CA960654A - Process for the demethylation of 3-amino macrolides - Google Patents

Process for the demethylation of 3-amino macrolides

Info

Publication number
CA960654A
CA960654A CA123,226A CA123226A CA960654A CA 960654 A CA960654 A CA 960654A CA 123226 A CA123226 A CA 123226A CA 960654 A CA960654 A CA 960654A
Authority
CA
Canada
Prior art keywords
demethylation
macrolides
amino
amino macrolides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA123,226A
Other languages
English (en)
Other versions
CA123226S (en
Inventor
Leslie A. Freiberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of CA960654A publication Critical patent/CA960654A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
CA123,226A 1970-11-02 1971-09-20 Process for the demethylation of 3-amino macrolides Expired CA960654A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8631470A 1970-11-02 1970-11-02

Publications (1)

Publication Number Publication Date
CA960654A true CA960654A (en) 1975-01-07

Family

ID=22197754

Family Applications (1)

Application Number Title Priority Date Filing Date
CA123,226A Expired CA960654A (en) 1970-11-02 1971-09-20 Process for the demethylation of 3-amino macrolides

Country Status (6)

Country Link
US (1) US3725385A (en:Method)
CA (1) CA960654A (en:Method)
DE (1) DE2154032C3 (en:Method)
FR (1) FR2113423A5 (en:Method)
GB (1) GB1334964A (en:Method)
ZA (1) ZA716324B (en:Method)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX3676E (es) * 1975-07-15 1981-04-23 Abbott Lab Procedimiento para obtener derivados del antibiotico xk-62-2
MA21697A1 (fr) * 1988-12-19 1990-07-01 Dow Agrosciences Llc Composes de macrolides.
DE4200145A1 (de) * 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
ES2099604T3 (es) * 1993-03-12 1997-05-16 Dowelanco Nuevos compuestos a83543 y procedimiento para su produccion.
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5922849A (en) * 1996-11-22 1999-07-13 Abbott Laboratories Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
US5883236A (en) * 1997-11-19 1999-03-16 Abbott Laboratories Process for N-desmethylating erythromycins and derivatives thereof
US6084079A (en) * 1998-05-15 2000-07-04 Keyes; Robert F. Process for preparing N-demethyl-N-alkyl erythromycin derivatives
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
US7348309B2 (en) * 2001-03-30 2008-03-25 Wisconsin Alumni Research Foundation Glycorandomization and production of novel vancomycin analogs
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
WO2004092736A2 (en) * 2003-04-17 2004-10-28 Sandoz Ag Derivatives of azithromycin
CA2530581A1 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
US8278281B2 (en) 2005-08-24 2012-10-02 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
CA2632779A1 (en) * 2005-12-08 2007-06-14 Pfizer Inc. Method for demethylating the 3'-dimethylamino group of erythromycin compounds
JP2009539866A (ja) * 2006-06-05 2009-11-19 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換エリスロマイシンアナログの調製および有用性
SI2102226T1 (sl) * 2006-12-12 2012-12-31 Zambon S.P.A. Makrolidne spojine s protivnetno aktivnostjo
WO2009006403A2 (en) * 2007-06-29 2009-01-08 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof
US8871728B2 (en) 2007-06-29 2014-10-28 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
JP2012516305A (ja) 2009-01-30 2012-07-19 グラクソ グループ リミテッド 好中球優位の炎症性疾患の治療のための９−デオキソ−９ａ−メチル−９ａ−アザ−９ａ−ホモエリスロマイシンａ誘導体
BRPI1006114A2 (pt) 2009-01-30 2018-02-06 Glaxo Group Ltd "macrolídeo antiinflamatório".
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
CN108727445B (zh) * 2018-06-29 2021-06-11 宜昌东阳光生化制药有限公司 一种阿奇霉素杂质f的合成方法
WO2024194494A1 (en) 2023-03-22 2024-09-26 Epiendo Pharmaceuticals Ehf Azithromycin derivatives for use in the treatment of eosinophil-related diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2812323A (en) * 1954-11-03 1957-11-05 Lilly Co Eli Des-n-methyl erythromycin
US3583972A (en) * 1969-06-11 1971-06-08 Upjohn Co N-dealkylation of cyclic tertiary amines

Also Published As

Publication number Publication date
GB1334964A (en) 1973-10-24
FR2113423A5 (en:Method) 1972-06-23
ZA716324B (en) 1972-05-31
DE2154032C3 (de) 1980-01-03
DE2154032B2 (de) 1979-05-10
US3725385A (en) 1973-04-03
AU3385571A (en) 1973-03-29
DE2154032A1 (de) 1972-05-04

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