CA962665A - Acyl derivatives of the digoxin and process for the production thereof - Google Patents
Acyl derivatives of the digoxin and process for the production thereofInfo
- Publication number
- CA962665A CA962665A CA132,333A CA132333A CA962665A CA 962665 A CA962665 A CA 962665A CA 132333 A CA132333 A CA 132333A CA 962665 A CA962665 A CA 962665A
- Authority
- CA
- Canada
- Prior art keywords
- digoxin
- production
- acyl derivatives
- acyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 title 1
- 125000002252 acyl group Chemical group 0.000 title 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title 1
- 229960005156 digoxin Drugs 0.000 title 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712101595 DE2101595A1 (de) | 1971-01-14 | 1971-01-14 | Neue Acylderivate des Digoxins und Verfahren zu deren Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA962665A true CA962665A (en) | 1975-02-11 |
Family
ID=5795884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA132,333A Expired CA962665A (en) | 1971-01-14 | 1972-01-13 | Acyl derivatives of the digoxin and process for the production thereof |
Country Status (24)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987031A (en) * | 1970-12-23 | 1976-10-19 | Boehringer Ingelheim Gmbh | Acyl derivatives of proscillaridin a |
| DE2354119A1 (de) * | 1973-10-29 | 1975-05-15 | Boehringer Sohn Ingelheim | Neue orthoformiatderivate des digitoxins, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| US3884905A (en) * | 1974-05-02 | 1975-05-20 | Interx Research Corp | Pro-drug forms of digoxin |
| US4021535A (en) * | 1975-01-14 | 1977-05-03 | Beckman Instruments, Inc. | Reagents used in the radioimmunoassay of digoxin |
| EP1202056A1 (en) * | 2000-10-30 | 2002-05-02 | Vrije Universiteit Amsterdam | Continuous-flow homogeneous bio-chemical assays based on mass spectrometric detection of known ligands |
| CN112552367B (zh) * | 2020-12-11 | 2023-06-06 | 郑州安图生物工程股份有限公司 | 一种地高辛衍生物及其制备方法 |
-
1971
- 1971-01-14 DE DE19712101595 patent/DE2101595A1/de active Pending
-
1972
- 1972-01-03 BG BG022617A patent/BG18877A3/xx unknown
- 1972-01-05 US US00215666A patent/US3804825A/en not_active Expired - Lifetime
- 1972-01-11 BG BG019442A patent/BG18190A3/xx unknown
- 1972-01-12 HU HUBO1345A patent/HU162743B/hu unknown
- 1972-01-12 PH PH13181A patent/PH10692A/en unknown
- 1972-01-12 NL NL7200446A patent/NL7200446A/xx unknown
- 1972-01-12 SE SE7200327A patent/SE379048B/xx unknown
- 1972-01-12 ES ES398804A patent/ES398804A1/es not_active Expired
- 1972-01-13 PL PL1972152879A patent/PL82940B1/pl unknown
- 1972-01-13 FI FI720070A patent/FI51359C/fi active
- 1972-01-13 ZA ZA720241A patent/ZA72241B/xx unknown
- 1972-01-13 GB GB172972A patent/GB1371937A/en not_active Expired
- 1972-01-13 AU AU37868/72A patent/AU465777B2/en not_active Expired
- 1972-01-13 CH CH46072A patent/CH571025A5/xx not_active IP Right Cessation
- 1972-01-13 IL IL38550A patent/IL38550A/en unknown
- 1972-01-13 CS CS230A patent/CS178403B2/cs unknown
- 1972-01-13 CA CA132,333A patent/CA962665A/en not_active Expired
- 1972-01-13 DK DK16872AA patent/DK126938B/da unknown
- 1972-01-13 BE BE778014A patent/BE778014A/xx unknown
- 1972-01-13 CH CH720075A patent/CH575435A5/xx not_active IP Right Cessation
- 1972-01-14 SU SU1737660A patent/SU511015A3/ru active
- 1972-01-14 AT AT32772A patent/AT317444B/de not_active IP Right Cessation
- 1972-01-14 RO RO7200069393A patent/RO62477A/ro unknown
- 1972-01-14 FR FR7201256A patent/FR2121851B1/fr not_active Expired
- 1972-01-14 IE IE55/72A patent/IE36060B1/xx unknown
- 1972-01-14 RO RO7271661A patent/RO68217A/ro unknown
- 1972-04-17 ES ES401836A patent/ES401836A1/es not_active Expired
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