CH474541A - Verfahren zum Überführen saurer kristalliner Triterpen-Saponine in Triterpen-Saponine erhöhter Wasserlöslichkeit - Google Patents

Verfahren zum Überführen saurer kristalliner Triterpen-Saponine in Triterpen-Saponine erhöhter Wasserlöslichkeit

Info

Publication number
CH474541A
CH474541A CH1488663A CH1488663A CH474541A CH 474541 A CH474541 A CH 474541A CH 1488663 A CH1488663 A CH 1488663A CH 1488663 A CH1488663 A CH 1488663A CH 474541 A CH474541 A CH 474541A
Authority
CH
Switzerland
Prior art keywords
triterpene saponins
water solubility
increased water
acidic crystalline
triterpene
Prior art date
Application number
CH1488663A
Other languages
English (en)
Inventor
Rolf Dr Madaus
Hans Dr Erbring
Wilhelm Dr Winkler
Original Assignee
Madaus & Co Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr
Publication of CH474541A publication Critical patent/CH474541A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/256Polyterpene radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1488663A 1962-12-14 1963-12-04 Verfahren zum Überführen saurer kristalliner Triterpen-Saponine in Triterpen-Saponine erhöhter Wasserlöslichkeit CH474541A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEM55118A DE1282852B (de) 1962-12-14 1962-12-14 Peroral anwendbares aescinhaltiges Arzneimittel
CH1488763 1963-12-06

Publications (1)

Publication Number Publication Date
CH474541A true CH474541A (de) 1969-06-30

Family

ID=25715271

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1488663A CH474541A (de) 1962-12-14 1963-12-04 Verfahren zum Überführen saurer kristalliner Triterpen-Saponine in Triterpen-Saponine erhöhter Wasserlöslichkeit

Country Status (10)

Country Link
US (1) US3238104A (de)
AT (1) AT245733B (de)
BE (1) BE641151A (de)
CH (1) CH474541A (de)
DE (2) DE1282852B (de)
DK (1) DK107183C (de)
FR (1) FR3473M (de)
GB (1) GB1017960A (de)
IT (1) IT1150100B (de)
NL (2) NL142595B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51139613A (en) * 1975-05-24 1976-12-02 Nippon Shinyaku Co Ltd An absorbable non-crystalline sterol glycoside monopalmitate ester and a method for preparing its pharmaceutical
DE2530953C3 (de) * 1975-07-11 1994-07-07 Madaus Ag Verfahren zur Herstellung von röntgenamorphem Aescin, nach diesem Verfahren erhältliches röntgenamorphes Aescin und dieses enthaltende Arzneimittel
JPS5948810B2 (ja) * 1980-03-22 1984-11-29 山之内製薬株式会社 ニカルジピン持続性製剤用組成物
CN116115566A (zh) * 2021-11-15 2023-05-16 上海维洱生物医药科技有限公司 一种七叶皂苷钠脂质体及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2123248A (en) * 1937-01-14 1938-07-12 Louis N Markwood Insoluble reaction products of peat and process of making same
US2350804A (en) * 1939-07-22 1944-06-06 Ohta Masaki Derivatives of hesperidin and process for preparing the same
US2691654A (en) * 1952-06-11 1954-10-12 Buroughs Wellcome & Co U S A I Amino heterocycles and method of making
DE1134180B (de) * 1954-01-22 1962-08-02 Nitritfabrik Ges Mit Beschraen Verfahren zur Umwandlung von therapeutisch anwendbaren, in Wasser praktisch unloeslichen organischen Stoffen in ein echt wasserloesliches Produkt
US2780620A (en) * 1954-01-28 1957-02-05 Merle M Krider Partial acidic hydrolysis of steroidal saponins
US3110711A (en) * 1960-06-14 1963-11-12 Klinge Co Chem Pharm Fab Process of producing two escin isomers from horse chestnut extracts, and products

Also Published As

Publication number Publication date
DE1282852B (de) 1968-11-14
IT1150100B (it) 1986-12-10
DE1493999A1 (de) 1970-02-05
NL301747A (de)
DK107183C (da) 1967-05-01
NL142595B (nl) 1974-07-15
AT245733B (de) 1966-03-10
US3238104A (en) 1966-03-01
BE641151A (de) 1964-04-01
FR3473M (fr) 1965-08-09
GB1017960A (en) 1966-01-26

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Legal Events

Date Code Title Description
PL Patent ceased