CH503736A - Benzenesulphonamide derivs hypoglycaemic - Google Patents

Benzenesulphonamide derivs hypoglycaemic

Info

Publication number
CH503736A
CH503736A CH1213070A CH1213070A CH503736A CH 503736 A CH503736 A CH 503736A CH 1213070 A CH1213070 A CH 1213070A CH 1213070 A CH1213070 A CH 1213070A CH 503736 A CH503736 A CH 503736A
Authority
CH
Switzerland
Prior art keywords
benzenesulphonamide
hypoglycaemic
derivs
hypoglycaemics
recryst
Prior art date
Application number
CH1213070A
Other languages
German (de)
Inventor
Henri Dr Dietrich
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CH1213070A priority Critical patent/CH503736A/en
Publication of CH503736A publication Critical patent/CH503736A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C07D203/24—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/46—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(A) Cpds. of the general formula (I) R' = (1-4C)alkyl, (3-4C) alkenyl or (5-7C) cycloalkyl R2 = H, Me or Et X = H, F, Cl, Br, Me, MeS, MeO or CH3CO (B) Acid addn. salts of I. Oral and parenteral hypoglycaemics. Dose 100-500 mg/d. N-(2-methylaminoethyl)-p-methoxybenzene-sulphonamide (24.4 g.) was stirred with BrCN (10.6 g.) and 2N-NaOH (100 ml) at 20-30 deg., filtered, and recryst. from MeOH, giving the imidazoline, m.p. 104-7 deg.
CH1213070A 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic CH503736A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH1213070A CH503736A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH388268A CH505105A (en) 1968-03-14 1968-03-14 Process for the preparation of new derivatives of benzenesulfonamide
CH1213070A CH503736A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic

Publications (1)

Publication Number Publication Date
CH503736A true CH503736A (en) 1971-02-28

Family

ID=4265516

Family Applications (7)

Application Number Title Priority Date Filing Date
CH1212970A CH503735A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic
CH1213170A CH503737A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic
CH1213070A CH503736A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic
CH388268A CH505105A (en) 1966-03-24 1968-03-14 Process for the preparation of new derivatives of benzenesulfonamide
CH1213270A CH497431A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic
CH1213470A CH503739A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic
CH1213370A CH503738A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CH1212970A CH503735A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic
CH1213170A CH503737A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic

Family Applications After (4)

Application Number Title Priority Date Filing Date
CH388268A CH505105A (en) 1966-03-24 1968-03-14 Process for the preparation of new derivatives of benzenesulfonamide
CH1213270A CH497431A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic
CH1213470A CH503739A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic
CH1213370A CH503738A (en) 1968-03-14 1968-03-14 Benzenesulphonamide derivs hypoglycaemic

Country Status (11)

Country Link
AT (7) AT287702B (en)
BE (1) BE729836A (en)
BG (6) BG17546A3 (en)
CH (7) CH503735A (en)
DE (1) DE1912851A1 (en)
ES (6) ES364715A1 (en)
FR (1) FR2003886A1 (en)
GB (1) GB1262315A (en)
IE (1) IE32669B1 (en)
IL (1) IL31800A (en)
NL (1) NL6903837A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4720580A (en) * 1984-09-21 1988-01-19 American Home Products Corporation N-(aminoalkylene)benzenesulfonamides
SI9111433B (en) * 1991-08-22 1999-02-28 Pliva New N-sulphonyl-tetrahydro-/1,3/-dioxepino/5,6-b/azirines, preparation procedure, intermediates for their preparation and use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1224812A (en) * 1956-12-28 1960-06-27 Geigy Ag J R Novel 2-imino-1.3-di-n-heterocycles and their preparation process

Also Published As

Publication number Publication date
CH503735A (en) 1971-02-28
GB1262315A (en) 1972-02-02
AT287699B (en) 1971-02-10
BG17545A3 (en) 1973-11-10
AT284839B (en) 1970-09-25
CH505105A (en) 1971-03-31
CH503738A (en) 1971-02-28
AT287697B (en) 1971-02-10
ES364716A1 (en) 1970-12-16
AT287700B (en) 1971-02-10
BG17546A3 (en) 1973-11-10
NL6903837A (en) 1969-09-16
ES364715A1 (en) 1970-12-16
BE729836A (en) 1969-09-15
DE1912851A1 (en) 1969-10-16
ES364719A1 (en) 1970-12-16
IL31800A (en) 1972-04-27
IE32669B1 (en) 1973-10-17
ES364717A1 (en) 1970-12-16
FR2003886A1 (en) 1969-11-14
BG17550A3 (en) 1973-11-10
ES364718A1 (en) 1970-12-16
IL31800A0 (en) 1969-05-28
BG17549A3 (en) 1973-11-10
AT287701B (en) 1971-02-10
CH503739A (en) 1971-02-28
AT287698B (en) 1971-02-10
ES364720A1 (en) 1970-12-16
AT287702B (en) 1971-02-10
BG17548A3 (en) 1973-11-10
CH503737A (en) 1971-02-28
BG17547A3 (en) 1973-11-10
IE32669L (en) 1969-09-14
CH497431A (en) 1970-10-15

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Legal Events

Date Code Title Description
PL Patent ceased