CA3235262A1 - Constructions d'arni pour inhiber l'expression de gpam et leurs methodes d'utilisation - Google Patents
Constructions d'arni pour inhiber l'expression de gpam et leurs methodes d'utilisation Download PDFInfo
- Publication number
- CA3235262A1 CA3235262A1 CA3235262A CA3235262A CA3235262A1 CA 3235262 A1 CA3235262 A1 CA 3235262A1 CA 3235262 A CA3235262 A CA 3235262A CA 3235262 A CA3235262 A CA 3235262A CA 3235262 A1 CA3235262 A1 CA 3235262A1
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- invab
- rnai construct
- gpam
- nucleotides
- rnai
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Classifications
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/321—2'-O-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Abstract
La divulgation concerne des constructions d'ARNi, telles que l'ARNsi, pour réduire l'expression du gène GPAM. La divulgation concerne également des méthodes d'utilisation de ces constructions d'ARNi pour traiter ou prévenir une maladie hépatique, telle qu'une stéatose hépatique non alcoolique (NAFLD).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US202163270813P | 2021-10-22 | 2021-10-22 | |
US63/270,813 | 2021-10-22 | ||
PCT/US2022/047491 WO2023069754A2 (fr) | 2021-10-22 | 2022-10-21 | Constructions d'arni pour inhiber l'expression de gpam et leurs méthodes d'utilisation |
Publications (1)
Publication Number | Publication Date |
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CA3235262A1 true CA3235262A1 (fr) | 2023-04-27 |
Family
ID=84360886
Family Applications (1)
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CA3235262A Pending CA3235262A1 (fr) | 2021-10-22 | 2022-10-21 | Constructions d'arni pour inhiber l'expression de gpam et leurs methodes d'utilisation |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2022370883A1 (fr) |
CA (1) | CA3235262A1 (fr) |
WO (1) | WO2023069754A2 (fr) |
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ATE241426T1 (de) | 1991-11-22 | 2003-06-15 | Affymetrix Inc A Delaware Corp | Verfahren zur herstellung von polymerarrays |
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JP4597976B2 (ja) | 2003-04-17 | 2010-12-15 | アルナイラム ファーマシューティカルズ インコーポレイテッド | 修飾iRNA剤 |
US8017762B2 (en) | 2003-04-17 | 2011-09-13 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
WO2008131419A2 (fr) | 2007-04-23 | 2008-10-30 | Alnylam Pharmaceuticals, Inc. | Glycoconjugués d'agents d'interférence arn |
CA3146103A1 (fr) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Conjugues glucidiques utilises en tant qu'agents d'administration pour des oligonucleotides |
AU2009265836A1 (en) * | 2008-07-03 | 2010-01-07 | Santaris Pharma A/S | RNA antagonist compounds for the inhibition of expression of mitochondrial glycerol-3-phosphate acyltransferase 1 (mtGPAT1) |
EP2536411A4 (fr) * | 2010-02-18 | 2013-08-07 | Univ Princeton | Inhibiteurs du métabolisme d'acide gras à longue et très longue chaîne comme antiviraux à large spectre |
AU2012272908A1 (en) | 2011-06-21 | 2013-12-19 | Alnylam Pharmaceuticals, Inc. | Assays and methods for determining activity of a therapeutic agent in a subject |
AR090905A1 (es) | 2012-05-02 | 2014-12-17 | Merck Sharp & Dohme | Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica |
EP3564374A1 (fr) | 2013-06-21 | 2019-11-06 | Ionis Pharmaceuticals, Inc. | Compositions et procédés de modulation d'acides nucléiques cibles |
-
2022
- 2022-10-21 CA CA3235262A patent/CA3235262A1/fr active Pending
- 2022-10-21 WO PCT/US2022/047491 patent/WO2023069754A2/fr active Application Filing
- 2022-10-21 AU AU2022370883A patent/AU2022370883A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2023069754A2 (fr) | 2023-04-27 |
WO2023069754A3 (fr) | 2023-05-25 |
AU2022370883A1 (en) | 2024-04-18 |
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