CA968803A - Pyridone anti-inflammatory agents - Google Patents
Pyridone anti-inflammatory agentsInfo
- Publication number
- CA968803A CA968803A CA097,512A CA97512A CA968803A CA 968803 A CA968803 A CA 968803A CA 97512 A CA97512 A CA 97512A CA 968803 A CA968803 A CA 968803A
- Authority
- CA
- Canada
- Prior art keywords
- pyridone
- inflammatory agents
- inflammatory
- agents
- pyridone anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87605969A | 1969-11-12 | 1969-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA968803A true CA968803A (en) | 1975-06-03 |
Family
ID=25366913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA097,512A Expired CA968803A (en) | 1969-11-12 | 1970-11-05 | Pyridone anti-inflammatory agents |
Country Status (14)
Country | Link |
---|---|
US (1) | US3654291A (en) |
JP (1) | JPS4815950B1 (en) |
BE (1) | BE758759A (en) |
CA (1) | CA968803A (en) |
CH (1) | CH549569A (en) |
DE (1) | DE2055513A1 (en) |
ES (1) | ES385397A1 (en) |
FR (1) | FR2073341B1 (en) |
GB (1) | GB1299100A (en) |
IL (1) | IL35568A (en) |
NL (1) | NL7015826A (en) |
NO (1) | NO133669C (en) |
SE (1) | SE386439B (en) |
ZA (1) | ZA707636B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3721676A (en) * | 1969-11-12 | 1973-03-20 | Merck & Co Inc | Certain 3-amino-2(1h)pyridones |
GB1419994A (en) * | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
US4578459A (en) * | 1973-05-03 | 1986-03-25 | Smithkline & French Laboratories Limited | Heterocyclic alkylaminoheterocycles |
US4260744A (en) * | 1973-05-03 | 1981-04-07 | Smith Kline & French Laboratories Limited | Pharmacologically active compounds |
US4035374A (en) * | 1973-05-03 | 1977-07-12 | Smith Kline & French Laboratories Limited | Imidazolyl alkylaminopyridone and pyridinethione compounds |
US4467087A (en) * | 1973-05-03 | 1984-08-21 | Smith Kline & French Laboratories Limited | 1,2,4-Triazines |
DE3106460A1 (en) * | 1980-03-03 | 1982-01-28 | Sandoz-Patent-GmbH, 7850 Lörrach | 2 (1H) -PYRIDINONE DERIVATIVES, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME |
US4371537A (en) * | 1981-08-13 | 1983-02-01 | The Dow Chemical Company | Sulfur-substituted phenoxypyridines having antiviral activity |
US4412077A (en) * | 1982-03-15 | 1983-10-25 | Sterling Drug Inc. | Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone |
US4524149A (en) * | 1982-03-15 | 1985-06-18 | Sterling Drug Inc. | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use |
US4451469A (en) * | 1982-12-16 | 1984-05-29 | Sterling Drug Inc. | Selected 6-alkyl-and 4,6-dialkyl-2(1H)-pyridinones as cardiotonics |
US4681873A (en) * | 1985-07-29 | 1987-07-21 | Warner-Lambert Company | 4-amino-3-halo-2-pyridinone nucleoside and nucleotide compounds |
US5032602A (en) * | 1988-12-14 | 1991-07-16 | Bayer Aktiengesellschaft | Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and pyrid-2-thiones |
US5164506A (en) * | 1988-12-14 | 1992-11-17 | Bayer Aktiengesellschaft | Substituted 2-pyridones and pyrid-2-thiones compounds |
US5308854A (en) * | 1990-06-18 | 1994-05-03 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
GB9016578D0 (en) * | 1990-07-27 | 1990-09-12 | Ici Plc | Fungicides |
AP1822A (en) * | 2002-02-14 | 2008-01-30 | Pharmacia Corp | Substituted pyridinones as modulators of P38 MAP kinase. |
KR100901931B1 (en) | 2002-02-14 | 2009-06-10 | 파마시아 코포레이션 | Substituted Pyridinones as Modulators of P38 MAP Kinase |
AU2007202607B2 (en) * | 2002-02-14 | 2008-12-18 | Pharmacia Corporation | Substituted Pyridinones as Modulators of p38 MAP Kinase |
NL1026826C2 (en) * | 2003-08-13 | 2007-01-04 | Pharmacia Corp | Substituted pyridinones. |
CN109311813B (en) * | 2016-04-18 | 2023-02-28 | 斯克利普斯研究院 | Palladium-catalyzed meta-C-H functionalized universal ligands |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE596728C (en) * | 1932-10-26 | 1934-05-09 | Chem Fab Von Heyden Akt Ges | Process for the preparation of 2-oxy-5-aminopyridine or its core substitution products |
DE626687C (en) * | 1934-07-05 | 1936-09-01 | Chem Fab Von Heyden Akt Ges | Process for the preparation of alkoxyaminopyridines |
NL6816241A (en) * | 1967-12-01 | 1969-06-03 |
-
0
- BE BE758759D patent/BE758759A/en unknown
-
1969
- 1969-11-12 US US876059A patent/US3654291A/en not_active Expired - Lifetime
-
1970
- 1970-10-28 NL NL7015826A patent/NL7015826A/xx not_active Application Discontinuation
- 1970-11-02 IL IL35568A patent/IL35568A/en unknown
- 1970-11-05 CA CA097,512A patent/CA968803A/en not_active Expired
- 1970-11-09 GB GB53254/70A patent/GB1299100A/en not_active Expired
- 1970-11-10 FR FR707040455A patent/FR2073341B1/fr not_active Expired
- 1970-11-10 CH CH1670070A patent/CH549569A/en not_active IP Right Cessation
- 1970-11-10 ES ES385397A patent/ES385397A1/en not_active Expired
- 1970-11-11 SE SE7015220A patent/SE386439B/en unknown
- 1970-11-11 NO NO4295/70A patent/NO133669C/no unknown
- 1970-11-11 ZA ZA707636A patent/ZA707636B/en unknown
- 1970-11-11 DE DE19702055513 patent/DE2055513A1/en active Pending
- 1970-11-12 JP JP45099159A patent/JPS4815950B1/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA707636B (en) | 1972-06-28 |
NL7015826A (en) | 1971-05-14 |
NO133669B (en) | 1976-03-01 |
NO133669C (en) | 1976-06-09 |
BE758759A (en) | 1971-05-10 |
FR2073341A1 (en) | 1971-10-01 |
ES385397A1 (en) | 1973-11-01 |
SE386439B (en) | 1976-08-09 |
DE2055513A1 (en) | 1971-05-19 |
FR2073341B1 (en) | 1973-08-10 |
JPS4815950B1 (en) | 1973-05-18 |
CH549569A (en) | 1974-05-31 |
IL35568A0 (en) | 1971-01-28 |
GB1299100A (en) | 1972-12-06 |
US3654291A (en) | 1972-04-04 |
IL35568A (en) | 1974-09-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA968803A (en) | Pyridone anti-inflammatory agents | |
AU2279270A (en) | Tricarboxystarch derivatives | |
CA945991A (en) | Pyridone and thiopyridone anti-inflammatory agents | |
CA948642A (en) | Phenazone-paracetamol complex | |
CA927830A (en) | Pyridone anti-inflammatory agents | |
AU1654170A (en) | Benzoisothiazol derivatives | |
ZA707637B (en) | Pyridone anti-inflammatory agents | |
CA827685A (en) | Pyridine compounds | |
CA827684A (en) | Pyridine compounds | |
CA814460A (en) | Bismuth-chlorhydroxyquinoline complex | |
AU447382B2 (en) | Uniersal joints | |
CA925483A (en) | Enceintes demontables et superposables | |
AU446019B2 (en) | New hydrazinecarbodithioate derivatives | |
CA804023A (en) | Pyridine derivatives | |
CA821752A (en) | Short construction | |
AU435024B2 (en) | New diphenylethylenediamines | |
AU438656B2 (en) | 2-iminobenzodiazepine derivatives | |
AU447115B2 (en) | Pyrimidinylpurazole derivatives | |
AU442701B2 (en) | Dihyrobenzazepine derivatives | |
AU455293B2 (en) | Propargyle derivatives | |
AU426674B2 (en) | Nitrofurane derivatives | |
AU443547B2 (en) | Phenylaminoethanol derivatives | |
AU436551B2 (en) | Pyrimidopyridazine derivatives | |
AU456690B2 (en) | Pleuromutalin derivatives | |
AU454318B2 (en) | Benzodiazephine derivatives |