CA3235802A1 - Compositions and methods for treating muscular dystrophy - Google Patents

Compositions and methods for treating muscular dystrophy Download PDF

Info

Publication number
CA3235802A1
CA3235802A1 CA3235802A CA3235802A CA3235802A1 CA 3235802 A1 CA3235802 A1 CA 3235802A1 CA 3235802 A CA3235802 A CA 3235802A CA 3235802 A CA3235802 A CA 3235802A CA 3235802 A1 CA3235802 A1 CA 3235802A1
Authority
CA
Canada
Prior art keywords
antibody
clq
seq
amino acid
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3235802A
Other languages
English (en)
French (fr)
Inventor
Stefano BIRESSI
Francesca FLORIO
Yaisa Andrews-Zwilling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Trento
Fondazione Telethon
Annexon Inc
Original Assignee
Universita degli Studi di Trento
Fondazione Telethon
Annexon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Trento, Fondazione Telethon, Annexon Inc filed Critical Universita degli Studi di Trento
Publication of CA3235802A1 publication Critical patent/CA3235802A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3235802A 2021-10-21 2022-10-21 Compositions and methods for treating muscular dystrophy Pending CA3235802A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163270352P 2021-10-21 2021-10-21
US63/270,352 2021-10-21
PCT/US2022/078510 WO2023070087A1 (en) 2021-10-21 2022-10-21 Compositions and methods for treating muscular dystrophy

Publications (1)

Publication Number Publication Date
CA3235802A1 true CA3235802A1 (en) 2023-04-27

Family

ID=86059727

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3235802A Pending CA3235802A1 (en) 2021-10-21 2022-10-21 Compositions and methods for treating muscular dystrophy

Country Status (5)

Country Link
US (1) US20250230225A1 (https=)
EP (1) EP4419144A4 (https=)
JP (1) JP2024539141A (https=)
CA (1) CA3235802A1 (https=)
WO (1) WO2023070087A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117174164B (zh) * 2023-10-30 2024-02-13 晨伫(杭州)生物科技有限责任公司 基于预测蛋白质-小分子结合姿势筛选先导化合物的方法
EP4670793A1 (en) * 2024-06-24 2025-12-31 Montis Biosciences BV C1Q ANTIGEN BINDING MOLECULES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3019240T3 (da) * 2013-07-09 2024-06-03 Annexon Inc Anti-komplementfaktor C1Q antistoffer og anvendelser deraf

Also Published As

Publication number Publication date
EP4419144A4 (en) 2026-01-14
JP2024539141A (ja) 2024-10-28
EP4419144A1 (en) 2024-08-28
US20250230225A1 (en) 2025-07-17
WO2023070087A1 (en) 2023-04-27

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