CA3255671A1 - 5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression - Google Patents

5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression

Info

Publication number
CA3255671A1
CA3255671A1 CA3255671A CA3255671A CA3255671A1 CA 3255671 A1 CA3255671 A1 CA 3255671A1 CA 3255671 A CA3255671 A CA 3255671A CA 3255671 A CA3255671 A CA 3255671A CA 3255671 A1 CA3255671 A1 CA 3255671A1
Authority
CA
Canada
Prior art keywords
dmt
meo
acceptable salt
pharmaceutically acceptable
score
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3255671A
Other languages
English (en)
French (fr)
Inventor
Theis Terwey
Conor Burke
Naoise GAFFNEY
Original Assignee
GH Research Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GH Research Ireland Ltd filed Critical GH Research Ireland Ltd
Priority claimed from PCT/EP2023/057874 external-priority patent/WO2023186827A1/en
Publication of CA3255671A1 publication Critical patent/CA3255671A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3255671A 2022-03-27 2023-03-27 5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression Pending CA3255671A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP22000085 2022-03-27
EP22000084.8 2022-03-27
EP22000085.5 2022-03-27
EP22000084 2022-03-27
EP23154014.7 2023-01-30
EP23153996 2023-01-30
EP23154014 2023-01-30
EP23153996.6 2023-01-30
PCT/EP2023/057874 WO2023186827A1 (en) 2022-03-27 2023-03-27 5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression

Publications (1)

Publication Number Publication Date
CA3255671A1 true CA3255671A1 (en) 2023-10-05

Family

ID=93292078

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3255671A Pending CA3255671A1 (en) 2022-03-27 2023-03-27 5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression

Country Status (8)

Country Link
US (1) US20250205200A1 (enExample)
EP (1) EP4499080A1 (enExample)
JP (1) JP2025510915A (enExample)
KR (1) KR20240167886A (enExample)
CN (1) CN119156213A (enExample)
AU (1) AU2023242438A1 (enExample)
CA (1) CA3255671A1 (enExample)
IL (1) IL315894A (enExample)

Also Published As

Publication number Publication date
KR20240167886A (ko) 2024-11-28
AU2023242438A1 (en) 2024-11-07
EP4499080A1 (en) 2025-02-05
US20250205200A1 (en) 2025-06-26
JP2025510915A (ja) 2025-04-15
IL315894A (en) 2024-11-01
CN119156213A (zh) 2024-12-17

Similar Documents

Publication Publication Date Title
WO2023186827A1 (en) 5-methoxy-n,n-dimethyltryptamine for the treatment of postpartum depression
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