CH282623A - Process for the preparation of a peptide-like derivative of the lysergic acid series. - Google Patents

Process for the preparation of a peptide-like derivative of the lysergic acid series.

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Publication number
CH282623A
CH282623A CH282623DA CH282623A CH 282623 A CH282623 A CH 282623A CH 282623D A CH282623D A CH 282623DA CH 282623 A CH282623 A CH 282623A
Authority
CH
Switzerland
Prior art keywords
dihydro
preparation
lysergic acid
peptide
derivative
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Sandoz
Original Assignee
Ag Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Sandoz filed Critical Ag Sandoz
Publication of CH282623A publication Critical patent/CH282623A/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

  

  Verfahren zur Darstellung eines     peptidartigen    Derivates der     Lysergsäure-Reihe.       Das vorliegende Patent betrifft ein Ver  fahren zur Darstellung von     Dihydro-d-lyser-          gyl-g@ycyl-g@ycin,        Eielches    dadurch gekenn  zeichnet ist, dass man     Dihydro-d-lysergsäure-          azid    mit     (Tly        ey        1-glycin    kondensiert.  



  <I>Beispiel:</I>  Die Lösungen von 1,0g     Dihydro-d-lyserg-          säure-azid    in 13     cm3        Dioxan    und von 0,43 g       Gly        cyl-gl@#cin    in 7.6     cm3    Wasser werden bei       Raumtemperatur    gemischt. Im Verlauf von  wenigen Minuten scheidet sich das Konden  sationsprodukt als weisse Kristallmasse aus der  Reaktionslösung ab. Ausbeute 1,0     g.     



  Das     Dihydro-d-lysergi-l-glyeyl-glycin    wird       dureh    Auflösen in     konz.    wässerigem Ammo  niak und Einengen der filtrierten Lösung um  kristallisiert. Es werden so kurze Nadeln vom       Smp.    239      (korr.)    erhalten, die in Alkohol  mässig, in den übrigen organischen Lösungs  mitteln schwer löslich sind.    Bruttoformel     C2OH2404N4          Ber.        N        14,57%        Gef.        N        14,75%     
EMI0001.0032  
   (c = 0,2 in     5o/oigem    wässe  rigem Ammoniak).



  Process for the preparation of a peptide-like derivative of the lysergic acid series. The present patent relates to a process for the preparation of dihydro-d-lysergyl-g @ ycyl-g @ ycin, Eielches is characterized in that dihydro-d-lysergic acid azide is condensed with (Tly ey 1-glycine.



  <I> Example: </I> The solutions of 1.0 g of dihydro-d-lysergic acid azide in 13 cm3 of dioxane and of 0.43 g of gly cyl-gl @ # cin in 7.6 cm3 of water are mixed at room temperature. In the course of a few minutes, the condensation product separates out of the reaction solution as a white crystal mass. Yield 1.0g.



  The dihydro-d-lysergi-l-glyeyl-glycine is dissolved in conc. aqueous ammonia and concentration of the filtered solution to crystallize. There are thus short needles with a melting point of 239 (corr.) Obtained which are moderately soluble in alcohol and sparingly soluble in other organic solvents. Gross formula C2OH2404N4 Calc. N 14.57% found N 14.75%
EMI0001.0032
   (c = 0.2 in 50% aqueous ammonia).

Claims (1)

PATENTANSPRUCH Verfahren zur Darstellung von Dihydro- d-lysergyl-glycyl-glycin, dadurch gekennzeich net, dass man Dihydro-d-lysergsäure-azid mit Glycyl-gly ein kondensiert. Die neue Verbindung, das Dihydro-d- lysergyl-glyeyl-glycin, besitzt die Bruttofor mel C2oH2404N,4 und kristallisiert aus wäs serigem Ammoniak in kurzen Nadeln vom Smp. 239 (korr.). rigem Ammoniak). PATENT CLAIM Process for the preparation of dihydro- d-lysergyl-glycyl-glycine, characterized in that dihydro-d-lysergic acid-azide is condensed with glycyl-gly. The new compound, dihydro-d-lysergyl-glyeyl-glycine, has the gross formula C2oH2404N, 4 and crystallizes from aqueous ammonia in short needles with a melting point of 239 (corr.). ammonia). EMI0001.0043 (c = 0,2 in 5o/oigem wässe- Das Dihydro-d-ly sergy 1-glycyl-glycin soll als Zwischenprodukt zur Herstellung thera peutisch wirksamer Verbindungen Verwen dung finden. EMI0001.0043 (c = 0.2 in 50% water) The dihydro-d-ly sergy 1-glycyl-glycine is to be used as an intermediate for the production of therapeutically active compounds.
CH282623D 1948-09-17 1948-09-17 Process for the preparation of a peptide-like derivative of the lysergic acid series. CH282623A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH269795T 1948-09-17
CH282623T 1948-09-17

Publications (1)

Publication Number Publication Date
CH282623A true CH282623A (en) 1952-04-30

Family

ID=25731124

Family Applications (1)

Application Number Title Priority Date Filing Date
CH282623D CH282623A (en) 1948-09-17 1948-09-17 Process for the preparation of a peptide-like derivative of the lysergic acid series.

Country Status (1)

Country Link
CH (1) CH282623A (en)

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