CH246387A - Process for the preparation of an ephedrine derivative. - Google Patents
Process for the preparation of an ephedrine derivative.Info
- Publication number
- CH246387A CH246387A CH246387DA CH246387A CH 246387 A CH246387 A CH 246387A CH 246387D A CH246387D A CH 246387DA CH 246387 A CH246387 A CH 246387A
- Authority
- CH
- Switzerland
- Prior art keywords
- ephedrine
- preparation
- derivative
- bromo
- ephedrine derivative
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines Ephedrinderivates. Ephedrin und dessen Salze werden in der Therapie zur Reizung de Sympathicus an gewandt. Diese Stoffe haben aber eine starke blutdrucksteigernde Wirkung, so dass sie z. B. hauptsächlich bei der Behandlung älte rer Patienten nicht zur Anwendung kommen können.
Die vorliegende Erfindung betrifft nun ein Verfahren zur Herstellung eines Ephe- drinderivates, das dadurch gekennzeichnet ist, dass man Ephedrin mit a-Brom-isoval@e- riansäure umsetzt. Das so erhaltene Ephedrin- a-bromisovalerianat ist eine weisse, kristalli sierte, wasserlösliche Substanz, die bei 12-9-1.311 C schmilzt und zu pharmazeu tischen Zwecken Verwendung finden soll.
Das Ephedrin-a-brom-isovalerianat hat z. B: neben der bekannten Ephedrin-Wir- kung den Vorteil, in geringerem Masse als die bisher bekannten Ephedrinpräparate den Blutdruck zu steigern. Ausserdem zeigt das neue Produkt durch die Sedativ-Komponente der Brom-isovaleriansäureeine stark desensi bilisierende Wirkung gegen Allergene im allgemeinen und wirkt insbesondere bei mit Juckreiz verbundenen allergischen Zuständen beruhigend.
<I>Beispiel:</I> 165 g Ephedrin werden mit<B>181</B> g a-Brom- isovaleriansäure unter starkem Schütteln ver mischt, einige Stundenstehen gelassen. wobei sich das kristallisierte Ephedrin-a-brom-iso- valerianat ausscheidet. Die Kristalle werden durch Umkristallisieren aus Methanol gerei- nizt.
Process for the preparation of an ephedrine derivative. Ephedrine and its salts are used in therapy to stimulate the sympathetic nervous system. However, these substances have a strong blood pressure-increasing effect, so that they B. mainly in the treatment of elderly patients can not be used.
The present invention relates to a process for the production of an epherrin derivative, which is characterized in that ephedrine is reacted with a-bromo-isoval @ eric acid. The ephedrine a-bromoisovalerianate obtained in this way is a white, crystallized, water-soluble substance which melts at 12-9-1,311 C and is intended to be used for pharmaceutical purposes.
The ephedrine-a-bromine isovalerate z. B: In addition to the well-known ephedrine effect, the advantage of increasing blood pressure to a lesser extent than the previously known ephedrine preparations. In addition, thanks to the sedative component of bromoisovaleric acid, the new product has a strong desensitizing effect against allergens in general and has a calming effect in particular in allergic conditions associated with itching.
<I> Example: </I> 165 g ephedrine are mixed with <B> 181 </B> g a-bromo-isovaleric acid with vigorous shaking, left to stand for a few hours. the crystallized ephedrine-a-bromo-isovalerianate separates out. The crystals are purified by recrystallization from methanol.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH246387T | 1945-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH246387A true CH246387A (en) | 1946-12-31 |
Family
ID=4465506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH246387D CH246387A (en) | 1945-06-12 | 1945-06-12 | Process for the preparation of an ephedrine derivative. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH246387A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008071948A2 (en) * | 2006-12-12 | 2008-06-19 | Sosei R & D Ltd. | Aminoalcohol derivatives and their therapeutic use |
-
1945
- 1945-06-12 CH CH246387D patent/CH246387A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008071948A2 (en) * | 2006-12-12 | 2008-06-19 | Sosei R & D Ltd. | Aminoalcohol derivatives and their therapeutic use |
| WO2008071948A3 (en) * | 2006-12-12 | 2008-07-31 | Sosei R & D Ltd | Aminoalcohol derivatives and their therapeutic use |
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