CA3238531A1 - Methods and compositions for discovery of receptor-ligand specificity by engineered cell entry - Google Patents

Methods and compositions for discovery of receptor-ligand specificity by engineered cell entry Download PDF

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Publication number
CA3238531A1
CA3238531A1 CA3238531A CA3238531A CA3238531A1 CA 3238531 A1 CA3238531 A1 CA 3238531A1 CA 3238531 A CA3238531 A CA 3238531A CA 3238531 A CA3238531 A CA 3238531A CA 3238531 A1 CA3238531 A1 CA 3238531A1
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cell
cells
lentivirus
antigen
protein
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CA3238531A
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English (en)
French (fr)
Inventor
Howard Y. Chang
Ansuman Satpathy
Bingfei YU
Quanming SHI
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/622—Single chain antibody (scFv)
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    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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CA3238531A 2021-12-06 2022-12-05 Methods and compositions for discovery of receptor-ligand specificity by engineered cell entry Pending CA3238531A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163286507P 2021-12-06 2021-12-06
US63/286,507 2021-12-06
US202263382860P 2022-11-08 2022-11-08
US63/382,860 2022-11-08
PCT/US2022/080915 WO2023107886A1 (en) 2021-12-06 2022-12-05 Methods and compositions for discovery of receptor-ligand specificity by engineered cell entry

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CA3238531A1 true CA3238531A1 (en) 2023-06-15

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CA3238531A Pending CA3238531A1 (en) 2021-12-06 2022-12-05 Methods and compositions for discovery of receptor-ligand specificity by engineered cell entry

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US (1) US20250027073A1 (enExample)
EP (1) EP4444878A4 (enExample)
JP (1) JP2024542811A (enExample)
KR (1) KR20240112950A (enExample)
AU (1) AU2022405508A1 (enExample)
CA (1) CA3238531A1 (enExample)
IL (1) IL312832A (enExample)
WO (1) WO2023107886A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4281569A4 (en) * 2021-01-25 2025-04-02 The Regents Of The University Of California Methods and compositions for labeling and selecting antigen-specific T cells
EP4602174A1 (en) * 2022-10-13 2025-08-20 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells
WO2025036498A1 (zh) * 2023-08-16 2025-02-20 深圳市济因生物科技有限公司 一种病毒载体及其在感染b细胞中的应用
KR20260114539A (ko) 2023-09-29 2026-07-22 오비탈 테라퓨틱스, 인크. 스플린트형 라이게이션에 의해 rna를 제조하는 개선된 방법 및 그의 조성물
WO2025212851A2 (en) 2024-04-03 2025-10-09 Orbital Therapeutics, Inc. mRNA COMPOSITIONS AND USES THEREOF IN VARICELLA ZOSTER VIRUS VACCINES
WO2025259931A1 (en) 2024-06-14 2025-12-18 Orbital Therapeutics, Inc. Compositions and methods for rna circularization
WO2026006203A2 (en) 2024-06-24 2026-01-02 Orbital Therapeutics, Inc. Compositions and methods for making circular rna
WO2026006687A1 (en) 2024-06-28 2026-01-02 Orbital Therapeutics, Inc. Circular rna compositions and uses thereof for diseases caused by varicella-zoster virus
CN122128364A (zh) * 2026-05-07 2026-06-02 浙江大学 一种基于胞啃作用的TCR与pMHC双向识别高通量筛选方法

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WO2021178701A1 (en) * 2020-03-05 2021-09-10 Exuma Biotech Corp. Methods and compositions for the delivery of modified lymphocyte aggregates
PT3684786T (pt) * 2017-09-22 2024-10-30 Centre Nat Rech Scient Glicoproteína mutante do vírus da estomatite vesicular
US11535865B2 (en) * 2018-02-06 2022-12-27 The Broad Institute, Inc. Co-packaging to mitigate intermolecular recombination
CN114127305A (zh) * 2019-05-23 2022-03-01 麻省理工学院 经由逆转录病毒表面展示的配体发现和基因递送
US12195723B2 (en) * 2019-11-08 2025-01-14 The Broad Institute, Inc. Engineered antigen presenting cells and uses thereof

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Publication number Publication date
EP4444878A4 (en) 2026-04-29
JP2024542811A (ja) 2024-11-15
EP4444878A1 (en) 2024-10-16
WO2023107886A1 (en) 2023-06-15
US20250027073A1 (en) 2025-01-23
KR20240112950A (ko) 2024-07-19
IL312832A (en) 2024-07-01
AU2022405508A1 (en) 2024-05-30

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