CH585214A5 - Prepn. of anthelmintic (6)-isothiocyano-benzo-thiazoles - from (6)-amino-benzothiazoles - Google Patents
Prepn. of anthelmintic (6)-isothiocyano-benzo-thiazoles - from (6)-amino-benzothiazolesInfo
- Publication number
- CH585214A5 CH585214A5 CH1241774A CH1241774A CH585214A5 CH 585214 A5 CH585214 A5 CH 585214A5 CH 1241774 A CH1241774 A CH 1241774A CH 1241774 A CH1241774 A CH 1241774A CH 585214 A5 CH585214 A5 CH 585214A5
- Authority
- CH
- Switzerland
- Prior art keywords
- formula
- isothiocyano
- benzothiazoles
- prepn
- cpds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Prepn. of 6-isothiocyano-benzothiazoles of formula (I): (where R1 is 2-6C alkyl, 3-6C cycloalkyl or CF3; R2 is 1-6C alk(en)yl, 3-6C alk(en)ylthio, 3-6C cycloalkyl(alkyl)thio, halogen or CF3) comprises subjecting the corresp. 6-aminobenzothiazole of formula (II): to e.g. (a) reaction with a thiocarbonic acid deriv. of formula Hal-CS-Y (where Hal is Cl or Br; Y is Cl, Br or dialkylamino), or (b) reaction with a sulphide of formula (S)m CS-N(R)2 2 (where R is 1-4C alkyl; m=1 or 2). Cpds. (I) are special cases of the cpds. described in the Parent Patent and have a similar broad range of anthelmintic activity (against cestodes, trematodes and nematodes). Unlike the other cpds., however, they are also active against the nematode Oesophagostomum columbianum, e.g. in sheep.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1241774A CH585214A5 (en) | 1974-09-12 | 1974-09-12 | Prepn. of anthelmintic (6)-isothiocyano-benzo-thiazoles - from (6)-amino-benzothiazoles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1241774A CH585214A5 (en) | 1974-09-12 | 1974-09-12 | Prepn. of anthelmintic (6)-isothiocyano-benzo-thiazoles - from (6)-amino-benzothiazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
CH585214A5 true CH585214A5 (en) | 1977-02-28 |
Family
ID=4382815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH1241774A CH585214A5 (en) | 1974-09-12 | 1974-09-12 | Prepn. of anthelmintic (6)-isothiocyano-benzo-thiazoles - from (6)-amino-benzothiazoles |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH585214A5 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0007616A1 (en) * | 1978-07-27 | 1980-02-06 | Ciba-Geigy Ag | Isothiocyanobenzothiazole compound, process for its preparation and its use in anthelmintic compositions |
WO1999065886A1 (en) * | 1998-06-18 | 1999-12-23 | Novartis Ag | Benzazole compounds and their use |
-
1974
- 1974-09-12 CH CH1241774A patent/CH585214A5/en not_active IP Right Cessation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0007616A1 (en) * | 1978-07-27 | 1980-02-06 | Ciba-Geigy Ag | Isothiocyanobenzothiazole compound, process for its preparation and its use in anthelmintic compositions |
US4428957A (en) | 1978-07-27 | 1984-01-31 | Ciba-Geigy Corporation | 6-Isothiocyano-5-methoxy-2-tert.-butylbenzthiazole and a method of controlling ruminant liver flukes therewith |
WO1999065886A1 (en) * | 1998-06-18 | 1999-12-23 | Novartis Ag | Benzazole compounds and their use |
US6410578B1 (en) | 1998-06-18 | 2002-06-25 | Novartis Animal Health Us, Inc. | Benzazole compounds and their use |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PL | Patent ceased |