CH454888A - Process for the preparation of benzodiazepine derivatives - Google Patents

Process for the preparation of benzodiazepine derivatives

Info

Publication number
CH454888A
CH454888A CH1719566A CH1719566A CH454888A CH 454888 A CH454888 A CH 454888A CH 1719566 A CH1719566 A CH 1719566A CH 1719566 A CH1719566 A CH 1719566A CH 454888 A CH454888 A CH 454888A
Authority
CH
Switzerland
Prior art keywords
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
CH1719566A
Other languages
German (de)
Inventor
Keller Oscar
Steiger Norbert
Henryk Sternbach Leo
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH454888A publication Critical patent/CH454888A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH1719566A 1962-03-21 1963-02-12 Process for the preparation of benzodiazepine derivatives CH454888A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18144062A 1962-03-21 1962-03-21

Publications (1)

Publication Number Publication Date
CH454888A true CH454888A (en) 1968-04-30

Family

ID=22664289

Family Applications (3)

Application Number Title Priority Date Filing Date
CH175363A CH441342A (en) 1962-03-21 1963-02-12 Process for the preparation of benzodiazepine derivatives
CH1719566A CH454888A (en) 1962-03-21 1963-02-12 Process for the preparation of benzodiazepine derivatives
CH1719666A CH455814A (en) 1962-03-21 1963-02-12 Process for the preparation of benzodiazepine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH175363A CH441342A (en) 1962-03-21 1963-02-12 Process for the preparation of benzodiazepine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH1719666A CH455814A (en) 1962-03-21 1963-02-12 Process for the preparation of benzodiazepine derivatives

Country Status (7)

Country Link
BR (1) BR6347165D0 (en)
CH (3) CH441342A (en)
DE (1) DE1445872A1 (en)
DK (1) DK107100C (en)
ES (1) ES286241A1 (en)
GB (1) GB1039372A (en)
SE (1) SE312808B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2529203A1 (en) * 1982-06-24 1983-12-30 Fabre Sa Pierre Flunitrazepam hypnotic prepn. and purificn. - by 7-nitration of 5-ortho-fluoro-phenyl 1,3-di:hydro-2H-1,4- benzodiazepine-2-one and methylation of the prod.

Also Published As

Publication number Publication date
ES286241A1 (en) 1963-11-16
CH441342A (en) 1967-08-15
CH455814A (en) 1968-05-15
DE1445872A1 (en) 1969-04-10
SE312808B (en) 1969-07-28
DK107100C (en) 1967-04-24
GB1039372A (en) 1966-08-17
BR6347165D0 (en) 1973-07-19

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