CH460753A - Procédé de préparation de spiro(stéroïde-6,1'-cyclopropanes) - Google Patents

Procédé de préparation de spiro(stéroïde-6,1'-cyclopropanes)

Info

Publication number
CH460753A
CH460753A CH1133065A CH1133065A CH460753A CH 460753 A CH460753 A CH 460753A CH 1133065 A CH1133065 A CH 1133065A CH 1133065 A CH1133065 A CH 1133065A CH 460753 A CH460753 A CH 460753A
Authority
CH
Switzerland
Prior art keywords
cyclopropanes
steroid
preparing spiro
spiro
preparing
Prior art date
Application number
CH1133065A
Other languages
English (en)
Inventor
B Colton Frank
T Nicholson Robert
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of CH460753A publication Critical patent/CH460753A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH1133065A 1964-08-12 1965-08-12 Procédé de préparation de spiro(stéroïde-6,1'-cyclopropanes) CH460753A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US389224A US3412154A (en) 1964-08-12 1964-08-12 Amino-substituted phenone compounds
US389183A US3261829A (en) 1964-08-12 1964-08-12 Spiro(steroidal-6,3'-1-pyrazolines) and process
US39175964A 1964-08-24 1964-08-24

Publications (1)

Publication Number Publication Date
CH460753A true CH460753A (fr) 1968-08-15

Family

ID=27409883

Family Applications (3)

Application Number Title Priority Date Filing Date
CH1122365A CH450454A (fr) 1964-08-12 1965-08-10 Procédé de préparation de sels de nouvelles amines organiques
CH1125265A CH460027A (de) 1964-08-12 1965-08-11 Verfahren zur Herstellung von Spiro-steroid-6,3'-1-pyrazolinen
CH1133065A CH460753A (fr) 1964-08-12 1965-08-12 Procédé de préparation de spiro(stéroïde-6,1'-cyclopropanes)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CH1122365A CH450454A (fr) 1964-08-12 1965-08-10 Procédé de préparation de sels de nouvelles amines organiques
CH1125265A CH460027A (de) 1964-08-12 1965-08-11 Verfahren zur Herstellung von Spiro-steroid-6,3'-1-pyrazolinen

Country Status (9)

Country Link
US (3) US3261829A (fr)
BE (3) BE668124A (fr)
BR (1) BR6571997D0 (fr)
CH (3) CH450454A (fr)
DE (2) DE1620111C3 (fr)
DK (2) DK134222B (fr)
FR (2) FR4851M (fr)
GB (3) GB1078163A (fr)
SE (1) SE336786B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3475417A (en) * 1965-03-24 1969-10-28 Upjohn Co 6,1'-spirocyclopropyl pregnanes
US3476745A (en) * 1965-06-04 1969-11-04 Smithkline Corp 6,6-ethylene corticoids
US3579509A (en) * 1965-06-21 1971-05-18 Smith Kline French Lab Process and 6-beta-substituted ethyl intermediates for preparing 6,6-ethylene-3-keto-delta**4 steroids
US3422097A (en) * 1965-08-27 1969-01-14 Smithkline Corp 6,6-ethylene spirolactones
US3373157A (en) * 1965-09-17 1968-03-12 Smith Kline French Lab 6, 6-ethylene-19 nortestosterones
GB1089945A (en) * 1965-09-23 1967-11-08 British Drug Houses Ltd Steroidal-6-spirocyclopropyl-4-en-3-ones
US3470156A (en) * 1967-01-30 1969-09-30 Smithkline Corp 6,6-ethylene-1,2-methylenesteroids
US4001312A (en) * 1970-12-09 1977-01-04 Sumitomo Chemical Company, Limited Aminoalcohols
US4018778A (en) * 1972-05-24 1977-04-19 Cassella Farbwerke Mainkur Aktiengesellschaft Derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production
LU65414A1 (fr) * 1972-05-24 1973-12-04
LU69043A1 (fr) * 1973-12-20 1975-08-20
US3920635A (en) * 1974-11-27 1975-11-18 Searle & Co (6S)-17{40 -hydroxy-3{40 -oxospiro{8 oxirane-2,6{40 -{8 17{60 {9 pregn{8 4{9 ene{9 -21{40 -carboxylic acid {65 -lactone, the {66 {hu 1,4 {b analog, and intermediates
SE7807408L (sv) * 1978-06-30 1979-12-31 Haessle Ab Hjertaktiva foreningar
US5118816A (en) * 1990-12-26 1992-06-02 American Cyanamid Company 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles
US6835853B2 (en) * 2001-10-31 2004-12-28 Synthon Bv Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
EP1905758A1 (fr) * 2001-10-31 2008-04-02 Synthon B.V. Base tamsulosine et son procédé d'obtention
EP1506156A1 (fr) * 2002-05-07 2005-02-16 Mcm Pharma Gmbh Procede de preparation de 2-alkoxyphenoxyethanamines a partir de 2-alkoxyphenoxyethylacetamides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1165845A (fr) * 1955-05-28 1958-10-29 Philips Nv Amines secondaires portant des substituants et leur préparation
NL275411A (fr) * 1962-01-29

Also Published As

Publication number Publication date
DE1620111B2 (de) 1974-04-04
DK121904B (da) 1971-12-20
SE336786B (fr) 1971-07-19
CH460027A (de) 1968-07-31
US3412154A (en) 1968-11-19
BR6571997D0 (pt) 1973-08-14
CH450454A (fr) 1968-01-31
DE1493080C3 (de) 1974-11-28
DK134222C (fr) 1977-02-28
BE668219A (fr) 1966-02-14
FR7120M (fr) 1969-07-21
DE1620111A1 (de) 1970-01-02
US3261829A (en) 1966-07-19
BE668218A (fr) 1966-02-14
GB1078163A (en) 1967-08-02
DK134222B (da) 1976-10-04
DE1493080B2 (de) 1974-04-25
US3499891A (en) 1970-03-10
GB1041090A (en) 1966-09-01
GB1087828A (en) 1967-10-18
BE668124A (fr) 1965-12-01
DE1620111C3 (de) 1974-11-07
DE1493080A1 (de) 1969-06-12
FR4851M (fr) 1967-02-20

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