CA3235762A1 - Petites molecules inhibitrices de la protease 1 specifique de l'ubiquitine (usp1) et leurs utilisations - Google Patents
Petites molecules inhibitrices de la protease 1 specifique de l'ubiquitine (usp1) et leurs utilisations Download PDFInfo
- Publication number
- CA3235762A1 CA3235762A1 CA3235762A CA3235762A CA3235762A1 CA 3235762 A1 CA3235762 A1 CA 3235762A1 CA 3235762 A CA3235762 A CA 3235762A CA 3235762 A CA3235762 A CA 3235762A CA 3235762 A1 CA3235762 A1 CA 3235762A1
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- Prior art keywords
- optionally substituted
- alkyl
- heterocycloalkyl
- cycloalkyl
- compound
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- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 description 1
- 208000030045 thyroid gland papillary carcinoma Diseases 0.000 description 1
- 208000019179 thyroid gland undifferentiated (anaplastic) carcinoma Diseases 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- NNBZCPXTIHJBJL-UHFFFAOYSA-N trans-decahydronaphthalene Natural products C1CCCC2CCCCC21 NNBZCPXTIHJBJL-UHFFFAOYSA-N 0.000 description 1
- NNBZCPXTIHJBJL-MGCOHNPYSA-N trans-decalin Chemical compound C1CCC[C@@H]2CCCC[C@H]21 NNBZCPXTIHJBJL-MGCOHNPYSA-N 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000005580 triphenylene group Chemical group 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000037965 uterine sarcoma Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 201000005102 vulva cancer Diseases 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Abstract
L'invention concerne de petites molécules inhibitrices de la protéase 1 spécifique de l'ubiquitine (USP1) et des compositions les comprenant. L'invention concerne en outre des méthodes de ciblage de la protéase 1 spécifique de l'ubiquitine (USP1) et des méthodes de traitement de maladies ou de troubles associés à l'USP1, tels que des cancers.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2021/130289 | 2021-11-12 | ||
| CN2021130289 | 2021-11-12 | ||
| PCT/CN2022/131359 WO2023083297A1 (fr) | 2021-11-12 | 2022-11-11 | Petites molécules inhibitrices de la protéase 1 spécifique de l'ubiquitine (usp1) et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3235762A1 true CA3235762A1 (fr) | 2023-05-19 |
Family
ID=90823033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3235762A Pending CA3235762A1 (fr) | 2021-11-12 | 2022-11-11 | Petites molecules inhibitrices de la protease 1 specifique de l'ubiquitine (usp1) et leurs utilisations |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA3235762A1 (fr) |
-
2022
- 2022-11-11 CA CA3235762A patent/CA3235762A1/fr active Pending
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