CA999592A - 1,4-dihydropyridines, their production and use - Google Patents

1,4-dihydropyridines, their production and use

Info

Publication number
CA999592A
CA999592A CA173,419A CA173419A CA999592A CA 999592 A CA999592 A CA 999592A CA 173419 A CA173419 A CA 173419A CA 999592 A CA999592 A CA 999592A
Authority
CA
Canada
Prior art keywords
dihydropyridines
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA173,419A
Other languages
English (en)
Other versions
CA173419S (en
Inventor
Wulf Vater
Friedrich Bossert
Horst Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of CA999592A publication Critical patent/CA999592A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA173,419A 1972-06-10 1973-06-07 1,4-dihydropyridines, their production and use Expired CA999592A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2228363A DE2228363A1 (de) 1972-06-10 1972-06-10 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
CA999592A true CA999592A (en) 1976-11-09

Family

ID=5847399

Family Applications (1)

Application Number Title Priority Date Filing Date
CA173,419A Expired CA999592A (en) 1972-06-10 1973-06-07 1,4-dihydropyridines, their production and use

Country Status (19)

Country Link
US (1) US3923818A (fr)
JP (1) JPS4948680A (fr)
AT (2) AT329561B (fr)
AU (1) AU473996B2 (fr)
BE (1) BE800679A (fr)
CA (1) CA999592A (fr)
CH (7) CH589058A5 (fr)
CS (5) CS178900B2 (fr)
DD (1) DD109383A5 (fr)
DE (1) DE2228363A1 (fr)
ES (5) ES415749A1 (fr)
FR (1) FR2187347B1 (fr)
GB (1) GB1425059A (fr)
HU (1) HU166354B (fr)
IE (1) IE37773B1 (fr)
IL (1) IL42458A (fr)
NL (1) NL7308059A (fr)
SU (5) SU511856A3 (fr)
ZA (1) ZA733880B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981882A (en) * 1972-08-31 1976-09-21 Bayer Aktiengesellschaft Process for preparing 4-aryl of hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
US3971796A (en) * 1973-07-12 1976-07-27 Bayer Aktiengesellschaft 1,4-Dihydropyridine esters
US4466972A (en) * 1977-06-20 1984-08-21 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4252956A (en) * 1979-03-19 1981-02-24 Vigante Brigita A Derivatives of 1,4-dihydropyridine-3-carbothiol acids
GB2111978B (en) * 1981-10-19 1985-05-01 Maruko Pharmaceutical Co 1 4-dihydropyridine compounds
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
JPS60210640A (ja) * 1984-10-05 1985-10-23 Hitachi Chem Co Ltd 積層板の製造法
GB8503425D0 (en) * 1985-02-11 1985-03-13 Ici Plc Alkanolamine derivatives
GB8503427D0 (en) * 1985-02-11 1985-03-13 Ici Plc Basic compounds
GB8503428D0 (en) * 1985-02-11 1985-03-13 Ici Plc Nitrogen-containing compounds
GB8503429D0 (en) * 1985-02-11 1985-03-13 Ici Plc Chemical compounds
US4593033A (en) * 1985-04-24 1986-06-03 Merck & Co., Inc. Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
US4605660A (en) * 1985-06-03 1986-08-12 Merck & Co., Inc. Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers
US4670443A (en) * 1985-07-02 1987-06-02 Merck & Co., Inc. Benzo(f)isoquinoline compounds useful as calcium entry blockers
EP0226271B1 (fr) * 1985-08-21 1990-11-22 GLAXO S.p.A. Dihydro-1,4 pyridines, leur préparation et composition pharmaceutique
ES2001104A6 (es) * 1985-08-21 1988-04-16 Glaxo Spa Un procedimiento para la preparacion de nuevos derivados sustituidos del acido 1,4-dihidro-3,5-piridindicarboxilico.
US4735956A (en) * 1985-09-13 1988-04-05 Merck & Co., Inc. Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
US4788203A (en) * 1985-11-26 1988-11-29 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders
US4721708A (en) * 1985-11-26 1988-01-26 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
EP0330470A3 (fr) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. Dérivés de 1,4-dihydropyridine utiles contre les cellules tumorales
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
FR2672890A1 (fr) * 1991-02-20 1992-08-21 Inst Investigacion Desarrol Derives de 2,6-dimethyl-4-(4'-hydroxy-3',5'-di-t-butylphenyl)-1,4-dihydropyridine, leur procede de preparation et leur utilisation comme capteurs de radicaux libres.
EP1108710A4 (fr) * 1998-07-23 2001-11-21 Chen Ing Jun Guaiacoxypropanolamines a activite alpha/beta-adrenolytique
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US20030153773A1 (en) * 2002-02-14 2003-08-14 Wayne Gregory S. Process for the production of dihydropyridines
WO2005016885A2 (fr) * 2003-08-14 2005-02-24 Artesian Therapeutics, Inc. Composes contenant un bloqueur des canaux calciques combine a un antagoniste $g(b)-adrenergique ou presentant des activites agonistes partielles utilises pour traiter les cardiopathies
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
EP2063905B1 (fr) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
ZA7152B (en) * 1970-01-24 1971-10-27 Bayer Ag New pharmaceutically active 1,4-dihydropyridines

Also Published As

Publication number Publication date
SU511856A3 (ru) 1976-04-25
IL42458A0 (en) 1973-08-29
DD109383A5 (fr) 1974-11-05
NL7308059A (fr) 1973-12-12
ES415749A1 (es) 1976-06-16
IE37773L (en) 1973-12-10
DE2228363A1 (de) 1974-01-03
AT329561B (de) 1976-05-25
IE37773B1 (en) 1977-10-12
CS178888B2 (en) 1977-10-31
GB1425059A (en) 1976-02-18
ATA177075A (de) 1975-08-15
ZA733880B (en) 1974-05-29
SU510997A3 (ru) 1976-04-15
CH591443A5 (fr) 1977-09-15
ES440622A1 (es) 1977-03-01
CS178897B2 (en) 1977-10-31
CH591444A5 (fr) 1977-09-15
AU473996B2 (en) 1976-07-08
FR2187347A1 (fr) 1974-01-18
ES440619A1 (es) 1977-03-01
JPS4948680A (fr) 1974-05-11
AU5672573A (en) 1974-12-12
IL42458A (en) 1977-07-31
HU166354B (fr) 1975-03-28
US3923818A (en) 1975-12-02
ES440621A1 (es) 1977-03-01
CH588462A5 (fr) 1977-06-15
BE800679A (fr) 1973-12-10
CS178898B2 (en) 1977-10-31
CS178900B2 (en) 1977-10-31
SU512708A3 (ru) 1976-04-30
CH589629A5 (fr) 1977-07-15
SU509221A3 (ru) 1976-03-30
ES440620A1 (es) 1977-03-01
CS178899B2 (en) 1977-10-31
SU507234A3 (ru) 1976-03-15
CH589628A5 (fr) 1977-07-15
ATA507473A (de) 1975-06-15
CH593260A5 (fr) 1977-11-30
FR2187347B1 (fr) 1977-09-09
AT328447B (de) 1976-03-25
CH589058A5 (fr) 1977-06-30

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