CA983503A - Method of preparing 4-substituted-1-(4-ar1-4-ar2-butyl)-piperidines - Google Patents

Method of preparing 4-substituted-1-(4-ar1-4-ar2-butyl)-piperidines

Info

Publication number
CA983503A
CA983503A CA154,791A CA154791A CA983503A CA 983503 A CA983503 A CA 983503A CA 154791 A CA154791 A CA 154791A CA 983503 A CA983503 A CA 983503A
Authority
CA
Canada
Prior art keywords
piperidines
butyl
substituted
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA154,791A
Other languages
English (en)
Other versions
CA154791S (fr
Inventor
Marcel A.C. Janssen
Henri E. F. D'haen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of CA983503A publication Critical patent/CA983503A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA154,791A 1971-11-25 1972-10-25 Method of preparing 4-substituted-1-(4-ar1-4-ar2-butyl)-piperidines Expired CA983503A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9485771A JPS5527915B2 (da) 1971-11-25 1971-11-25

Publications (1)

Publication Number Publication Date
CA983503A true CA983503A (en) 1976-02-10

Family

ID=14121686

Family Applications (1)

Application Number Title Priority Date Filing Date
CA154,791A Expired CA983503A (en) 1971-11-25 1972-10-25 Method of preparing 4-substituted-1-(4-ar1-4-ar2-butyl)-piperidines

Country Status (14)

Country Link
JP (1) JPS5527915B2 (da)
AR (2) AR198393A1 (da)
BG (2) BG20348A3 (da)
CA (1) CA983503A (da)
CH (1) CH579048A5 (da)
CS (1) CS168014B2 (da)
ES (1) ES408926A1 (da)
FR (1) FR2161007A1 (da)
HU (1) HU165208B (da)
IL (1) IL40917A (da)
NL (1) NL7214913A (da)
RO (2) RO63063A (da)
SU (1) SU462333A3 (da)
YU (1) YU35120B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106187863A (zh) * 2016-07-15 2016-12-07 湖南中南制药有限责任公司 五氟利多的制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082755A (en) * 1977-02-14 1978-04-04 Janssen Pharmaceutica N.V. 1-[(Diarylmethyl)aminoalkyl]piperidimes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (da) * 1962-06-13

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106187863A (zh) * 2016-07-15 2016-12-07 湖南中南制药有限责任公司 五氟利多的制备方法

Also Published As

Publication number Publication date
SU462333A3 (ru) 1975-02-28
JPS4860092A (da) 1973-08-23
IL40917A (en) 1976-10-31
RO63063A (fr) 1978-07-15
YU35120B (en) 1980-09-25
AR198393A1 (es) 1974-06-21
ES408926A1 (es) 1976-03-01
BG20349A3 (da) 1975-11-05
BG20348A3 (da) 1975-11-05
FR2161007B1 (da) 1976-03-05
IL40917A0 (en) 1973-01-30
CH579048A5 (da) 1976-08-31
JPS5527915B2 (da) 1980-07-24
NL7214913A (da) 1973-05-29
HU165208B (da) 1974-07-27
AR199497A1 (es) 1974-09-09
YU291672A (en) 1980-03-15
RO62760A (fr) 1978-02-15
CS168014B2 (da) 1976-05-28
FR2161007A1 (en) 1973-07-06

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