CH682541A5 - Biochemical Inactivation of RNA viruses. - Google Patents

Biochemical Inactivation of RNA viruses. Download PDF

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Publication number
CH682541A5
CH682541A5 CH1957/92A CH195792A CH682541A5 CH 682541 A5 CH682541 A5 CH 682541A5 CH 1957/92 A CH1957/92 A CH 1957/92A CH 195792 A CH195792 A CH 195792A CH 682541 A5 CH682541 A5 CH 682541A5
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Switzerland
Prior art keywords
rna viruses
rnases
viruses
agents
detergents
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CH1957/92A
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German (de)
Inventor
Urs Viktor Dr Wirth
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Urs Viktor Dr Wirth
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Filing date
Publication date
Application filed by Urs Viktor Dr Wirth filed Critical Urs Viktor Dr Wirth
Priority to CH1957/92A priority Critical patent/CH682541A5/en
Priority to AU32526/93A priority patent/AU3252693A/en
Priority to PCT/CH1992/000249 priority patent/WO1994000016A1/en
Priority to CA002116661A priority patent/CA2116661A1/en
Publication of CH682541A5 publication Critical patent/CH682541A5/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

Ribonucleases (RNases) are highly active, easily used and extremely stable enzymes. Together with detergents, RNases deactivate and destroy irreversible RNA viruses. Agents containing RNase(s) and detergents are therefore suitable for disinfecting instruments, clothing and surfaces from contaminating RNA viruses. Special application forms for coating the skin surfaces of human beings, animals or plants reduce the risk of infection from RNA viruses. Agents with RNases and detergents, possibly combined with substances, may be regarded as "anti-infectives against RNA viruses (=aiRVi).

Description

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Beschreibung description

RNasen sind hochaktive, anspruchsarme und extrem stabile Enzyme. RNasen inaktivieren in Zusammenwirkung mit Deteroentien (= Mittel mit RNasen) RNA-Viren rasch und irreversibel: RNases are highly active, low-demanding and extremely stable enzymes. RNases quickly and irreversibly inactivate RNA viruses in conjunction with detergents (= agents with RNases):

RNasen können mit verschiedensten herkömmlichen flüssigen oder getrockneten Substanzen zur Reinigung, Desinfektion oder Körperpflege kombiniert oder als neue optimierte Reagentien in verschiedenen Kombinationen mit neuen Formulierungen angewendet werden. RNases can be combined with a wide variety of conventional liquid or dried substances for cleaning, disinfection or personal care or used as new optimized reagents in various combinations with new formulations.

Mittel mit RNasen sind geeignet Gegenstände, wie zum Beispiel Geräte und Kleidung von kontaminierenden RNA-Viren zu reinigen und zu desinfizieren. Agents with RNases are suitable for cleaning and disinfecting objects, such as equipment and clothing, from contaminating RNA viruses.

Mittel mit RNasen appliziert auf Gegenstände und vor allem auf die Hautoberfläche eignen sich als Schutz (Prävention) für Mensch und/oder Tier vor krankheitserregenden RNA-Viren. Agents with RNases applied to objects and especially to the skin surface are suitable as protection (prevention) for humans and / or animals against pathogenic RNA viruses.

Mittel mit RNasen können auch zur Bekämpfung von RNA-Viren im Pflanzenschutz angewendet werden. Agents with RNases can also be used to control RNA viruses in crop protection.

ai Beispiele und Bedeutung einiger RNA-Viren: ai Examples and meaning of some RNA viruses:

Unter den RNA-Viren findet man eine immense Anzahl von Erregern gravierender und oft tödlicher Krankheiten bei Mensch und Tier: (Quelle: E. Wiesmann, Medizinische Mikrobiologie, Thieme-Ver-lag,1974) The RNA viruses contain an immense number of pathogens of serious and often fatal diseases in humans and animals: (Source: E. Wiesmann, medical microbiology, Thieme-Ver-lag, 1974)

- Picornaviren: - Picorna viruses:

- Enteroviren: - Enteroviruses:

- Poliomyelitis Viren: Kinderlähmung - Poliomyelitis viruses: polio

- Coxsackieviren: Meningitis - Coxsackieviruses: meningitis

- ECHO Viren: Meningitis & Meningoenzephalitis - ECHO viruses: meningitis & meningoencephalitis

- Rhinoviren: Schnupfen und Erkältungen - Rhinoviruses: runny nose and colds

- Encephalomyokarditisvirus: - Encephalomyocarditis virus:

- Maul- und Klauenseucheviren: - Foot and mouth disease viruses:

- Reoviren:? - Reoviruses :?

- Arboviren: Enzephalitis oder Enzephalomyelitis - Arboviruses: encephalitis or encephalomyelitis

- Myxoviren: - Myxoviruses:

- Ortho-M.: Influenzaviren - Ortho-M .: influenza viruses

- Para-M.: Parainfluenza, Mumps, ... - Para-M .: Parainfluenza, mumps, ...

- Myxoähnliche Viren: Masern, Röteln, Staupe, Rinderpest, Schweinepest, ... - Myxo-like viruses: measles, rubella, distemper, rinderpest, swine fever, ...

+ gewisse Hepatitisviren: Leberentzündung und -tumoren + certain hepatitis viruses: inflammation of the liver and tumors

+ Retroviren: RNA-Tumorviren, ... + Retroviruses: RNA tumor viruses, ...

++ RSV: Hühnersarkom, Geflügelleukose, MMLV: Mäuseleukämie, MMTV: Maus-Mammakarzinom, ... ++ RSV: chicken sarcoma, poultry leukosis, MMLV: mouse leukemia, MMTV: mouse breast cancer, ...

++ Lentiviren: Visna (Tiere); HTLV (Menschen): ++ Lentiviruses: Visna (animals); HTLV (people):

+++ HTLVIII = HIV = LAV: Verursacher von AIDS (aquired immune deficiency) bei Mensch und ähnliche Viren bei Tieren: SIV (simian), BIV (bovine), FIV (feline), ... +++ HTLVIII = HIV = LAV: cause of AIDS (aquired immune deficiency) in humans and similar viruses in animals: SIV (simian), BIV (bovine), FIV (feline), ...

RNA-Viren lösen auch bei Pflanzen unerwünschte Schädigungen aus: (Quelle: F. Schönbeck, Pflanzenkrankheiten, Teubner, 1979) RNA viruses also trigger undesirable damage in plants: (Source: F. Schönbeck, plant diseases, Teubner, 1979)

- Blatt-Mosaikviren: Como-, Tobamo-, Bromo-, und weitere Gruppen. - Leaf mosaic viruses: Como, Tobamo, Bromo, and other groups.

- Rhabdoviren: - Rhabdoviruses:

- Reoviren: - Reoviruses:

bi Eigenschaften von RNasen am Beispiel RNase A: bi properties of RNases using the example of RNase A:

- Stabilität: hitzestabil (volle Aktivität auch nach kochen!) und trockenstabil - Stability: heat stable (full activity even after cooking!) And dry stable

- Aktivität: wenig beeinflusst vom pH (5-8 optimal), von Salzkonzentrationen (0.3 Mol/I NaCl Optimum) und von Detergentien (z.B. SLS= Sodium Lauryl Sulphate). - Activity: little influenced by pH (5-8 optimal), salt concentrations (0.3 mol / I NaCl Optimum) and detergents (e.g. SLS = Sodium Lauryl Sulphate).

ci Effekt von RNase und Detergentien auf RNA-Viren: ci Effect of RNase and Detergents on RNA Viruses:

- RNA-Viren sind aufgebaut aus ihrer Erbsubstanz RNA und einem Gerüstmantel (=Kapsid) aus Proteinen. Gewisse RNA-Viren besitzen auch eine Membranhülle bestehend aus Lipiden und Proteinen. - RNA viruses are made up of their genetic material RNA and a framework (= capsid) made of proteins. Certain RNA viruses also have a membrane envelope consisting of lipids and proteins.

- Mit geeigneten Detergentien wird die Membranhülle aufgelöst und der Gerüstmantel aufgebrochen, so dass RNasen die Erbsubstanz der RNA-Viren zersetzen können, was zu einer vollständigen Vernichtung der RNA-Viren führt. Damit werden nicht nur Aufnahmefähigkeit durch den Organismus, sondern auch jegliches Vermehrungspotential der RNA-Viren vollständig eliminiert. Diese neuartige Vernichtung der Erbsubstanz RNA zur Inaktivierung scheint sogar wichtig zu sein, da kürzlich gezeigt wurde, dass zum Beispiel Polio-Viren sich allein mit ihrer RNA in intakten oder sogar in aufgelösten Zellen noch vermehren (Science News, Vol. 140, p. 390, 1991). - With suitable detergents, the membrane shell is broken up and the scaffold is broken open so that RNases can break down the genetic material of the RNA virus, which leads to a complete destruction of the RNA virus. This completely eliminates not only the ability of the organism to absorb, but also any potential for multiplication of the RNA viruses. This novel destruction of the genetic material RNA for inactivation even seems to be important, since it has recently been shown that, for example, polio viruses alone multiply with their RNA in intact or even in dissolved cells (Science News, Vol. 140, p. 390 , 1991).

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CH 682 541 A5 CH 682 541 A5

dì Mittel mit RNasen: dì means with RNases:

RNasen können mit verschiedensten herkömmlichen flüssigen oder getrockneten Substanzen zur Reinigung, Desinfektion oder Körperpflege kombiniert oder als neue optimierte Reagentien in verschiedenen Kombinationen mit neuen Formulierungen angewendet werden: RNases can be combined with a wide variety of conventional liquid or dried substances for cleaning, disinfection or personal care or used as new optimized reagents in various combinations with new formulations:

- Zur Reinigung und Desinfektion braucht es mindestens eine RNase und ein Detergens (optimal z.B. Sodium Lauryl Sulfate). Von der Grundlagenforschung ist bekannt, dass RNasen unter verschiedensten Bedingungen wirkungsvoll arbeiten. - For cleaning and disinfection at least one RNase and a detergent (optimal e.g. sodium lauryl sulfate) are required. It is known from basic research that RNases work effectively under various conditions.

- Für den Schutz vor Infektion eignen sich Mittel mit RNase in allen Körperpflegemitteln, wie zum Beispiel Waschlotions, Cremes, Haar-Shampoos, Dusch-Gels, Puders, etc. Je nach Zusammensetzung wirken diese Mittel kurzfristig inaktivierend auf RNA-Viren oder vermitteln eine länger anhaltende Inakti-vierungsfähigkeit auf RNA-Viren. Für eine erwünschte längere protektive Wirkung empfiehlt sich die Anwendung von Mitteln, die einen relativ widerstandsfähigen Film auf den behandelten Oberflächen (Geräte, Kleider, Haut) hinterlassen. Solche Mittel, basierend auf Gelen, Ölen oder Wachsen sind schon zum Teil patentiert und werden in der Praxis angewendet. - To protect against infection, agents with RNase are suitable in all personal care products, such as washing lotions, creams, hair shampoos, shower gels, powders, etc. Depending on their composition, these agents have a short-term inactivating effect on RNA viruses or mediate a longer one persistent inactivation ability on RNA viruses. For a desired longer protective effect, the use of agents that leave a relatively resistant film on the treated surfaces (devices, clothes, skin) is recommended. Such agents, based on gels, oils or waxes, have already been patented in part and are used in practice.

ei Anwenriunn von Mittel mit RNasen: An application of means with RNases:

- Im Pflanzenschutz zur Desinfektion von kontaminierten Geräten und vor allem als Schutzmöglichkeit in Form von widerstandsfähigen protektiven Filmen (Wachse oder Öle) zusammen mit anderen Pflanzenschutzmittel. - In crop protection for the disinfection of contaminated devices and above all as a protection option in the form of resistant protective films (waxes or oils) together with other crop protection products.

- Bei Tieren zur Desinfektion der Geräte, Hausungen und der Tiere selber. - For animals to disinfect the devices, housings and the animals themselves.

- Beim Menschen zur Reinigung und Desinfektion von kontaminierten Geräten, Oberflächen, Kleidung oder sogar der Körperoberfläche (Haut und Schleimhäute). Vor allem für Orte mit grossem Risiko (Spitäler, Labors, Arztpraxen, Lebensräume von RNA-Viren ausscheidenden Personen,...) aber auch zur generellen Prävention drängt sich der Einsatz dieser Mittel mit RNase auf. Der Gebrauch für den Schutz von Personen durch einen «Schutzfilm» ist vor allem zu empfehlen für speziell gefährdete Risikogruppen (z.B. Ärzte, Pflegepersonal, Reinigungspersonal, ...), die mit grosser Wahrscheinlichkeit in Kontakt mit RNA-Viren ausscheidenden Personen oder möglicherweise kontaminierten Gegenständen kommen. - In humans for cleaning and disinfecting contaminated devices, surfaces, clothing or even the body surface (skin and mucous membranes). Above all for places with a high risk (hospitals, laboratories, doctor's surgeries, habitats of people who excrete RNA viruses, ...) but also for general prevention, the use of these agents with RNase is imperative. The use for the protection of people through a «protective film» is especially recommended for especially vulnerable risk groups (e.g. doctors, nursing staff, cleaning staff, ...) who are very likely to come into contact with people who excrete RNA viruses or possibly contaminated objects come.

Im Zusammenhang mit den AIDS auslösenden HIV-RNA-Viren ist ein Schutz der betroffenen Risikogruppen angebracht. Zu gebräuchlichen äusserlichen Kontrazeptiva können Mittel mit RNase zugegeben werden. Condome als momentan bestwirksamer Schutz vor Übertragung von HIV-RNA-Viren können mit einem RNase enthaltenden Schutzfilm beschichtet werden oder zu Gleitmitteln beigefügt werden. Mittel mit RNasen können zudem mit herkömmlichen Gleit-, Massage- oder allgemein mit Körperpflegemitteln kombiniert werden. Protection of the affected risk groups is appropriate in connection with the AIDS-causing HIV-RNA viruses. RNase agents can be added to common external contraceptives. Condoms, as currently the best effective protection against transmission of HIV-RNA viruses, can be coated with a protective film containing RNase or added to lubricants. Agents with RNases can also be combined with conventional lubricants, massage or generally with personal care products.

Da diese Mittel alle die Wahrscheinlichkeit und somit das Risiko einer Infektion mit RNA-Viren vermindern, kann man sie als «anti-infektiva für RNA-Viren» (= aiRVi) bezeichnen. Since these agents all reduce the probability and thus the risk of infection with RNA viruses, they can be described as "anti-infectives for RNA viruses" (= aiRVi).

f. Anhang: f. Attachment:

erfindungsgemässes Mittel: bewirkt: Agent according to the invention:

Anwendung: Application:

RNase + Detergentium Inaktivierung von RNA-Viren als (=aiRVi) Krankheitserreger für Mensch, RNase + detergent inactivating RNA viruses as (= aiRVi) pathogens for humans,

Tier & Pflanze Animal & plant

Beispiele: Enzephalitis, Tumoren und AIDS. Examples: encephalitis, tumors and AIDS.

- Reinigung und Desinfektion von Geräten und Kleidung - Cleaning and disinfection of equipment and clothing

- Schutz und Prävention bei Mensch, Tier & Pflanze. - Protection and prevention in humans, animals and plants.

aiRVi = anti-infectiva für RNA-Viren, basierend auf RNasen und einem geeigneten Detergentium: aiRVi = anti-infectives for RNA viruses, based on RNases and a suitable detergent:

- Detergentium: geeignet ist z.B. Sodium Lauryl Sulphate (SLS) Detergent: suitable is e.g. Sodium Lauryl Sulphate (SLS)

- RNasen = Ribonukleasen (RNA abbauende Enzyme) - RNases = ribonucleases (RNA-degrading enzymes)

geeignet sind zum Beispiel: suitable examples are:

- RNase A: EC 3.1.27.5.: isoliert von bovinen Pankreas; mit obig beschriebenen Eigenschaften, käuflich bei Sigma (No L5125) RNase A: EC 3.1.27.5 .: isolated from bovine pancreas; with the properties described above, available from Sigma (No L5125)

- RNase T1: EC 3.1.27.3: isoliert aus Aspergillus oryzam RNase T1: EC 3.1.27.3: isolated from Aspergillus oryzam

Claims (2)

PatentansprücheClaims 1. Mittel zur biochemischen Inaktivierung von RNA-Viren, dadurch gekennzeichnet, dass sie RNase zusammen mit einem Detergens enthalten.1. Agent for the biochemical inactivation of RNA viruses, characterized in that they contain RNase together with a detergent. 2. Mittel nach Anspruch 1, dadurch gekennzeichnet, dass sie in Form von Reinigungsmittel, Desinfektionsmittel, Körperpflegemittel oder Beschichtungsmittel vorliegen.2. Composition according to claim 1, characterized in that they are in the form of cleaning agents, disinfectants, personal care products or coating agents. 33rd
CH1957/92A 1992-06-23 1992-06-23 Biochemical Inactivation of RNA viruses. CH682541A5 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CH1957/92A CH682541A5 (en) 1992-06-23 1992-06-23 Biochemical Inactivation of RNA viruses.
AU32526/93A AU3252693A (en) 1992-06-23 1992-12-31 Biochemical deactivation of RNA viruses
PCT/CH1992/000249 WO1994000016A1 (en) 1992-06-23 1992-12-31 Biochemical deactivation of rna viruses
CA002116661A CA2116661A1 (en) 1992-06-23 1992-12-31 Biochemical deactivation of rna viruses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1957/92A CH682541A5 (en) 1992-06-23 1992-06-23 Biochemical Inactivation of RNA viruses.

Publications (1)

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CH682541A5 true CH682541A5 (en) 1993-10-15

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CH1957/92A CH682541A5 (en) 1992-06-23 1992-06-23 Biochemical Inactivation of RNA viruses.

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AU (1) AU3252693A (en)
CA (1) CA2116661A1 (en)
CH (1) CH682541A5 (en)
WO (1) WO1994000016A1 (en)

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US6017046A (en) * 1998-01-21 2000-01-25 Markovic; Vladimir Wheelchair apparatus
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US10238107B2 (en) 2014-07-31 2019-03-26 Kimberly-Clark Worldwide, Inc. Anti-adherent composition
AU2015297023B2 (en) 2014-07-31 2019-11-07 Kimberly-Clark Worldwide, Inc. Anti-adherent composition
GB2553715B (en) 2015-04-01 2021-08-04 Kimberly Clark Co Fibrous substrate for capture of gram negative bacteria
BR112018014040A2 (en) 2016-01-28 2018-12-11 Kimberly Clark Co "composition and handkerchief for inhibiting DNA virus binding to a surface, and method for inhibiting DNA virus adherence to a surface."
US11168287B2 (en) 2016-05-26 2021-11-09 Kimberly-Clark Worldwide, Inc. Anti-adherent compositions and methods of inhibiting the adherence of microbes to a surface
WO2020070014A1 (en) * 2018-10-02 2020-04-09 Novozymes A/S Cleaning composition comprising anionic surfactant and a polypeptide having rnase activity

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AU624331B2 (en) * 1988-05-26 1992-06-11 Nika Health Products Ltd. A composition having as its active ingredient lysozyme or ribonuclease dimer in a pharmaceutically acceptable carrier
DE3939771A1 (en) * 1989-12-01 1991-06-06 Behringwerke Ag PROCESS FOR THE BIOLOGICAL INACTIVATION OF NUCLEIC ACIDS
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
DE102004001590A1 (en) * 2004-01-09 2005-08-04 Gerhard Knapp Inhibition of allergies caused by e.g. fungal spores and keratin of animal hairs comprises enzymatic (e.g. papain and bromelain) degradation of polypeptides of the causative agents into oligopeptides
DE102004001590B4 (en) * 2004-01-09 2012-12-06 Gerhard Knapp Use of an active substance and a combination of active substances for inhibiting mite faeces and / or mold spores and / or plant pollen and spores and / or for denaturing the keratin of animal hair

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CA2116661A1 (en) 1994-01-06
AU3252693A (en) 1994-01-24
WO1994000016A1 (en) 1994-01-06

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