CH505854A - Verfahren zur Herstellung von pharmazeutisch wirksamen Verbindungen der 7-Acylamino-Cephalosporansäure - Google Patents

Verfahren zur Herstellung von pharmazeutisch wirksamen Verbindungen der 7-Acylamino-Cephalosporansäure

Info

Publication number
CH505854A
CH505854A CH1257968A CH1257968A CH505854A CH 505854 A CH505854 A CH 505854A CH 1257968 A CH1257968 A CH 1257968A CH 1257968 A CH1257968 A CH 1257968A CH 505854 A CH505854 A CH 505854A
Authority
CH
Switzerland
Prior art keywords
acylamino
preparation
active compounds
pharmaceutically active
cephalosporanic acid
Prior art date
Application number
CH1257968A
Other languages
English (en)
Inventor
Truman Holdrege Charles
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CH505854A publication Critical patent/CH505854A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH1257968A 1967-08-18 1968-08-19 Verfahren zur Herstellung von pharmazeutisch wirksamen Verbindungen der 7-Acylamino-Cephalosporansäure CH505854A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66152067A 1967-08-18 1967-08-18

Publications (1)

Publication Number Publication Date
CH505854A true CH505854A (de) 1971-04-15

Family

ID=24653945

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1257968A CH505854A (de) 1967-08-18 1968-08-19 Verfahren zur Herstellung von pharmazeutisch wirksamen Verbindungen der 7-Acylamino-Cephalosporansäure

Country Status (8)

Country Link
US (1) US3464985A (de)
BE (1) BE719594A (de)
CH (1) CH505854A (de)
DE (1) DE1795151C3 (de)
FR (2) FR7996M (de)
GB (4) GB1247712A (de)
IL (1) IL30546A (de)
NL (1) NL154740B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714146A (en) * 1970-10-05 1973-01-30 Bristol Myers Co Novel syntheses of cephalexin and intermediates therefor
US4007173A (en) * 1973-05-07 1977-02-08 Smithkline Corporation α-amino-α-(ureidophenyl)acetamidocephalosporins
US4018921A (en) * 1973-08-01 1977-04-19 Smithkline Corporation Substituted phenylglycylcephalosporins
US4022895A (en) * 1973-08-01 1977-05-10 Smithkline Corporation Substituted phenylglycylcephalosporins
US3931160A (en) * 1974-05-15 1976-01-06 Smithkline Corporation α-Amino-α-(acylamidophenyl)acetamidocephalosporins
US4107440A (en) * 1975-12-15 1978-08-15 Smithkline Corporation Intermediates for preparing substituted phenylglycylcephalosporins
DE2836613A1 (de) * 1978-08-22 1980-03-13 Bayer Ag Alpha -aminophenylessigsaeurederivate
WO2016063246A1 (en) * 2014-10-22 2016-04-28 Sun Pharmaceutical Industries Limited Crystalline form r of tedizolid phosphate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3311621A (en) * 1966-04-07 1967-03-28 Bristol Myers Co Derivatives of cephalosporanic acid

Also Published As

Publication number Publication date
DE1795151C3 (de) 1975-04-24
DE1795151A1 (de) 1972-03-23
IL30546A (en) 1972-02-29
FR7996M (de) 1970-06-08
GB1247713A (en) 1971-09-29
GB1247712A (en) 1971-09-29
IL30546A0 (en) 1968-10-24
BE719594A (de) 1969-02-17
GB1247711A (en) 1971-09-29
GB1247714A (en) 1971-09-29
DE1795151B2 (de) 1974-08-29
NL154740B (nl) 1977-10-17
NL6811676A (de) 1969-02-20
FR1603727A (de) 1971-05-24
US3464985A (en) 1969-09-02

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Legal Events

Date Code Title Description
PL Patent ceased