutico; util en el tratamiento de artritis reumatoidea.

Info

Publication number
CL2008002700A1
CL2008002700A1 CL2008002700A CL2008002700A CL2008002700A1 CL 2008002700 A1 CL2008002700 A1 CL 2008002700A1 CL 2008002700 A CL2008002700 A CL 2008002700A CL 2008002700 A CL2008002700 A CL 2008002700A CL 2008002700 A1 CL2008002700 A1 CL 2008002700A1
Authority
CL
Chile
Prior art keywords
difluoro
phenyl
ureido
nicotinamide
useful
Prior art date
Application number
CL2008002700A
Other languages
English (en)
Inventor
Mohanlai Ramon
Kauffman Robert
Alam John
Godfrey Christopher
Irina Kadiyala
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of CL2008002700A1 publication Critical patent/CL2008002700A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)

Abstract

Composición farmacéutica que comprende 2-(2,4-difluoro-fenil)-6-[1-(2,6-difluoro-fenil)-ureido]-nicotinamida; envase farmacéutico; útil en el tratamiento de artritis reumatoidea.
CL2008002700A 2006-03-07 2008-09-11 Composicion farmaceutica que comprende 2-(2,4-difluoro-fenil)-6-[1-(2,6-difluoro-fenil)-ureido]-nicotinamida; envase farmaceutico; util en el tratamiento de artritis reumatoidea. CL2008002700A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77986206P 2006-03-07 2006-03-07
US78027706P 2006-03-08 2006-03-08
PCT/US2007/005882 WO2007103468A2 (en) 2006-03-07 2007-03-07 Use of vx-702 for treating rheumatoid arthritis

Publications (1)

Publication Number Publication Date
CL2008002700A1 true CL2008002700A1 (es) 2009-05-29

Family

ID=38475547

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002700A CL2008002700A1 (es) 2006-03-07 2008-09-11 Composicion farmaceutica que comprende 2-(2,4-difluoro-fenil)-6-[1-(2,6-difluoro-fenil)-ureido]-nicotinamida; envase farmaceutico; util en el tratamiento de artritis reumatoidea.

Country Status (15)

Country Link
US (1) US20070225339A1 (es)
EP (1) EP2026806A2 (es)
JP (1) JP2009529529A (es)
KR (1) KR20080100484A (es)
AR (1) AR062248A1 (es)
AU (1) AU2007223901A1 (es)
BR (1) BRPI0708645A2 (es)
CA (1) CA2644421A1 (es)
CL (1) CL2008002700A1 (es)
IL (1) IL193825A0 (es)
MX (1) MX2008011490A (es)
NO (1) NO20084190L (es)
RU (1) RU2008139625A (es)
TW (1) TW200808313A (es)
WO (1) WO2007103468A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010077119A (ja) * 2008-08-25 2010-04-08 Santen Pharmaceut Co Ltd ウレイド基、アミノカルボニル基及び置換フェニル基を置換基として有するピロール誘導体を有効成分として含有する骨・関節疾患の予防又は治療剤
WO2010038428A1 (ja) * 2008-09-30 2010-04-08 武田薬品工業株式会社 タキサン系抗がん剤の置き換え薬
US20140128633A1 (en) * 2008-12-31 2014-05-08 Raymond A. Miller Compositions containing nitro fatty acids
GB0908317D0 (en) * 2009-05-14 2009-06-24 Argenta Discovery Ltd Pharmaceutical compounds and compositions
HUE032947T2 (en) 2009-09-30 2017-11-28 Toray Industries 2,3-dihydro-1H-inden-2-yl urea and its pharmaceutical use
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US11479770B2 (en) 2017-10-05 2022-10-25 Fulcrum Therapeutics, Inc. Use of p38 inhibitors to reduce expression of DUX4

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2562158A1 (en) * 2003-02-10 2013-02-27 Vertex Pharmaceuticals Incorporated Processes for the preparation of n-heteroaryl-N-aryl-amines by reacting an N-aryl carbamic acid ester with a halo-heteroaryl and analogous processes
US20050192261A1 (en) * 2003-09-15 2005-09-01 Jost-Price Edward R. Methods and reagents for the treatment of immunoinflammatory disorders
RU2006120408A (ru) * 2003-11-13 2007-12-20 Комбинаторкс, Инкорпорейтед (Us) Способы и реагенты для лечения воспалительных нарушений

Also Published As

Publication number Publication date
KR20080100484A (ko) 2008-11-18
NO20084190L (no) 2008-11-25
EP2026806A2 (en) 2009-02-25
RU2008139625A (ru) 2010-04-20
US20070225339A1 (en) 2007-09-27
BRPI0708645A2 (pt) 2011-06-07
WO2007103468A3 (en) 2008-05-29
AR062248A1 (es) 2008-10-29
WO2007103468A2 (en) 2007-09-13
IL193825A0 (en) 2009-08-03
AU2007223901A1 (en) 2007-09-13
CA2644421A1 (en) 2007-09-13
JP2009529529A (ja) 2009-08-20
MX2008011490A (es) 2009-01-07
TW200808313A (en) 2008-02-16

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