CA3256789A1 - COMBINATION OF AN ALPHA 2-ADRENOCEPTOR SUBTYPE C ANTAGONIST (ALPHA-2 C) WITH A NOREPINEPHRINE RECOUPLE INHIBITOR FOR THE TREATMENT OF SLEEP APNEA - Google Patents
COMBINATION OF AN ALPHA 2-ADRENOCEPTOR SUBTYPE C ANTAGONIST (ALPHA-2 C) WITH A NOREPINEPHRINE RECOUPLE INHIBITOR FOR THE TREATMENT OF SLEEP APNEAInfo
- Publication number
- CA3256789A1 CA3256789A1 CA3256789A CA3256789A CA3256789A1 CA 3256789 A1 CA3256789 A1 CA 3256789A1 CA 3256789 A CA3256789 A CA 3256789A CA 3256789 A CA3256789 A CA 3256789A CA 3256789 A1 CA3256789 A1 CA 3256789A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- carboxamide
- thiazole
- bipiperidin
- difluoropyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21216872 | 2021-12-22 | ||
| EP21216872.8 | 2021-12-22 | ||
| PCT/EP2022/086965 WO2023118123A1 (en) | 2021-12-22 | 2022-12-20 | Combination of an α2-adrenoceptor subtype c (alpha-2c) antagonist with a norepinephrine reuptake inhibitor for the treatment of sleep apnea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3256789A1 true CA3256789A1 (en) | 2023-06-29 |
Family
ID=80225456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3256789A Pending CA3256789A1 (en) | 2021-12-22 | 2022-12-20 | COMBINATION OF AN ALPHA 2-ADRENOCEPTOR SUBTYPE C ANTAGONIST (ALPHA-2 C) WITH A NOREPINEPHRINE RECOUPLE INHIBITOR FOR THE TREATMENT OF SLEEP APNEA |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250049779A1 (https=) |
| EP (1) | EP4452242A1 (https=) |
| JP (1) | JP2025500344A (https=) |
| KR (1) | KR20240124995A (https=) |
| CN (1) | CN118475347A (https=) |
| AU (1) | AU2022418121A1 (https=) |
| CA (1) | CA3256789A1 (https=) |
| IL (1) | IL313646A (https=) |
| MX (1) | MX2024007768A (https=) |
| TW (1) | TW202342033A (https=) |
| WO (1) | WO2023118123A1 (https=) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966781A (en) | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
| HRP20041026A2 (en) | 2002-04-03 | 2005-06-30 | Orion Corporation | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
| US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2017031319A1 (en) | 2015-08-18 | 2017-02-23 | Massachusetts Institute Of Technology | Noradrenergic drug treatment of obstructive sleep apnea |
| GEAP202416602A (en) | 2017-04-28 | 2024-10-10 | Brigham & Womens Hospital Inc | Methods and compositions for treating sleep apnea |
| KR102874891B1 (ko) | 2018-01-30 | 2025-10-21 | 애프니메드, 인코포레이티드 (델라웨어) | 수면 무호흡증을 치료하기 위한 방법 및 조성물 |
| MX2021004883A (es) * | 2018-10-31 | 2021-08-05 | Apnimed Inc Delaware | Metodos y composiciones para tratar apnea del sue?o. |
| PE20221025A1 (es) | 2019-11-06 | 2022-06-16 | Bayer Ag | Inhibidores de los receptores a2c adrenergicos |
-
2022
- 2022-12-20 KR KR1020247023957A patent/KR20240124995A/ko active Pending
- 2022-12-20 CN CN202280085098.8A patent/CN118475347A/zh active Pending
- 2022-12-20 EP EP22840709.4A patent/EP4452242A1/en active Pending
- 2022-12-20 US US18/722,189 patent/US20250049779A1/en active Pending
- 2022-12-20 CA CA3256789A patent/CA3256789A1/en active Pending
- 2022-12-20 MX MX2024007768A patent/MX2024007768A/es unknown
- 2022-12-20 AU AU2022418121A patent/AU2022418121A1/en active Pending
- 2022-12-20 TW TW111148911A patent/TW202342033A/zh unknown
- 2022-12-20 WO PCT/EP2022/086965 patent/WO2023118123A1/en not_active Ceased
- 2022-12-20 IL IL313646A patent/IL313646A/en unknown
- 2022-12-20 JP JP2024537375A patent/JP2025500344A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023118123A1 (en) | 2023-06-29 |
| CN118475347A (zh) | 2024-08-09 |
| US20250049779A1 (en) | 2025-02-13 |
| JP2025500344A (ja) | 2025-01-09 |
| TW202342033A (zh) | 2023-11-01 |
| EP4452242A1 (en) | 2024-10-30 |
| AU2022418121A1 (en) | 2024-07-04 |
| MX2024007768A (es) | 2024-07-01 |
| KR20240124995A (ko) | 2024-08-19 |
| IL313646A (en) | 2024-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20220218700A1 (en) | Combination of an ?2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea | |
| JP7592007B2 (ja) | 睡眠時無呼吸の治療のためのα２‐アドレナリン受容体サブタイプＣ （ＡＬＰＨＡ‐２Ｃ）拮抗薬 | |
| US20250049779A1 (en) | Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonist with a norepinephrine reuptake inhibitor for the treatment of sleep apnea | |
| US20250057828A1 (en) | Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonist with a norepinephrine reuptake inhibitor for the treatment of sleep apnea | |
| HK40116247A (zh) | 用於治疗睡眠呼吸暂停的α2-肾上腺素受体亚型C(α-2C)拮抗剂与降肾上腺素重摄取抑制剂的结合物 | |
| HK40114784A (zh) | 用於治疗睡眠呼吸暂停的α 2-肾上腺素受体亚型C(α -2C)拮抗剂与毒蕈碱受体拮抗剂的结合物 | |
| HK40115354A (zh) | 用於治疗睡眠呼吸暂停的2 ,3-二氢苯并[b][1，4]二恶英-2-基甲基)哌嗪-1-基衍生物 | |
| US20250049788A1 (en) | 2,3-dihydrobenzo [b][1, 4]dioxin-2-ylmethyl)piperazin-1-yl derivates for the treatment of sleep apnea | |
| US20220016113A1 (en) | ?2-adrenoceptor subtype c (alpha-2c) antagonists for the treatment of sleep apnea | |
| US20250074899A1 (en) | A2-adrenoceptor subtype c antagonists for the treatment of sleep apnea | |
| EA045860B1 (ru) | АНТАГОНИСТЫ α2-АДРЕНОРЕЦЕПТОРОВ ПОДТИПА С (АЛЬФА-2С АДРЕНОРЕЦЕПТОРОВ) ДЛЯ ЛЕЧЕНИЯ АПНОЭ ВО СНЕ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A00 | Application filed |
Free format text: ST27 STATUS EVENT CODE: A-1-1-A10-A00-A102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: COMPLIANCE REQUIREMENTS DETERMINED MET Effective date: 20241205 |
|
| A15 | Pct application entered into the national or regional phase |
Free format text: ST27 STATUS EVENT CODE: A-1-1-A10-A15-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: NATIONAL ENTRY REQUIREMENTS DETERMINED COMPLIANT Effective date: 20241205 |
|
| P18 | Priority claim added or amended |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P18-P105 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRIORITY CLAIM REQUIREMENTS DETERMINED COMPLIANT Effective date: 20241205 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20241205 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 2ND ANNIV.) - STANDARD Year of fee payment: 2 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241209 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20241209 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD Year of fee payment: 3 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251028 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251028 |