CH248346A - Disinfection method. - Google Patents
Disinfection method.Info
- Publication number
- CH248346A CH248346A CH248346DA CH248346A CH 248346 A CH248346 A CH 248346A CH 248346D A CH248346D A CH 248346DA CH 248346 A CH248346 A CH 248346A
- Authority
- CH
- Switzerland
- Prior art keywords
- ethyl
- phenoxy
- dimethyl
- dodecyl
- ammonium bromide
- Prior art date
Links
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 7
- -1 phenoxy-ethyl-dimethyl-ammonium compounds Chemical class 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- MIHINWMALJZIBX-UHFFFAOYSA-N cyclohexa-2,4-dien-1-ol Chemical class OC1CC=CC=C1 MIHINWMALJZIBX-UHFFFAOYSA-N 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- YXUPZGKORWTXID-UHFFFAOYSA-N domiphen Chemical compound CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 YXUPZGKORWTXID-UHFFFAOYSA-N 0.000 description 2
- XBFHXTNTGDRBFN-UHFFFAOYSA-N n-methyl-n-(phenoxymethyl)ethanamine Chemical compound CCN(C)COC1=CC=CC=C1 XBFHXTNTGDRBFN-UHFFFAOYSA-N 0.000 description 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- PBLNBZIONSLZBU-UHFFFAOYSA-N 1-bromododecane Chemical compound CCCCCCCCCCCCBr PBLNBZIONSLZBU-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- GIDDQKKGAYONOU-UHFFFAOYSA-N octylazanium;bromide Chemical compound Br.CCCCCCCCN GIDDQKKGAYONOU-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
Verfahren zur Desinfektion. Es ist bekannt, dass Aryloxyalkyl-ammo- niumverbindungen, die sich von zweiwertigen Phenolen ableiten, desinfizierend wirken.
Es wurde nun gefunden, dass auch Phen- oxv-äthy1-dimethyl - ammoniumver bindungen der Reihe der einwertigen Phenole, die am quaternären Stickstoffatom ausserdem einen Kohlenwasserstoffrest mit mindestens 8 Koh- lenstoffatomen enthalten, gut desinfizierend wirken und infolgedessen zur Desinfektion Verwendung finden können, gegebenenfalls im Gemisch mit andern Stoffen. Der Phenyl- kern kann z.
B. auch Halogenatome oder Alkylreste tragen. Erwähnt seien beispiels weise folgende Verbindungen: (ss-Phenoxy- äthyl) -dimethyl- dodecyl-ammoniumbromid, Phenoxy - äthyl) -dimethyl - dodecyl-ammo- niumchlorid, (ss-Phenoxy-äthyl) - dimethyl- dodeeyl-p-toluolsulfonat, (ss-Phenoxy-äthyl)
- dimethy 1- octyl - ammoniumbromid, (ss - Phen- oxy-äthyl) -dimethyl - äthylhexyl - ammonium- bromid, (ss-Phenoxy-äthyl)-dimethyl-hexa- decyl-ammoniizmbromid, [ss-(p-Chlor-phen- oxy)
- äthyl ] - dimethyl - dodecyl - ainmonium- bromid, [ss- (p - Methyl - phenoxy) - äthyl]- di- methyl-dodecyl-ammoniumbromid, [ss-(o-Me- thyl -phenoxy) -äthyll - dimethyl-dodecyl-am- moniumbromid, [ss-(p-Hexyl-phenoxy)
-äthyl] - dimethyl-dodecyl-ammoniumbromid, [ss-(p- tert. Butyl-phenoxy) -äthyll-dimethyl-dode- cyl-ammoniumbromid, [ss-(p-Isooctyl-phen- oxy) - äthyl] - dümethyl - dodecyl - ammonium- bromid und rss-(p-tert. Octyl-phenoxy)
-äthyll- dimethyl-dodecyl-ammoniumbromid. Die ge nannten Verbindungen sind in Wasser leicht löslich und zum Teil gut kristallisiert.
Das erfindungsgemässe Verfahren zur Desinfektion lässt sich auf den verschieden sten Gebieten verwenden. So ist es geeignet für die Desinfektion von Instrumenten, Ver bandstoffen, Wäsche oder dergleichen.
Die angeführten Phenoxy-äthyl-dimethyl- ammoniumverbindungen können in Form von Lösungen oder Emulsionen gemischt mit an dern desinfizierend wirkenden oder inerten Stoffen oder auch in Form von Trocken pulvern zur Anwendung kommen.
Die Phenoxy-äthyl-dimethyl-ammonium- verbindungen der genannten Art sind neu. Sie lassen sich z. B. durch Behandlung der ent sprechenden Phenoxy - äthyl - dimethyl - amine mit den geeigneten quaternisierenden Mitteln darstellen. Die Phenoxy-äthyl-dimethyl-amine ihrerseits sind bekannt oder können z. B. nach üblichen Methoden hergestellt werden.
<I>Beispiel:</I> Ärztliche Instrumente werden in eine 1 /ooige wässerige Lösung von (ss-Phenoxy- äthyl) - dimethyl - dodecyl - ammoniumbromid (erhalten z. B. durch Erwärmen von (ss-P'hen- oxy-äthyl)-dimethylaminmitDodecyl-bromid) unter Zusatz von etwas .Soda oder Natrium nitrit gelegt. Nach ca. 10 Minuten sind die Instrumente keimfrei.
Disinfection method. It is known that aryloxyalkylammonium compounds which are derived from dihydric phenols have a disinfecting effect.
It has now been found that phenoxy-ethy1-dimethylammonium compounds of the series of monohydric phenols, which also contain a hydrocarbon radical with at least 8 carbon atoms on the quaternary nitrogen atom, have a good disinfecting effect and can therefore be used for disinfection, if appropriate mixed with other substances. The phenyl nucleus can, for.
B. also carry halogen atoms or alkyl radicals. The following compounds may be mentioned, for example: (ss-phenoxy-ethyl) -dimethyl-dodecyl-ammonium bromide, phenoxy-ethyl) -dimethyl-dodecyl-ammonium chloride, (s-phenoxy-ethyl) - dimethyl-dodeeyl-p-toluenesulfonate, (ss-phenoxy-ethyl)
- dimethy 1- octyl - ammonium bromide, (ss - phenoxy-ethyl) -dimethyl - ethylhexyl - ammonium bromide, (ss-phenoxy-ethyl) -dimethyl-hexadecyl-ammonium bromide, [ss- (p-chloro- phenoxy)
- ethyl] - dimethyl - dodecyl - ammonium bromide, [ss- (p - methyl - phenoxy) - ethyl] - dimethyl dodecyl ammonium bromide, [ss- (o-methyl phenoxy) ethyl - dimethyl -dodecyl-ammonium bromide, [ss- (p-hexyl-phenoxy)
-ethyl] - dimethyl-dodecyl-ammonium bromide, [ss- (p-tert. butyl-phenoxy) -ethyl-dimethyl-dodecyl-ammonium bromide, [ss- (p-isooctyl-phenoxy) - ethyl] - dimethyl - dodecyl - ammonium bromide and rss- (p-tert. octyl-phenoxy)
-äthyll- dimethyl-dodecyl-ammonium bromide. The compounds mentioned are easily soluble in water and some of them are well crystallized.
The inventive method for disinfection can be used in a wide variety of fields. So it is suitable for the disinfection of instruments, band fabrics, linen or the like.
The listed phenoxy-ethyl-dimethylammonium compounds can be used in the form of solutions or emulsions mixed with other disinfecting or inert substances or in the form of dry powders.
The phenoxy-ethyl-dimethyl-ammonium compounds of the type mentioned are new. You can z. B. by treating the corresponding phenoxy - ethyl - dimethyl - amine with the appropriate quaternizing agents. The phenoxy-ethyl-dimethyl-amines in turn are known or can be, for. B. be prepared by conventional methods.
<I> Example: </I> Medical instruments are immersed in a 1 / o aqueous solution of (ss-phenoxy-ethyl) - dimethyl - dodecyl - ammonium bromide (obtained e.g. by heating (ss-p'henoxy -äthyl) -dimethylamine with dodecyl bromide) with the addition of some soda or sodium nitrite. The instruments are sterile after approx. 10 minutes.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH248346T | 1944-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH248346A true CH248346A (en) | 1947-04-30 |
Family
ID=4466848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH248346D CH248346A (en) | 1944-11-24 | 1944-11-24 | Disinfection method. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH248346A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2786797A (en) * | 1954-05-18 | 1957-03-26 | Hollingshead Corp | Corrosion-inhibited quaternary ammonium compositions |
| US3260643A (en) * | 1962-04-18 | 1966-07-12 | Ciba Ltd | Combating plant diseases with phenoxy-ethyl-dimethyl-dodecyl-ammonium halides |
-
1944
- 1944-11-24 CH CH248346D patent/CH248346A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2786797A (en) * | 1954-05-18 | 1957-03-26 | Hollingshead Corp | Corrosion-inhibited quaternary ammonium compositions |
| US3260643A (en) * | 1962-04-18 | 1966-07-12 | Ciba Ltd | Combating plant diseases with phenoxy-ethyl-dimethyl-dodecyl-ammonium halides |
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