CH132446A - Process for the preparation of bismuth thiosalicylic acid i-amyl ester. - Google Patents

Process for the preparation of bismuth thiosalicylic acid i-amyl ester.

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Publication number
CH132446A
CH132446A CH132446DA CH132446A CH 132446 A CH132446 A CH 132446A CH 132446D A CH132446D A CH 132446DA CH 132446 A CH132446 A CH 132446A
Authority
CH
Switzerland
Prior art keywords
bismuth
amyl ester
acid
preparation
thiosalicylic acid
Prior art date
Application number
Other languages
German (de)
Inventor
Schering-Kahlbaum A G
Original Assignee
Schering Kahlbaum Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Kahlbaum Ag filed Critical Schering Kahlbaum Ag
Publication of CH132446A publication Critical patent/CH132446A/en

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Description

  

  Verfahren zur Darstellung von     Wismutthiosalieylsäure-i-amylester.       Das     therrapeutisch    wirksame Wismut.       zeigt    eine besonders günstige therapeutische  Wirkung, wenn man es in den kranken Or  ganismus in Form eines Depots einführt, aus  dem dasselbe erst allmählich in Wirksam  keit tritt.  



  Als besonders geeignet erweist sich hier  für, wie Versuche gezeigt haben, der     Wis-          mutthiosalicylsäure-i-amylester,    der sich  in Olivenöl, Sesamöl,     Äthylin    oder andern  zur Injektion geeigneten organischen Mitteln  löst.  



  Man gelangt zu     dieserWismutverbindung,     indem man eine     schwefelfr,eiie    Verbindung  des Wismuts auf     Thiosalicylsäure-i-amyl-          ester    einwirken lässt.  



  <I>Beispiel:</I>  24,4 Teile     Thiosalicylsäure-i-amylester     vom Kochpunkt 172   bei 20 mm Druck wer  den unter Rühren in einem     Wasserstoff-          oder        Kohlensäurestrom    mit 7,7 Teilen     Wis-          mutoxyd    eine Stunde lang im     Olbad    auf  <B>170'</B> erwärmt, wobei sich das     Wismutoxyd       allmählich fast vollständig auflöst. Das ent  stehende Reaktionswasser lässt man dabei       abdestillieren.    Nach dem Erkalten erstarrt  die ganze     Masse    zu einem grüngelben Ku  chen.

   Die Verbindung bildet, aus Alkohol  umkristallisiert, gelbgrüne Nadeln vom  Schmelzpunkt 83  .  



  Sie ist leicht löslich in Äther, Essigester,       Benzoesäure,        Cyclohexylester    und andern  Estern, wie Olivenöl, unlöslich in Wasser,  schwer löslich in kaltem Alkohol. Sie hat  einen     Wismutgehalt    von<B>23,7</B>      ä    (berechnet  23,7



  Process for the preparation of i-amyl bismuth thiosalieylate. The therapeutically effective bismuth. shows a particularly beneficial therapeutic effect when it is introduced into the sick organism in the form of a depot, from which the same only gradually comes into effect.



  As tests have shown, the bismutthiosalicylic acid i-amyl ester, which dissolves in olive oil, sesame oil, ethylin or other organic agents suitable for injection, has proven to be particularly suitable here.



  This bismuth compound is obtained by letting a sulfur-free compound of bismuth act on i-amyl thiosalicylate.



  <I> Example: </I> 24.4 parts of i-amyl thiosalicylate with a boiling point of 172 at 20 mm pressure are mixed with 7.7 parts of bismuth oxide in an oil bath for one hour while stirring in a stream of hydrogen or carbon dioxide B> 170 '</B>, the bismuth oxide gradually dissolving almost completely. The resulting water of reaction is allowed to distill off. After cooling, the whole mass solidifies into a green-yellow cake.

   Recrystallized from alcohol, the compound forms yellow-green needles with a melting point of 83.



  It is easily soluble in ether, ethyl acetate, benzoic acid, cyclohexyl ester and other esters such as olive oil, insoluble in water, sparingly soluble in cold alcohol. It has a bismuth content of <B> 23.7 </B> ä (calculated 23.7

Claims (1)

PATENTANSPRUCH: \% erfahren zur Herstellung von uTisrnut- th'iosalicylsäure-i-amylester, dadurch gekenn zeichnet, dass man eine schwefelfreie Wis- mutverbindung mit Thiosalicylsäure-i-amyl- ester umsetzt. Die erhaltene Wismutverbindung bildet. aus Alkohol umkristallisiert, gelbgrüne Na- dein vom Schmelzpunkt $$ . PATENT CLAIM: \% experienced in the production of uTisrnut- th'iosalicylic acid i-amyl ester, characterized in that a sulfur-free bismuth compound is reacted with thiosalicylic acid i-amyl ester. The bismuth compound obtained forms. Recrystallized from alcohol, yellow-green needles with a melting point of $$. Sie ist leicht löslich in Äther, 'Essigester, ssenzoesäure, Cyclohexylester und andern Estern, wie Olivenöl, unlöslich in Wasser, schwer löslich in kaltem Alkohol. Sie hat einen Wismut gehalt von 23,7 % (berechnet 23,7 %). It is easily soluble in ether, ethyl acetate, ssenzoic acid, cyclohexyl ester and other esters such as olive oil, insoluble in water, sparingly soluble in cold alcohol. It has a bismuth content of 23.7% (calculated 23.7%).
CH132446D 1926-12-16 1927-11-16 Process for the preparation of bismuth thiosalicylic acid i-amyl ester. CH132446A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE132446X 1926-12-16

Publications (1)

Publication Number Publication Date
CH132446A true CH132446A (en) 1929-04-15

Family

ID=5664530

Family Applications (1)

Application Number Title Priority Date Filing Date
CH132446D CH132446A (en) 1926-12-16 1927-11-16 Process for the preparation of bismuth thiosalicylic acid i-amyl ester.

Country Status (1)

Country Link
CH (1) CH132446A (en)

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