CA3236073A1 - Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk - Google Patents

Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk Download PDF

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Publication number
CA3236073A1
CA3236073A1 CA3236073A CA3236073A CA3236073A1 CA 3236073 A1 CA3236073 A1 CA 3236073A1 CA 3236073 A CA3236073 A CA 3236073A CA 3236073 A CA3236073 A CA 3236073A CA 3236073 A1 CA3236073 A1 CA 3236073A1
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CA
Canada
Prior art keywords
compound
cancer
formula
certain embodiments
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3236073A
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English (en)
French (fr)
Inventor
Robert J. Brown
Arthur T. Sands
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nurix Therapeutics Inc
Original Assignee
Nurix Therapeutics Inc
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Filing date
Publication date
Application filed by Nurix Therapeutics Inc filed Critical Nurix Therapeutics Inc
Publication of CA3236073A1 publication Critical patent/CA3236073A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3236073A 2021-10-26 2022-10-25 Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk Pending CA3236073A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163263081P 2021-10-26 2021-10-26
US63/263,081 2021-10-26
US202263391671P 2022-07-22 2022-07-22
US63/391,671 2022-07-22
PCT/US2022/047767 WO2023076303A1 (en) 2021-10-26 2022-10-25 Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk

Publications (1)

Publication Number Publication Date
CA3236073A1 true CA3236073A1 (en) 2023-05-04

Family

ID=84361163

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3236073A Pending CA3236073A1 (en) 2021-10-26 2022-10-25 Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk

Country Status (9)

Country Link
US (1) US12377106B2 (enExample)
EP (1) EP4422630A1 (enExample)
JP (1) JP2024542984A (enExample)
KR (1) KR20240090898A (enExample)
AU (1) AU2022379494A1 (enExample)
CA (1) CA3236073A1 (enExample)
IL (1) IL312357A (enExample)
MX (1) MX2024004899A (enExample)
WO (1) WO2023076303A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113412259B (zh) 2018-10-15 2024-07-16 紐力克斯治疗公司 通过泛素蛋白酶体途径降解btk的双官能化合物
WO2020167518A1 (en) 2019-02-13 2020-08-20 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
MX2022006672A (es) 2019-12-04 2022-08-08 Nurix Therapeutics Inc Compuestos bifuncionales para la degradacion de btk a traves de la via de proteosomas de ubiquitina.
WO2023076303A1 (en) 2021-10-26 2023-05-04 Nurix Therapeutics, Inc. Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk

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WO2023076303A1 (en) 2021-10-26 2023-05-04 Nurix Therapeutics, Inc. Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk

Also Published As

Publication number Publication date
KR20240090898A (ko) 2024-06-21
MX2024004899A (es) 2024-05-24
WO2023076303A1 (en) 2023-05-04
US12377106B2 (en) 2025-08-05
US20230149416A1 (en) 2023-05-18
IL312357A (en) 2024-06-01
JP2024542984A (ja) 2024-11-19
EP4422630A1 (en) 2024-09-04
AU2022379494A1 (en) 2024-05-30

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