CA3237341A1 - Bcma-targeted car-t cell therapy for multiple myeloma - Google Patents

Bcma-targeted car-t cell therapy for multiple myeloma Download PDF

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Publication number
CA3237341A1
CA3237341A1 CA3237341A CA3237341A CA3237341A1 CA 3237341 A1 CA3237341 A1 CA 3237341A1 CA 3237341 A CA3237341 A CA 3237341A CA 3237341 A CA3237341 A CA 3237341A CA 3237341 A1 CA3237341 A1 CA 3237341A1
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CA
Canada
Prior art keywords
approximately
response
cells
effective
car
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3237341A
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English (en)
French (fr)
Inventor
Muhammad AKRAM
Kevin DEBRAGANCA
Xiaohu FAN
Dong GENG
Tonia NESHEIWAT
Lida PACAUD
Jordan SCHECTER
Helen VARSOS
Enrique ZUDAIRE UBANI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Legend Biotechnology Co Ltd
Janssen Biotech Inc
Legend Biotech USA Inc
Original Assignee
Nanjing Legend Biotechnology Co Ltd
Janssen Biotech Inc
Legend Biotech USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2021/128578 external-priority patent/WO2023077343A1/en
Application filed by Nanjing Legend Biotechnology Co Ltd, Janssen Biotech Inc, Legend Biotech USA Inc filed Critical Nanjing Legend Biotechnology Co Ltd
Publication of CA3237341A1 publication Critical patent/CA3237341A1/en
Pending legal-status Critical Current

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K2319/00—Fusion polypeptide
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CA3237341A 2021-11-04 2022-11-03 Bcma-targeted car-t cell therapy for multiple myeloma Pending CA3237341A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163275471P 2021-11-04 2021-11-04
CNPCT/CN2021/128578 2021-11-04
US63/275,471 2021-11-04
PCT/CN2021/128578 WO2023077343A1 (en) 2021-11-04 2021-11-04 Bcma-targeted car-t cell therapy for multiple myeloma
PCT/US2022/079216 WO2023081752A1 (en) 2021-11-04 2022-11-03 Bcma-targeted car-t cell therapy for multiple myeloma

Publications (1)

Publication Number Publication Date
CA3237341A1 true CA3237341A1 (en) 2023-05-11

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ID=84370104

Family Applications (1)

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CA3237341A Pending CA3237341A1 (en) 2021-11-04 2022-11-03 Bcma-targeted car-t cell therapy for multiple myeloma

Country Status (11)

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US (1) US20230277589A1 (https=)
EP (1) EP4426737A1 (https=)
JP (1) JP2024540275A (https=)
KR (1) KR20240117530A (https=)
CN (1) CN118510801A (https=)
AU (1) AU2022381186A1 (https=)
CA (1) CA3237341A1 (https=)
IL (1) IL312602A (https=)
JO (1) JOP20240104A1 (https=)
MX (1) MX2024005461A (https=)
WO (1) WO2023081752A1 (https=)

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AU2020378263A1 (en) 2019-11-05 2022-06-23 Janssen Biotech, Inc. BCMA-targeted CAR-T cell therapy of multiple myeloma
WO2025006799A1 (en) 2023-06-27 2025-01-02 Capstan Therapeutics, Inc. Extracorporeal and ex vivo engineering of select cell populations from peripheral blood
WO2025076341A1 (en) * 2023-10-05 2025-04-10 Janssen Biotech, Inc. Improved methods in lentiviral manufacturing for production of car-t cell drug products
WO2025096878A1 (en) 2023-11-02 2025-05-08 Capstan Therapeutics, Inc. Rna for in vivo transfection with increased expression
US20250269024A1 (en) * 2024-02-05 2025-08-28 Legend Biotech Usa Inc. Bcma-targeted car-t cell therapy for multiple myeloma
WO2026072671A1 (en) 2024-09-24 2026-04-02 City Of Hope Methods comprising oncolytic viruses expressing bcmat and bcma-targeted therapies

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