CH614935A5 - Process for the preparation of novel 9-thia-, 9-oxothia- and 9-dioxothia-11,12-secoprostaglandins - Google Patents

Process for the preparation of novel 9-thia-, 9-oxothia- and 9-dioxothia-11,12-secoprostaglandins

Info

Publication number
CH614935A5
CH614935A5 CH820875A CH820875A CH614935A5 CH 614935 A5 CH614935 A5 CH 614935A5 CH 820875 A CH820875 A CH 820875A CH 820875 A CH820875 A CH 820875A CH 614935 A5 CH614935 A5 CH 614935A5
Authority
CH
Switzerland
Prior art keywords
secoprostaglandins
dioxothia
oxothia
thia
novel
Prior art date
Application number
CH820875A
Other languages
English (en)
Inventor
Edward Jethro Cragoe Jr
John Beeh Bicking
Robert Lawrence Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH614935A5 publication Critical patent/CH614935A5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
CH820875A 1974-06-25 1975-06-24 Process for the preparation of novel 9-thia-, 9-oxothia- and 9-dioxothia-11,12-secoprostaglandins CH614935A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48317874A 1974-06-25 1974-06-25
US56656675A 1975-04-09 1975-04-09

Publications (1)

Publication Number Publication Date
CH614935A5 true CH614935A5 (en) 1979-12-28

Family

ID=27047557

Family Applications (1)

Application Number Title Priority Date Filing Date
CH820875A CH614935A5 (en) 1974-06-25 1975-06-24 Process for the preparation of novel 9-thia-, 9-oxothia- and 9-dioxothia-11,12-secoprostaglandins

Country Status (16)

Country Link
JP (1) JPS51125020A (xx)
CA (1) CA1064961A (xx)
CH (1) CH614935A5 (xx)
DE (1) DE2528070A1 (xx)
DK (1) DK263775A (xx)
ES (1) ES438765A1 (xx)
FI (1) FI751730A (xx)
FR (1) FR2276037A1 (xx)
GB (1) GB1476262A (xx)
IE (1) IE41258B1 (xx)
IL (1) IL47487A (xx)
LU (1) LU72797A1 (xx)
NL (1) NL7507020A (xx)
NO (1) NO142219C (xx)
NZ (1) NZ177843A (xx)
SE (1) SE7506804L (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010518108A (ja) * 2007-02-06 2010-05-27 ユニバーシティ オブ ルーイビル リサーチ ファウンデーション，インコーポレーテッド 治療化合物
US9383364B2 (en) 2011-03-07 2016-07-05 University Of Louisville Research Foundation, Inc. Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker
US9737493B2 (en) 2012-09-07 2017-08-22 University Of Louisville Research Foundation, Inc. Compositions and methods for modulating DNMT1 inhibitor activity

Also Published As

Publication number Publication date
DK263775A (da) 1975-12-26
FI751730A (xx) 1975-12-26
GB1476262A (en) 1977-06-10
IL47487A0 (en) 1975-08-31
FR2276037B1 (xx) 1979-03-02
DE2528070A1 (de) 1976-01-08
AU8221675A (en) 1976-12-23
NO142219C (no) 1980-07-16
NZ177843A (en) 1978-04-03
NO752091L (xx) 1975-12-30
CA1064961A (en) 1979-10-23
IL47487A (en) 1979-05-31
FR2276037A1 (fr) 1976-01-23
SE7506804L (sv) 1975-12-29
ES438765A1 (es) 1977-07-01
IE41258B1 (en) 1979-11-21
JPS51125020A (en) 1976-11-01
IE41258L (en) 1975-12-25
NO142219B (no) 1980-04-08
NL7507020A (nl) 1975-12-30
LU72797A1 (xx) 1976-04-13

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Legal Events

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