CA983039A - 3,4-dihydro-2h-isoquinoline-1-ones and process for preparing them - Google Patents

3,4-dihydro-2h-isoquinoline-1-ones and process for preparing them

Info

Publication number
CA983039A
CA983039A CA148,981A CA148981A CA983039A CA 983039 A CA983039 A CA 983039A CA 148981 A CA148981 A CA 148981A CA 983039 A CA983039 A CA 983039A
Authority
CA
Canada
Prior art keywords
isoquinoline
dihydro
ones
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA148,981A
Other languages
English (en)
Other versions
CA148981S (en
Inventor
Ernold Granzer
Gunther Seidl
Rudolf Kunstmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of CA983039A publication Critical patent/CA983039A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C49/215—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA148,981A 1971-09-01 1972-08-09 3,4-dihydro-2h-isoquinoline-1-ones and process for preparing them Expired CA983039A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2143744A DE2143744A1 (de) 1971-09-01 1971-09-01 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
CA983039A true CA983039A (en) 1976-02-03

Family

ID=5818353

Family Applications (1)

Application Number Title Priority Date Filing Date
CA148,981A Expired CA983039A (en) 1971-09-01 1972-08-09 3,4-dihydro-2h-isoquinoline-1-ones and process for preparing them

Country Status (12)

Country Link
JP (1) JPS4834886A (ja)
AU (1) AU4610372A (ja)
BE (1) BE788322A (ja)
BG (3) BG19375A3 (ja)
CA (1) CA983039A (ja)
DD (1) DD102147A5 (ja)
DE (1) DE2143744A1 (ja)
FR (1) FR2151043A1 (ja)
HU (1) HU165204B (ja)
IL (1) IL40249A0 (ja)
NL (1) NL7211626A (ja)
ZA (1) ZA725996B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10376497B2 (en) 2012-10-02 2019-08-13 Intermune, Inc. Anti-fibrotic pyridinones

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5650682B2 (ja) * 1974-03-25 1981-12-01
DE2438966A1 (de) * 1974-08-14 1976-03-04 Hoechst Ag Basisch substituierte 3,,4-dihydro2h-isochinolin-1-one und verfahren zu ihrer herstellung
GB1576511A (en) * 1977-03-29 1980-10-08 Parcor Thieno(2,3 - c) and (3,2 - c) pyridines process for their preparation and therapeutic applications thereof
DE3443994A1 (de) * 1984-06-14 1985-12-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von gegebenenfalls substituierten benz(c,d)-indol-2-onen
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
WO2015153683A1 (en) 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10376497B2 (en) 2012-10-02 2019-08-13 Intermune, Inc. Anti-fibrotic pyridinones
US10898474B2 (en) 2012-10-02 2021-01-26 Intermune, Inc. Anti-fibrotic pyridinones

Also Published As

Publication number Publication date
FR2151043A1 (en) 1973-04-13
JPS4834886A (ja) 1973-05-22
DE2143744A1 (de) 1973-03-08
NL7211626A (ja) 1973-03-05
DD102147A5 (ja) 1973-12-05
AU4610372A (en) 1974-03-07
ZA725996B (en) 1973-06-27
BG20410A3 (ja) 1975-11-05
IL40249A0 (en) 1972-10-29
BG19799A3 (ja) 1975-10-10
BE788322A (fr) 1973-03-01
HU165204B (ja) 1974-07-27
BG19375A3 (ja) 1975-06-15

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