CH514622A - Verfahren zur Herstellung von Estern der 7(a-Amino-a-phenylacetamido)-cephalosporansäure - Google Patents

Verfahren zur Herstellung von Estern der 7(a-Amino-a-phenylacetamido)-cephalosporansäure

Info

Publication number
CH514622A
CH514622A CH136869A CH136869A CH514622A CH 514622 A CH514622 A CH 514622A CH 136869 A CH136869 A CH 136869A CH 136869 A CH136869 A CH 136869A CH 514622 A CH514622 A CH 514622A
Authority
CH
Switzerland
Prior art keywords
phenylacetamido
esters
amino
preparation
cephalosporanic acid
Prior art date
Application number
CH136869A
Other languages
English (en)
Inventor
Ole Godtfredsen Wagn
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of CH514622A publication Critical patent/CH514622A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02Preparation
    • C07D501/04Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/187-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/28Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F23COMBUSTION APPARATUS; COMBUSTION PROCESSES
    • F23JREMOVAL OR TREATMENT OF COMBUSTION PRODUCTS OR COMBUSTION RESIDUES; FLUES 
    • F23J13/00Fittings for chimneys or flues 
    • F23J13/08Doors or covers specially adapted for smoke-boxes, flues, or chimneys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Cephalosporin Compounds (AREA)
CH136869A 1968-01-30 1969-01-29 Verfahren zur Herstellung von Estern der 7(a-Amino-a-phenylacetamido)-cephalosporansäure CH514622A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB482168 1968-01-30

Publications (1)

Publication Number Publication Date
CH514622A true CH514622A (de) 1971-10-31

Family

ID=9784446

Family Applications (2)

Application Number Title Priority Date Filing Date
CH265871A CH522680A (de) 1968-01-30 1969-01-29 Verfahren zur Herstellung von Estern der 7(a-Amino-a-phenylacetamido)-cephalosporansäure
CH136869A CH514622A (de) 1968-01-30 1969-01-29 Verfahren zur Herstellung von Estern der 7(a-Amino-a-phenylacetamido)-cephalosporansäure

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH265871A CH522680A (de) 1968-01-30 1969-01-29 Verfahren zur Herstellung von Estern der 7(a-Amino-a-phenylacetamido)-cephalosporansäure

Country Status (3)

Country Link
US (1) US3655658A (de)
CH (2) CH522680A (de)
GB (1) GB1229453A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH563396A5 (de) * 1970-06-05 1975-06-30 Ciba Geigy Ag
US3856785A (en) * 1972-07-24 1974-12-24 Squibb & Sons Inc Cephalosporin esters
PL98296B1 (pl) * 1973-02-07 1978-04-29 Politechnika Gdanskapo Sposob otrzymywania estrow acetoksymetylowych cefalosporyn
US3965099A (en) * 1974-06-26 1976-06-22 Smithkline Corporation Cephalosporin esters with antibacterial activity
FR2297048A1 (fr) * 1975-01-07 1976-08-06 Squibb & Sons Inc Esters acylthiomethyliques de cephalosporines
US4026887A (en) 1975-10-24 1977-05-31 Yeda Research & Development Co. Ltd. Cephalosporin antibiotics
US4045438A (en) 1975-10-24 1977-08-30 Yeda Research And Development Co. Ltd. Cephalosporin antibiotics
US4031083A (en) 1975-10-24 1977-06-21 Yeda Research And Development Co., Ltd. Cephalosporin antibiotics
US4236002A (en) 1977-12-23 1980-11-25 Yeda Research & Development Co., Ltd. Cephalosporin derivatives
WO1984001949A1 (en) * 1982-11-10 1984-05-24 Kyoto Pharma Ind Cephalosporin derivatives, process and their preparation, and prophylactic and treating agent against bacterial infection

Also Published As

Publication number Publication date
CH522680A (de) 1972-05-15
DE1904585B2 (de) 1977-02-03
GB1229453A (de) 1971-04-21
DE1904585A1 (de) 1969-08-28
US3655658A (en) 1972-04-11

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Legal Events

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